β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
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Exercise has beneficial effects on metabolism and on tissues. The exercise-induced muscle factor β-aminoisobutyric acid (BAIBA) plays a critical role in the browning of white fat and in insulin resistance. Here we show another function for BAIBA, that of a bone-protective factor that prevents osteocyte cell death induced by reactive oxygen species (ROS). l-BAIBA was as or more protective than estrogen or N-acetyl cysteine, signaling through the Mas-Related G Protein-Coupled Receptor Type D (MRGPRD) to prevent the breakdown of mitochondria due to ROS. BAIBA supplied in drinking water prevented bone loss and loss of muscle function in the murine hindlimb unloading model, a model of osteocyte apoptosis. The protective effect of BAIBA was lost with age, not due to loss of the muscle capacity to produce BAIBA but likely to reduced Mrgprd expression with aging. This has implications for understanding the attenuated effect of exercise on bone with aging.
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Exercise-related paracrine effects occur in the nervous system, adipose tissue, bone, cartilage, extracellular matrix and immune system.
“Exercise-related paracrine effects are also observed in the nervous system53, adipose tissue42,54–58, bone59–61, cartilage62, extracellular matrix63,64 and the immune system65,66.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [59]
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Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works
Self-citationBlair, S. N. (1995) · JAMA · doi:10.1001/jama.273.14.1093 · Cited by 2,088 · see citing works
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works
Self-citationThe Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
Self-citationvan Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works
Fatigue of long duration in human skeletal muscle after exercise.
Edwards, R. H. T., Hill, D. K., Jones, D. A., & Merton, P. A. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012072 · Cited by 773 · see citing works
Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.60 · Cited by 731 · see citing works
Cavanaugh, D. J., Lee, H., Lo, L., Shields, S. D., Zylka, M. J., Basbaum, A. I., & Anderson, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901507106 · Cited by 706 · see citing works
Zylka, M. J., Rice, F. L., & Anderson, D. J. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.015 · Cited by 677 · see citing works
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works
Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works
Establishment of an Osteocyte-like Cell Line, MLO-Y4
Kato, Y., Windle, J. J., Koop, B. A., Mundy, G. R., & Bonewald, L. F. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.12.2014 · Cited by 549 · see citing works
Self-citationThe myokine irisin increases cortical bone mass
Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lü, P., Sartini, L., Comite, M. D., Mori, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516622112 · Cited by 513 · see citing works
Human Skeletal Muscle Function: Description of Tests and Normal Values
Edwards, R. H. T., Young, A., Hosking, G., & Jones, D. A. (1977) · Clinical Science · doi:10.1042/cs0520283 · Cited by 499 · see citing works
Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects
Giltay, E. J., Gooren, L. J., Toorians, A. W. F. T., Katan, M., & Zock, P. L. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1167 · Cited by 355 · see citing works
Bone and muscle: Interactions beyond mechanical
Brotto, M. A. P., & Bonewald, L. F. (2015) · Bone · doi:10.1016/j.bone.2015.02.010 · Cited by 347 · see citing works
Self-citationThe metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Xiong, J., Piemontese, M., Onal, M., Campbell, J., Goellner, J. J., Dusevich, V., Bonewald, L., Manolagas, S. C., & O’Brien, C. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138189 · Cited by 323 · see citing works
Self-citationQin, Y., Peng, Y., Zhao, W., Pan, J., Ksiȩżak-Reding, H., Cardozo, C. P., Wu, Y., Pajevic, P. D., Bonewald, L. F., Bauman, W. A., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770941 · Cited by 282 · see citing works
Self-citationKennedy, O. D., Herman, B. C., Laudier, D. M., Majeska, R. J., Sun, H. B., & Schaffler, M. B. (2012) · Bone · doi:10.1016/j.bone.2012.01.025 · Cited by 275 · cited 1× · see citing works
“Programmed osteocyte cell death is necessary to repair damaged bone (Kennedy et al., 2012; Verborgt et al., 2000, 2002).”
