Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis.
Open accessAbstract
// Luqian Zhao 1 , Zhigang Zhu 1 , Huiling Lou 1 , Guodong Zhu 1 , Weimin Huang 1 , Shaogang Zhang 1 and Feng Liu 1 1 Department of Geriatrics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China Correspondence to: Feng Liu, email: // Keywords : PCOS; cardiovascular disease; association; meta-analysis; Pathology Section Received : April 03, 2016 Accepted : May 13, 2016 Published : May 22, 2016 Abstract Some studies reported a significant association between polycystic ovary syndrome (PCOS) and risk of cardiovascular disease (CVD). However, the results are controversial. A systematic search was conducted in the PubMed, Science Direct, EMBASE, and Cochrane Library databases. Five case-control studies and 5 cohort studies were selected, involving a total of 104392 subjects in this meta-analysis. PCOS was significantly associated with the increased risk of CVD (OR = 1.30; 95% CI 1.09 – 1.56; P = 0.004). In the subgroup analysis of study design, both case-control studies and prospective cohort studies showed significant results (OR = 1.79; 95% CI 1.16 – 2.77; P = 0.009; OR = 1.20; 95% CI 1.06 – 1.37; P = 0.005), while retrospective cohort studies did not show positive result (OR = 0.91; 95% CI 0.60 – 1.40; P = 0.68). In a further stratified analysis by type of CVD, a significant association was found between PCOS and coronary heart disease (CHD) (OR = 1.44; 95% CI 1.13 – 1.84; P = 0.004). However, no significant association was observed between PCOS and myocardial infarction (MI) (OR = 1.01; 95% CI 0.68 – 1.51; P = 0.95). In conclusion, this meta-analysis suggested that PCOS is significantly associated with increased CHD risk.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Women with PCOS have a 30% increased risk of developing cardiovascular disease and a 44% increased risk of coronary heart disease compared with age- and BMI-matched healthy women.
“a meta-analysis recently reported that women with PCOS have a 30% increased risk of developing CVD and 44% increased risk of coronary heart disease compared with age and BMI-matched healthy women (1).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [1]
Women with polycystic ovary syndrome have a 1.3-fold greater risk of developing composite cardiovascular disease than women who do not have polycystic ovary syndrome.
“Women with polycystic ovary syndrome had a 1.3-fold greater risk of developing composite cardiovascular disease than women who did not have polycystic ovary syndrome (table 1).66”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [66]
The increased risk of composite cardiovascular disease in women with polycystic ovary syndrome is maintained when examining ischaemic heart disease separately.
“This increased risk was maintained when examining ischaemic heart disease66 and stroke85 separately (supplementary table 3).”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609 · see citing works
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386 · see citing works
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715 · see citing works
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Asunción, M., Calvo, R. M., Millán, J. L. S., Sancho, J., Ávila, S., & Escobar-Morreale, H. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6682 · Cited by 1,328 · see citing works
Wild, S., Pierpoint, T., McKeigue, P., & Jacobs, H. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01000.x · Cited by 970 · see citing works
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802 · see citing works
Menstrual cycle irregularity and risk for future cardiovascular disease
Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J. E., Stampfer, M. J., Willett, W. C., Speizer, F. E., & Manson, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8471 · Cited by 528 · see citing works
de Groot, P. C. M., Dekkers, O. M., Romijn, J. A., Dieben, S. W. M., & Helmerhorst, F. M. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr001 · Cited by 394 · see citing works
Birdsall, M. A., Farquhar, C. M., & White, H. D. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-1-199701010-00005 · Cited by 327 · cited 1× · see citing works
“However, the results are controversial [7-16].”
