Role of NFκB in age-related vascular endothelial dysfunction in humans
Open accessAbstract
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the United States and other industrialized societies.Older age is the major risk factor for development of CVD [1].Emerging evidence over the past 20 years suggests that the arterial vascular endothelium plays a critical role in the development of CVD, most notably, atherosclerosis.A healthy vascular endothelium is characterized by a tightly regulated balance of pro-and anti-oxidants, vasodilators and vasoconstrictors, and pro-and anti-inflammatory molecules.A diseased or dysfunctional endothelium displays a "pro-atherogenic" phenotype, losing its tightly regulated balance and adopting a prooxidant/vasoconstrictor/pro-inflammatory phenotype.A hallmark of arterial endothelial dysfunction is impaired endothelial dependent dilation, which is predictive of future CVD events [1,2].Aging leads to impaired endothelial dependent dilation associated elevated oxidative stress and a proinflammatory endothelial cell phenotype.Recent studies in humans by our group and by others in rodents suggest a critical role of nuclear factor κB (NFκB) in the pro-inflammatory / pro-oxidant linked suppression of endothelial dependent dilation with advancing aging [3][4][5][6][7].This perspective will discuss new information concerning the role of increased NFκB signaling in mediating vascular endothelial dysfunction with aging in humans.
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Chronic low-grade inflammation is a key mechanism mediating age-related arterial dysfunction.
“and is a key mechanism mediating age-related arterial dysfunction (34, 45, 149, 162)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [45]
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Cites
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 1× · see citing works
“A hallmark of arterial endothelial dysfunction is impaired endothelial dependent dilation, which is predictive of future CVD events [1, 2].”
BackgroundInflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Nuclear Factor κB Signaling in Atherogenesis
de Winther, M. P. J., Kanters, E., Kraal, G., & Hofker, M. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160340.72641.87 · Cited by 586 · see citing works
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
Donato, A. J., Eskurza, I., Silver, A., Levy, A., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558 · see citing works
Self-citationInflammation and endothelial dysfunction during aging: role of NF-κB
Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90470.2008 · Cited by 441 · see citing works
NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91
Anrather, J., Racchumi, G., & Iadecola, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506172200 · Cited by 387 · see citing works
Pierce, G. L., Lesniewski, L. A., Lawson, B. R., Beske, S. D., & Seals, D. R. (2009) · Circulation · doi:10.1161/circulationaha.108.804294 · Cited by 262 · see citing works
Self-citationDonato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works
Self-citationVgontzas, A. N., Zoumakis, M., Bixler, E. O., Lin, H.-M., Prolo, P., Vela‐Bueno, A., Kales, A., & Chrousos, G. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021176 · Cited by 235 · see citing works
Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging
Csiszár, A., Labinskyy, N., Smith, K. E., Rivera, A., Orosz, Z. Z., & Ungvari, Z. I. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060708 · Cited by 214 · see citing works
Davis, M. E., Grumbach, I. M., Fukai, T., Cutchins, A. C., & Harrison, D. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307528200 · Cited by 213 · see citing works
Silver, A., Beske, S. D., Christou, D. D., Donato, A. J., Moreau, K. L., Eskurza, I., Gates, P. E., & Seals, D. R. (2007) · Circulation · doi:10.1161/circulationaha.106.657486 · Cited by 190 · see citing works
Self-citationIncreased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats
Belmin, J., Bernard, C., Corman, B., Merval, R., Esposito, B., & Tedgui, A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.6.h2288 · Cited by 93 · see citing works
Nuclear factor kappa B signaling in atherogenesis
de Winther, M. (2005) · Medical Entomology and Zoology · Cited by 47 · see citing works
Endothelial NF-κB As a Mediator of Kidney Damage
Guzik, T. J., & Harrison, D. G. (2007) · Circulation Research · doi:10.1161/circresaha.107.158295 · Cited by 40 · see citing works
Clinical implications of endothelial dysfunction
Furgerson, J. L. (1999) · Clinical Cardiology · doi:10.1002/clc.4960220619 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?
