Protein phosphatase 2A regulatory subunit B55α functions in mouse oocyte maturation and early embryonic development

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

Nakamura, N., Ramaswamy, S., Vázquez, F., Signoretti, S., Loda, M. F., & Sellers, W. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8969-8982.2000 · Cited by 571 · see citing works

The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

McCright, B., Rivers, A. M., Audlin, S., & Virshup, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22081 · Cited by 382 · see citing works

Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt

Kuo, Y.-C., Huang, K.-Y., Yang, C.-H., Yang, Y.-S., Lee, W.-Y., & Chiang, C.-W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709585200 · Cited by 367 · see citing works

Roles of NPM2 in Chromatin and Nucleolar Organization in Oocytes and Embryos

Burns, K. H., Viveiros, M. M., Ren, Y., Wang, P., DeMayo, F. J., Frail, D. E., Eppig, J. J., & Matzuk, M. M. (2003) · Science · doi:10.1126/science.1081813 · Cited by 361 · see citing works

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

Schmitz, M. H. A., Held, M., Janssens, V., Hutchins, J. R. A., Hudecz, O., Ivanova, E., Goris, J., Trinkle‐Mulcahy, L., Lamond, A. I., Poser, I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2092 · Cited by 316 · see citing works

The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A., Bernis, C., Vigneron, S., Labbé, J., & Lorca, T. (2005) · Oncogene · doi:10.1038/sj.onc.1207973 · Cited by 287 · see citing works

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies

Valdiglesias, V., Giunta, S., Fenech, M., Neri, M., & Bonassi, S. (2013) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2013.02.001 · Cited by 277 · see citing works

ATM-dependent DNA Damage-independent Mitotic Phosphorylation of H2AX in Normally Growing Mammalian Cells

McManus, K. J., & Hendzel, M. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0065 · Cited by 242 · see citing works

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

McGuinness, B. E., Anger, M., Kouznetsova, A., Gil-Bernabé, A. M., Helmhart, W., Kudo, N. R., Wünsche, A., Taylor, S. S., Höög, C., Novák, B., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.01.064 · Cited by 220 · see citing works

Quantitative evaluation and selection of reference genes in mouse oocytes and embryos cultured in vivo and in vitro

Mamo, S., Gal, A. B., Bodó, S., & Dinnyés, A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-14 · Cited by 206 · see citing works

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

Cundell, M. J., Hutter, L. H., Nunes Bastos, R., Poser, E., Holder, J., Mohammed, S., Novak, B., & Barr, F. A. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201606033 · Cited by 193 · see citing works

Inactivation of HAUSP in vivo modulates p53 function.

Kon, N., Kobayashi, Y., Li, M., Brooks, C. L., Ludwig, T., & Gu, W. (2010) · Oncogene · doi:10.1038/onc.2009.427 · Cited by 176 · see citing works

The FoxO transcription factors and metabolic regulation

Nakae, J., Oki, M., & Cao, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.025 · Cited by 176 · see citing works

Towards a new understanding on the regulation of mammalian oocyte meiosis resumption

Sun, Q., Miao, Y., & Schatten, H. (2009) · Cell Cycle · doi:10.4161/cc.8.17.9471 · Cited by 161 · see citing works

Oocyte ageing and its cellular basis

Eichenlaub-Ritter, U. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.120141ue · Cited by 158 · see citing works

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

Reid, M. A., Wang, W.-I., Rosales, K. R., Welliver, M. X., Pan, M., & Kong, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.008 · Cited by 154 · see citing works

Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition

Kalev, P., Šimíček, M., Vázquez, I., Munck, S., Chen, L., Soin, T., Danda, N., Chen, W. L., & Sablina, A. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1667 · Cited by 127 · see citing works

A Developmentally Regulated, Neuron-specific Splice Variant of the Variable Subunit Bβ Targets Protein Phosphatase 2A to Mitochondria and Modulates Apoptosis

Dagda, R. K., Zaucha, J. A., Wadzinski, B. E., & Strack, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302832200 · Cited by 92 · see citing works

