The Mitochondria-Targeted Antioxidant SkQ1 but Not N-Acetylcysteine Reverses Aging-Related Biomarkers in Rats

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works

The Free Radical Theory of Aging

Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 926 · see citing works

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 663 · see citing works

Oxidative stress and aberrant signaling in aging and cognitive decline

Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479 · see citing works

mTOR Signaling in Disease

Dazert, E., & Hall, M. N. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.003 · Cited by 460 · see citing works

The antioxidants α‐lipoic acid and <i>N</i> ‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., Butterfield, D. A., & Morley, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01580.x · Cited by 459 · see citing works

The ageing immune system: is it ever too old to become young again?

Dorshkind, K., Montecino-Rodriguez, E., & Signer, R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 445 · see citing works

An Attempt to Prevent Senescence: A Mitochondrial Approach

Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430 · see citing works

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

Cho, R. H., Sieburg, H. B., & Muller-Sieburg, C. E. (2008) · Blood · doi:10.1182/blood-2007-11-123547 · Cited by 377 · see citing works

Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

Blagosklonny, M. V. (2006) · Cell Cycle · doi:10.4161/cc.5.18.3288 · Cited by 373 · see citing works

Sirtuins in Aging and DiseasePreprint

Guarente, L. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.024 · Cited by 371 · see citing works

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., Rosenfeld, S. V., & Blagosklonny, M. V. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18486 · Cited by 347 · see citing works

The TOR pathway comes of age

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 339 · see citing works

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

Antonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Y., Izyumov, D. S., Khailova, L. S., Klishin, S. S., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120018 · Cited by 326 · see citing works

If Started Early in Life, Metformin Treatment Increases Life Span and Postpones Tumors in Female SHR Mice

Anisimov, V. N., Berstein, L. M., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Piskunova, T. S., Semenchenko, A. V., Tyndyk, M. L., Yurova, M. N., Kovalenko, I. G., et al. (2011) · Aging · doi:10.18632/aging.100273 · Cited by 285 · see citing works

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.

Korotchkina, L. G., Leontieva, O. V., Bukreeva, E. I., Demidenko, Z. N., Gudkov, A. V., & Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100160 · Cited by 278 · see citing works

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

Witte, M. E., Geurts, J. J. G., de Vries, H. E., van der Valk, P., & van Horssen, J. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.014 · Cited by 236 · see citing works

p53, ROS and senescence in the control of aging

Vigneron, A., & Vousden, K. H. (2010) · Aging · doi:10.18632/aging.100189 · Cited by 221 · see citing works

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213 · see citing works

Relationship Between Low Levels of Anabolic Hormones and 6-Year Mortality in Older Men The Aging in the Chianti Area (InCHIANTI) Study

Maggio, M. G. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.20.2249 · Cited by 201 · see citing works

Circulating insulin-like growth factor I and cognitive function: Neuromodulation throughout the lifespan

Aleman, A., & Torres‐Alemán, I. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.008 · Cited by 184 · see citing works

Regulation of energy metabolism by inflammation: A feedback response in obesity and calorie restriction

Ye, J., & Keller, J. N. (2010) · Aging · doi:10.18632/aging.100155 · Cited by 171 · see citing works

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

Kondratov, R. V., Vykhovanets, O., Kondratova, A. A., & Antoch, M. P. (2009) · Aging · doi:10.18632/aging.100113 · Cited by 159 · see citing works

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Leontieva, O. V., & Blagosklonny, M. V. (2010) · Aging · doi:10.18632/aging.100265 · Cited by 159 · see citing works

Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

V. Skulachev, M., N. Antonenko, Y., N. Anisimov, V., V. Chernyak, B., A. Cherepanov, D., A. Chistyakov, V., V. Egorov, M., G. Kolosova, N., A. Korshunova, G., G. Lyamzaev, K., et al. (2011) · Current Drug Targets · doi:10.2174/138945011795528859 · Cited by 156 · see citing works

