HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells
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. In addition, we found that inhibition of HSP90 by IPI504 reduces SA-β-Gal's protein expression and enzyme activity in a dose-dependent manner. HSP90 interacts with and regulates SA-β-Gal protein stabilization in senescent ARPE-19 cells. Taken together, these results suggest that HSP90 regulates the SASP and SA-β-Gal activity in senescent RPE cells through associating with distinctive mechanism including NF-κB, HIF1α and lysosomal SA-β-Gal. HSP90 inhibitors (e.g. IPI504) could be a promising senomorphic drug candidate for AMD intervention.
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Inhibition of HSP90 might help regulate the SASP.
“Additionally, the inhibition of heat-shock protein 90 (HSP90) might help regulate the SASP [128].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [128]
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The role of cellular senescence and SASP in tumour microenvironment
Takasugi, M., Yoshida, Y., Hara, E., & Ohtani, N. (2023) · The FEBS Journal · doi:10.1111/febs.16381 · Cited by 144 · see citing works
- Authors
- Chen, D.-D., Peng, X., Wang, Y., Jiang, M., Xue, M., Shang, G., Liu, X., Jia, X., Liu, B., Lu, Y., Mu, H., Zhang, F., & Hu, Y.
- Affiliations
- The Division of Ophthalmology and Vision Science, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhengzhou University (CN)
- Kaifeng Key laboratory of Cataracts and Myopia, Eye Disease Institute, Kaifeng Central Hospital, Kaifeng, China
- Henan University (CN)
- Corresponding author
- Zhang, Fengyan
- Hu, Yanzhong
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2021-09-08
- Volume
- 13
- Issue
- 17
- Pages
- 21547-21570
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC8457597
- OpenAlex
- W3197316461
- Cited by
- 38
- References
- 51
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 10 · 2023: 5 · 2022: 6
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81900843, 31802314, 81570825, 81970785, U1604171)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- HSP90, retinal pigment epithelium, cellular senescence, Hsp90 inhibitors, senescence-associated secretory phenotype, senescence-associated β-galactosidase, lysosomal beta-galactosidase, NF-κB, HIF-1α, age-related macular degeneration, ARPE-19 cells
- MeSH terms
- Senotherapeutics, Animals, Cell Line, Cells, Cultured, Cytokinins, Epithelial Cells, Humans, Hydrogen Peroxide, Macaca mulatta, Macular Degeneration, Retina, Benzoquinones, Cellular Senescence, HSP90 Heat-Shock Proteins, Lactams, Macrocyclic, Retinal Pigment Epithelium
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