Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Abstract
In the present study, the effect of mangiferin (a xanthone glucoside, isolated from the leaves of Mangifera indica) on the atherogenic potential of streptozotocin (STZ)-diabetes was investigated. In addition, the effect of mangiferin on oral glucose tolerance in glucose-loaded normal rats was also determined. The chronic intraperitoneal (i.p.) administration of mangiferin (10 and 20 mg/kg) once daily (o.d.) for 28 days exhibited antidiabetic activity by significantly lowering fasting plasma glucose level at different time intervals in STZ-diabetic rats. Further, mangiferin (10 and 20 mg/kg, i.p.) showed significant antihyperlipidemic and antiatherogenic activities as evidenced by significant decrease in plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) levels coupled together with elevation of high-density lipoprotein cholesterol (HDL-C) level and diminution of atherogenic index in diabetic rats. In addition, the chronic administration of mangiferin (10 and 20 mg/kg, i.p.) for 14 days significantly as well as markedly improved oral glucose tolerance in glucose-loaded normal rats suggesting its potent antihyperglycemic activity. The accumulating evidences suggest that both pancreatic and extrapancreatic mechanisms might be involved in its antidiabetic or antihyperglycemic action. In conclusion, the present study demonstrates that mangiferin possesses significant antidiabetic, antihyperlipidemic and antiatherogenic properties thus suggesting i…
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Mangiferin exerts significant antidiabetic, antihyperlipidemic and antiatherogenic effects in diabetic rat models.
“Similarly, Muruganandan et al (28), Miura et al (29,30) and Suman et al (31) verified that mangiferin exerted significant antidiabetic, antihyperlipidemic and antiatherogenic effects in diabetic rat models.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [28]
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- Authors
- Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J.
- Affiliations
- Indian Veterinary Research Institute (IN)
- National Institute of Pharmaceutical Education and Research (IN)
- Corresponding author
- Muruganandan, S.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 97
- Issue
- 3
- Pages
- 497-501
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2062384175
- Cited by
- 426
- References
- 2
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 14 · 2023: 21 · 2022: 29 · 2021: 24 · 2020: 15 · 2019: 20 · 2018: 29 · 2017: 22 · 2016: 39 · 2015: 27 · 2014: 33 · 2013: 28 · 2012: 26
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Keywords
- mangiferin, mango, streptozotocin-induced diabetes, hyperglycemia, antidiabetic activity, hypolipidemic activity, anti-atherogenic activity, oral glucose tolerance, atherogenic index, plasma lipids, diabetes mellitus, cardiovascular complications
- MeSH terms
- Animals, Arteriosclerosis, Diabetes Mellitus, Experimental, Hyperglycemia, Male, Plant Extracts, Rats, Wistar, Plant Leaves, Xanthones, Rats
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