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Genome-wide association study of hippocampal atrophy rate in non-demented elders

Guo, Yu, on behalf of Alzheimer’s Disease Neuroimaging Initiative, Xu, Wei, Li, Jie-Qiong, Ou, Ya-Nan, Shen, Xue-Ning, Huang, Yu-Yuan, Dong, Qiang, Tan, Lan, Yu, Jin-Tai·2019·Aging

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  • In TOMM40-APOC1, SNPs including rs4420638, rs56131196, and rs157582 have been identified as significant loci associated with hippocampal volume atrophy and accelerated cognitive decline in patients with MCI.

    “In the TOMM40-APOC1, single-nucleotide polymorphisms (SNPs), including rs4420638, rs56131196, and rs157582, have been identified as significant loci associated with hippocampal volume (HV) atrophy and accelerated cognitive decline in patients with mild cognitive impairment (MCI) [24].”

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Metadata

Authors
Guo, Y., Initiative, O. B. O. A. D. N., Xu, W., Li, J.-Q., Ou, Y.-N., Shen, X.-N., Huang, Y.-Y., Dong, Q., Tan, L., & Yu, J.-T.
Affiliations
  • Department of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China
  • Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Venue
Aging
Published
2019-11-23
Volume
11
Issue
22
Pages
10468-10484
ISSN
1945-4589
Cited by
20
References
5
Language
en

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