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Cited by 298

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Cancer stem cells in progression of colorectal cancer

Open access
Zhou, Yujuan, Xia, Longzheng, Wang, Heran, Oyang, Linda, Su, Min, Liu, Qiang, Lin, Jingguan, Tan, Shiming, Tian, Yutong, Liao, Qianjin, Cao, Deliang·2018·Oncotarget

Abstract

// Yujuan Zhou 1, * , Longzheng Xia 1, * , Heran Wang 1 , Linda Oyang 1 , Min Su 1 , Qiang Liu 1 , Jingguan Lin 1 , Shiming Tan 1 , Yutong Tian 1 , Qianjin Liao 1 and Deliang Cao 1, 2 1 Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China 2 Department of Medical Microbiology, Immunology & Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL, 62794, USA * These authors contributed equally to this work Correspondence to: Deliang Cao, email: dcao@siumed.edu Qianjin Liao, email: march-on@126.com Keywords: colorectal cancer; cancer stem cells; metastasis; epithelial mesenchymal transition; tumor microenvironment Received: August 28, 2017 Accepted: November 05, 2017 Epub: December 22, 2017 Published: September 07, 2018 ABSTRACT Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique properties of self-renewal, infinite division and multi-directional differentiation potential. Colorectal CSCs are defined with a group of cell surface markers, such as CD44, CD133, CD24, EpCAM, LGR5 and ALDH. They are highly tumorigenic, chemoresistant and radioresistant and thus are critical in the metastasis and recurrence of colorectal cancer and disease-free survival. This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse.

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Metadata

Authors
Zhou, Y., Xia, L., Wang, H., Oyang, L., Su, M., Liu, Q., Lin, J., Tan, S., Tian, Y., Liao, Q., & Cao, D.
Venue
Oncotarget
Published
2017-12-22
Volume
9
Issue
70
Pages
33403-33415
ISSN
1949-2553 (ISSN-L)
OpenAlex
W2777795295
Cited by
298
References
111
FWCI
8.08
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Cancer stem cells in progression of colorectal cancer. https://app.cochat.ai/papers/10.18632/oncotarget.23607
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Zhou, Y., Xia, L., Wang, H., Oyang, L., Su, M., Liu, Q., Lin, J., Tan, S., Tian, Y., Liao, Q., & Cao, D. (2018). Cancer stem cells in progression of colorectal cancer. Oncotarget. https://doi.org/10.18632/oncotarget.23607

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