Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

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New data on programmed aging — slow phenoptosis

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Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

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Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

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A mitochondria-targeted protonophoric uncoupler derived from fluorescein

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The Mitochondria-Targeted Antioxidants and Remote Kidney Preconditioning Ameliorate Brain Damage through Kidney-to-Brain Cross-Talk

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Programmed aging of mammals: Proof of concept and prospects of biochemical approaches for anti-aging therapy

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Pros and Cons of Use of Mitochondria-Targeted Antioxidants

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Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

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A comparative study of the efficiency of mitochondria-targeted antioxidants MitoTEMPO and SKQ1 under oxidative stress

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Efficacy of Mitochondrial Antioxidant Plastoquinonyl‐decyl‐triphenylphosphonium Bromide (SkQ1) in the Rat Model of Autoimmune Arthritis

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Suppression of AMD-Like Pathology by Mitochondria-Targeted Antioxidant SkQ1 Is Associated with a Decrease in the Accumulation of Amyloid β and in mTOR Activity

Muraleva, N. A., Kozhevnikova, O. S., Фурсова, А. Ж., & Kolosova, N. G. (2019) · Antioxidants · doi:10.3390/antiox8060177 · Cited by 31 · see citing works

Perspectives of Homo sapiens lifespan extension: focus on external or internal resources?

Skulachev, V. P., Shilovsky, G. A., Putyatina, T. S., Popov, N. A., Markov, A. V., Skulachev, M. V., & Садовничий, В. А. (2020) · Aging · doi:10.18632/aging.102981 · Cited by 32 · see citing works

The phenoptosis problem: What is causing the death of an organism? Lessons from acute kidney injury

Zorov, D. B., Plotnikov, E. Y., Jankauskas, S. S., Исаев, Н. К., Silachev, D. N., Zorova, L. D., Pevzner, I. B., Pulkova, N. V., Zorov, S. D., & Morosanova, M. A. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912070073 · Cited by 31 · see citing works

Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1.

Манских, В. Н., Gancharova, O. S., Никифорова, А. И., Krasilshchikova, M. S., Shabalina, I. G., Egorov, M. V., Karger, E. M., Milanovsky, G. E., Galkin, I. I., Skulachev, V. P., et al. (2015) · PubMed · doi:10.14670/hh-30.353 · Cited by 30 · see citing works

Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury

Stelmashook, E. V., Исаев, Н. К., Генрихс, Е. Е., & Novikova, S. V. (2019) · Antioxidants · doi:10.3390/antiox8050124 · Cited by 28 · see citing works

Perspectives of mitochondrial medicine

Zorov, D. B., Исаев, Н. К., Plotnikov, E. Y., Silachev, D. N., Zorova, L. D., Pevzner, I. B., Morosanova, M. A., Jankauskas, S. S., Zorov, S. D., & Babenko, V. А. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913090034 · Cited by 28 · see citing works

Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders

Kim, H. K., & Han, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_32 · Cited by 27 · see citing works

SkQ1 as a Tool for Controlling Accelerated Senescence Program: Experiments with OXYS Rats

Kolosova, N. G., Kozhevnikova, O. S., Muraleva, N. A., Rudnitskaya, E. A., Rumyantseva, Y. V., Stefanova, N. A., Telegina, D. V., Tyumentsev, M. A., & Фурсова, А. Ж. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120124 · Cited by 28 · see citing works

Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation

Eichwald, T., Solano, A. F., Souza, J., de Miranda, T. B., Carvalho, L. B., Sanna, P. L. D. S., da Silva, R. A., & Latini, A. (2023) · Antioxidants · doi:10.3390/antiox12030554 · Cited by 26 · see citing works

SkQ1 treatment and food restriction — two ways to retard an aging program of organisms

Skulachev, V. P. (2011) · Aging · doi:10.18632/aging.100410 · Cited by 26 · see citing works

Design, synthesis, and some aspects of the biological activity of mitochondria-targeted antioxidants

Korshunova, G. A., Shishkina, A. V., & Skulachev, M. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917070021 · Cited by 26 · see citing works

Mitochondrial Targeted Therapies: Where Do We Stand in Mental Disorders?