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

Pavlides, S., Tsirigos, A., Vera, I., Flomenberg, N., Frank, P. G., Casimiro, M. C., Wang, C., Pestell, R. G., Martinez‐Outschoorn, U., Howell, A., et al. (2010) · Aging · doi:10.18632/aging.100134 · Cited by 151 · see citing works

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals

Neroev, V. V., Archipova, M. M., Bakeeva, L. E., Фурсова, А. Ж., Григорян, Э. Н., Grishanova, A. Y., Иомдина, Е. Н., Ivashchenko, Z. N., Катаргина, Л. А., Хорошилова-Маслова, И. П., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120043 · Cited by 141 · see citing works

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Anisimov, V. N., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Тындык, М. Л., Egormin, P. A., Yurova, M. N., Rosenfeld, S. V., Semenchenko, A. V., Kovalenko, I. G., et al. (2010) · Aging · doi:10.18632/aging.100245 · Cited by 126 · see citing works

Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster

Tong, J. J., Schriner, S. E., McCleary, D. F., Day, B. J., & Wallace, D. C. (2007) · Nature Genetics · doi:10.1038/ng2004 · Cited by 122 · see citing works

Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents

Anisimov, V. N., Egorov, M. V., Krasilshchikova, M. S., Lyamzaev, K. G., Манских, В. Н., Moshkin, M. P., Новиков, Е. А., Popovich, I. G., Rogovin, K. A., Shabalina, I. G., et al. (2011) · Aging · doi:10.18632/aging.100404 · Cited by 119 · see citing works

Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways

Taub, D. D., Murphy, W. J., & Longo, D. L. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.015 · Cited by 119 · see citing works

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila

Sanz, A., Fernández‐Ayala, D. J. M., Stefanatos, R. K. A., & Jacobs, H. T. (2010) · Aging · doi:10.18632/aging.100137 · Cited by 119 · see citing works

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Goldberg, A. A., Richard, V. R., Kyryakov, P., Bourque, S. D., Beach, A., Burstein, M. T., Glebov, A., Koupaki, O., Boukh‐Viner, T., Gregg, C., et al. (2010) · Aging · doi:10.18632/aging.100168 · Cited by 115 · see citing works

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Филенко, О. Ф., Филипповна, И. Е., Манских, В. Н., Mikhelson, V. M., Panteleeva, A. A., PASYUKOVA, E. G., Pilipenko, D. I., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120055 · Cited by 113 · see citing works

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

Hwang, A. B., & Lee, S. (2011) · Aging · doi:10.18632/aging.100292 · Cited by 108 · see citing works

Mitochondria-Targeted Antioxidant SkQ1 Inhibits Age-Dependent Involution of the Thymus in Normal and Senescence-Prone Rats

Obukhova, L. A., Skulachev, V. P., & Kolosova, N. G. (2009) · Aging · doi:10.18632/aging.100043 · Cited by 106 · see citing works

Protein aggregation as a paradigm of aging

Lindner, A. B., & Démarez, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.005 · Cited by 106 · see citing works

Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

Château, M., Araiz, C., Descamps, S., & Galas, S. (2010) · Aging · doi:10.18632/aging.100195 · Cited by 101 · see citing works

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

Leontieva, O. V., & Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100402 · Cited by 101 · see citing works

Immunosenescence of Polymorphonuclear Neutrophils

Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works

Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline.

Conrad, C., & Bimonte-Nelson, H. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82002-3 · Cited by 80 · see citing works

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

Stefanova, N. A., Фурсова, А. Ж., & Kolosova, N. G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091675 · Cited by 78 · see citing works

Changes with ageing in several leukocyte functions of male and female rats

la Fuente, M. D., Baeza, I., Guayerbas, N., Puerto, M., Castillo, C., Salazar, V., Ariznavarreta, C., & F-Tresguerres, J. A. (2004) · Biogerontology (Dordrecht) · doi:10.1007/s10522-004-3201-8 · Cited by 76 · see citing works

Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans

Weiss, E. P., Villareal, D. T., Fontana, L., Han, D., & Holloszy, J. O. (2011) · Aging · doi:10.18632/aging.100327 · Cited by 72 · see citing works

