Cited by 219Bone Metabolism and DiseasesBone health and osteoporosis researchSpaceflight effects on biology

β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

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Kitase, Yukiko, Vallejo, Julian A., Gutheil, William, Vemula, Harika, Jähn, Katharina, Yi, Jianxun, Zhou, Jingsong, Brotto, Marco +1 more·2018·Cell Reports

Abstract

Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.

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Crossref · 10.1016/j.celrep.2018.01.041

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  • Exercise-related paracrine effects occur in the nervous system, adipose tissue, bone, cartilage, extracellular matrix and immune system.

    “Exercise-related paracrine effects are also observed in the nervous system53, adipose tissue42,54–58, bone59–61, cartilage62, extracellular matrix63,64 and the immune system65,66.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [59]

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Authors
Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F.
Affiliations
  • Indiana University Indianapolis (US)
  • University of Missouri–Kansas City (US)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Kansas City University (US)
  • The University of Texas at Arlington (US)
Corresponding author
  • Kitase, Yukiko
  • Bonewald, Lynda F.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2018-02
Volume
22
Issue
6
Pages
1531-1544
ISSN
2211-1247 (ISSN-L)
OpenAlex
W2785863351
Cited by
219
References
63
Citations by year
2026: 20 · 2025: 25 · 2024: 39 · 2023: 36 · 2022: 18 · 2021: 26 · 2020: 23 · 2019: 25 · 2018: 7
FWCI
7.20
Type
journal article
Language
en
Open access
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • IUScholarWorks (Indiana University) (submittedVersion)
  • PMC
Funders
  • Indiana Clinical and Translational Sciences Institute
  • Clinical and Translational Science Institute, University of California, San Francisco
  • Center for Outcomes Research and Evaluation, Yale School of Medicine
  • School of Medicine, Indiana University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Keywords
beta-aminoisobutyric acid, osteocyte survival, osteocyte apoptosis, reactive oxygen species, MRGPRD, bone loss, hindlimb unloading, muscle-derived factors, aging, exercise and bone, mitochondrial damage, estrogen
MeSH terms
Aging, Aminoisobutyric Acids, Animals, Female, Male, Osteocytes, Oxidative Stress, Muscle, Skeletal, Hindlimb Suspension, Mice

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