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Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery

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Map of epigenetic age acceleration: A worldwide analysis

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Distinct sex-specific DNA methylation differences in Alzheimer’s disease

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The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis

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Environmental DNA methylation of Lymnaea stagnalis varies with age and is hypermethylated compared to tissue DNA

Zhao, B., van Bodegom, P. M., & Trimbos, K. B. (2022) · Molecular Ecology Resources · doi:10.1111/1755-0998.13691 · Cited by 31 · see citing works

Influence of biological sex on neuroinflammatory dynamics in the aging brain

Müller, L., Benedetto, S. D., & Müller, V. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1670175 · Cited by 30 · see citing works

DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson’s Disease

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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes

Pangrazzi, L., & Meryk, A. (2024) · Biology · doi:10.3390/biology14010017 · Cited by 30 · see citing works

Current Challenges of Methylation-Based Liquid Biopsies in Cancer Diagnostics

Rendek, T., Pös, O., Duranova, T., Saade, R., Budiš, J., Repiská, V., & Szemes, T. (2024) · Cancers · doi:10.3390/cancers16112001 · Cited by 29 · see citing works

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation

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Targeting MEX3A attenuates metastasis of breast cancer via β-catenin signaling pathway inhibition

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Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

Jacob, S. M., Lee, S., Kim, S. H., Sharkey, K. A., Pfeffer, G., & Nguyen, M. D. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00991-7 · Cited by 25 · see citing works

A Review of the Epigenetic Clock: Emerging Biomarkers for Asthma and Allergic Disease

Vasileva, D., Greenwood, C. M. T., & Daley, D. (2023) · Genes · doi:10.3390/genes14091724 · Cited by 24 · see citing works

Neuroimmune dynamics and brain aging: mechanisms and consequences

Müller, L., Benedetto, S. D., & Müller, V. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1715045 · Cited by 22 · see citing works

Ageing-associated changes in DNA methylation in X and Y chromosomes

Kananen, L., & Marttila, S. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-021-00407-6 · Cited by 20 · see citing works

The role of genetics and epigenetics in sex differences in human survival

Iannuzzi, V., Bacalini, M. G., Franceschi, C., & Giuliani, C. (2023) · Genus · doi:10.1186/s41118-023-00181-1 · Cited by 20 · see citing works

Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus

Achiro, J. M., Tao, Y., Gao, F., Lin, C.-H., Watanabe, M., Neumann, S., Coppola, G., Black, D. L., & Martin, K. C. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1334862 · Cited by 19 · see citing works

Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases

Stoccoro, A. (2025) · Biology · doi:10.3390/biology14010098 · Cited by 17 · see citing works

Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging

Okada, D., Cheng, J. H., Zheng, C., Kumaki, T., & Yamada, R. (2023) · Human Genomics · doi:10.1186/s40246-023-00453-z · Cited by 17 · see citing works

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

Czamara, D., Neufang, A., Dieterle, R., Iurato, S., Arloth, J., Martins, J., Ising, M., Binder, E. B., & Erhardt, A. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01274-y · Cited by 19 · see citing works

Toxicoepigenetics and Environmental Health: Challenges and Opportunities

Svoboda, L. K., Perera, B. P. U., Morgan, R. K., Polemi, K. M., Pan, J., & Dolinoy, D. C. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00445 · Cited by 16 · see citing works

Sex and Gender in Ageing and Longevity: Highlights from an International Course

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Forensic prediction of sex, age, height, body mass index, hip-to-waist ratio, smoking status and lipid lowering drugs using epigenetic markers and plasma proteins.

Llobet, M., Johansson, Å., Gyllensten, U., Allen, M., & Enroth, S. (2023) · Forensic Science International: Genetics · doi:10.1016/j.fsigen.2023.102871 · Cited by 11 · see citing works

Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function

Veser, C., Carlier, A., Dubois, V., Mihaila, S. M., & Swapnasrita, S. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00662-8 · Cited by 18 · see citing works

Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

Shahal, T., Segev, E., Konstantinovsky, T., Marcus, Y., Shefer, G., Pasmanik‐Chor, M., Buch, A., Ebenstein, Y., Zimmet, P., & Stern, N. (2022) · Epigenetics & Chromatin · doi:10.1186/s13072-022-00441-y · Cited by 13 · see citing works

Epigenetics of the far northern Yakutian population

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Epigenetic Drift Association with Cancer Risk and Survival, and Modification by Sex

Yu, C., Wong, E. M., Joo, J. E., Hodge, A. M., Makalic, E., Schmidt, D. F., Buchanan, D. D., Severi, G., Hopper, J. L., English, D. R., et al. (2021) · Cancers · doi:10.3390/cancers13081881 · Cited by 12 · see citing works

A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review

Chambers, T. L., & Murach, K. A. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00968.2024 · Cited by 11 · see citing works

