Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1
Abstract
Ppp2r1a encodes the scaffold subunit Aalpha of protein phosphatase 2A (PP2A), which is an important and ubiquitously expressed serine threonine phosphatase family and plays a critical role in many fundamental cellular processes. To identify the physiological role of PP2A in female germ cell meiosis, we selectively disrupted Ppp2r1a expression in oocytes by using the Cre-Loxp conditional knockout system. Here we report for the first time that oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation. PP2A-Aalpha was essential for regulating oocyte meiotic maturation because depletion of PP2A-Aalpha facilitated germinal vesicle breakdown, causing elongation of the MII spindle and precocious separation of sister chromatids. The resulting eggs had high risk of aneuploidy, though they could be fertilized, leading to defective embryonic development and thus subfertility. Our findings provide strong evidence that PP2A-Aalpha within the oocyte plays an indispensable role in oocyte meiotic maturation, though it is dispensable for folliculogenesis in the mouse ovary.
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In these mice, a meiotic maturation defect was observed: normal meiosis-I, but abnormal elongated spindle formation during meiosis-II, precocious sister chromatid separation due to loss of centromeric cohesion, and increased germinal vesicle breakdown.
“Again, a meiotic maturation defect was observed, with in this case, a normal meiosis-I, but abnormal elongated spindle formation during meiosis-II, precocious sister chromatid separation due to loss of centromeric cohesion, and increased germinal vesicle breakdown.”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [29]
Fertilization was followed by impaired embryonic development: at E0.5 efficient pronuclear formation was defective, and at E4.0 the blastocyst stage was rarely reached and signs of apoptosis were seen.
“Fertilization was however followed by impaired embryonic development.At E0.5, efficient pronuclear formation was defective, and at E4.0, the blastocyst stage was rarely reached and signs of apoptosis were seen.”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [29]
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- Authors
- Hu, M.-W., Wang, Z.-B., Jiang, Z.-Z., Qi, S.-T., Huang, L., Liang, Q.-X., Schatten, H., & Sun, Q.-Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of Missouri (US)
- Corresponding author
- Sun, Qing-Yuan
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07-01
- Volume
- 91
- Issue
- 1
- Pages
- 19-19
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2129736177
- Cited by
- 48
- References
- 38
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 12 · 2019: 2 · 2018: 8 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- protein phosphatase 2A, PPP2R1A, oocyte maturation, female fertility, subfertility, germinal vesicle breakdown, aneuploidy, sister chromatid separation, folliculogenesis, embryonic development
- MeSH terms
- Animals, Female, Fertility, Meiosis, Oocytes, Oogenesis, Ovulation, Mice, Knockout, Protein Subunits, Mice, Protein Phosphatase 2
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