Cited by 41Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceInflammatory mediators and NSAID effects

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice

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Kim, Joohwee, Vaish, Vivek, Feng, Mingxiao, Field, Kevin, Chatzistamou, Ioulia, Shim, Minsub·2016·Aging

Abstract

Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be increased in the tissues of aged humans and mice, which suggests the involvement of COX2 in the aging process. However, it is not clear whether the increased COX2 expression is causal to or a result of aging. We have now addressed this question by creating an inducible COX2 transgenic mouse model. Here we show that post-natal expression of COX2 led to a panel of aging-related phenotypes. The expression of p16, p53, and phospho-H2AX was increased in the tissues of COX2 transgenic mice. Additionally, adult mouse lung fibroblasts from COX2 transgenic mice exhibited increased expression of the senescence-associated β-galactosidase. Our study reveals that the increased COX2 expression has an impact on the aging process and suggests that modulation of COX2 and its downstream signaling may be an approach for intervention of age-related disorders.

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  1. [42]Maronpot RR Boorman GA Gaul BW 1999 Pathology of the mouse: reference and atlas Vienna, IL Cache River Press

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Authors
Kim, J., Vaish, V., Feng, M., Field, K., Chatzistamou, I., & Shim, M.
Affiliations
University of South Carolina (US)
Corresponding author
Shim, Minsub
Venue
Aging
Published
2016-10-07
Volume
8
Issue
10
Pages
2392-2406
ISSN
1945-4589 (ISSN-L)
OpenAlex
W2527996622
Cited by
41
References
71
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 1
FWCI
1.62
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
cyclooxygenase-2, premature aging, transgenic mice, prostanoids, cellular senescence, senescence-associated β-galactosidase, p16, p53, lung fibroblasts, age-related diseases, inducible transgene expression
MeSH terms
Aging, Animals, beta-Galactosidase, Fibroblasts, Histones, Mice, Transgenic, Phenotype, Phosphorylation, Aging, Premature, Mice, Cyclooxygenase 2

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