Accelerated aging in the tumor microenvironment

Lisanti, M. P., Martinez‐Outschoorn, U., Pavlides, S., Whitaker‐Menezes, D., Pestell, R. G., Howell, A., & Sotgia, F. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16233 · Cited by 67 · see citing works

Dehydroepiandrosterone and age-related cognitive decline

Sorwell, K. G., & Urbanski, H. F. (2009) · AGE · doi:10.1007/s11357-009-9113-4 · Cited by 66 · see citing works

Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats

Markovets, A. M., Saprunova, V. B., Александровна, Ж. А., Фурсова, А. Ж., Bakeeva, L. E., & Kolosova, N. G. (2010) · Aging · doi:10.18632/aging.100243 · Cited by 66 · see citing works

Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Moskalev, A., & Shaposhnikov, M. V. (2011) · Aging · doi:10.18632/aging.100314 · Cited by 62 · see citing works

Gerosuppressant Metformin: less is more

Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Vellón, L., Joven, J., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100316 · Cited by 57 · see citing works

ROS induced DNA damage and checkpoint responses: Influences on aging?

Guachalla, L. M., & Rudolph, K. L. (2010) · Cell Cycle · doi:10.4161/cc.9.20.13577 · Cited by 54 · see citing works

Anti‐ageing strategies: prevention or therapy?

Rattan, S. I. S. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400401 · Cited by 52 · see citing works

Progeria, rapamycin and normal aging: recent breakthrough

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100352 · Cited by 50 · see citing works

Aging as a particular case of phenoptosis, the programmed death of an organism (A response to Kirkwood and Melov “On the programmed/non-programmed nature of ageing within the life history”)

Skulachev, V. P. (2011) · Aging · doi:10.18632/aging.100403 · Cited by 45 · see citing works

Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats

Li, E., Kim, D. H., Cai, M., Lee, S., Kim, Y., Lim, E., Ryu, J. H., Unterman, T. G., & Park, S. (2011) · Endocrine Journal · doi:10.1507/endocrj.k11e-006 · Cited by 45 · see citing works

P66SHC and Ageing: ROS and TOR?

Pani, G. (2010) · Aging · doi:10.18632/aging.100182 · Cited by 41 · see citing works

Development of behavioural dysfunctions in accelerated-senescence OXYS rats is associated with early postnatal alterations in brain phosphate metabolism

Sergeeva, S. V., Bagryanskaya, E. G., Korbolina, E. E., & Kolosova, N. G. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.009 · Cited by 38 · see citing works

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer

Hofseth, L. J., Singh, U. P., Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2010) · Aging · doi:10.18632/aging.100143 · Cited by 36 · see citing works

Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats

Stefanova, N. A., Фурсова, А. Ж., Sarsenbayev, K. N., & Kolosova, N. G. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.10.017 · Cited by 34 · see citing works

Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked?

Papaconstantinou, J., & Hsieh, C.-C. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13324 · Cited by 34 · see citing works

mTOR pathway activation in age-related retinal disease

Zhao, C., & Vollrath, D. (2011) · Aging · doi:10.18632/aging.100303 · Cited by 32 · see citing works

Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing

Puerto, M., Guayerbas, N., Víctor, V. M., & la Fuente, M. D. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00902-4 · Cited by 29 · see citing works

One size may not fit all: anti-aging therapies and sarcopenia

Burks, T. N., & Cohn, R. D. (2011) · Aging · doi:10.18632/aging.100409 · Cited by 28 · see citing works

Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1

Shipounova, I. N., Svinareva, D. A., Petrova, T. V., Lyamzaev, K. G., Chernyak, B. V., Дризе, Н. И., & Skulachev, V. P. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.003 · Cited by 27 · see citing works

SkQ1 treatment and food restriction — two ways to retard an aging program of organisms

Skulachev, V. P. (2011) · Aging · doi:10.18632/aging.100410 · Cited by 26 · see citing works

Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals

Лоскутова, Л. В., & Kolosova, N. G. (2000) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf02766083 · Cited by 23 · see citing works