An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples

Harbs, J., Rinaldi, S., Keski‐Rahkonen, P., Liu, X., Palmqvist, R., Guelpen, B. R. V., & Harlid, S. (2023) · Epigenetics · doi:10.1080/15592294.2023.2196759 · Cited by 11 · see citing works

Epigenetic age estimation in a long-lived, deepwater scorpionfish: insights into epigenetic clock development

Weber, D. N., Fields, A. T., Chamberlin, D. W., Patterson, W. F., & Portnoy, D. S. (2024) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/cjfas-2023-0296 · Cited by 12 · see citing works

Designing Epigenetic Clocks for Wildlife Research

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Epigenetic Studies for Evaluation of NPS Toxicity: Focus on Synthetic Cannabinoids and Cathinones

Mazdai, L., Fabbri, M., Tirri, M., Corli, G., Arfè, R., Marchetti, B., Bilel, S., Bergamin, E., Gaudio, R. M., Rubini, M., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10061398 · Cited by 11 · see citing works

A systematic review on the contribution of DNA methylation to hearing loss

Patil, V., Perez‐Carpena, P., & Lopez-Escamez, J. A. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01697-9 · Cited by 9 · see citing works

A systematic review of associations between the environment, DNA methylation, and cognition

Glover, S., Illyuk, J., Hill, C., McGuinness, B., McKnight, A. J., & Hunter, R. F. (2024) · Current Zoology · doi:10.1093/eep/dvae027 · Cited by 9 · see citing works

Age-related changes in DNA methylation in a sample of elderly Brazilians

Welsh, H., Batalha, C. M. P. F., Li, W., de Souza-Pinto, N. C., Duarte, Y. A. O., Naslavsky, M. S., & Parra, E. J. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01821-3 · Cited by 9 · see citing works

DNA Methylation Dynamics Reflect Sex and Status Differences in Mortality Rates in a Polygynous Bat

Adams, D. M., Rayner, J. G., Hex, S. B. S. W., & Wilkinson, G. S. (2025) · Molecular Ecology · doi:10.1111/mec.17745 · Cited by 8 · see citing works

Sex-specific variations in global DNA methylation levels with age: a population-based exploratory study from North India

Kaushik, A., Chaudhary, V., Longkumer, I., Saraswathy, K. N., & Jain, S. G. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1038529 · Cited by 8 · see citing works

Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications

Ajayi, A. F., Oyovwi, M. O., Olatinwo, G. O., & Akano, O. P. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09823-9 · Cited by 8 · see citing works

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localizationPreprint

Nguyen, V. T. C., Nguyen, T. H., Doan, N. N. T., Pham, T. M. Q., Nguyen, G. T. H., Nguyen, T. D., Tran, T. T. T., Long, V. D., Phan, T. H., Jasmine, T. X., et al. (2023) · medRxiv · doi:10.1101/2023.04.12.23288460 · Cited by 8 · see citing works

Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model

Abudahab, S., Kronfol, M. M., Dozmorov, M. G., Campbell, T. J., Jahr, F. M., Nguyen, J., AlAzzeh, O., Saeedy, D. A., Victor, A., Lee, S., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01137-9 · Cited by 7 · see citing works

Noninvasive, epigenetic age estimation in an elasmobranch, the cownose ray (Rhinoptera bonasus)

Weber, D. N., Wyffels, J. T., Buckner, C., George, R., Latson, F. E., LePage, V., Lyons, K., & Portnoy, D. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-78004-2 · Cited by 7 · see citing works

DNA methylation–based age prediction and sex-specific epigenetic aging in a lizard with female-biased longevity

Shealy, E. P., Schwartz, T. S., Cox, R. M., Reedy, A. M., & Parrott, B. B. (2025) · Science Advances · doi:10.1126/sciadv.adq3589 · Cited by 7 · see citing works

Epigenetic aging in Williams syndrome

Okazaki, S., Kimura, R., Otsuka, I., Tomiwa, K., Funabiki, Y., Hagiwara, M., Murai, T., & Hishimoto, A. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13613 · Cited by 7 · see citing works

Age-related trajectories of DNA methylation network markers: A parenclitic network approach to a family-based cohort of patients with Down Syndrome

Krivonosov, M., Nazarenko, T., Bacalini, M. G., Vedunova, M., Franceschi, C., Zaikin, A. A., & Ivanchenko, M. (2022) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2022.112863 · Cited by 7 · see citing works

Intricacies of aging and Down syndrome

Kozlov, G., Franceschi, C., & Vedunova, M. V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105794 · Cited by 6 · see citing works

Where are we in the implementation of tissue-specific epigenetic clocks?