Involvement of microRNA Lethal-7a in the Regulation of Embryo Implantation in Mice

Liu, W., Pang, R. T. K., Cheong, A. W. Y., Ng, E. H. Y., Lao, K., Lee, C., & Yeung, W. S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037039 · Cited by 89 · see citing works

Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development

Cánovas, S., Cibelli, J. B., & Ross, P. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119112109 · Cited by 87 · see citing works

Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A

Strack, S., Chang, D., Zaucha, J. A., Colbran, R. J., & Wadzinski, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01377-0 · Cited by 83 · see citing works

Pleiotropic effect of okadaic acid on maturing mouse oocytes

Alexandre, H., Cauwenberge, A. V., Tsukitani, Y., & Mulnard, J. (1991) · Development · doi:10.1242/dev.112.4.971 · Cited by 71 · see citing works

The APC/C in female mammalian meiosis I

Homer, H. A. (2013) · Reproduction · doi:10.1530/rep-13-0163 · Cited by 70 · see citing works

Dependency of the Spindle Assembly Checkpoint on Cdk1 Renders the Anaphase Transition Irreversible

Rattani, A., Vinod, P. K. U., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B., & Nasmyth, K. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.033 · Cited by 64 · see citing works

Use of proteomics to identify highly abundant maternal factors that drive the egg-to-embryo transition

Yurttas, P., Morency, E., & Coonrod, S. A. (2010) · Reproduction · doi:10.1530/rep-09-0538 · Cited by 59 · see citing works

Mouse blastocyst outgrowth and implantation rates following exposure to ethanol or A23187 during culture in vitro

Stachecki, J. J., Yelian, F. D., Leach, R. E., & Armant, D. R. (1994) · Reproduction · doi:10.1530/jrf.0.1010611 · Cited by 55 · see citing works

JMY is required for asymmetric division and cytokinesis in mouse oocytes

Sun, S. C., Sun, Q. Y., & Kim, N. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar006 · Cited by 53 · see citing works

The spatiotemporal hormonal orchestration of human folliculogenesis, early embryogenesis and blastocyst implantation

Atwood, C., & Meethal, S. V. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.039 · Cited by 53 · see citing works

Regulation of Spindle Formation by Active Mitogen-Activated Protein Kinase and Protein Phosphatase 2A During Mouse Oocyte Meiosis1

Lu, Q. R., Dunn, R. L., Angeles, R., & Smith, G. D. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.1.29 · Cited by 51 · see citing works

Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α

Wang, L., Guo, Q., Fisher, L. A., Liu, D., & Peng, A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.986392 · Cited by 39 · see citing works

The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

Yan, L., Guo, S., Brault, M. A., Harmon, J. S., Robertson, R. P., Hamid, R., Stein, R. W., & Yang, E. (2012) · Biochemical Journal · doi:10.1042/bj20111606 · Cited by 31 · see citing works

Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation

Álvarez‐Fernández, M., Halim, V. A., Aprelia, M., Mohammed, S., & Medema, R. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253724 · Cited by 30 · see citing works

A short exposure to polychlorinated biphenyls deregulates cellular autophagy in mammalian blastocyst in vitro

Ptak, G., Zacchini, F., Czernik, M., Fidanza, A., Palmieri, C., Salda, L. D., Scapolo, P. A., & Loi, P. (2012) · Human Reproduction · doi:10.1093/humrep/der454 · Cited by 30 · see citing works

PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer

Kurimchak, A., & Graña, X. (2012) · Genes & Cancer · doi:10.1177/1947601912473479 · Cited by 26 · see citing works

Phosphorylated histone H2A.x in porcine embryos produced by IVF and somatic cell nuclear transfer

Bohrer, R. C., Che, L., Gonçalves, P. B. D., Duggavathi, R., & Bordignon, V. (2013) · Reproduction · doi:10.1530/rep-13-0271 · Cited by 22 · see citing works

Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice

Kong, X., Wang, D., Zhou, C., Zhou, H., & Liang, C. (2016) · Molecular Reproduction and Development · doi:10.1002/mrd.22744 · Cited by 19 · see citing works

Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development

Song, S.-J., Wang, Q.-C., Jia, R.-X., Cui, X., Kim, N., & Sun, S. (2016) · Scientific Reports · doi:10.1038/srep34415 · Cited by 17 · see citing works

Visualization of Subunit Interactions and Ternary Complexes of Protein Phosphatase 2A in Mammalian Cells

Mo, S.-T., Chiang, S.-J., Lai, T.-Y., Cheng, Y.-L., Chung, C.-E., Kuo, S. C. H., Reece, K. M., Chen, Y.-C., Chang, N., Wadzinski, B. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116074 · Cited by 16 · see citing works

Zfp207 is a Bub3 binding protein regulating meiotic chromosome alignment in mouse oocytes

Dai, X., Xiong, H., Zhang, M., Sun, S., & Xiong, B. (2016) · Oncotarget · doi:10.18632/oncotarget.9310 · Cited by 11 · see citing works

Polo-like kinase 4 regulates spindle and actin assembly in meiosis and influence of early embryonic development in bovine oocytes

Liang, S., Zhao, M., Guo, J., Choi, J., Kim, N., & Cui, X. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.10.021 · Cited by 7 · see citing works

Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation

Liu, X., Li, X., Ma, R., Xiong, B., Sun, S., Liu, H., & Gu, L. (2016) · Oncotarget · doi:10.18632/oncotarget.10755 · Cited by 7 · see citing works

Regulating the orderly progression of oocyte meiotic maturation events in mammals

Sun, Q. (2013) · Reproduction Fertility and Development · doi:10.1071/rdv25n3_fo · Cited by 3 · see citing works

Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig

Wang, T., Gao, Y., Chen, L., Nie, Z., Cheng, W., Liu, X., Schatten, H., Zhang, X., & Miao, Y. (2017) · Aging · doi:10.18632/aging.101252 · Cited by 108 · see citing works

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93 · see citing works

Structural variant landscapes reveal convergent signatures of evolution in sheep and goats

Yang, J. H., Wang, D.-F., Huang, J.-H., Zhu, Q., Luo, L.-Y., Lu, R., Xie, X.-L., Salehian-Dehkordi, H., Esmailizadeh, A., Liu, G. E., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03288-6 · Cited by 49 · see citing works

Sodium fluoride exposure exerts toxic effects on porcine oocyte maturation

Liang, S., Nie, Z., Zhao, M., Niu, Y., Shin, K., & Cui, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-17357-3 · Cited by 44 · see citing works

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development

Panicker, N., Coutman, M., Lawlor-O’Neill, C., Kahl, R. G. S., Roselli, S., & Verrills, N. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00358 · Cited by 27 · see citing works

Resveratrol Hinders Postovulatory Aging by Modulating Oxidative Stress in Porcine Oocytes

Abbasi, B., Dong, Y., & Rui, R. (2021) · Molecules · doi:10.3390/molecules26216346 · Cited by 27 · see citing works

Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development

Sanchez-Ribas, I., Díaz-Gimeno, P., Sebastián-León, P., Mercader, A., Quiñonero, A., Ballesteros, A., Pellicer, A., & Domı́nguez, F. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.01.023 · Cited by 25 · see citing works

A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I

Keating, L., Touati, S. A., & Wassmann, K. (2020) · Cells · doi:10.3390/cells9020390 · Cited by 21 · see citing works

C-Phycocyanin supplementation during in vitro maturation enhances pre-implantation developmental competence of parthenogenetic and cloned embryos in pigs

Liang, S., Guo, J., Jin, Y. X., Yuan, B., Zhang, J., & Kim, N. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.09.001 · Cited by 17 · see citing works

Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals

Ahmad, H. I., Ahmad, M. J., Adeel, M. M., Asif, A. R., & Du, X. (2018) · Oncotarget · doi:10.18632/oncotarget.24240 · Cited by 17 · see citing works