Ben‐Shachar, D., & Ene, H. M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.007 · Cited by 26 · see citing works

Therapeutic Effect of the Mitochondria-Targeted Antioxidant SkQ1 on the Culture Model of Multiple Sclerosis

Константиновна, Ф. Е., Muntyan, M. S., Lyamzaev, K. G., & Chernyak, B. V. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2082561 · Cited by 25 · see citing works

Depletion of mitochondrial reactive oxygen species downregulates epithelial-to-mesenchymal transition in cervical cancer cells

Shagieva, G. S., Domnina, L. V., Makarevich, O. A., Chernyak, B. V., Skulachev, V. P., & Dugina, V. B. (2016) · Oncotarget · doi:10.18632/oncotarget.13612 · Cited by 25 · see citing works

Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and Gd@C82

Mikheev, I. V., Sozarukova, M. M., Izmailov, D. Y., Kareev, I. E., Proskurnina, E. V., & Proskurnin, М. А. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115838 · Cited by 24 · see citing works

CORM‐3 Attenuates Oxidative Stress‐Induced Bone Loss via the Nrf2/HO‐1 Pathway

Jin, C., Lin, B., Zheng, G., Tan, K., Liu, G., Yao, Z., Xie, J., Chen, W., Chen, L., Xu, T.-H., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5098358 · Cited by 24 · see citing works

Advances in Development of Rechargeable Mitochondrial Antioxidants

Lukashev, A. N., Skulachev, M. V., Ostapenko, V., Savchenko, A. Y., Pavshintsev, V. V., & Skulachev, V. P. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00010-6 · Cited by 24 · see citing works

Novel Penetrating Cations for Targeting Mitochondria

Chernyak, B. V., Antonenko, Y. N., Domnina, L. V., Ivanova, O. Y., Lyamzaev, K. G., Pustovidko, A. V., Rokitskaya, T. I., Severina, I. I., Simonyan, R. A., Trendeleva, T. A., et al. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319150015 · Cited by 23 · see citing works

Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria

Pustovidko, A. V., Rokitskaya, T. I., Severina, I. I., Simonyan, R. A., Trendeleva, T. A., Lyamzaev, K. G., Antonenko, Y. N., Rogov, A. G., Zvyagilskaya, R. A., Skulachev, V. P., et al. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.09.006 · Cited by 22 · see citing works

Interaction of tetraphenylphosphonium and dodecyltriphenylphosphonium with lipid membranes and mitochondria

Trendeleva, T. A., Rogov, A. G., Cherepanov, D. A., Sukhanova, E. I., Ilyasova, T. M., Severina, I. I., & Zvyagilskaya, R. A. (2012) · Biochemistry (Moscow) · doi:10.1134/s000629791209009x · Cited by 22 · see citing works

Molecular Mechanism of Aerobic Exercise Ameliorating Myocardial Mitochondrial Injury in Mice with Heart Failure

Jia, H., Song, Y., Hua, Y., Li, K., Li, S., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052136 · Cited by 21 · see citing works

Novel mitochondria-targeted compounds composed of natural constituents: Conjugates of plant alkaloids berberine and palmatine with plastoquinone

Chernyak, B. V., Antonenko, Y. N., Galimov, E. R., Domnina, L. V., Dugina, V. B., Zvyagilskaya, R. A., Ivanova, O. Y., Izyumov, D. S., Lyamzaev, K. G., Pustovidko, A. V., et al. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912090040 · Cited by 19 · see citing works

Cardiolipin alterations and mitochondrial dysfunction in heart ischemia/reperfusion injury

Paradies, G., Paradies, V., Ruggiero, F. M., & Petrosillo, G. (2015) · Clinical Lipidology · doi:10.2217/clp.15.31 · Cited by 17 · see citing works

Ameliorative effects of SkQ1 eye drops on cataractogenesis in senescence-accelerated OXYS rats

Rumyantseva, Y. V., Ryabchikova, E. I., Фурсова, А. Ж., & Kolosova, N. G. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2806-0 · Cited by 13 · see citing works

Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review

Banerjee, P., Saha, I., Sarkar, D., & Maiti, A. K. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00501-x · Cited by 13 · see citing works

The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy

Perepechaeva, M. L., Grishanova, A. Y., Rudnitskaya, E. A., & Kolosova, N. G. (2014) · Journal of Ophthalmology · doi:10.1155/2014/530943 · Cited by 13 · see citing works

