Anti-Inflammatory Effect of Resveratrol in Old Mice Liver

Tung, Bui Thanh; Rodríguez-Bies, Elisabeth; Talero, Elena; Gamero-Estévez, Enrique; Motilva, Virginia; Navas, Plácido; López-Lluch, Guillermo

doi:10.1016/j.exger.2015.02.004

Cited by 71Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsAlcohol Consumption and Health Effects

Anti-Inflammatory Effect of Resveratrol in Old Mice Liver

Tung, Bui Thanh, Rodríguez-Bies, Elisabeth, Talero, Elena, Gamero-Estévez, Enrique, Motilva, Virginia, Navas, Plácido, López-Lluch, Guillermo·2015·Experimental Gerontology

DOI 10.1016/j.exger.2015.02.004

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Abstract

Inflammation is a hallmark of aging. Caloric restriction and resveratrol (RSV) have shown important effects on prevention of oxidative stress and inflammation. Here, we investigate the progression of proinflammatory markers in liver during aging and the effect of RSV on inflammation markers in the liver of old male C57BL/6J mice. Young (2 months), mature (12 months) and old (18 months) mice were fed during 6 months with RSV. Levels of IL-1β, IL-6, IL-10, IL-17 and TNF-α were evaluated by ELISA in mice liver. Levels of pro-inflammatory cytokines, IL-1β, IL-6, IL-17 and TNF-α and also their respective mRNA increased in the liver from old mice. However, RSV decreased these levels in the case of IL-1β and TNF-α but only in old mice showing no effect on young and mature animals. This reduction was also found at the mRNA level. Levels of mRNA of the components of NALP-3 inflammasome, ASC, CASP-1, NALP-1 and NALP-3, also showed an age-dependent increase that was reversed by RSV. Furthermore, cyclooxygenase 2 levels, a marker of proinflammatory innate immune activity, were also upregulated in aged liver and reversed again by RSV. In conclusion, our study confirms that aging is accompanied by an increase in the proinflammatory pattern in the liver and that RSV reduces this pattern in old mice liver.

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RSV can reduce oxidative damage in the brain of aged mice by increasing levels of SOD and plasma GPx, decreasing malondialdehyde, and lowering expression of pro-inflammatory proteins (IL1β and TNFα) in old mice, as well as in patients with coronary artery disease.
“It has been demonstrated that RSV can reduce oxidative damage in the brain of aged mice by increasing the levels of SOD and plasma GPx, decreasing malondialdehyde, and lowering the expression of several pro-inflammatory proteins (IL1β and tumour necrosis factor α) in old mice, as well as in patients with coronary artery disease [321,322].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [322]

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Authors: Tung, B. T., Rodríguez-Bies, E., Talero, E., Gamero-Estévez, E., Motilva, V., Navas, P., & López-Lluch, G.
Affiliations: Universidad de Sevilla (ES)
Centro Andaluz de Biología del Desarrollo (ES)
ORCID: Talero, Elena
Gamero-Estévez, Enrique
Motilva, Virginia
Navas, Plácido
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2015-04
Volume: 64
Pages: 1-7
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2015.02.004
OpenAlex: W2032134401
Cited by: 71
References: 46
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 10 · 2018: 5 · 2017: 8 · 2016: 8 · 2015: 7
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Andalusian Government
Spanish Government (DEP2012-39985)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, aging, liver inflammation, inflammatory cytokines, cyclooxygenase-2, caloric restriction, oxidative stress, IL-1β, TNF-α, interleukin-6, IL-17, IL-10, C57BL/6J mice
MeSH terms: Resveratrol, Aging, Animals, Anti-Inflammatory Agents, Non-Steroidal, Inflammation, Liver, Male, Mice, Inbred C57BL, RNA, Messenger, Stilbenes, Biomarkers, Cytokines, Oxidative Stress, Mice

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Anti-Inflammatory Effect of Resveratrol in Old Mice Liver

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