BackgroundBone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication
Karsenty, G., & Olson, E. N. (2016) · Cell · doi:10.1016/j.cell.2016.02.043 · Cited by 274 · see citing works
Nielsen, A. R., Mounier, R., Plomgaard, P., Mortensen, O. H., Penkowa, M., Speerschneider, T., Pilegaard, H., & Pedersen, B. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139618 · Cited by 266 · see citing works
Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability
Bellido, T., & Plotkin, L. I. (2010) · Bone · doi:10.1016/j.bone.2010.08.008 · Cited by 265 · see citing works
Dankbar, B., Fennen, M., Brunert, D., Hayer, S., Frank, S., Wehmeyer, C., Beckmann, D., Paruzel, P., Bertrand, J., Redlich, K., et al. (2015) · Nature Medicine · doi:10.1038/nm.3917 · Cited by 262 · see citing works
Feng, J., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T. W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L. F., et al. (2003) · Journal of Dental Research · doi:10.1177/154405910308201003 · Cited by 236 · see citing works
Self-citationEhrenborg, E., & Krook, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001560 · Cited by 213 · see citing works
Isolation and Culture of Primary Osteocytes from the Long Bones of Skeletally Mature and Aged Mice
Stern, A. R., Stern, M. M., Dyke, M. E. V., Jähn, K., Prideaux, M., & Bonewald, L. F. (2012) · BioTechniques · doi:10.2144/0000113876 · Cited by 207 · see citing works
Self-citationBasic Biology of Skeletal Aging: Role of Stress Response Pathways
Almeida, M., & O’Brien, C. A. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt079 · Cited by 202 · see citing works
Jilka, R. L., Noble, B., & Weinstein, R. S. (2012) · Bone · doi:10.1016/j.bone.2012.11.038 · Cited by 202 · see citing works
Kitase, Y., Barragan, L., Qing, H., Kondoh, S., Jiang, J. X., Johnson, M. L., & Bonewald, L. F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.168 · Cited by 199 · see citing works
Self-citationVerborgt, O., Tatton, N. A., Majeska, R. J., & Schaffler, M. B. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.5.907 · Cited by 192 · see citing works
Zuckerman, P. C., Frikha-Benayed, D., Majeska, R. J., Tuthill, A., Yakar, S., Judex, S., & Schaffler, M. B. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2807 · Cited by 189 · see citing works
Role of muscle-derived growth factors in bone formation.
Hamrick, M. W., McNeil, P. L., & Patterson, S. L. (2010) · PubMed · Cited by 181 · see citing works
Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis
Joeng, K. S., Lee, Y., Lim, J., Chen, Y., Jiang, M., Munivez, E. M., Ambrose, C. G., & Lee, B. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92617 · Cited by 181 · see citing works
Identification of a G Protein-coupled Receptor Specifically Responsive to β-Alanine
Shinohara, T., Harada, M., Ogi, K., Maruyama, M., Fujii, R., Tanaka, H., Fukusumi, S., Komatsu, H., Hosoya, M., Noguchi, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314240200 · Cited by 175 · see citing works
Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets
Bakewell, L., Burdge, G. C., & Calder, P. C. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061801 · Cited by 165 · see citing works
Zhou, J., Yi, J., Fu, R., Liu, E., Siddique, T., Rı́os, E., & Deng, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041319 · Cited by 147 · see citing works
Self-citationJung, T. W., Hwang, H.-J., Hong, H. C., Yoo, H. J., Baik, S. H., & Choi, K. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3663-z · Cited by 145 · see citing works
The Role of Osteocytes in Age-Related Bone Loss
Jilka, R. L., & O’Brien, C. A. (2016) · Current Osteoporosis Reports · doi:10.1007/s11914-016-0297-0 · Cited by 136 · see citing works
Mo, C., Romero‐Suarez, S., Bonewald, L. F., Johnson, M. L., & Brotto, M. (2012) · Recent Patents on Biotechnology · doi:10.2174/1872208311206030223 · Cited by 134 · see citing works
Self-citationForum on Bone and Skeletal Muscle Interactions: Summary of the Proceedings of an ASBMR Workshop
Bonewald, L., Kiel, D., Clemens, T., Esser, K., Orwoll, E., O'Keefe, R. J., & Fielding, R. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1980 · Cited by 119 · see citing works
Self-citationJähn, K., Lara-Castillo, N., Brotto, L. S., Mo, C., Johnson, M., Brotto, M., & Bonewald, L. F. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a14 · Cited by 117 · see citing works
Self-citationShi, C.-X., Zhao, M.-X., Shu, X.-D., Xiong, X.-Q., Wang, J.-J., Gao, X.-Y., Chen, Q., Li, Y.-H., Kang, Y.-M., & Zhu, G.-Q. (2016) · Scientific Reports · doi:10.1038/srep21924 · Cited by 108 · see citing works