Influence of SkQ1 on expression of Nrf2 transcription factor gene, ARE-controlled genes of antioxidant enzymes and their activity in rat blood leukocytes

Внуков, В. В., Gutsenko, O. I., Milutina, N. P., Ananyan, A. A., Danilenko, A. O., Panina, S., & Корниенко, И. В. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915050107 · Cited by 13 · see citing works

Mitochondria-targeted antioxidant SkQ1 reduces age-related alterations in the ultrastructure of the lacrimal gland

Bakeeva, L. E., Eldarov, C. M., Vangeli, I. M., Kolosova, N. G., & Vays, V. B. (2016) · Oncotarget · doi:10.18632/oncotarget.13303 · Cited by 13 · see citing works

Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

Kirpatovsky, V. I., Plotnikov, E. Y., Mudraya, I. S., Голованов, С. А., Дрожжева, В. В., Khromov, R. A., Chernikov, D. Y., Skulachev, V. P., & Zorov, D. B. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913050131 · Cited by 13 · see citing works

Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations

Ilyasova, T. M., Rokitskaya, T. I., Severina, I. I., Antonenko, Y. N., & Skulachev, V. P. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912090118 · Cited by 13 · see citing works

Superoxide scavenging activity of plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1)

Chistyakov, V. A., Prazdnova, E. V., Гутникова, Л. В., Sazykina, M. A., & Sazykin, I. S. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912070103 · Cited by 11 · see citing works

Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants

Lokhmatikov, A. V., Voskoboynikova, N. E., Cherepanov, D. A., Sumbatyan, N. V., Korshunova, G. A., Skulachev, M. V., Steinhoff, H., Skulachev, V. P., & Mulkidjanian, A. Y. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914100101 · Cited by 11 · see citing works

Proteomic analysis of oxidized proteins in the brain and liver of the Nile tilapia (Oreochromis niloticus) exposed to a water-accommodated fraction of Maya crude oil

Salazar-Coria, L., Rocha-Gómez, M. A., Matadamas‐Martínez, F., Yépez‐Mulia, L., & López, A. V. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.01.033 · Cited by 11 · see citing works

Effect of liposomes on energy-dependent uptake of the antioxidant SkQR1 by isolated mitochondria

Antonenko, Y. N., Perevoshchikova, I. V., Rokitskaya, T. I., Simonyan, R. A., Tashlitsky, V. N., & Skulachev, V. P. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9449-9 · Cited by 12 · see citing works

Targeting Hydroxybenzoic Acids to Mitochondria as a Strategy to Delay Skin Ageing: An In Vitro Approach

Fernandes, C., Cagide, F., Simões, J., Pita, C., Pereira, E., Videira, A. J. C., Soares, P., Duarte, J. F. S., Santos, A. M. S., Oliveira, P. J., et al. (2022) · Molecules · doi:10.3390/molecules27196183 · Cited by 11 · see citing works

Aging: The Mitochondrial Connection

Brown, K. V. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-003 · Cited by 10 · see citing works

Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract – Stimulation of anti-oxidative enzyme expression

Schild, L., Cotte, T., Keilhoff, G., & Brödemann, R. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.03.012 · Cited by 10 · see citing works

Mitochondrial genome and longevity

Zinovkin, R. A., Skulachev, M. V., & Skulachev, V. P. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916120014 · Cited by 10 · see citing works

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Филенко, О. Ф., Филипповна, И. Е., Манских, В. Н., Mikhelson, V. M., Panteleeva, A. A., PASYUKOVA, E. G., Pilipenko, D. I., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120055 · Cited by 113 · see citing works

Interruption of the organismal senescence program

Skulachev, V. P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.036 · Cited by 1 · see citing works

An Attempt to Prevent Senescence: A Mitochondrial Approach

Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430 · see citing works

Possible Medical Applications of Membrane Bioenergetics: Mitochondria-Targeted Antioxidants as Geroprotectors

Skulachev, V. P., Bogachev, A. V., & Kasparinsky, F. O. (2012) · Springer eBooks · doi:10.1007/978-3-642-33430-6_16

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies

Antonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Y., Izyumov, D. S., Khailova, L. S., Klishin, S. S., et al. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908120018 · Cited by 326 · see citing works