Skin Autofluorescence – A Non-invasive Measurement for Assessing Cardiovascular Risk and Risk of Diabetes
Open accessAbstract
The results of the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) study have strengthened the ‘glycaemic memory’ concept, postulating that the quality of metabolic control over several years predicts the development of diabetic complications. To mirror long-term metabolic control, the degree of glycated haemoglobin (HbA 1c ) might not represent the optimal biomarker. Other substances with a longer persistence, like the so-called advanced glycation end-products (AGEs), which probably form the substrate of the glycaemic memory, might perform better. Newly developed methods such as the assessment of skin autofluorescence (SAF), enable fast, uncomplicated and non-invasive AGEs assessment. SAF was validated for diabetes screening and shows a good predictive value for the development of diabetic and cardiovascular complications. This article deals with the theoretical background and with available clinical data on this new variable.
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Skin AF measurement correlates well with total amount of AGEs in skin biopsies.
“The measurement correlates well with the total amount of AGEs in skin biopsies”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [161]
The section on skin autofluorescence as a surrogate for AGE accumulation says SAF measurements were validated against biochemical analyses of skin biopsies. However, the Measurement of the Skin Autofluorescence section explains that some AGEs do not fluoresce and that other substances also contribute to autofluorescence. The paper supports SAF as a surrogate for skin AGE accumulation, but does not establish that it correlates well with the total amount of AGEs in biopsies. (LLM, conf=0.83)
Experimental — accuracy not yet measuredSkin AF has been applied in clinical settings, indicating elevated AGE levels in several diseases and aging.
“has been applied in clinical settings, indicating elevated AGE levels in several diseases and aging, as shown in Table 5”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [161]
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- Authors
- Stirban, A., Heinemann, L., Complications, D. E. A. D., & Senior Scientific Consultant, P.
- Corresponding author
- Stirban, Alin
- ORCID
- Heinemann, Lutz
- Venue
- European Endocrinology
- Publisher
- Touch Medical Media, Ltd.
- Published
- 2014
- Volume
- 10
- Issue
- 2
- Pages
- 106
- ISSN
- 1758-3772 (ISSN-L)
- PMC
- PMC5983078
- OpenAlex
- W2494719080
- Cited by
- 38
- References
- 70
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2015: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- touchREVIEWS in Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- skin autofluorescence, advanced glycation end products, cardiovascular risk, diabetes risk, non-invasive biomarkers, long-term glycemic control, diabetes complications, diabetes screening
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