Cibula, D. (2000) · Human Reproduction · doi:10.1093/humrep/15.4.785 · Cited by 265 · see citing works
Schmidt, J., Landin-Wilhelmsen, K., Brännström, M., & Dahlgren, E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1677 · Cited by 241 · see citing works
Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome
Toulis, K. A., Goulis, D. G., Mintziori, G., Kintiraki, E., Eukarpidis, E., Mouratoglou, S., Pavlaki, A., Stergianos, S., Poulasouchidou, M., Tzellos, T., et al. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr025 · Cited by 229 · see citing works
Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Literature
Oskui, P. M., French, W. J., Herring, M. J., Mayeda, G. S., Burstein, S., & Kloner, R. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000272 · Cited by 225 · see citing works
Mani, H., Levy, M. J., Davies, M. J., Morris, D. H., Gray, L. J., Bankart, J., Blackledge, H., Khunti, K. K., & Howlett, T. A. (2012) · Clinical Endocrinology · doi:10.1111/cen.12068 · Cited by 192 · see citing works
Childhood risk factors for adult cardiovascular disease and primary prevention in childhood
Celermajer, D. S., & Ayer, J. G. (2006) · Heart · doi:10.1136/hrt.2005.081760 · Cited by 126 · see citing works
Menstrual irregularity and cardiovascular mortality.
Wang, E., Cirillo, P. M., Vittinghoff, E., Bibbins-Domingo, K., Cohn, B., & Cedars, M. (2011) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-1709 · Cited by 109 · see citing works
Searching for polycystic ovary syndrome in postmenopausal women
Krentz, A. J., von Mühlen, D. G., & Barrett-Connor, E. L. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31802cc7ab · Cited by 108 · see citing works
Anderson, S., Barry, J. A., & Hardiman, P. J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.079 · Cited by 77 · see citing works
Risk of cardiovascular events in patients with polycystic ovary syndrome.
Iftikhar, S., Collazo–Clavell, M. L., Roger, V. L., Sauver, J. L. S., Brown, R. D., Cha, S., & Dj, R. (2012) · PubMed · Cited by 73 · see citing works
Lunde, O., & Tanbo, T. G. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701705189 · Cited by 43 · see citing works
Cardiometabolic risk in patients with polycystic ovary syndrome.
Ozegowska, K., & Pawelczyk, L. (2015) · Polish Gynaecology · doi:10.17772/gp/59131 · Cited by 15 · cited 1× · see citing works
“indicated that PCOS patients had higher CVD risk factors, such as body mass index (BMI), waist circumference, and waist-to-hip ratio [20].”
Background
Flagged first, then by citations
Cited by
Sorted by citations
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485 · see citing works
The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030
Vogel, B., Mónica Acevedo, B., Appelman, Y., Merz, C. N. B., Chieffo, A., Figtree, G. A., Guerrero, M. E., Kunadian, V., Lam, C. S. P., Maas, A. H. E. M., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00684-x · Cited by 1,536 · see citing works
Cooney, L. G., Lee, I., Sammel, M. D., & Dokras, A. (2017) · Human Reproduction · doi:10.1093/humrep/dex044 · Cited by 631 · see citing works
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 565 · see citing works
Osibogun, O., Ogunmoroti, O., & Michos, E. D. (2020) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2019.08.010 · Cited by 423 · see citing works
Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences
Anagnostis, P. G., Tarlatzis, B. C., & Kauffman, R. P. (2017) · Metabolism · doi:10.1016/j.metabol.2017.09.016 · Cited by 429 · see citing works
Okoth, K., Chandan, J. S., Marshall, T., Thangaratinam, S., Thomas, G. N., Nirantharakumar, K., & Adderley, N. J. (2020) · BMJ · doi:10.1136/bmj.m3502 · Cited by 416 · see citing works
Kakoly, N. S., Khomami, M. B., Joham, A. E., Cooray, S. D., Misso, M. L., Norman, R. J., Harrison, C. L., Ranasinha, S., Teede, H. J., & Moran, L. J. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy007 · Cited by 384 · see citing works