Senoner, T., & Dichtl, W. (2019) · Nutrients · doi:10.3390/nu11092090 · Cited by 880 · see citing works
Role of free fatty acids in endothelial dysfunction
Ghosh, A., Gao, L., Thakur, A., Siu, P. M., & Lai, C. W. K. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0357-5 · Cited by 420 · see citing works
Vitamin D and Endothelial Function
Kim, D., Meza, C., Clarke, H. E., Kim, J., & Hickner, R. C. (2020) · Nutrients · doi:10.3390/nu12020575 · Cited by 382 · see citing works
Aerobic exercise training and vascular function with ageing in healthy men and women
Seals, D. R., Nagy, E., & Moreau, K. L. (2019) · The Journal of Physiology · doi:10.1113/jp277764 · Cited by 231 · see citing works
Self-citationThe Role of Oxidative Stress and Inflammation in Cardiovascular Aging
Wu, J., Xia, S., Kalionis, B., Wan, W., & Sun, T. (2014) · BioMed Research International · doi:10.1155/2014/615312 · Cited by 220 · see citing works
Oxidized LDL and NO synthesis—Biomarkers of endothelial dysfunction and ageing
Grădinaru, D., Borșa, C., Ionescu, C., & Prada, G. I. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.003 · Cited by 174 · see citing works
The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases
Izzo, C., Vitillo, P., Pietro, P. D., Visco, V., Strianese, A., Virtuoso, N., Ciccarelli, M., Galasso, G., Carrizzo, A., & Vecchione, C. (2021) · Life · doi:10.3390/life11010060 · Cited by 167 · see citing works
Aerobic exercise reverses arterial inflammation with aging in mice
Lesniewski, L. A., Durrant, J., Connell, M. L., Henson, G. D., Black, A. D., Donato, A. J., & Seals, D. R. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01276.2010 · Cited by 144 · see citing works
Self-citationAerobic exercise and other healthy lifestyle factors that influence vascular aging
Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 141 · see citing works
Self-citationScioli, M. G., Bielli, A., Arcuri, G., Ferlosio, A., & Orlandi, A. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-19 · Cited by 132 · see citing works
Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities
Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 121 · see citing works
Wadley, A. J., Zanten, J. V., & Aldred, S. (2012) · AGE · doi:10.1007/s11357-012-9402-1 · Cited by 118 · see citing works
Cardiac and renal complications of carfilzomib in patients with multiple myeloma
Dimopoulos, M. A., Ρούσσου, Μ., Gavriatopoulou, M., Psimenou, E., Ziogas, D. C., Eleutherakis‐Papaiakovou, E., Fotiou, D., Migkou, M., Kanellias, N., Panagiotidis, I., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2016003269 · Cited by 106 · see citing works
Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium
Zinovkin, R. A., Romaschenko, V. P., Galkin, I. I., Zakharova, V., Pletjushkina, O. Y., Chernyak, B. V., & Popova, E. N. (2014) · Aging · doi:10.18632/aging.100685 · Cited by 89 · see citing works
Molecular damage in cancer: an argument for mTOR-driven aging
Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100422 · Cited by 87 · see citing works
Vascular Function and Uric Acid-Lowering in Stage 3 CKD
Jalal, D. I., Decker, E., Perrenoud, L., Nowak, K. L., Bispham, N. Z., Mehta, T. H., Smits, G., You, Z., Seals, D. R., Chonchol, M., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016050521 · Cited by 84 · see citing works
Self-citationWalker, A. E., Kaplon, R. E., Pierce, G. L., Nowlan, M. J., & Seals, D. R. (2014) · Clinical Science · doi:10.1042/cs20140030 · Cited by 81 · see citing works
Self-citationDiabetes, Endothelial Dysfunction, and Vascular Repair: What Should a Diabetologist Keep His Eye on?
