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A meta-analysis of hippocampal atrophy rates in Alzheimer's disease
Abstract
Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such rates are heterogeneous, leading to differences in reported annualised rates. We performed a meta-analysis of hippocampal atrophy rates in AD patients and matched controls from studies reported in the peer-reviewed literature. Studies reporting longitudinal volume change in hippocampi in AD subjects together with controls were systematically identified and appraised. All authors were contacted either to confirm the results or to provide missing data. Meta-analysis and meta-regression were then performed on this data. Nine studies were included from seven centres, with data from a total of 595 AD and 212 matched controls. Mean (95% CIs) annualised hippocampal atrophy rates were found to be 4.66% (95% CI 3.92, 5.40) for AD subjects and 1.41% (0.52, 2.30) for controls. The difference between AD and control subject in this rate was 3.33% (1.73, 4.94).
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Reduced hippocampal volume is closely associated with cognitive decline and progression to dementia.
“and reduced HV is closely associated with cognitive decline and progression to dementia [91–93].”
From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [92]
Citations
Cites
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“N IH -PA Author M anuscript N IH -PA Author M anuscript entorhinal cortex and hippocampus, to encompass the whole cortex, whereas plaque pathology is largely cortical and increases with disease severity (Braak et al., 1993).”
BackgroundComparison of different MRI brain atrophy rate measures with clinical disease progression in AD
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“In addition, loss of tissue volume over time can also be detected in large regions such as the whole brain (Jack et al., 2004) and in smaller temporal areas such as the hippocampus (Jack et al., 2004) and entorhinal cortex (Du et al., 2004).”
BackgroundMethodInfluentialEffects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
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“, 2004, 2007a), three did not report annualised atrophy rate (Laakso et al., 2000; Krishnan et al., 2003; Hampel et al., 2005) and two included patients with Vascular Dementia (Cardenas et al.”
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Metadata
- Authors
- Barnes, J., Bartlett, J. W., van de Pol, L. A., Loy, C. T., Scahill, R. I., Frost, C., Thompson, P., & Fox, N. C.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 30
- Issue
- 11
- Pages
- 1711-1723
- ISSN
- 0197-4580
- Cited by
- 373
- References
- 7
- Language
- en
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