Crosstalk Between MLO‐Y4 Osteocytes and C2C12 Muscle Cells Is Mediated by the Wnt/β‐Catenin Pathway
Huang, J. M., Romero‐Suarez, S., Lara, N., Mo, C., Kaja, S., Brotto, L. S., Dallas, S. L., Johnson, M. L., Jähn, K., Bonewald, L. F., et al. (2017) · JBMR Plus · doi:10.1002/jbm4.10015 · Cited by 107 · see citing works
Self-citationBasso, N., & Heersche, J. N. M. (2006) · Bone · doi:10.1016/j.bone.2006.04.014 · Cited by 103 · see citing works
Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths
Rinholm, J. E., Vervaeke, K., Tadross, M. R., Tkachuk, A. N., Kopek, B. G., Brown, T. A., Bergersen, L. H., & Clayton, D. A. (2016) · Glia · doi:10.1002/glia.22965 · Cited by 102 · see citing works
β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency
Begriche, K., Massart, J., Abbey‐Toby, A., Igoudjil, A., Lettéron, P., & Fromenty, B. (2008) · Obesity · doi:10.1038/oby.2008.337 · Cited by 99 · see citing works
Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?
Holzerová, E., & Prokisch, H. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.01.021 · Cited by 97 · see citing works
Yi, J., Ma, C., Li, Y., Weisleder, N. L., Rı́os, E., Ma, J., & Zhou, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217711 · Cited by 87 · see citing works
Self-citationManolagas, S. C., & PARFITT, A. M. (2012) · Bone · doi:10.1016/j.bone.2012.09.017 · Cited by 64 · see citing works
An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice
Ferreira, J. A., Crissey, J. M., & Brown, M. (2011) · Journal of Visualized Experiments · doi:10.3791/2467 · Cited by 54 · see citing works
Identification of Physiologically Active Substances as Novel Ligands for MRGPRD
Uno, M., Nishimura, S., Fukuchi, K., Kaneta, Y., Oda, Y., Komori, H., Takeda, S., Haga, T., Agatsuma, T., & Nara, F. (2012) · BioMed Research International · doi:10.1155/2012/816159 · Cited by 48 · see citing works
ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes
Wang, H., Yi, J., Li, X., Xiao, Y., Dhakal, K. R., & Zhou, J. (2017) · Bone · doi:10.1016/j.bone.2017.10.010 · Cited by 43 · see citing works
Self-citationGaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers
Vemula, H., Kitase, Y., Ayon, N. J., Bonewald, L. F., & Gutheil, W. G. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.10.017 · Cited by 40 · see citing works
Self-citationWang, H., Qian, J., Zhao, X., Xing, C., & Sun, B. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.12.005 · Cited by 38 · see citing works
Frikha-Benayed, D., Basta‐Pljakic, J., Majeska, R. J., & Schaffler, M. B. (2016) · Bone · doi:10.1016/j.bone.2016.05.011 · Cited by 37 · see citing works
Benefield, L. E., & Holtzclaw, B. J. (2014) · Nursing Clinics of North America · doi:10.1016/j.cnur.2014.02.001 · Cited by 24 · see citing works
Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading
Maurel, D. B., Duan, P., Farr, J. N., Cheng, A.-L., Johnson, M. L., & Bonewald, L. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158381 · Cited by 19 · see citing works
Self-citationMcNeil, B. D., & Dong, X. (2014) · Itch · doi:10.1201/b16573-16 · Cited by 10 · see citing works
In Vitro Assembly and Analysis of the Apoptosome ComplexPreprint
Langlais, C., Hughes, M. A., Cain, K., & MacFarlane, M. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot087080 · Cited by 7 · see citing works
The determination of β-amino-isobutyric acid in urine
Smith, H., & Dymond, B. (1963) · Clinica Chimica Acta · doi:10.1016/0009-8981(63)90113-x · Cited by 6 · see citing works
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Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 727 · see citing works
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.025 · Cited by 638 · see citing works
Self-citationRobling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539 · see citing works
Myokines: The endocrine coupling of skeletal muscle and bone
Gomarasca, M., Banfi, G., & Lombardi, G. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.010 · Cited by 274 · see citing works
The osteocyte as a signaling cell
Delgado‐Calle, J., & Bellido, T. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2020 · Cited by 269 · see citing works
Regulation of Skeletal Muscle Function by Amino Acids
Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 262 · see citing works
Use it or lose it to age: A review of bone and muscle communication
Bonewald, L. F. (2018) · Bone · doi:10.1016/j.bone.2018.11.002 · Cited by 229 · see citing works