Sala, C., Lena, P. D., Durso, D. F., do Valle, Í. F., Bacalini, M. G., Dall’Olio, D., Franceschi, C., Castellani, G., Garagnani, P., & Nardini, C. (2024) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2024.1306244 · Cited by 5 · see citing works

Current evidence supporting associations of DNA methylation measurements with survivorship burdens in cancer survivors: A scoping review

Sayer, M., Ng, D. Q., Chan, R. J., Kober, K. M., & Chan, A. (2024) · Cancer Medicine · doi:10.1002/cam4.7470 · Cited by 6 · see citing works

Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults

Fornage, M., Tarraf, W., Daviglus, M. L., DeCarli, C. S., González, K. A., Isasi, C. R., Kuwayama, S., Lamar, M., Levin, B. E., Parada, H., et al. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01941-w · Cited by 5 · see citing works

Transcriptome-wide regulation of folate on neural mRNA m6A methylome via carbon metabolism in Drosophila and mammals

Liu, A., Huo, Z., Xu, Z., Liu, S., Jiao, Y., Li, R., Lu, Y., Yang, M., Huang, J., Huang, C., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08623-6 · Cited by 5 · see citing works

Building Minimized Epigenetic Clock by iPlex MassARRAY Platform

Davydova, E. A., Perenkov, A. D., & Vedunova, M. V. (2024) · Genes · doi:10.3390/genes15040425 · Cited by 5 · see citing works

Associations between inflammation and striatal dopamine D2-receptor availability in aging

Crine, V., Papenberg, G., Johansson, J. J., Boraxbekk, C., Wåhlin, A., Lindenberger, U., Lövdén, M., Riklund, K., Bäckman, L., Nyberg, L. H., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03355-0 · Cited by 5 · see citing works

Characterizing the human methylome across the life course: findings from eight UK-based studiesPreprint

Walton, E., Marioni, R. E., Elliott, H. R., Cox, S. R., Deary, I. J., Hughes, A. D., Tillin, T., Meena Kumari, B., Woofenden, T., Fernandez, J. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.18.460916 · Cited by 5 · see citing works

Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation

Grolaux, R., Jacques, M., Jones, B., Horvath, S., Teschendorff, A. E., & Eynon, N. (2026) · Genome biology · doi:10.1186/s13059-026-03952-z · Cited by 7 · see citing works

Sex-specific differences in DNA methylation defining prognostically relevant subgroups in glioblastoma

Kiesel, B., Borkovec, M., Furtner, J., Roetzer-Pejrimovsky, T., Nenning, K., Greutter, L., Miller-Michlits, Y., Widhalm, G., & Wöehrer, A. (2025) · Journal of neurosurgery · doi:10.3171/2024.9.jns24665 · Cited by 4 · see citing works

A Sex-Specific Minimal CpG-Based Model for Biological Aging Using ELOVL2 Methylation Analysis

Ibáñez-Cabellos, J. S., Sandoval, J., Pallardó, F. V., García‐Giménez, J. L., & Mena, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073392 · Cited by 4 · see citing works

Age and sex effects on DNA methylation sites linked to genes implicated in severe COVID-19 and SARS-CoV-2 host cell entry

Bohlin, J., Page, C. M., Lee, Y., Pettersson, J. H. ‐., Jugessur, A., Magnus, P. M., & Håberg, S. E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269105 · Cited by 4 · see citing works

Age estimation of captive Asian elephants (Elephas maximus) based on DNA methylation: An exploratory analysis using methylation-sensitive high-resolution melting (MS-HRM)

Arai, K., Qi, H., & Inoue‐Murayama, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294994 · Cited by 4 · see citing works

Methylome analysis in long-lived men deciphers DNA methylation modifications associated with male longevity in humans

Xiao, F., Wang, H., Zhao, L., Xia, T., Yang, L., Ma, S., & Kong, Q. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115158 · Cited by 4 · see citing works

Testosterone and Life Span or Why Women Live Longer than Men: A Hypothesis

Kulikov, A. V., & Архипова, Л. В. (2021) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392521030093 · Cited by 4 · see citing works

Biological underpinnings of sex differences in neurological disorders

Winek, K., Tzur, Y., & Soreq, H. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.06.009 · Cited by 3 · see citing works

Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns

Ciantar, J., Marttila, S., Rajić, S., Kostiniuk, D., Mishra, P. P., Lyytikäinen, L., Mononen, N., Kleber, M., März, W., Kähönen, M., et al. (2024) · Epigenetics · doi:10.1080/15592294.2024.2397297 · Cited by 3 · see citing works

The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms

Scheinman, S. B., & Dong, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241288709 · Cited by 3 · see citing works

Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice

Perazza, L. R., Bougher, C. M., & Thompson, L. V. (2024) · GeroScience · doi:10.1007/s11357-024-01430-7 · Cited by 3 · see citing works

