MicroRNA-124 is a subventricular zone neuronal fate determinant
Open accessAbstract
New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.
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miRNAs play an important role in neurodegenerative diseases, including ALS.
“Growing evidence suggests that miRNAs play an important role in neurodegenerative diseases, including ALS (Akerblom et al., 2012; Goodall et al., 2013; Zhu et al., 2013; Parisi et al., 2016).”
From Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells (2017) · cites this paper as Akerblom et al., 2012
The Introduction and Discussion describe miR-124’s role in neuronal differentiation and neurogenesis, not in neurodegenerative disease. Searches for ALS, amyotrophic lateral sclerosis, neurodegenerative disease, and pathology found no passage connecting miRNAs to ALS or neurodegenerative diseases in our copy. (LLM, conf=0.76)
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- Authors
- Akerblom, M., Sachdeva, R., Barde, I., Verp, S., Gentner, B., Trono, D., & Jakobsson, J.
- Affiliations
- Lund University (SE)
- École Polytechnique Fédérale de Lausanne (CH)
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Jakobsson, J.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-06-27
- Volume
- 32
- Issue
- 26
- Pages
- 8879-8889
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4434222
- OpenAlex
- W2170178888
- Cited by
- 207
- References
- 39
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 9 · 2020: 18 · 2019: 12 · 2018: 13 · 2017: 23 · 2016: 24 · 2015: 15 · 2014: 20 · 2013: 26 · 2012: 4
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- miR-124, subventricular zone, neuronal fate determination, postnatal neurogenesis, neural stem cells, astrocyte differentiation, olfactory bulb, transgenic reporter mice, microRNA inhibition, microRNA overexpression
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Cell Movement, Cerebral Ventricles, Female, Genetic Vectors, Glial Fibrillary Acidic Protein, Male, Neuroglia, Neurons, Olfactory Bulb, Transduction, Genetic, Lentivirus, MicroRNAs, Cell Proliferation, Mice, Neurogenesis, Neural Stem Cells
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