Self-citationFulzele, S., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M., & Hamrick, M. W. (2019) · Aging · doi:10.18632/aging.101874 · Cited by 216 · see citing works
Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166 · see citing works
Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen
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Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
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Gao, J., Qin, A., Liu, D., Ruan, R., Wang, Q., Yuan, J., Cheng, T. S., Filipovska, A., Papadimitriou, J. M., Dai, K., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw7215 · Cited by 117 · see citing works
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Molecular insights of exercise therapy in disease prevention and treatment
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Sheng, R., Cao, M., Song, M., Wang, M., Zhang, Y., Shi, L., Xie, T., Li, Y., Wang, J., & Rui, Y. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.09.007 · Cited by 74 · see citing works
Neuromuscular Diseases and Bone
Iolascon, G., Paoletta, M., Liguori, S., Curci, C., & Moretti, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00794 · Cited by 71 · see citing works
Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications
Cariati, I., Bonanni, R., Onorato, F., Mastrogregori, A., Rossi, D., Iundusi, R., Gasbarra, E., Tancredi, V., & Tarantino, U. (2021) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk6020055 · Cited by 76 · see citing works
Bone-Muscle Mutual Interactions
Lara-Castillo, N., & Johnson, M. L. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00602-6 · Cited by 68 · see citing works
Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans
Stautemas, J., Van Kuilenburg, A. B. P., Stroomer, L., Vaz, F., Blancquaert, L., Lefevere, F. B. D., Everaert, I., & Derave, W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01240 · Cited by 66 · see citing works
Bo, T., & Fujii, J. (2024) · Molecules · doi:10.3390/molecules30010056 · Cited by 65 · see citing works
Yan, Y., Wang, L., Ge, L., & Pathak, J. L. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00564-9 · Cited by 57 · see citing works
Bone-organ axes: bidirectional crosstalk
Deng, A.-F., Wang, F., Wang, S., Zhang, Y., Bai, L., & Su, J. (2024) · Military Medical Research · doi:10.1186/s40779-024-00540-9 · Cited by 60 · see citing works
Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases
Colaianni, G., Storlino, G., Sanesi, L., Colucci, S. C., & Grano, M. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00600-8 · Cited by 61 · see citing works
Myokines: Metabolic regulation in obesity and type 2 diabetes
Chen, Z.-T., Weng, Z.-X., Lin, J. D., & Meng, Z.-X. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae006 · Cited by 58 · see citing works
Regulatory mechanisms and clinical manifestations of musculoskeletal aging
Grote, C. W., Reinhardt, D., Zhang, M., & Wang, J. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24292 · Cited by 53 · see citing works
Adhikary, S., Choudhary, D., Tripathi, A. K., Karvande, A., Ahmad, N., Kothari, P., & Trivedi, R. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.022 · Cited by 47 · see citing works
Cancer cachexia: molecular basis and therapeutic advances
Tan, Y., Xue, R., Pan, Y., he, Z., Hu, X., Li, Y., Li, K., Zhang, X., Bian, X.-W., & Wang, B. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02331-7 · Cited by 48 · see citing works
Sawada, M., Yamamoto, H., Ogasahara, A., Tanaka, Y., & Kihara, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.141 · Cited by 44 · see citing works
Role of myokines and osteokines in cancer cachexia
Pin, F., Bonewald, L. F., & Bonetto, A. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211009213 · Cited by 43 · see citing works
Self-citationBosco, F., Musolino, V., Gliozzi, M., Nucera, S., Carresi, C., Zito, M. C., Scarano, F., Scicchitano, M., Reale, F., Ruga, S., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105427 · Cited by 45 · see citing works
Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells
Huang, J. M., Wang, K., Shiflett, L. A., Brotto, L. S., Bonewald, L. F., Wacker, M., Dallas, S. L., & Brotto, M. A. P. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1691796 · Cited by 42 · see citing works
Self-citationSaeki, C., & Tsubota, A. (2021) · Life · doi:10.3390/life11090899 · Cited by 40 · see citing works
Shero, J. A., Lindholm, M. E., Sandri, M. F., & Stanford, K. I. (2025) · Circulation Research · doi:10.1161/circresaha.124.325614 · Cited by 43 · see citing works
Senescent and apoptotic osteocytes and aging: Exercise to the rescue?
