Role of CB-NAAT in diagnosing Mycobacterial tuberculosis and rifampicin resistance in tubercular peripheral lymphadenopathy
Open accessAbstract
Introduction: Diagnosis of Extra Pulmonary TB (EPTB) remains a challenge. This study assessed the applicability of CB-NAAT in early diagnosis of EPTB, especially peripheral lymphadenopathy and early identification of MDR-TB in TB lymphadenopathy. Material & Method: This was a prospective, cross sectional study, carried out on all patients of age group 10 to 80 years, who were suspected cases of tubercular peripheral lymphadenopathy, visiting the OPD of the Department of Pulmonary Medicine, People’s Hospital, Bhopal, over a period of 1 year 6 months. FNA of peripheral lymph nodes of 57 patients was sent for cytology and CB-NAAT. Result: This study showed that statistical difference in diagnostic yield of FNAC (47/57 i.e. 82.4%) and CB-NAAT (44/57 i.e. 77.19%) in tubercular peripheral lymphnode sample was not significant. This implies that there was not much difference in these two test results. There was no rifampicin resistance in the population studied. Conclusion: CB-NAAT did not diagnose more cases of TB-LN than FNAC.
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The sensitivity of ZN in the present study was lower than that reported from India (91%).
“The sensitivity of ZN in the present study was lower than that reported from Tirupati, India (83.3%) [19] and India(91%) [20], while it was higher than that reported from Bangladesh (17.6%) [21] and Ethiopia (22.9%) [22].”
From Performance of fine needle aspiration cytology and Ziehl-Neelsen staining technique in the diagnosis of tuberculosis lymphadenitis (2024) · cites this paper as [20]
The Abstract and Discussion report FNAC and CB-NAAT results for patients in Bhopal, but do not report a 91% sensitivity for ZN staining. Searches for “ZN sensitivity 91%,” “Ziehl Neelsen staining,” and “91%” found no passage establishing the figure attributed to this paper. (LLM, conf=0.75)
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- Authors
- P.G Resident, D. O. P. M., Singh, D. K. G., Tandon, D. S., Professor and Head, D. O. P. M., Nagdeote, D. S. T., Professor, D. O. P. M., Sharma, D. K., Assistant Professor, D. O. P. M., Kumar, D. A., & P.G Resident, D. O. P. M.
- Venue
- International Journal of Medical Research and Review
- Published
- 2017-03-31
- Volume
- 5
- Issue
- 3
- Pages
- 242-246
- ISSN
- 2320-8686 (ISSN-L)
- 2321-127X
- OpenAlex
- W2754170296
- Cited by
- 18
- References
- 17
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- International Journal of Medical Research and Review (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- Mycobacterium tuberculosis, peripheral lymphadenopathy, rifampicin resistance, multidrug-resistant tuberculosis, extrapulmonary tuberculosis, fine needle aspiration cytology, diagnostic yield, molecular diagnosis
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