The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats
Open accessAbstract
One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus. Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.
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“As for CoQ10, SkQ1 given to senescence prone rats at the concentration of 250 µmol/kg/day may be sufficient to prevent the physiological age-related deterioration of immunological defences [98].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [98]
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Neuroprotective effects of berry fruits on neurodegenerative diseases
Essa, M. M., Subash, S., Al‐Adawi, S., Memon, M. A., Manivasagam, T., & Akbar, M. D. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.139483 · Cited by 178
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Metadata
- Authors
- Obukhova, L. A., Skulachev, V. P., & Kolosova, N. G.
- Affiliations
- Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk 630090, Russia
- Corresponding author
- Skulachev, Vladimir P.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2009-04-22
- Volume
- 1
- Issue
- 4
- Pages
- 389-401
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC2830050
- OpenAlex
- W1536029675
- Cited by
- 106
- References
- 27
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 23 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 2 · 2014: 12 · 2013: 6 · 2012: 5
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SkQ1, mitochondria-targeted antioxidants, thymic involution, OXYS rats, thymic cellularity, thymic cortex and medulla, CD3+ T cells, CD4+ T cells, CD8+ T cells, immunosenescence, infection susceptibility
- MeSH terms
- Aging, Animals, Antioxidants, Mitochondria, Plastoquinone, Thymus Gland, Rats, Wistar, Rats
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