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Cited by 83Mangiferin and Mango ExtractsCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1

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Ren, Kun, Li, Heng, Zhou, Hui-Fang, Liang, Yin, Tong, Min, Chen, Lu, Zheng, Xi-Long, Zhao, Guo-Jun·2019·Aging
DOI 10.18632/aging.102498PMC PMC6932905
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Abstract

H]-cholesterol efflux from acetylated LDL-loaded RAW264.7 macrophages with an increase in the expression of ATP binding cassette A1/G1 (ABCA1/G1), liver X receptor-α (LXRα) and peroxisome proliferator-activated receptor-γ (PPARγ). Moreover, transfection of PPARγ siRNA or LXRα siRNA markedly abolished the positive effects of mangiferin on ABCA1/G1 expression and cholesterol efflux. The opposite effects were observed after treatment with PPARγ agonist rosiglitazone or LXRα agonist T0901317. In conclusion, mangiferin may attenuate atherogenesis by promoting cholesterol efflux from macrophages via the PPARγ-LXRα-ABCA1/G1 pathway.

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  • Safety reporting is inconsistent, with limited long-term toxicity, immunomodulatory risk, and drug-drug interaction data.

    “Furthermore, safety reporting is inconsistent, with limited long-term toxicity, immunomodulatory risk and drug-drug interaction data, and with few studies that stratify patients by sex or age (184,185,190).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [190]

    The Discussion reports effects on cholesterol efflux and atherosclerosis, while Materials and Methods describes experiments in male mice; neither section assesses safety reporting across studies. Searches for long-term toxicity, immunomodulatory risk, drug–drug interactions, and sex- or age-stratified patient data found no passage addressing the claim. Page numbers were not available in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Ren, K., Li, H., Zhou, H.-F., Liang, Y., Tong, M., Chen, L., Zheng, X.-L., & Zhao, G.-J.
Affiliations
  • Anhui Medical University (CN)
  • University of South China (CN)
  • Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China
  • Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China
  • University of Calgary (CA)
  • Guilin Medical University (CN)
Corresponding author
Zhao, Guo-Jun
ORCID
Venue
Aging
Publisher
Impact Journals, LLC
Published
2019-12-02
Volume
11
Issue
23
Pages
10992-11009
ISSN
1945-4589 (ISSN-L)
DOI
10.18632/aging.102498
PMC
PMC6932905
OpenAlex
W2992802637
Cited by
83
References
4
Citations by year
2026: 7 · 2025: 9 · 2024: 15 · 2023: 16 · 2022: 18 · 2021: 12 · 2020: 5 · 2018: 1
FWCI
11.28
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
mangiferin, macrophage cholesterol efflux, atherosclerosis, ABCA1, ABCG1, PPARγ, liver X receptor alpha, acetylated LDL, RAW 264.7 macrophages, rosiglitazone, T0901317, atherogenesis
MeSH terms
RAW 264.7 Cells, ATP Binding Cassette Transporter, Subfamily G, Member 1, Animals, Cholesterol, Macrophages, Male, Mice, Knockout, Xanthones, Atherosclerosis, Mice, ATP Binding Cassette Transporter 1

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