Maas, A. H. E. M., Rosano, G. M. C., Cífková, R., Chieffo, A., van Dijken, D., Hamoda, H., Kunadian, V., Laan, E. T. M., Lambrinoudaki, I. V., Maclaran, K., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1044 · Cited by 361 · see citing works
Beyond fertility: polycystic ovary syndrome and long-term health
Cooney, L. G., & Dokras, A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.08.021 · Cited by 270 · see citing works
Menopause: a cardiometabolic transition
Nappi, R. E., Chedraui, P., Lambrinoudaki, I. V., & Simoncini, T. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00076-6 · Cited by 277 · see citing works
Rajendran, A., Minhas, A., Kazzi, B. E., Varma, B., Choi, E., Thakkar, A., & Michos, E. D. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117269 · Cited by 255 · see citing works
Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke
Zhu, T., Cui, J., & Goodarzi, M. O. (2021) · Diabetes · doi:10.2337/db20-0800 · Cited by 226 · see citing works
O’Reilly, M. W., Kempegowda, P., Walsh, M., Taylor, A. E., Manolopoulos, K. N., Allwood, J. W., Semple, R. K., Hebenstreit, D., Dunn, W. B., Tomlinson, J. W., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00947 · Cited by 215 · see citing works
Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome
Glintborg, D., Rubin, K. H., Nybo, M., Abrahamsen, B., & Andersen, M. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0680-5 · Cited by 200 · see citing works
The role of androgen and its related signals in PCOS
Ye, W., Xie, T., Song, Y., & Zhou, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16205 · Cited by 191 · see citing works
Comorbidities and complications of polycystic ovary syndrome: An overview of systematic reviews
Gilbert, E. W., Tay, C. T., Hiam, D. S., Teede, H. J., & Moran, L. J. (2018) · Clinical Endocrinology · doi:10.1111/cen.13828 · Cited by 166 · see citing works
Acute Myocardial Infarction: Etiologies and Mimickers in Young Patients
Krittanawong, C., Khawaja, M., Tamis‐Holland, J. E., Girotra, S. R., & Rao, S. V. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029971 · Cited by 152 · see citing works
Berni, T. R., Morgan, C. L., & Rees, D. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab392 · Cited by 146 · see citing works
Zhao, X., Jiang, Y., Xi, H., Chen, L., & Feng, X. (2020) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1081-2036 · Cited by 124 · see citing works
Unique cardiovascular risk factors in women
Young, L. D., & Cho, L. (2019) · Heart · doi:10.1136/heartjnl-2018-314268 · Cited by 122 · see citing works
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress in polycystic ovary syndrome
Rudnicka, E., Duszewska, A. M., Kucharski, M., Tyczyński, P., & Smolarczyk, R. (2022) · Reproduction · doi:10.1530/rep-22-0152 · Cited by 118 · see citing works
Cooney, L. G., Milman, L. W., Hantsoo, L., Kornfield, S., Sammel, M. D., Allison, K. C., Epperson, C. N., & Dokras, A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.03.028 · Cited by 117 · see citing works
Cardiovascular Disease in Women: From Pathophysiology to Novel and Emerging Risk Factors
Geraghty, L. E., Figtree, G. A., Schutte, A. E., Patel, S., Woodward, M., & Arnott, C. G. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.05.108 · Cited by 98 · see citing works
Zhang, J., Xu, J., Qu, Q.-Q., & Zhong, G.-Q. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.552421 · Cited by 97 · see citing works
Guía ESC 2021 sobre la prevención de la enfermedad cardiovascular en la práctica clínica
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J. M., Capodanno, D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.016 · Cited by 80 · see citing works
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges
Wang, C., Wu, W., Yang, H., Ye, Z., Zhao, Y., Liu, J., & Mu, L. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.01.005 · Cited by 74 · see citing works
Cardio-Metabolic Disease and Polycystic Ovarian Syndrome (PCOS): A Narrative Review
