CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells
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// Qin-qin Li 1, * , Le Zhang 1, * , Hai-ying Wan 1, * , Min Liu 1 , Xin Li 1 , Hua Tang 1 1 Tianjin Life Science Research Center and School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China * These authors have contributed equally to this work Correspondence to: Hua Tang, e-mail: htang2002@yahoo.com Keywords: CREB1, miR-320a, mitophagy, serum starvation, VDAC1 Received: April 26, 2015 Accepted: October 02, 2015 Published: October 14, 2015 ABSTRACT The altered expression of miRNAs in response to stresses contributes to cancer pathogenesis. However, little is known regarding the mechanism by which cellular stresses drive alterations in miRNA expression. Here, we found that serum starvation enhanced mitophagy by downregulating the mitophagy-associated protein voltage-dependent anion channel 1 (VDAC1) and by inducing the expression of miR-320a and the transcription factor cAMP responsive element binding protein 1(CREB1). Furthermore, we cloned the promoter of miR-320a and identified the core promoter of miR-320a in the upstream −16 to −130 region of pre-miR-320a. Moreover, CREB1 was found to bind to the promoter of miR-320a to activate its expression and to induce mitophagy during serum starvation. Collectively, our results reveal a new mechanism underlying serum starvation-induced mitophagy in which serum starvation induces CREB1 expression, in turn activating miR-320a expression, which then down-regulates VDAC1 expression to facilitate mitophagy. These findings may provide new insights into cancer cell survival in response to environmental stresses.
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miR-320a promotes mitophagy by targeting VDAC1.
“miR-320a promotes mitophagy by targeting VDAC1 [48].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [48]
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- Authors
- Li, Q.-Q., Zhang, L., Wan, H.-Y., Liu, M., Li, X., & Tang, H.
- Affiliations
- Tianjin Medical University (CN)
- Tianjin Life Science Research Center and School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
- Corresponding author
- Li, Qin-qin
- Zhang, Le
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2015-10-14
- Volume
- 6
- Issue
- 33
- Pages
- 34924-34940
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC4741499
- OpenAlex
- W2205143916
- Cited by
- 46
- References
- 58
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 8
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (09JCZDJC17500, 31071191, 91029714, 31101000, 31270818, 12JCZDJC25100, 30873017)
- Natural Science Foundation of Tianjin City (91029714, 09JCZDJC17500, 30873017, 31071191, 12JCZDJC25100)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- CREB1, miR-320a, mitophagy, VDAC1, serum deprivation, cervical cancer cells, microRNA promoters, transcriptional regulation, cellular stress response, tumor cell survival
- MeSH terms
- Uterine Cervical Neoplasms, Female, Humans, Transfection, Blotting, Western, Down-Regulation, Gene Expression Regulation, Neoplastic, Cyclic AMP Response Element-Binding Protein, Oligonucleotide Array Sequence Analysis, MicroRNAs, Cell Line, Tumor, Chromatin Immunoprecipitation, Voltage-Dependent Anion Channel 1, Real-Time Polymerase Chain Reaction, Mitophagy
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