The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
Open accessAbstract
Current models of stem cell biology assume that normal and neoplastic stem cells reside at the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner. Here we identify a subpopulation of basal-like human mammary epithelial cells that departs from that assumption, spontaneously dedifferentiating into stem-like cells. Moreover, oncogenic transformation enhances the spontaneous conversion, so that nonstem cancer cells give rise to cancer stem cell (CSC)-like cells in vitro and in vivo. We further show that the differentiation state of normal cells-of-origin is a strong determinant of posttransformation behavior. These findings demonstrate that normal and CSC-like cells can arise de novo from more differentiated cell types and that hierarchical models of mammary stem cell biology should encompass bidirectional interconversions between stem and nonstem compartments. The observed plasticity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds important implications for therapeutic strategies to eradicate cancer.
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Cites
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
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“It is becoming apparent, however, that the differentiation states of cells-of-origin can influence the organization of derived neoplastic cell populations (8, 9).”
BackgroundMethodResultInfluentialHypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
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Direct regulation of TWIST by HIF-1α promotes metastasis
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A specialized vascular niche for adult neural stem cells
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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
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Cited by
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876
Self-citationEMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539
Self-citationDrug resistance in cancer: An overview
Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., Snyder, N., & Sarkar, S. (2014) · Cancers · doi:10.3390/cancers6031769 · Cited by 2,463
Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., & Lander, E. S. (2011) · Cell · doi:10.1016/j.cell.2011.07.026 · Cited by 1,475
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Metadata
- Authors
- Chaffer, C. L., Brueckmann, I., Scheel, C., Kaestli, A. J., Wiggins, P. A., Rodrigues, L. O., Brooks, M., Reinhardt, F., Su, Y., Polyak, K., Arendt, L. M., Kuperwasser, C., Bierie, B., & Weinberg, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-15
- Volume
- 108
- Issue
- 19
- Pages
- 7950-7955
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2151948621
- Cited by
- 1,147
- References
- 6
- FWCI
- 49.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Chaffer, C. L., Brueckmann, I., Scheel, C., Kaestli, A. J., Wiggins, P. A., Rodrigues, L. O., Brooks, M., Reinhardt, F., Su, Y., Polyak, K., Arendt, L. M., Kuperwasser, C., Bierie, B., & Weinberg, R. A. (2011). Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1102454108
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