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Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death
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// Stefania Raimondo 1 , Flores Naselli 1 , Simona Fontana 1 , Francesca Monteleone 1 , Alessia Lo Dico 1 , Laura Saieva 1 , Giovanni Zito 2 , Anna Flugy 1 , Mauro Manno 3 , Maria Antonietta Di Bella 1 , Giacomo De Leo 1 , Riccardo Alessandro 1 1 Dipartimento di Biopatologia e Biotecnologie Mediche, Università degli Studi di Palermo, sezione di Biologia e Genetica, Palermo, Italy 2 Laboratorio di Ingegneria Tissutale – Piattaforme Innovative per l’Ingegneria Tissutale (PON01–00829), Istituto Ortopedico Rizzoli, Palermo, Italy 3 Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Palermo, Italy Correspondence to: Riccardo Alessandro, e-mail: riccardo.alessandro@unipa.it Keywords: cancer, exosome-like nanovesicles, Citrus limon L., TRAIL-mediated cell death Received: April 03, 2015 Accepted: May 08, 2015 Published: May 18, 2015 ABSTRACT Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice ( Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.
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Cites
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
Shevchenko, A., Wilm, M., Vorm, O., & Mann, M. (1996) · Analytical Chemistry · doi:10.1021/ac950914h · Cited by 8,995
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,537
Safety and antitumor activity of recombinant soluble Apo2 ligand
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,793
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158 · cited 1×
“com/oncotarget [9–12], the specific role of plant-derived nanovesicles to influence cancer progression is still unknown.”
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985
Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z.-B., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 862
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Johnstone, R. W., Frew, A. J., & Smyth, M. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2465 · Cited by 834
Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit
Wang, B., Zhuang, X., Deng, Z.-B., Jiang, H., Mu, J., Wang, Q., Xiang, X., Guo, H., Zhang, L., Dryden, G., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2013.190 · Cited by 634
Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation
Manthey, J., Guthrie, N., & Grohmann, K. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373723 · Cited by 566
Exosomes: Novel Biomarkers for Clinical Diagnosis
Lin, J., Li, J., Huang, B., Liu, J., Chen, X., Chen, X.-M., Xu, Y.-M., Huang, L.-F., & Wang, X.-Z. (2015) · The Scientific World Journal · doi:10.1155/2015/657086 · Cited by 562
TRAIL signalling: Decisions between life and death
Falschlehner, C., Emmerich, C. H., Gerlach, B., & Walczak, H. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.02.007 · Cited by 458
Corrado, C., Raimondo, S., Chiesi, A., Ciccia, F., De Leo, G., & Alessandro, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035338 · Cited by 396
Self-citationItinerant exosomes: emerging roles in cell and tissue polarity
Lakkaraju, A., & Rodriguez-Boulan, E. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.03.002 · Cited by 391
ExoCarta as a resource for exosomal research
Simpson, R. J., Kalra, H., & Mathivanan, S. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18374 · Cited by 383
Regente, M., Corti-Monzón, G., Maldonado, A. M., Pinedo, M., Jorrín, J., & de la Canal, L. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.041 · Cited by 302
Zhang, Y., & Zhang, B. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0313 · Cited by 237
Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism
Raimondo, S., Saieva, L., Corrado, C., Fontana, S., Flugy, A., Rizzo, A., De Leo, G., & Alessandro, R. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0086-x · Cited by 197
Self-citationCorrado, C., Raimondo, S., Saieva, L., Flugy, A. M., De Leo, G., & Alessandro, R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.03.009 · Cited by 173
Self-citationPlant natural products: from traditional compounds to new emerging drugs in cancer therapy
Ouyang, L., Luo, Y., Tian, M., Zhang, S. ‐., Lu, R., Wang, J. ‐., Kasimu, R., & Li, X. (2014) · Cell Proliferation · doi:10.1111/cpr.12143 · Cited by 163
Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
Wang, L., Wang, J., Fang, L., Zheng, Z., Zhi, D., Wang, S., Li, S., Ho, C., & Zhao, H. (2014) · BioMed Research International · doi:10.1155/2014/453972 · Cited by 138
Overcoming limitations of natural anticancer drugs by combining with artificial agents
Blagosklonny, M. V. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.002 · Cited by 99
Ishibashi, M., & Ohtsuki, T. (2008) · Medicinal Research Reviews · doi:10.1002/med.20123 · Cited by 92
Prospective strategies to enforce selectively cell death in cancer cells
Blagosklonny, M. V. (2004) · Oncogene · doi:10.1038/sj.onc.1207520 · Cited by 84
Nesterov, A., Nikrad, M. P., Johnson, T. R., & Kraft, A. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2219 · Cited by 80
Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract.
Alshatwi, A. A., Shafi, G., Hasan, T. N., Al‐Hazzani, A. A., Alsaif, M. A., Alfawaz, M. A., Lei, K. Y., & Munshi, A. (2011) · PubMed · Cited by 46
Tse, A. K., Chow, K.-Y., Cao, H., Cheng, C.-Y., Kwan, H. Y., Yu, H., Zhu, G., Wu, Y.-C., Fong, W. F., & Yu, Z. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483909 · Cited by 40
Corrado, C., Raimondo, S., Flugy, A. M., Fontana, S., Santoro, A., Stassi, G., Marfia, A., Iovino, F., Arlinghaus, R. B., Kohn, E. C., et al. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.10.007 · Cited by 10
Self-citation
Cited by
Advances in therapeutic applications of extracellular vesicles
Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav8521 · Cited by 1,039
Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms
Dad, H. A., Gu, T.-W., Zhu, A.-Q., Huang, L.-Q., & Peng, L.-H. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2020.11.030 · Cited by 745
Ginger‐derived nanoparticles protect against alcohol‐induced liver damage
Zhuang, X., Deng, Z., Mu, J., Zhang, L., Yan, J., Miller, D., Feng, W., McClain, C. J., & Zhang, H. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.28713 · Cited by 601
Klimek-Szczykutowicz, M., Szopa, A., & Ekiert, H. (2020) · Plants · doi:10.3390/plants9010119 · Cited by 465
Plant-derived exosome-like nanoparticles and their therapeutic activities
Kim, J., Li, S., Zhang, S., & Wang, J. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.05.006 · Cited by 396
Metadata
- Authors
- Raimondo, S., Naselli, F., Fontana, S., Monteleone, F., Lo Dico, A., Saieva, L., Zito, G., Flugy, A., Manno, M., Di Bella, M. A., De Leo, G., & Alessandro, R.
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2015-05-18
- Volume
- 6
- Issue
- 23
- Pages
- 19514-19527
- ISSN
- 1949-2553 (ISSN-L)
- OpenAlex
- W1596011791
- Cited by
- 521
- References
- 29
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- diamond
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