Altabas, V. (2015) · International Journal of Endocrinology · doi:10.1155/2015/848272 · Cited by 78 · see citing works
The role of senescence, telomere dysfunction and shelterin in vascular aging
Liu, Y., Bloom, S. I., & Donato, A. J. (2018) · Microcirculation · doi:10.1111/micc.12487 · Cited by 70 · see citing works
Self-citationEndothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation
Kim, B., Zhao, W., Tang, S. Y., Levin, M. G., Ibrahim, A., Yang, Y., Roberts, E., Lai, L., Li, J., Assoian, R. K., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci173160 · Cited by 68 · see citing works
Moreau, K. L., Deane, K. D., Meditz, A. L., & Kohrt, W. M. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.057 · Cited by 70 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Self-citationMost exposed: the endothelium in chronic kidney disease
Cuenca, M. V., Hordijk, P. L., & Vervloet, M. G. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz055 · Cited by 61 · see citing works
Effects of regular exercise on vascular function with aging: Does sex matter?
Moreau, K. L., Clayton, Z. S., DuBose, L. E., Rosenberry, R., & Seals, D. R. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00392.2023 · Cited by 54 · see citing works
Self-citationMolecular pathways of arterial aging
Paneni, F., Costantino, S., & Cosentino, F. (2014) · Clinical Science · doi:10.1042/cs20140302 · Cited by 52 · see citing works
Aird, A. L., Nevitt, C. D., Christian, K., Williams, S. K., Hoying, J. B., & LeBlanc, A. J. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.01.044 · Cited by 51 · see citing works
Wu, C., Mao, J., Wang, X., Yang, R., Wang, C., Li, C., & Zhou, X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02058-z · Cited by 44 · see citing works
Chronic Blood Pressure Reductions and Increments in Plasma Nitric Oxide Bioavailability
Tomeleri, C. M., Marcori, A. J., Ribeiro, A. S., Gerage, A. M., Padilha, C. S., Bortoloti, D. S., de Souza, M. F., Mayhew, J. L., do Nascimento, M. A., Venturini, D., et al. (2017) · International Journal of Sports Medicine · doi:10.1055/s-0042-121896 · Cited by 44 · see citing works
Migneault, F., Dieudé, M., Turgeon, J., Beillevaire, D., Hardy, M., Brodeur, A., Thibodeau, N., Perreault, C., & Hébert, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69548-0 · Cited by 42 · see citing works
Ibarrola, J., Lu, Q. R., Zennaro, M., & Jaffe, I. Z. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19213 · Cited by 37 · see citing works
Sharma, B., & Singh, N. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2718-9 · Cited by 36 · see citing works
Thrombin inhibition by dabigatran attenuates endothelial dysfunction in diabetic mice
Rahadian, A., Fukuda, D., Salim, H. M., Yagi, S., Kusunose, K., Yamada, H., Soeki, T., Shimabukuro, M., & Sata, M. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106632 · Cited by 32 · see citing works
Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?
Broxmeyer, H. E., Liu, Y., Kapur, R., Orschell, C. M., Aljoufi, A., Ropa, J. P., Trinh, T. L. P., Burns, S. S., & Capitano, M. L. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10065-y · Cited by 30 · see citing works
How Are Epigenetic Modifications Related to Cardiovascular Disease in Older Adults?