Sherk, V. D., & Rosen, C. J. (2019) · Bone · doi:10.1016/j.bone.2019.02.006 · Cited by 40 · see citing works
Current risks factors and emerging biomarkers for bone stress injuries in military personnel
Greeves, J. P., Beck, B. R., Nindl, B. C., & O’Leary, T. J. (2023) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2023.04.006 · Cited by 37 · see citing works
Zheng, X., Li, X., Chen, M., Yang, P., Zhao, X., Zeng, L., Ouyang, Y., Yang, Z., & Tian, Z. (2019) · Food & Function · doi:10.1039/c8fo01818a · Cited by 37 · see citing works
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review
Barros, D. G. M., Marques, E. A., Magalhães, J., & Carvalho, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101780 · Cited by 36 · see citing works
Yi, X., Yang, Y., Li, T., Li, M., Yao, T., Hu, G., Wan, G., & Chang, B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192458 · Cited by 36 · see citing works
Ionic Silicon Protects Oxidative Damage and Promotes Skeletal Muscle Cell Regeneration
Awad, K. R., Ahuja, N., Fiedler, M., Peper, S., Wang, Z., Aswath, P. B., Brotto, M., & Varanasi, V. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020497 · Cited by 36 · see citing works
Self-citationEnergy Metabolism of Osteocytes
Karthik, V., & Guntur, A. R. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00688-6 · Cited by 36 · see citing works
Crosstalk between muscle and bone
Kaji, H. (2023) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01472-5 · Cited by 38 · see citing works
Muscle-derived factors influencing bone metabolism
Gries, K. J., Zysik, V. S., Jobe, T. K., Griffin, N., Leeds, B. P., & Lowery, J. W. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.10.009 · Cited by 34 · see citing works
Zhang, Z., Li, X., Guo, J., He, B., Wu, L., Yang, R., Li, X., Fang, D., Yang, X., Yang, D., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00729-z · Cited by 33 · see citing works
Sui, H., Dou, J., Shi, B., & Cheng, X. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1349253 · Cited by 32 · see citing works
Barlow, J. P., Karstoft, K., Vigelsø, A., Gram, M., Helge, J. W., Dela, F., Pappan, K. L., O’Neil, D. M., Dunn, W. B., & Solomon, T. P. J. (2020) · Metabolism Open · doi:10.1016/j.metop.2020.100053 · Cited by 31 · see citing works
Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits
Yang, Y. R., & Kwon, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.602748 · Cited by 32 · see citing works
Minato, T., Nakamura, N., Saiki, T., Miyabe, M., Ito, M., Matsubara, T., & Naruse, K. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.12.001 · Cited by 32 · see citing works
Old and new biomarkers for volumetric muscle loss
Downing, K., Prisby, R. D., Varanasi, V. G., Zhou, J., Pan, Z., & Brotto, M. A. P. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.05.001 · Cited by 31 · see citing works
Self-citationLau, P., Vico, L., & Rittweger, J. (2022) · Biomedicines · doi:10.3390/biomedicines10020342 · Cited by 32 · see citing works
The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis
Gao, H., Zhao, Y., Zhao, L., Wang, Z., Yan, K., Gao, B., & Zhang, L. (2023) · Aging and Disease · doi:10.14336/ad.2023.0223 · Cited by 32 · see citing works
Advances in the research on myokine-driven regulation of bone metabolism
Shao, M., Wang, Q., Lv, Q., Zhang, Y., Gao, G., & Lu, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22547 · Cited by 30 · see citing works
Osteogenesis Imperfecta: Muscle–Bone Interactions when Bi-directionally Compromised
Phillips, C. L., & Jeong, Y. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0456-6 · Cited by 29 · see citing works