Rapamycin: Killing two birds with one stone

Khanna, A., & Kapahi, P. (2011) · Aging · doi:10.18632/aging.100405 · Cited by 19 · see citing works

Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants

la Fuente, M. D. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110003848 · Cited by 19 · see citing works

Effect of malate on the development of rotenone-induced brain changes in Wistar and OXYS rats: An MRI study

Kolosova, N. G., Евгеньевич, А. А., Stefanova, N. A., Moshkin, M. P., Savelov, A. A., Koptyug, I. V., Panov, A. V., & Андреевич, В. В. (2011) · Doklady Biological Sciences · doi:10.1134/s0012496611020049 · Cited by 18 · see citing works

Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats

Amstislavskaya, T. G., Maslova, L. N., Gladkikh, D. V., Belousova, I. I., Stefanova, N. A., & Kolosova, N. G. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.007 · Cited by 18 · see citing works

Activity of Cell Immune Response and Open Field Behavior in Wistar and Oxys Rats

Markova, E. V., Obukhova, L. A., & Kolosova, N. G. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000010957.87077.ae · Cited by 15 · see citing works

Stimulation of Cell Component of the Immune Response Activates Exploratory Behavior in Senescence Accelerated OXYS Rats

Markova, E. V., Va, K., Trofimova, N. A., & Kolosova, N. G. (2005) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-005-0486-9 · Cited by 9 · see citing works

[Impairment of latent inhibition in OXYS rats with hereditary syndrome of premature aging].

Лоскутова, Л. В., & Lm, Z. (2002) · PubMed · Cited by 9 · see citing works

Peculiarities of bone marrow hemopoiesis in early aging OXYS rats

Orlovskaya, I. A., Toporkova, L. B., Feofanova, N. A., & Kolosova, N. G. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0262-0 · Cited by 3 · see citing works

[Age-related aspects of male reproductive function in rats with normal and accelerated senescence].

Belousova, I. I., Gladkikh, D. V., Zhelezova, A. I., Stefanova, N. A., Kolosova, N. G., & Tg, A. (2009) · PubMed · Cited by 3 · see citing works

Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals

Лоскутова, Л. В., & Kolosova, N. G. (2000) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf02681934 · Cited by 3 · see citing works

[Age related changes in rat blood leucocyte count and morpho-metrical parameters of large granular lymphocytes under different light regimens].

Lb, U., Vinogradova, I. A., Ag, G., Чуров, А. В., & Iliukha, V. A. (2006) · PubMed · Cited by 1 · see citing works

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works

Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases

Zhang, Y.-J., Gan, R.-Y., Li, S., Zhou, Y., Li, A.-N., Xu, D.-P., & Li, H.-B. (2015) · Molecules · doi:10.3390/molecules201219753 · Cited by 1,369 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

Barnes, P. J., Baker, J. R., & Donnelly, L. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1975tr · Cited by 559 · see citing works

Oxidative stress-based therapeutics in COPD

Barnes, P. J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101544 · Cited by 501 · see citing works

Senescence in COPD and Its Comorbidities

Barnes, P. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034314 · Cited by 276 · see citing works

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

Hara, H., Araya, J., Ito, S., Kobayashi, K., Takasaka, N., Yoshii, Y., Wakui, H., Kojima, J., Shimizu, K., Numata, T., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2013 · Cited by 219 · see citing works

Mechanisms of development of multimorbidity in the elderly

Barnes, P. J. (2015) · European Respiratory Journal · doi:10.1183/09031936.00229714 · Cited by 200 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

Kim, S., Guerrero, N., Wassef, G., Xiao, J., Mehta, H. H., Cohen, P., & Yen, K. (2016) · Oncotarget · doi:10.18632/oncotarget.10380 · Cited by 114 · see citing works

SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model

Petrov, A., Perekhvatova, N., Skulachev, M. V., Stein, L., & Ousler, G. W. (2016) · Advances in Therapy · doi:10.1007/s12325-015-0274-5 · Cited by 111 · see citing works

Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium

Zinovkin, R. A., Romaschenko, V. P., Galkin, I. I., Zakharova, V., Pletjushkina, O. Y., Chernyak, B. V., & Popova, E. N. (2014) · Aging · doi:10.18632/aging.100685 · Cited by 89 · see citing works

Alzheimer’s Disease-Like Pathology in Senescence-Accelerated OXYS Rats Can Be Partially Retarded with Mitochondria-Targeted Antioxidant SkQ1

Stefanova, N. A., Muraleva, N. A., Skulachev, V. P., & Kolosova, N. G. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-131034 · Cited by 80 · see citing works

An antioxidant specifically targeting mitochondria delays progression of Alzheimer’s disease-like pathology

Stefanova, N. A., Muraleva, N. A., Maksimova, K. Y., Rudnitskaya, E. A., Владимировна, К. Е., Telegina, D. V., & Kolosova, N. G. (2016) · Aging · doi:10.18632/aging.101054 · Cited by 77 · see citing works

Beneficial effects of melatonin in a rat model of sporadic Alzheimer’s disease

Rudnitskaya, E. A., Maksimova, K. Y., Muraleva, N. A., Logvinov, S. V., Yanshole, L. V., Kolosova, N. G., & Stefanova, N. A. (2014) · Biogerontology · doi:10.1007/s10522-014-9547-7 · Cited by 72 · see citing works

Senotherapy

Baker, J. R., Donnelly, L., & Barnes, P. J. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.01.027 · Cited by 65 · see citing works

Rapamycin suppresses brain aging in senescence-accelerated OXYS rats

Kolosova, N. G., Vitovtov, A. O., Muraleva, N. A., Евгеньевич, А. А., Stefanova, N. A., & Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100573 · Cited by 65 · see citing works

Effects of GH/IGF on the Aging Mitochondria

Poudel, S. B., Dixit, M., Neginskaya, M. A., Nagaraj, K., Pavlov, E. V., Werner, H., & Yakar, S. (2020) · Cells · doi:10.3390/cells9061384 · Cited by 61 · see citing works

Health Benefits of Anti-aging Drugs

Piskovatska, V., Strilbytska, O. M., Koliada, A. K., Vaiserman, A. M., & Lushchak, O. V. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_13 · Cited by 62 · see citing works

Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis

Zhou, S., Zhu, J., Zhou, P., & Gu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999600 · Cited by 57 · see citing works

Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review

Dailah, H. G. (2022) · Molecules · doi:10.3390/molecules27175542 · Cited by 57 · see citing works

Mitochondria-Targeted Antioxidants as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease

Fairley, L. H., Das, S., Dharwal, V., Amorim, N. M. L., Hegarty, K. J., Wadhwa, R., Mounika, G., & Hansbro, P. M. (2023) · Antioxidants · doi:10.3390/antiox12040973 · Cited by 56 · see citing works

Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure

Vays, V. B., Eldarov, C. M., Vangeli, I. M., Kolosova, N. G., Bakeeva, L. E., & Skulachev, V. P. (2014) · Aging · doi:10.18632/aging.100636 · Cited by 51 · see citing works

Mitochondrial Targeted Antioxidant SKQ1 Ameliorates Acute Kidney Injury by Inhibiting Ferroptosis

Song, J., Sheng, J., Lei, J., Gan, W., & Yang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2223957 · Cited by 44 · see citing works

Mitochondrial membrane lipidome defines yeast longevity

Beach, A., Richard, V. R., Leonov, A., Burstein, M. T., Bourque, S. D., Koupaki, O., Juneau, M., Feldman, R., Iouk, T. L., & Titorenko, V. I. (2013) · Aging · doi:10.18632/aging.100578 · Cited by 43 · see citing works

Senescence-accelerated OXYS rats: A genetic model of premature aging and age-related diseases

Kolosova, N. G., Stefanova, N. A., Korbolina, E. E., Фурсова, А. Ж., & Kozhevnikova, O. S. (2014) · Advances in Gerontology · doi:10.1134/s2079057014040146 · Cited by 42 · see citing works

Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

Sgarbanti, R., Amatore, D., Celestino, I., Marcocci, M. E., Fraternale, A., Ciriolo, M. R., Magnani, M., Saladino, R., Garaci, E., Palamara, A. T., et al. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666141203125211 · Cited by 40 · see citing works

Pulmonary Diseases and Ageing

Barnes, P. J. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_3 · Cited by 37 · see citing works

Protective Effect of N-Acetylcysteine Pretreatment on Acute Kidney Injury in Septic Rats

Fan, H., Le, J., & Zhu, J. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2020.04.017 · Cited by 36 · see citing works

Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activity

Muraleva, N. A., Kozhevnikova, O. S., Фурсова, А. Ж., & Kolosova, N. G. (2019) · Antioxidants · doi:10.3390/antiox8060177 · Cited by 31 · see citing works

Influence of antioxidant SkQ1 on accumulation of mitochondrial DNA deletions in the hippocampus of senescence-accelerated OXYS rats

Loshchenova, P. S., Sinitsyna, O. I., Fedoseeva, L. A., Stefanova, N. A., & Kolosova, N. G. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915050120 · Cited by 30 · see citing works

Male infertility and somatic health — insights into lipid damage as a mechanistic link

Burke, N. D., Nixon, B., Roman, S. D., Schjenken, J. E., Walters, J. L. H., Aitken, R. J., & Bromfield, E. G. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00640-y · Cited by 30 · see citing works

The mitochondria-targeted antioxidant SkQ1 restoresαB-crystallin expression and protects against AMD-like retinopathy in OXYS rats

Muraleva, N. A., Kozhevnikova, O. S., Александровна, Ж. А., Stefanova, N. A., Karamysheva, T. V., Фурсова, А. Ж., & Kolosova, N. G. (2014) · Cell Cycle · doi:10.4161/15384101.2014.958393 · Cited by 31 · see citing works

Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging

Singh, A. K., Althoff, M. J., & Cancelas, J. A. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0128-6 · Cited by 27 · see citing works

SkQ1 as a Tool for Controlling Accelerated Senescence Program: Experiments with OXYS Rats

Kolosova, N. G., Kozhevnikova, O. S., Muraleva, N. A., Rudnitskaya, E. A., Rumyantseva, Y. V., Stefanova, N. A., Telegina, D. V., Tyumentsev, M. A., & Фурсова, А. Ж. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120124 · Cited by 28 · see citing works

Advances in Development of Rechargeable Mitochondrial Antioxidants

Lukashev, A. N., Skulachev, M. V., Ostapenko, V., Savchenko, A. Y., Pavshintsev, V. V., & Skulachev, V. P. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00010-6 · Cited by 24 · see citing works

The Role of Mitochondrial Quality Control in Chronic Obstructive Pulmonary Disease

Liu, Y., Hong, J., Jiang, N., Jin, L., Zhong, W., Zhang, C.-Y., Yang, H., Duan, J., & Zhou, Y. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100307 · Cited by 21 · see citing works

Revealing the pathogenic and ageing-related mechanisms of the enigmatic idiopathic pulmonary fibrosis (and chronic obstructive pulmonary disease)

Spagnolo, P., & Semenzato, U. (2022) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000876 · Cited by 16 · see citing works

Senotherapy for chronic lung disease

Barnes, P. J. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100069 · Cited by 17 · see citing works

Senotherapy for lung diseases

Barnes, P. J. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.04.001 · Cited by 14 · see citing works

Mitochondria-targeted antioxidant SkQ1 reduces age-related alterations in the ultrastructure of the lacrimal gland

Bakeeva, L. E., Eldarov, C. M., Vangeli, I. M., Kolosova, N. G., & Vays, V. B. (2016) · Oncotarget · doi:10.18632/oncotarget.13303 · Cited by 13 · see citing works

Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants

Lokhmatikov, A. V., Voskoboynikova, N. E., Cherepanov, D. A., Sumbatyan, N. V., Korshunova, G. A., Skulachev, M. V., Steinhoff, H., Skulachev, V. P., & Mulkidjanian, A. Y. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914100101 · Cited by 11 · see citing works