Epigenetic Control in Schizophrenia

D’Addario, C., & Bartolomeo, M. D. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_5 · Cited by 3 · see citing works

B Cells Isolated from Individuals Who Do Not Respond to the HBV Vaccine Are Characterized by Higher DNA Methylation-Estimated Aging Compared to Responders

Kwiatkowska, K. M., Anticoli, S., Salvioli, S., Calzari, L., Gentilini, D., Albano, C., Prinzio, R. R. D., Zaffina, S., Carsetti, R., Ruggieri, A., et al. (2024) · Vaccines · doi:10.3390/vaccines12080880 · Cited by 3 · see citing works

Blood-based sex-differential DNA methylation in Alzheimer’s disease

Yang, T., Li, C., Wei, Q., Cheng, Y., Xiao, Y., & Shang, H. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.28 · Cited by 3 · see citing works

Sex-Specific Age-Related Changes in Methylation of Certain Genes

Kondakova, E. V., Vershinina, O., Lopatenko, M. V., Franceschi, C., Ivanchenko, M., & Vedunova, M. V. (2021) · Современные технологии в медицине · doi:10.17691/stm2021.13.3.03 · Cited by 2 · see citing works

Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy

Huff, K., Bulka, C. M., Clark, J., Roell, K. R., O’Shea, T. M., & Fry, R. C. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01988-9 · Cited by 2 · see citing works

KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population

Yun, D., Oh, K., Kim, Y., Ahn, Y. M., Parikh, H. M., Meng, X., Wang, Z., & Song, N. (2025) · BMC Medicine · doi:10.1186/s12916-025-04564-3 · Cited by 2 · see citing works

Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses

Lou, C., Wang, G., Xiong, Z., Jiang, Y. C., Li, Y., Zhu, M. Q., Yang, H., Wang, L., He, L., Chang, H., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102481 · Cited by 2 · see citing works

Sex-specific differences in liver DNA methylation patterns and epigenetic aging in mice

Apelian, S., Mamillapalli, R., Uçar, A., Gawde, N., & Taylor, H. S. (2026) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00322.2025 · Cited by 2 · see citing works

Transcending genome-wide association studies to create useful multi-omic views of glaucoma

Li, K., Kang, J. H., Khawaja, A. P., Jardines, S., Vergroesen, J. E., Ramdas, W. D., Stuart, K. V., Luben, R., Hysi, P. G., Hanyuda, A., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101490 · Cited by 2 · see citing works

Age-Dependent DNA Methylation Variability on the X-Chromosome in Male and Female Twins

Tan, Q., Alo, H., Nygaard, M., Soerensen, M., Saleh, A., Mengel‐From, J., & Christensen, K. (2024) · Epigenomes · doi:10.3390/epigenomes8040043 · Cited by 2 · see citing works

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localizationPreprint

Nguyen, V. T. C., Nguyen, T. H., Doan, N. N. T., Pham, T. M. Q., Nguyen, G. T. H., Nguyen, T. D., Tran, T. T. T., Long, V. D., Phan, T. H., Jasmine, T. X., et al. (2023) · eLife · doi:10.7554/elife.89083.1 · Cited by 2 · see citing works

DNA methylation-based biomarkers for cardiometabolic-related traits and their importance for risk stratification

Colicino, E., & Fiorito, G. (2023) · Current Opinion in Epidemiology and Public Health · doi:10.1097/pxh.0000000000000020 · Cited by 1 · see citing works

Epigenetics as a target to mitigate excess stroke risk in people of African ancestry: A scoping review

Opare‐Addo, P. A., Sarfo, F. S., Aikins, M., Bediako, S. A., & Ovbiagele, B. I. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107585 · Cited by 2 · see citing works

Epigenetic aging acceleration among World Trade Center-exposed community members

Tuminello, S., Ashebir, Y. A., Schroff, C., Ramaswami, S., Durmuş, N., Chen, Y., Snuderl, M., Shao, Y., Reibman, J., & Arslan, A. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-10141-8 · Cited by 1 · see citing works

Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging

Téglás, T., Torma, F., Bori, Z., Aczél, D., Babszky, G., Kawamura, T., Higuchi, M., Gu, Y., Lee, M., Sm, H., et al. (2026) · GeroScience · doi:10.1007/s11357-025-02092-9 · Cited by 1 · see citing works

Epigenetic clocks and biological aging

Martynenko, A., & Ilnitski, A. (2026) · Vrach · doi:10.29296/25877305-2026-01-06 · Cited by 1 · see citing works

Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos

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Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localizationPreprint

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Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse SepsisPreprint

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Predicting Biological Age and Clinical Biomarkers from DNA Methylation Profiles of Cheek MucosaPreprint

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An epigenome-wide association study of sex-specific chronological ageing

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Sexually divergent DNA methylation patterns with hippocampal aging

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