Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss
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studies demonstrated that PTH protects osteocytes from oxidative stress-induced cell death. In summary, we reported that PPR signaling in osteocytes is important for protecting the skeleton from age-induced bone loss by restraining osteoclast's activity and protecting osteocytes from oxidative stresses.
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When PTHR1 was deleted in mouse osteocytes in vivo (Dmp1-PPRKO), the affected mice displayed age-dependent osteopenia related to a decrease in osteoblast activity with a parallel rise in osteoclast number and activity; the imbalanced bone remodeling was partially due to a sclerostin-dependent decrease in osteoblast activity and the lack of osteocyte protection from oxidative stress.
“When PTHR1 was deleted in mouse osteocytes in vivo (Dmp1-PPRKO), the affected mice displayed age-dependent osteopenia related to a decrease in osteoblast activity with a parallel rise in osteoclast number and activity. The imbalanced bone remodeling in these animals was partially due to a sclerostin-dependent decrease in osteoblast activity and the lack of osteocyte protection from oxidative”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [93]
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- Authors
- Uda, Y., Saini, V., Petty, C. A., Alshehri, M., Shi, C., Spatz, J. M., Santos, R., Newell, C. M., Huang, T. Y., Kochen, A., Kim, J. W., Constantinou, C. K., Saito, H., Held, K. D., Hesse, E., & Pajevic, P. D.
- Affiliations
- Boston University (US)
- Harvard University (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Pajevic, Paola Divieti
- ORCID
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2021-12-30
- Volume
- 13
- Issue
- 24
- Pages
- 25607-25642
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC8751595
- OpenAlex
- W4200071064
- Cited by
- 20
- References
- 55
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1s10od021652-01, DK079161)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK079161, AR060221, R01DK079161)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR060221, P30AR066261, UH3AR059655, UH2AR059655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- parathyroid hormone signaling, osteoblasts, osteocytes, age-related bone loss, osteoclast activity, oxidative stress, bone aging
- MeSH terms
- Animals, Bone and Bones, Bone Diseases, Metabolic, Bone Resorption, Homeostasis, Osteoblasts, Osteoclasts, Osteocytes, Osteoporosis, Parathyroid Hormone, Signal Transduction, Mice, Knockout, Receptor, Parathyroid Hormone, Type 1, Mice
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