Mitochondrial Targeted Interventions for AgingPreprint

Liu, S. Z., Chiao, Y. A., Rabinovitch, P. S., & Marcinek, D. J. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041199 · Cited by 10 · see citing works

Blood Leukocyte Indices in Male Rats of Different Ages

Lomako, V. (2020) · Advances in Gerontology · doi:10.1134/s2079057020020101 · Cited by 7 · see citing works

SKQ1: a mitochondria-targeted antioxidant with therapeutic potential

Wu, R., & Wu, Y. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2613054 · Cited by 6 · see citing works

Effects of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats: modulation of it by rutin and other micronutrients

Gatineau, E., Cluzet, S., Krisa, S., Papet, I., Migné, C., Rémond, D., Dardevet, D. P., Polakof, S., Richard, T., & Mosoni, L. (2018) · Food & Function · doi:10.1039/c7fo01953j · Cited by 6 · see citing works

Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity

Asejeje, F. O., Asejeje, G. I., Ogunro, O. B., Adedara, A. O., & Abolaji, A. O. (2024) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-024-00792-0 · Cited by 5 · see citing works

Comparative analysis of the complete nucleotide sequences of mitochondrial DNA of rat strains Wistar and oxys of the institute of cytology and genetics, Siberian Branch, Russian Academy of Sciences

Maksyutov, R. А., Gavrilova, E. V., Nepomnyashchikh, T. S., Rotskaya, U. N., Loshchenova, P. S., Kolosova, N. G., Sinitsyna, O. I., & Shchelkunov, S. N. (2015) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059715010062 · Cited by 3 · see citing works

Mild mitochondrial uncoupling as potentially effective intervention to slow aging

Padalko, V. (2014) · Oxidants and Antioxidants in Medical Science · doi:10.5455/oams.161213.rv.012 · Cited by 3 · see citing works

Disulfiram inhibits cataract development in OXYS rats

Фурсова, А. Ж., Rumyantseva, Y. V., Kolosova, N. G., Кедик, С. А., Panov, A. V., & Tyukova, V. S. (2016) · Advances in Gerontology · doi:10.1134/s207905701603005x · Cited by 1 · see citing works

HEALTHY AGING

Munteanu, C. (2013) · Romanian Association of Balneology eBooks · doi:10.12680/978-606-93550-0-8

Accelerated Lung Aging and Cellular Senescence in COPD

Barnes, P. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00058-5

Diet induced mitochondrial DNA replication instability in Rad51c mutant mice drives sex-bias in anemia of inflammationPreprint

Tomaszowski, K.-H., Chen, Y., Roy, S., Harris, M., Zhang, J., Tsai, C.-L., & Schlacher, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.21.613572

Mitochondria-Targeted Antioxidant SkQ1 Inhibits Age-Dependent Involution of the Thymus in Normal and Senescence-Prone Rats

Obukhova, L. A., Skulachev, V. P., & Kolosova, N. G. (2009) · Aging · doi:10.18632/aging.100043 · Cited by 106 · see citing works

Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1

Shipounova, I. N., Svinareva, D. A., Petrova, T. V., Lyamzaev, K. G., Chernyak, B. V., Дризе, Н. И., & Skulachev, V. P. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.003 · Cited by 27 · see citing works

Effect of mitochondria-targeted antioxidant SkQ1 on aging, lifespan, and spontaneous carcinogenesis in three strains of mice

Yurova, M. N., Zabezhinski, M. A., Piskunova, T. S., Тындык, М. Л., Popovich, I. G., & Anisimov, V. N. (2011) · Advances in Gerontology · doi:10.1134/s2079057011030155 · Cited by 6 · see citing works

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Филенко, О. Ф., Филипповна, И. Е., Манских, В. Н., Mikhelson, V. M., Panteleeva, A. A., PASYUKOVA, E. G., Pilipenko, D. I., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120055 · Cited by 113 · see citing works

Aging as Evolution-Facilitating Program and a Biochemical Approach to Switch It Off

Skulachev, V. P. (2009) · NATO science for peace and security series. B, Physics and biophysics · doi:10.1007/978-1-4020-8761-5_11