Invernizzi, M., Alessandro de, S. I. R. E., Carda, S., Venetis, K., Renò, F., Cisari, C., & Fusco, N. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00601-7 · Cited by 29 · see citing works
Shochat, C., Wang, Z., Mo, C.-L., Nelson, S., Donaka, R., Huang, J., Karasik, D., & Brotto, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa189 · Cited by 25 · see citing works
Self-citationSarcopenic obesity and osteoporosis: Research progress and hot spots
Fan, S., Cai, Y., Wei, Y., Yang, J., Gao, J., & Yang, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112544 · Cited by 27 · see citing works
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review
Mitchell, A. K., Bliss, R. R., & Church, F. (2024) · Biomolecules · doi:10.3390/biom14101241 · Cited by 32 · see citing works
Invernizzi, M., Alessandro de, S. I. R. E., & Fusco, N. (2021) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.02.003 · Cited by 26 · see citing works
Wang, L., Lavier, J., Hua, W., Wang, Y., Gong, L., Hao, W., Wang, J., Pellegrin, M., Millet, G. P., & Zhang, Y. (2021) · Antioxidants · doi:10.3390/antiox10070992 · Cited by 26 · see citing works
Hahn, A. K., Batushansky, A., Rawle, R. A., Lopes, E. B. P., June, R. K., & Griffin, T. M. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.08.008 · Cited by 26 · see citing works
Yu, Y., Chen, W., Yu, M., Liu, J., Sun, H., & Yang, P. C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.803510 · Cited by 25 · see citing works
Uda, Y., Saini, V., Petty, C. A., Alshehri, M., Shi, C., Spatz, J. M., Santos, R., Newell, C. M., Huang, T. Y., Kochen, A., et al. (2021) · Aging · doi:10.18632/aging.203808 · Cited by 20 · see citing works
Effects of Muscles on Bone Metabolism—with a Focus on Myokines
Kim, B. (2022) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.22.0054 · Cited by 25 · see citing works
Qin, T., Shi, M., Zhang, C., Wu, J., Huang, Z., Zhang, X., Li, S., Wu, Y., Han, W., Gao, B., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01345-5 · Cited by 23 · see citing works
Cell-Free Fat Extract Prevents Tail Suspension–Induced Bone Loss by Inhibiting Osteocyte Apoptosis
Xu, M.-M., Du, J., Cui, J.-Q., Zhang, S.-Y., Zhang, S., Deng, M., Zhang, W.-J., Li, H., & Yu, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.818572 · Cited by 17 · see citing works
Metabokines in the regulation of systemic energy metabolism
MacCannell, A. D. V., & Roberts, L. D. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102286 · Cited by 23 · see citing works
Arora, R., Theemsche, K. M. V., Remoortel, S. V., Snyders, D. J., Labro, A. J., & Timmermans, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413254 · Cited by 22 · see citing works
Pignolo, R. J. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00253.x · Cited by 21 · see citing works
Physical Activity, Exerkines, and Their Role in Cancer Cachexia
Bilski, J., Szlachcic, A., Ptak‐Belowska, A., & Brzozowski, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168011 · Cited by 22 · see citing works
Zhao, W., Peng, Y., Hu, Y., Guo, X., Li, J., Cao, J., Pan, J., Feng, J. Q., Cardozo, C. P., Jarvis, J. C., et al. (2020) · Bone · doi:10.1016/j.bone.2020.115825 · Cited by 21 · see citing works
Li, G., Zhang, L., Lu, Z., Yang, B., Yang, H., Shang, P., Jiang, J. X., Wang, D., & Xu, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113506 · Cited by 21 · see citing works
Audzeyenka, I., Szrejder, M., Rogacka, D., Angielski, S., Saleem, M. A., & Piwkowska, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-27914-8 · Cited by 21 · see citing works
Roles of Amino Acid Derivatives in the Regulation of Obesity
Zheng, J., Xiao, H., Duan, Y., Song, B., Zheng, C., Guo, Q., Li, F., & Li, T. (2021) · Food & Function · doi:10.1039/d1fo00780g · Cited by 20 · see citing works