Gharipour, M., Mani, A., Baghbahadorani, M. A., Cardoso, C. K. D. S., Jahanfar, S., Sarrafzadegan, N., de Oliveira, C. M., & Silveira, É. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189949 · Cited by 30 · see citing works
Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms
Liu, S., He, Y., Zhang, Y., Zhang, Z., Huang, K., Deng, L., Liao, B., Zhong, Y., & Feng, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290331 · Cited by 31 · see citing works
Afonso, P., Auclair, M., Caron-Debarle, M., & Capeau, J. (2017) · Antiviral Therapy · doi:10.3851/imp3160 · Cited by 28 · see citing works
Sharma, B., & Singh, N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.013 · Cited by 28 · see citing works
Experimental reduction of miR-92a mimics arterial aging
Hazra, S., Henson, G. D., Morgan, R. G., Breevoort, S. R., Ives, S. J., Richardson, R. S., Donato, A. J., & Lesniewski, L. A. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.007 · Cited by 27 · see citing works
Self-citationGupta, S., & Sharma, B. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.02.007 · Cited by 25 · see citing works
Chade, A., Williams, M. L., Engel, J. E., Williams, E., & Bidwell, G. L. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00155.2020 · Cited by 24 · see citing works
Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice
Greiten, L. E., Zhang, B., Roos, C. M., Hagler, M. A., Jahns, F., & Miller, J. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.753501 · Cited by 20 · see citing works
Ngo, D., Kang, K., Jung, W., Byun, H., & Kim, S. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.06.021 · Cited by 19 · see citing works
A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL
Gabriele, M., Pucci, L., Marca, M. L., Lucchesi, D., Croce, C. M. D., Longo, V. G., & Lubrano, V. (2016) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-016-0015-z · Cited by 14 · see citing works
Age associated endothelial dysfunction: Role of oxidative stress, inflammation and Western Diet
Edirisinghe, I., & Burton‐Freeman, B. M. (2014) · Nutrition and Aging · doi:10.3233/nua-140047 · Cited by 13 · see citing works
Al-Sroji, R. Y., Laham, S. A., & Almandili, A. (2023) · Pharmaceutical Biology · doi:10.1080/13880209.2023.2204916 · Cited by 13 · see citing works
Fonseca, C. L., Taatjes, D. J., CALLAS, P. W., Ittleman, F. P., & Bovill, E. G. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0966-8 · Cited by 12 · see citing works
Novel pathophysiological roles of α‐synuclein in age‐related vascular endothelial dysfunction
Takami, Y., Wang, C., Hironori Nakagami, A., Yamamoto, K. I., Nozato, Y., Imaizumi, Y., Nagasawa, M., Takeshita, H., Nakajima, T., Takeda, S., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101621r · Cited by 10 · see citing works
Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction
Saravi, S. S. S., Bonetti, N. R., Vukolic, A., Vdovenko, D., Lee, P., Liberale, L., Basso, C., Rizzo, S., Akhmedov, A. T., Lüscher, T. F., et al. (2023) · Vascular Pharmacology · doi:10.1016/j.vph.2023.107175 · Cited by 9 · see citing works
Vascular Health Triad in Humans With Hypertension—Not the Usual Suspects
Ranadive, S. M., Dillon, G. A., Mascone, S. E., & Alexander, L. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746278 · Cited by 9 · see citing works
Speranza, L., Pesce, M., Franceschelli, S., Mastrangelo, F., Patruno, A., Lutiis, M. A. D., Tetè, S., Felaco, M., & Grilli, A. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1838 · Cited by 8 · see citing works
Key Data from the 17th International Workshop on Co-morbidities and Adverse Drug Reactions in HIV
Coughlan, R., & Cameron, S. (2016) · Antiviral Therapy · doi:10.3851/imp3031 · Cited by 8 · see citing works
Yuan, S., Kuai, Z., Zhao, F., Xu, D., & Wu, W. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05124-8 · Cited by 7 · see citing works
Bedreag, O. H., Rogobete, A. F., Cradigati, C. A., Sărăndan, M., Nartiţă, R., Horhat, F. G., Popovici, S. E., Săndesc, D., & Păpurică, M. (2016) · Revista română de medicină de laborator · doi:10.1515/rrlm-2016-0015 · Cited by 7 · see citing works
Peixoto, P., Vieira-Alves, I., Couto, G. K., Lemos, V. S., Rossoni, L. V., Bissoli, N. S., & dos Santos, R. L. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120917 · Cited by 6 · see citing works
