The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells
Open accessAbstract
Cancer stem cells (CSCs) represent a unique subset of cells within a tumor that possess self-renewal capacity and pluripotency, and can drive tumor initiation and maintenance. First identified in hematological malignancies, CSCs are now thought to play an important role in a wide variety of solid tumors such as NSCLC, breast and colorectal cancer. The role of CSCs in driving tumor formation illustrates the dysregulation of differentiation in tumorigenesis. The Wnt, Notch and Hedgehog (HH) pathways are developmental pathways that are commonly activated in many types of cancer. While substantial progress has been made in developing therapeutics targeting Notch and HH, the Wnt pathway has remained an elusive therapeutic target. This review will focus on the clinical relevance of the Wnt pathway in CSCs and tumor cell biology, as well as points of therapeutic intervention and recent advances in targeting Wnt/β-catenin signaling.
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Cites
Tumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
Wnt proteins are lipid-modified and can act as stem cell growth factors
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A role for Wnt signalling in self-renewal of haematopoietic stem cells
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Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
Li, L., & Clevers, H. (2010) · Science · doi:10.1126/science.1180794 · Cited by 1,247
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
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β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628
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Cited by
Wei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L., & Varga, J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34424 · Cited by 226
Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy
Wu, C., Zhu, X., Liu, W., Ruan, T., & Tao, K. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s139639 · Cited by 82
Regression of metastatic melanoma by targeting cancer stem cells
Schlaak, M., Schmidt, P., Bangard, C., Kurschat, P., Mauch, C., & Abken, H. (2012) · Oncotarget · doi:10.18632/oncotarget.437 · Cited by 71
Metadata
- Authors
- Curtin, J. C., & Lorenzi, M. V.
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2010-10-30
- Volume
- 1
- Issue
- 7
- Pages
- 563-577
- ISSN
- 1949-2553 (ISSN-L)
- OpenAlex
- W1590222856
- Cited by
- 182
- References
- 9
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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