Critical Functions of PP2A-Like Protein Phosphotases in Regulating Meiotic Progression

Lei, W., Qian, W., & Sun, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.638559 · Cited by 11 · see citing works

H2A.Z is essential for oocyte maturation and fertility in female mouse

Xu, Q., Huang, C., Ming, J., Lu, X., Liu, L., Du, Z., Chen, Z., Na, J., Li, G., Xiang, Y., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01580-y · Cited by 9 · see citing works

TIP60 contributes to porcine embryonic development by regulating DNA damage response

Guo, J., Zhou, W., Niu, Y., Shin, K., Heo, Y. T., Kim, N., & Cui, X. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.11.033 · Cited by 4 · see citing works

Transcriptomics analyses reveal the effects of Pentagamaboronon-0-ol on PI3K/Akt and cell cycle of HER2+ breast cancer cells

Hermawan, A., Wulandari, F., Utomo, R. Y., Susidarti, R. A., Kirihata, M., & Meiyanto, E. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101847 · Cited by 3 · see citing works

Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes

Wang, D., Liu, X., Chen, B., Shang, Y., Wan, T., Zhang, S., Liu, H., Shi, Y., Chen, X., & Sun, H. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10096-5 · Cited by 3 · see citing works

EB1 Is Essential for Spindle Formation and Chromosome Alignment During Oocyte Meiotic Maturation in Mice

Zhou, D., Nie, Z., & Cui, X. (2021) · Microscopy and Microanalysis · doi:10.1017/s1431927620024897 · Cited by 3 · see citing works

Transcriptomic analysis based on RNA-seq reveals differential gene expression patterns in gonads of adult snakeskin gourami (Trichopodus pectoralis)

Jantawongsri, K., Phonsiri, K., Jangprai, A., Na‐Nakorn, U., & Boonanuntanasarn, S. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.742361 · Cited by 2 · see citing works

PPP2R2A promotes Hu sheep pituitary cell proliferation and gonadotropin secretion associated with prolificacy

Xu, H., Cai, Y., Yang, H., Li, S., Chen, P., Wei, Z., Wang, F., Wang, Z., & Zhang, Y. (2024) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2024.107457

miR-10a Expression Is Altered by Folic Acid during H2O2-Exposure-Induced Oxidative Stress in Mouse Oocytes

Wang, X., Zhang, C., Gou, J., Zhang, L., Wang, Y., Du, Z., Gao, J. Q., & Xia, H. (2025) · Russian Journal of Developmental Biology · doi:10.1134/s1062360425700213

Phenotypic and genome-wide associations underlying rotifer diapausing egg dispersal

Arenas‐Sánchez, C., Montero‐Pau, J., García-Roger, E. M., Ortells, R., & Carmona, M. J. (2026) · Hydrobiologia · doi:10.1007/s10750-026-06283-z

Down-Regulation of PP2A-B55α Impairs Mouse Preimplantation Embryo Development

Liang, S., Kim, H. N., & Cui, X. (2016)

Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1

Hu, M.-W., Wang, Z.-B., Jiang, Z.-Z., Qi, S.-T., Huang, L., Liang, Q.-X., Schatten, H., & Sun, Q.-Y. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.120220 · Cited by 48 · see citing works

Functional Relevance of PP2A-B55 Phosphatases in the Mammalian Cell Cycle

Flores, M. S. (2017) · Biblos-e Archivo (Universidad Autónoma de Madrid)

Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility

Hu, M., Wang, Z., Teng, Y., Jiang, Z., Ma, X., Hou, N., Cheng, X., Schatten, H., Xu, X., Yang, X., et al. (2015) · Development · doi:10.1242/dev.132100 · Cited by 5 · see citing works

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte

Tang, A., Shi, P., Song, A., Zou, D., Zhou, Y., Gu, P., Huang, Z., Wang, Q., Lin, Z., & Gao, X. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1175256 · Cited by 29 · see citing works