Freise, C., Jernej, T., Metzkow, S., Schnorr, J., & Taupitz, M. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2567528 · Cited by 5 · see citing works
Oxidative Stress: Meeting Multiple Targets in Pathogenesis of Vascular Endothelial Dysfunction
Gupta, V., Garg, A., Tomar, R., & Arora, M. K. (2022) · Current Drug Targets · doi:10.2174/1389450123666220303090413 · Cited by 5 · see citing works
Avecilla, V., Doke, M., Das, M., Alcazar, O., Appunni, S., Tondin, A. R., Watts, B., Ramamoorthy, V., Rubens, M., & Das, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084502 · Cited by 5 · see citing works
Hypertension: Potential Player in Cardiovascular Disease Incidence in Preeclampsia
Amini, P., Amrovani, M., Nassaj, Z. S., Ajorlou, P., Pezeshgi, A., & Ghahrodizadehabyaneh, B. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09734-w · Cited by 5 · see citing works
Chronic kidney disease enhances alternative pathway activity: a new paradigm
Jalal, D. I., Thurman, J. M., & Smith, R. J. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188353 · Cited by 7 · see citing works
Дорофиенко, Н. Н., Andrievskaya, I. A., & Ishutina, N. A. (2021) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2021-6.2.10 · Cited by 2 · see citing works
Mechanisms of vascular disease
Li, Y., Faraci, F. M., Heistad, D. D., Lamping, K. G., Rahmouni, K., & Sigmund, C. D. (2014) · doi:10.17077/etd.7otf4nv9 · Cited by 2 · see citing works
Mechanisms of Cardiovascular Aging
Paneni, F., Costantino, S., Cosentino, F., & Lüscher, T. F. (2013) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-013-0061-6 · Cited by 1 · see citing works
The Clock Is Ticking as the Clot Thickens
Conway, E. M. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.235754 · Cited by 1 · see citing works
Faltz, M. (2013) · University of Brighton Repository (University of Brighton)
Tomić, J. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)
The Effect of Dietary Zinc on Vascular Function with Aging
Kanaoka, T. (2013) · CU Scholar (University of Colorado Boulder)
influence vascular aging Aerobic exercise and other healthy lifestyle factors that
Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2015)
Self-citationThe efficacy of oral trehalose therapy to reverse age-associated vascular dysfunction in humans
Kaplan, R. E. (2015) · CU Scholar (University of Colorado Boulder)
Endothelial dysfunction in nonalcoholic fatty liver disease
PELTEC, A. I., & ALNABGHALIE, M. (2021) · One Health & Risk Management · doi:10.38045/ohrm.2022.1.01
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Doğan, N. (2023) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2022.07282
Travezani, T. S., Nascimento, M. H. C., CUNHA, T. R. D., dos Santos, R. L., Martin, F. L., & Baraúna, V. G. (2025) · ACS Omega · doi:10.1021/acsomega.4c08831
Antigen accumulation in the B cell follicle is impaired in aged micePreprint
Ge, X., Fra-Bidó, S., Innocentin, S., Okkenhaug, H., Linterman, M. A., & Webb, L. M. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.30.702770
IMPACT OF COMMON CHRONIC DISEASES ON SEMEN QUALITY: A NARRATIVE REVIEW
Śliwiński, W., Matecka, D., Mazur, J., Chołuj, D., Pura, W., Zarówna, K., Kosowski, M., & Marciniak, J. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5223
- Authors
- Donato, A. J., Pierce, G. L., Lesniewski, L. A., & Seals, D. R.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Donato, Anthony J.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2009-08-10
- Volume
- 1
- Issue
- 8
- Pages
- 678-680
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC2806047
- OpenAlex
- W1503756158
- Cited by
- 73
- References
- 17
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 5 · 2012: 5
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K01AG029337, K01AG033196)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- NF-κB signaling, endothelial dysfunction, oxidative stress, inflammation, atherosclerosis, cardiovascular disease
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cardiovascular Diseases, Endothelium, Vascular, Humans, Inflammation, NF-kappa B, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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