Osteocytic Connexin43 Channels Regulate Bone–Muscle Crosstalk
Li, G., Zhang, L., Ning, K., Yang, B., Acosta, F. M., Shang, P., Jiang, J. X., & Xu, H. (2021) · Cells · doi:10.3390/cells10020237 · Cited by 20 · see citing works
Impact of Intrinsic Muscle Weakness on Muscle–Bone Crosstalk in Osteogenesis Imperfecta
Gremminger, V. L., & Phillips, C. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094963 · Cited by 20 · see citing works
Omosule, C. L., Gremminger, V. L., AGUILLARD, A., Jeong, Y., Harrelson, E. N., Miloscio, L., Mastaitis, J. W., Rafique, A., Kleiner, S., Pfeiffer, F. M., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4223 · Cited by 19 · see citing works
Pignolo, R. J. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220012 · Cited by 42 · see citing works
Pin, F., Prideaux, M., Bonewald, L. F., & Bonetto, A. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00712-9 · Cited by 19 · see citing works
Self-citationShanmugasundaram, D., Fan, Q., Wang, M., Yi, R., & Wang, O. (2022) · International Journal of Toxicology · doi:10.1177/10915818221094487 · Cited by 18 · see citing works
Sakamoto, E., Kitase, Y., Fitt, A. J., Zhu, Z., Awad, K. R., Brotto, M. A. P., White, K. E., Welc, S. S., Bergwitz, C., & Bonewald, L. F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114397 · Cited by 18 · see citing works
Self-citationSkeletal muscle-derived exosomes prevent osteoporosis by promoting osteogenesis
Xing, Z., Guo, L., Li, S., Huang, W., Su, J., Chen, X., Li, Y., & Zhang, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123079 · Cited by 20 · see citing works
Amino acids at the intersection of nutrition and insulin sensitivity
Zhang, X., Shao, H., & Zheng, X. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.02.008 · Cited by 19 · see citing works
Qin, X., Liu, P., Jin, L., Zhu, K., Yang, Y., Hou, Z., Zhang, H., & Zheng, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116137 · Cited by 17 · see citing works
Colitti, M., Boschi, F., & Montanari, T. (2018) · European Journal of Histochemistry · doi:10.4081/ejh.2018.2984 · Cited by 17 · see citing works
- Authors
- Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F.
- Affiliations
- Indiana University Indianapolis (US)
- University of Missouri–Kansas City (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Kansas City University (US)
- The University of Texas at Arlington (US)
- Corresponding author
- Kitase, Yukiko
- Bonewald, Lynda F.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 22
- Issue
- 6
- Pages
- 1531-1544
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5832359
- OpenAlex
- W2785863351
- Cited by
- 219
- References
- 63
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 39 · 2023: 36 · 2022: 18 · 2021: 26 · 2020: 23 · 2019: 25 · 2018: 7
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IUScholarWorks (Indiana University) (submittedVersion)
- PMC
- Funders
- Indiana Clinical and Translational Sciences Institute
- Clinical and Translational Science Institute, University of California, San Francisco
- Center for Outcomes Research and Evaluation, Yale School of Medicine
- School of Medicine, Indiana University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- beta-aminoisobutyric acid, osteocyte survival, osteocyte apoptosis, reactive oxygen species, MRGPRD, bone loss, hindlimb unloading, muscle-derived factors, aging, exercise and bone, mitochondrial damage, estrogen
- MeSH terms
- Aging, Aminoisobutyric Acids, Animals, Female, Male, Osteocytes, Oxidative Stress, Muscle, Skeletal, Hindlimb Suspension, Mice
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