Alive and well? Exploring disease by studying lifespan
Open accessAbstract
A common concept in aging research is that chronological age is the most important risk factor for the development of diverse diseases, including degenerative diseases and cancers. The mechanistic link between the aging process and disease pathogenesis, however, is still enigmatic. Nevertheless, measurement of lifespan, as a surrogate for biological aging, remains among the most frequently used assays in aging research. In this review, we examine the connection between 'normal aging' and age-related disease from the point of view that they form a continuum of aging phenotypes. This notion of common mechanisms gives rise to the converse postulate that diseases may be risk factors for accelerated aging. We explore the advantages and caveats associated with using lifespan as a metric to understand cell and tissue aging, focusing on the elucidation of molecular mechanisms and potential therapies for age-related diseases.
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Measured lifespan can be uncoupled, at least to a large extent, from the consequences of aging.
“Therefore, it is possible for measured lifespan to be uncoupled, at least to a large extent, from the consequences of aging – recording of the death of a person provides no information as to how functional that person was over the previous decades.”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [16]
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How should clinical care of the aged differ?
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Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation
Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00451-9 · Cited by 134 · see citing works
Asynchronous, contagious and digital aging
Rando, T. A., & Wyss-Coray, T. (2021) · Nature Aging · doi:10.1038/s43587-020-00015-1 · Cited by 121 · see citing works
Self-citationKatsimpardi, L., Kuperwasser, N., Camus, C., Moigneu, C., Chiche, A., Tolle, V., Li, H., Kokovay, E., & Lledo, P. (2020) · Aging Cell · doi:10.1111/acel.13038 · Cited by 47 · see citing works
- Authors
- Brett, J. O., & Rando, T. A.
- Affiliations
- Stanford Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Rando, Thomas A
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 26
- Pages
- 33-40
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC4253307
- OpenAlex
- W1974681862
- Cited by
- 12
- References
- 124
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG023806, T32AG047126, R01AG047820, P01AG036695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- lifespan, biological aging, age-related diseases, normal aging, accelerated aging, degenerative diseases, cancer, aging phenotypes, molecular mechanisms of aging
- MeSH terms
- Aging, Animals, Disease, Humans, Longevity, Models, Biological, Mutation, Phenotype, Signal Transduction, Gene-Environment Interaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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