Sangaraju, S. L., Yepez, D., Grandes, X. A., Manjunatha, R. T., & Habib, S. (2022) · Cureus · doi:10.7759/cureus.25076 · Cited by 71 · see citing works
Cardiometabolic risks in PCOS: a review of the current state of knowledge
Kakoly, N. S., Moran, L., Teede, H. J., & Joham, A. E. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2019.1556094 · Cited by 64 · see citing works
Long‐term health outcomes in young women with polycystic ovary syndrome: A narrative review
Allen, L. A., Shrikrishnapalasuriyar, N., & Rees, A. (2021) · Clinical Endocrinology · doi:10.1111/cen.14609 · Cited by 73 · see citing works
McCullough, D., Webb, R., Enright, K. J., Lane, K. E., McVeigh, J., Stewart, C. E., & Davies, I. G. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09616-y · Cited by 62 · see citing works
Sex Differences in Acute Coronary Syndromes: A Global Perspective
Cader, F. A., Banerjee, S., & Gulati, M. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9080239 · Cited by 68 · see citing works
Coronary artery disease risk in young women with polycystic ovary syndrome
Ding, D., Tsai, I., Wang, J., Lin, S., & Sung, F. (2018) · Oncotarget · doi:10.18632/oncotarget.23985 · Cited by 61 · see citing works
de Medeiros, S. F. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0313-y · Cited by 53 · see citing works
Jensterle, M., Herman, R., & Janež, A. (2022) · Biomedicines · doi:10.3390/biomedicines10081989 · Cited by 50 · see citing works
Mukherjee, A. G., Wanjari, U. R., Kannampuzha, S., Murali, R., Namachivayam, A., Ganesan, R., Dey, A., Babu, A., Renu, K., Vellingiri, B., et al. (2023) · Metabolites · doi:10.3390/metabo13010129 · Cited by 52 · see citing works
Nylander, M., Frøssing, S., Kistorp, C., Faber, J., & Skouby, S. O. (2017) · Endocrine Connections · doi:10.1530/ec-16-0113 · Cited by 44 · see citing works
Cardiometabolic Risk in Polycystic Ovary Syndrome
Cooney, L. G., & Dokras, A. (2021) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2020.11.001 · Cited by 44 · see citing works
Why does Polycystic Ovary Syndrome (PCOS) Need Long-term Management?
Ruan, X., Li, M., & Mueck, A. O. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130104922 · Cited by 43 · see citing works
Rani, R., Hajam, Y. A., Kumar, R., Bhat, R. A., Rai, S., & Rather, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100161 · Cited by 43 · see citing works
Anxiety, depression, and body image among infertile women with and without polycystic ovary syndrome
Jannink, T. I., Bordewijk, E. M., Aalberts, J. L., Hendriks, J., Lehmann, V., Hoek, A., Goddijn, M., van Wely, M., ANDES study group, de Bruin, J. P., et al. (2024) · Human Reproduction · doi:10.1093/humrep/deae016 · Cited by 39 · see citing works
Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS
Frøssing, S., Nylander, M., Kistorp, C., Skouby, S. O., & Faber, J. (2018) · Endocrine Connections · doi:10.1530/ec-17-0327 · Cited by 38 · see citing works
Pililis, S., Lampsas, S., Kountouri, A., Pliouta, L., Korakas, E., Livadas, S., Thymis, J., Peppa, Μ., Kalantaridou, S., Oikonomou, E. K., et al. (2024) · Medicina · doi:10.3390/medicina60101656 · Cited by 46 · see citing works
Diagnosis and follow-up of type 2 diabetes in women with PCOS: a role for OGTT?
Andersen, M., & Glintborg, D. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0237 · Cited by 36 · see citing works
Polycystic Ovary Syndrome, Insulin Resistance, and Cardiovascular Disease
Dubey, P., Reddy, S., Sharma, K., Johnson, S., Hardy, G., & Dwivedi, A. K. (2024) · Current Cardiology Reports · doi:10.1007/s11886-024-02050-5 · Cited by 38 · see citing works
Sueldo, M. D., Rivera, M. A. M., Sanchez-Zambrano, M. B., Zilberman, J. M., Múnera, A. G., Paniagua, M., Campos-Alcántara, L., Almonte, C., Paix-Gonzales, A., Anchique-Santos, C. V., et al. (2022) · Archivos de cardiología de México · doi:10.24875/acm.22000071 · Cited by 35 · see citing works
Rashid, N., Nigam, A., Saxena, P., Jain, S., & Wajid, S. (2017) · Inflammation Research · doi:10.1007/s00011-017-1045-3 · Cited by 31 · see citing works
Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis
Cai, X., Qiu, S., Li, L., Zügel, M., Steinacker, J. M., & Schümann, U. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.10.114 · Cited by 31 · see citing works
Wanderley, M. D. S., Pereira, L. C. R., Santos, C. B., da Cunha, V. S., & Neves, M. V. J. (2018) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0038-1642634 · Cited by 28 · see citing works
Zahid, S., Khan, M. Z., Gowda, S. N., Faza, N. N., Honigberg, M. C., Vaught, A. “. J., Guan, C. S., Minhas, A., & Michos, E. D. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025839 · Cited by 28 · see citing works
Rashad, N. M., El‐Shal, A. S., Abomandour, H. G., Aboelfath, A. M. K., Rafeek, M., Badr, M. S., Ali, A. E., Yousef, M. S., Fathy, M. A., & el din, M. T. A. S. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0566-5 · Cited by 27 · see citing works
Dwivedi, A. K., Vishwakarma, D., Dubey, P., & Reddy, S. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad067 · Cited by 27 · see citing works
Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease
Alvarez, Y. R., Pico, M. G., Ashokprabhu, N. D., Abou-Amro, K., Bailey, S., Pung, E., Oberholster, E., & Quesada, O. (2023) · Current Atherosclerosis Reports · doi:10.1007/s11883-023-01168-1 · Cited by 25 · see citing works
Osibogun, O. I., Ogunmoroti, O., Kolade, O. B., Hays, A. G., Okunrintemi, V., Minhas, A., Gulati, M., & Michos, E. D. (2022) · Journal of Women s Health · doi:10.1089/jwh.2021.0608 · Cited by 26 · see citing works
Huang, T., Howse, F. M., Stachenfeld, N. S., & Usselman, C. W. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00399.2022 · Cited by 26 · see citing works
Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets
Tan, W., Zhang, J., Dai, F., Yang, D., Gu, R., Tang, L., Liu, H., & Cheng, Y. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04736-w · Cited by 25 · see citing works
Aptamers as a new frontier in targeted cancer therapy
Li, Y., Zamay, T. N., Luzan, N. A., Pryakhin, E. A., Владимировна, С. Е., Osminkina, L. A., Kolovskaya, O. S., Dymova, M. A., Kuligina, E. V., Richter, V. A., et al. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115692 · Cited by 27 · see citing works
Kalyanaraman, R., & Pal, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094905 · Cited by 23 · see citing works
Khorshidi, A., Azami, M., Tardeh, S., & Tardeh, Z. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.06.008 · Cited by 23 · see citing works
Frøssing, S., Nylander, M. C., Chabanova, E., Kistorp, C., Skouby, S. O., & Faber, J. (2017) · Acta Radiologica · doi:10.1177/0284185117711475 · Cited by 22 · see citing works
Oberai, P., Lamba, C. D., Manchanda, R., Rath, P., Ponnam, H. B., & Padmanabhan, M. (2018) · Indian Journal of Research in Homoeopathy · doi:10.4103/ijrh.ijrh_18_18 · Cited by 22 · see citing works
Metabolic Features of Women With Polycystic Ovary Syndrome in Latin America: A Systematic Review
Marchesan, L. B., Ramos, R. B., & Spritzer, P. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.759835 · Cited by 22 · see citing works
Phimphasone-Brady, P., Palmer, B., Vela, A., Johnson, R. L., Harnke, B., Hoffecker, L., Coons, H. L., & Epperson, C. N. (2022) · F&S Reviews · doi:10.1016/j.xfnr.2021.11.004 · Cited by 20 · see citing works
Bennett, C., Mansfield, D. R., Mo, L., Joham, A. E., Cain, S. W., Blumfield, M., Hodge, A. M., & Moran, L. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002361 · Cited by 21 · see citing works
Merza, W. M., Yaseen, A. K., & Mahmood, M. A. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106773 · Cited by 19 · see citing works
Interplay between PCOS and microbiome: The road less travelled
Batra, M., Bhatnager, R., Kumar, A., Suneja, P., & Dang, A. S. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13580 · Cited by 19 · see citing works
Mental health and body image in polycystic ovary syndrome.
