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Inflammatory factors and amyloid β-induced microglial polarization promote inflammatory crosstalk with astrocytes
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This coordinated shift in crosstalk between microglial polarization and astrocytic responses mirrors findings reported in other AD studies.
“This coordinated shift in crosstalk between microglial polarization and astrocytic responses mirrors findings reported in other AD studies [45].”
From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [45]
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Neurotoxic reactive astrocytes are induced by activated microglia
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“In a previous study, Aβ plaques surrounded by M2 microglia were observed in 6-month-old PS1/APP mice, but more abundant plaques were observed in 18-month-old mice when M2 microglia began to convert to the M1 phenotype [29].”
BackgroundTGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation
Norden, D. M., Fenn, A. M., Dugan, A., & Godbout, J. P. (2014) · Glia · doi:10.1002/glia.22647 · Cited by 332
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice
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“A previous report indicated that Arg1 reduced inflammatory signaling in microglia by activating Stat6 pathways [12].”
BackgroundInfluentialThe LPS receptor (CD14) links innate immunity with Alzheimer's disease
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Self-citationSecreted protein lipocalin‐2 promotes microglial M1 polarization
Jang, E., Lee, S., Kim, J., Kim, J., Seo, J., Lee, W., Mori, K., Nakao, K., & Suk, K. (2013) · The FASEB Journal · doi:10.1096/fj.12-222257 · Cited by 198
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
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Cited by
Sorted by citations
Cai, Y., Liu, J., Wang, B., Sun, M., & Yang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856376 · Cited by 351
The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration
Mitroshina, E. V., & Vedunova, M. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094581 · Cited by 48
Ramonet, D., Daerr, A., & Hallbeck, M. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02096-8 · Cited by 7
Metadata
- Authors
- Xie, L., Zhang, N., Zhang, Q., Li, C., Sandhu, A. F., III, G. W., Lin, S., Lv, P., Liu, Y., Wu, Q., & Yu, S.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2020-11-09
- ISSN
- 1945-4589
- PMC
- PMC7746366
- Cited by
- 48
- References
- 12
- Language
- en
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