The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1
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In the citing paper
“miR-124-5p and miR-9-5p, abundantly expressed in mouse and human brain and both comprising sequences conserved in mouse and human, represent brain-specific miRNAs [35–38].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“miR-124-5p and miR-9-5p, abundantly expressed in mouse and human brain and both comprising sequences conserved in mouse and human, represent brain-specific miRNAs [35–38].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [35]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“miR-124-5p and miR-9-5p, abundantly expressed in mouse and human brain and both comprising sequences conserved in mouse and human, represent brain-specific miRNAs [35–38].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“While miR-124-5p expression in AD brain is reduced [35], miR-9-5p expression is increased in brain tissue and CSF of AD patients [39, 40].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [35]
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Citations
Cites
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741
MicroRNA-124 is a subventricular zone neuronal fate determinant
Akerblom, M., Sachdeva, R., Barde, I., Verp, S., Gentner, B., Trono, D., & Jakobsson, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0558-12.2012 · Cited by 207
Research works printed but not linked: 17
- Park, 2017, Cadmium and Alzheimer's disease mortality in U.S. adults: updated evidence with a urinary biomarker and extended follow-up time, Environ Res, 157, 44, 10.1016/j.envres.2017.05.011 · DOI
- Crunkhorn, 2016, Alzheimer disease: BACE1 inhibitor reduces beta-amyloid production in humans, Nat Rev Drug Discov, 16, 18, 10.1038/nrd.2016.271 · DOI
- Bartel, 2009, MicroRNAs: target recognition and regulatory functions, Cell, 136, 215, 10.1016/j.cell.2009.01.002 · DOI · Paper page
- Wang, 2017, microRNAs: important regulators of stem cells, Stem Cell Res Ther, 8, 110, 10.1186/s13287-017-0551-0 · DOI
- Sonenberg, 2008, Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?, Nat Rev Genet, 9, 102, 10.1038/nrg2290 · DOI
- De Strooper, 2008, Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression, Proc Natl Acad Sci U S A, 105, 6415, 10.1073/pnas.0710263105 · DOI · Paper page
- Rengo, 2015, The emerging role of microRNAs in Alzheimer's disease, Front Physiol, 6, 40, 10.3389/fphys.2015.00040 · DOI
- Gu, 2017, MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma, Oncotarget, 8, 25005, 10.18632/oncotarget.15334 · DOI
- Schumacher, 2012, miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling, EMBO J, 31, 2908, 10.1038/emboj.2012.130 · DOI
- Iliopoulos, 2011, An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis, Cell, 147, 1233, 10.1016/j.cell.2011.10.043 · DOI
- Lu, 2015, NF-kappaB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10, Oncotarget, 6, 8244, 10.18632/oncotarget.3135 · DOI
- Langeland, 2014, Asynchronous evolutionary origins of Abeta and BACE1, Mol Biol Evol, 31, 696, 10.1093/molbev/mst262 · DOI
- Ruberti, 2010, MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons, J Biol Chem, 285, 18344, 10.1074/jbc.M110.112664 · DOI
- Nelson, 2008, The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1, J Neurosci, 28, 1213, 10.1523/jneurosci.5065-07.2008 · DOI · Paper page
- Krichevsky, 2013, MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons, J Neurosci, 33, 14645, 10.1523/jneurosci.1327-13.2013 · DOI · Paper page
- Ji, 2016, MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer, J Gene Ther
- Han, 2012, The miR-124 regulates the expression of BACE1/beta-secretase correlated with cell death in Alzheimer's disease, Toxicol Lett, 209, 94, 10.1016/j.toxlet.2011.11.032 · DOI
Cited by
Sorted by citations
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01091-6 · Cited by 55
MicroRNAs change the games in central nervous system pharmacology
Marangon, D., Raffaele, S., Fumagalli, M., & Lecca, D. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.019 · Cited by 22
Kumbol, V., Ivanov, A., McGurran, H., Schüler, J., Zhai, Y., Ludwik, K., Hinkelmann, L., Brehm, M., Krüger, C., Küchler, J., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02199-8 · Cited by 8
Metadata
- Authors
- An, F., Gong, G., Wang, Y., Bian, M., Yu, L., & Wei, C.
- Affiliations
- Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for The Nationalities, Tongliao, Inner Mongolia, P.R. China
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2017-12-09
- Volume
- 8
- Issue
- 69
- Pages
- 114065-114071
- ISSN
- 1949-2553
- PMC
- PMC5768386
- Cited by
- 126
- References
- 3
- Language
- en
- Status
- Retracted
- Update notices
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- CoChat. (2026). Citation check: MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1. https://app.cochat.ai/papers/10.18632/oncotarget.23119
- The paper
- An, F., Gong, G., Wang, Y., Bian, M., Yu, L., & Wei, C. (2017). MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1. Oncotarget. https://doi.org/10.18632/oncotarget.23119