Lee, I., & Dokras, A. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.04.004 · Cited by 18 · see citing works
Padhi, B. K., Singh, S. K., Gaidhane, A. M., Serhan, H. A. A., Khatib, M. N., Zahiruddin, Q. S., Rustagi, S., Sharma, R., Sharma, D., Arora, M., et al. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102605 · Cited by 17 · see citing works
Mirzohreh, S., Panahi, P., & Heidari, F. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02617-x · Cited by 17 · see citing works
Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis
He, J., Ruan, X., & Li, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1418933 · Cited by 16 · see citing works
Polycystic Ovary Syndrome and Pelvic Floor Dysfunction: A Narrative Review
Naz, M. S. G., Tehrani, F. R., Behroozi-Lak, T., Mohammadzadeh, F., Badr, F. K., & Ozgoli, G. (2020) · Research and Reports in Urology · doi:10.2147/rru.s249611 · Cited by 16 · see citing works
Challenges in Optimizing Lipid Management in Women
Peterson, K., Kaur, G., Gianos, E., Mookherjee, S., Poli, K. A., Sidhu, M. S., & Lyubarova, R. (2021) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-021-07273-0 · Cited by 17 · see citing works
Li, L., Yu, J., & Zhou, Z. (2022) · Medicine · doi:10.1097/md.0000000000030579 · Cited by 15 · see citing works
The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date
Kolnikaj, T. S., Herman, R., Janež, A., & Jensterle, M. (2024) · Medicina · doi:10.3390/medicina60020244 · Cited by 17 · see citing works
Midlife women’s health consequences associated with polycystic ovary syndrome
Ali, A. T., & Guidozzi, F. (2019) · Climacteric · doi:10.1080/13697137.2019.1679111 · Cited by 16 · see citing works
Cardiovascular Risk in Postmenopausal Women with Polycystic Ovary Syndrome
Armeni, E., & Lambrinoudaki, I. V. (2018) · Current Vascular Pharmacology · doi:10.2174/1570161116666180828154006 · Cited by 15 · see citing works
Genotype based Risk Predictors for Polycystic Ovary Syndrome in Western Saudi Arabia
Bakhashab, S. (2019) · Bioinformation · doi:10.6026/97320630015812 · Cited by 14 · see citing works
Female-specific risk factors for cardiovascular disease: an update
Theodorou, A., Karagiannakis, D. S., Stefanaki, K., Kassi, E., Peppa, Μ., Vryonidou, A., & Paschou, S. Α. (2024) · HORMONES · doi:10.1007/s42000-024-00576-5 · Cited by 13 · see citing works
Vascular Diseases in Women: Do Women Suffer from Them Differently?
Farkas, K., Stanek, A., Zbinden, S., Borea, B., Ciurica, S., Moore, V., Maguire, P., Abola, M. T. B., Alajar, E. B., Marcoccia, A., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041108 · Cited by 13 · see citing works
Bir, A., Ghosh, A., & Chowdhury, S. (2023) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1605_22 · Cited by 12 · see citing works
Amiri, M., Mousavi, M., Noroozzadeh, M., Azizi, F., & Tehrani, F. R. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01346-7 · Cited by 12 · see citing works
Association of serum androgens and coronary artery calcium scores in women
Penn, C. A., Chan, J. L., Mesaros, C., Snyder, N. W., Rader, D. J., Sammel, M. D., & Dokras, A. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.04.024 · Cited by 12 · see citing works
Scannell, N., Villani, A., Moran, L., & Mantzioris, E. (2025) · Proceedings of the Nutrition Society · doi:10.1017/s0029665124007584 · Cited by 12 · see citing works
Coronary artery disease in women
Montarello, N. L., & Chan, W. P. A. (2022) · Australian Prescriber · doi:10.18773/austprescr.2022.065 · Cited by 11 · see citing works
Female Infertility and Cardiovascular Risk - A Hype or an Underestimated Reality?
Bosdou, J. Κ., Anagnostis, P. G., Lainas, G. T., & Kolibianakis, E. M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200821114552 · Cited by 11 · see citing works
Ryu, K.-J., Park, H., Kim, M. S., Jeong, H. G., & Kim, T. (2024) · Scientific Reports · doi:10.1038/s41598-023-50650-y · Cited by 10 · see citing works
Association of lipid profile and obesity in patients with polycystic ovary syndrome
Parveen, S., Khan, S., Khan, M. M., Gupta, B., Ahmad, A., & Alam, R. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0009 · Cited by 9 · see citing works
Rashad, N. M., El-Fatah, A. H. A., Lashin, M. E.-B., Abomandour, H. G., & Allam, R. M. (2019) · Middle East Fertility Society Journal · doi:10.1186/s43043-019-0005-y · Cited by 9 · see citing works
Polycystic οvary syndrome revisited: An interactions network approach
Geronikolou, S. A., Pavlopoulou, A., Cokkinos, D. V., Bacopoulou, F., & Chrousos, G. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13578 · Cited by 9 · see citing works
Huang, Y., Zhang, Y., Zhou, Y., Chen, Y., & Zhu, Q. (2022) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001405 · Cited by 9 · see citing works
Polycystic ovarian syndrome and long-term risk of acute myocardial infarction and ischaemic stroke
Havers‐Borgersen, E., Ekelund, C. K., Svendsen, P. F., Reinert, M. S., Vistisen, H. T., Butt, J. H., Østergaard, L., Schou, M., Køber, L., & Fosbøl, E. L. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf351 · Cited by 8 · see citing works
de Medeiros, S. F., Soares, J. M., de Medeiros, M. A. S., Yamamoto, A. K. L. W., de Medeiros, C. L. W., Carvalho, A. B. D. S., Yamamoto, M. M. W., & Baracat, E. C. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07637-5 · Cited by 8 · see citing works
Cardiovascular health and menopause in aging women with polycystic ovary syndrome
Helvacı, N., & Yıldız, B. O. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1719067 · Cited by 8 · see citing works
Janež, A., Herman, R., Poredoš, P., Mikhailidis, D. P., Blinc, A., Šabović, M., Studen, K. B., Jezovnik, M. K., Schernthaner, G.-H., Anagnostis, P. G., et al. (2023) · Current Vascular Pharmacology · doi:10.2174/0115701611269146230920073301 · Cited by 8 · see citing works
Nielsen, J. H., Birukov, A., Jensen, R. C., Kyhl, H. B., Jørgensen, J. S., Andersen, M., & Glintborg, D. (2020) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13914 · Cited by 10 · see citing works
Scannell, N., Mantzioris, E., Cowan, S., Moran, L., & Villani, A. M. (2025) · Proceedings of The Nutrition Society · doi:10.1017/s0029665126104054 · Cited by 7 · see citing works
Chao, T.-H., Lin, T., Cheng, C., Wu, Y., Ueng, K., Wu, Y., Lin, W.-W., Leu, H.-B., Cheng, H., Huang, C., et al. (2024) · PubMed Central · doi:10.6515/acs.202409_40(5).20240724a · Cited by 7 · see citing works
Serum visfatin as predictive marker of cardiometabolic risk in women with polycystic ovary syndrome
Rashad, N. M., Abd-Elrahman, M. N. A., El‐Shal, A. S., & Amin, A. I. (2018) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2018.04.008 · Cited by 7 · see citing works
Mujica, L. K. S., Stein, C. S., Miyazato, L. G., Valente, F. S., Premaor, M. O., Antoniazzi, A. Q., Moresco, R. N., & Comim, F. V. (2021) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0077 · Cited by 7 · see citing works
Zhang, J., Xu, W., Li, S., Zhang, J., Shang, Y., & Gui, J. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.09.017 · Cited by 7 · see citing works
- Authors
- Zhao, L., Zhu, Z., Lou, H., Zhu, G., Huang, W., Zhang, S., & Liu, F.
- Affiliations
- Guangzhou First People's Hospital (CN)
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2016-05-22
- Volume
- 7
- Issue
- 23
- Pages
- 33715-33721
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC5085114
- OpenAlex
- W2402673221
- Cited by
- 174
- References
- 22
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 31 · 2023: 16 · 2022: 23 · 2021: 22 · 2020: 17 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- polycystic ovary syndrome, coronary artery disease, cardiovascular risk, myocardial infarction, cardiovascular risk factors, hyperinsulinemia, dyslipidemia, insulin resistance, hyperandrogenism, type 2 diabetes, hypertension, smoking, physical inactivity, menopause, hormone replacement therapy, cardiovascular risk stratification
- MeSH terms
- Coronary Disease, Female, Humans, Polycystic Ovary Syndrome, Risk Factors, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
