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The neuronal genome of Caenorhabditis elegans

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Hobert, Oliver·2013·WormBook

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Abstract

The ~100 MB genome of C. elegans codes for ~20,000 protein-coding genes many of which are required for the function of the nervous system, composed of 302 neurons in the adult hermaphrodite and of 383 neurons in the adult male. In addition to housekeeping genes, a differentiated neuron is thought to express many hundreds if not thousands of genes that define its functional properties. These genes code for ion channels, G-protein-coupled receptors, neurotransmitter-synthesizing enzymes, transporters and receptors, neuropeptides and their receptors, cell adhesion molecules, motor proteins, signaling molecules and many others. Collectively such genes have been referred to as "terminal differentiation genes" or "effector genes". The differential expression of distinct combinations of terminal differentiation genes define different neuron types. This paper provides a compendium of more than 2,800 putative terminal differentiation genes. One pervasive theme revealed by the analysis of many gene families is the nematode-specific expansions of many neuron function-related gene families, including, for example, many types of ion channel families, sensory receptors and neurotransmitter receptors. The gene lists provided here can serve multiple purposes. They can serve as quick reference guides for individual gene families or they can be used to mine large datasets (e.g., expression datasets) for genes with likely functions in the nervous system. They also serve as a starting point for future projects. For example, a comprehensive understanding of the regulation of the often complex expression patterns of these genes in the nervous system will eventually explain how nervous systems are built.

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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316
InterProScan – an integration platform for the signature-recognition methods in InterPro
Zdobnov, E. M., & Apweiler, R. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.9.847 · Cited by 2,939
TRP Channels
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,909
Structural diversity of G protein-coupled receptors and significance for drug discovery
Lagerström, M. C., & Schiöth, H. B. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2518 · Cited by 1,492
SMART: a web-based tool for the study of genetically mobile domains
Schultz, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.231 · Cited by 1,378
Imaging Calcium in Neurons
Grienberger, C., & Konnerth, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.011 · Cited by 1,354
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
Conti, M., & Beavo, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060305.150444 · Cited by 1,183
Piezo proteins are pore-forming subunits of mechanically activated channels
Coste, B., Xiao, B., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., et al. (2012) · Nature · doi:10.1038/nature10812 · Cited by 1,167
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
Catterall, W. A., Perez-Reyes, E., Snutch, T. P., & Striessnig, J. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.5 · Cited by 1,162
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease
Hirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138
ION CHANNELS IN EXCITABLE MEMBRANES
Hucho, F. (1978) · Transport by proteins · doi:10.1515/9783111710013-017 · Cited by 1,136
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Jasti, J., Furukawa, H., Gonzales, E. B., & Gouaux, E. (2007) · Nature · doi:10.1038/nature06163 · Cited by 1,043
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Gerstein, M. B., Lu, Z. J., Van Nostrand, E. L., Cheng, C., Arshinoff, B. I., Liu, T., Yip, K. Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., et al. (2010) · Science · doi:10.1126/science.1196914 · Cited by 955
Neurobiology of the Caenorhabditis elegans Genome
Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson, H. M., Warr, C. G., & Carlson, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335847100 · Cited by 804
Chemosensation in C. elegans
Bargmann, C. (2006) · WormBook · doi:10.1895/wormbook.1.123.1 · Cited by 777
Ancient Protostome Origin of Chemosensory Ionotropic Glutamate Receptors and the Evolution of Insect Taste and Olfaction
Croset, V., Rytz, R., Cummins, S. F., Budd, A., Brawand, D., Kaessmann, H., Gibson, T. J., & Benton, R. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001064 · Cited by 751
Mammalian Zinc Transporters: Nutritional and Physiologic Regulation
Lichten, L. A., & Cousins, R. J. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-033009-083312 · Cited by 741
Tyramine and octopamine: ruling behavior and metabolism
Roeder, T. (2005) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130404 · Cited by 711
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans
Troemel, E. R., Chou, J. H., Dwyer, N. D., Colbert, H. A., & Bargmann, C. I. (1995) · Cell · doi:10.1016/0092-8674(95)90162-0 · Cited by 690
PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification
Thomas, P. D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg115 · Cited by 665
Octopamine in invertebrates
Roeder, T. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00016-7 · Cited by 602
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
Gray, J. M., Karow, D. S., Lu, H., Chang, A. J., Chang, J. S., Ellis, R. E., Marletta, M. A., & Bargmann, C. I. (2004) · Nature · doi:10.1038/nature02714 · Cited by 590
odr-10 Encodes a Seven Transmembrane Domain Olfactory Receptor Required for Responses to the Odorant Diacetyl
Sengupta, P., Chou, J. H., & Bargmann, C. I. (1996) · Cell · doi:10.1016/s0092-8674(00)81068-5 · Cited by 558
Traffic control: regulation of kinesin motors
Verhey, K. J., & Hammond, J. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2782 · Cited by 546
TreeFam: a curated database of phylogenetic trees of animal gene families
Li, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj118 · Cited by 523
Recent advances in Cys-loop receptor structure and function
Sine, S. M., & Engel, A. G. (2006) · Nature · doi:10.1038/nature04708 · Cited by 521
Nonvertebrate Hemoglobins: Functions and Molecular Adaptations
Weber, R. E., & Vinogradov, S. N. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.569 · Cited by 510
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily
Yu, F. H., Yarov-Yarovoy, V., Gutman, G. A., & Catterall, W. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.13 · Cited by 495
Dopaminergic neurons in the nematode Caenorhabditis elegans
Sulston, J., Dew, M., & Brenner, S. (1975) · Journal of Comparative Neurology · doi:10.1002/cne.901630207 · Cited by 476
New insights into copper monooxygenases and peptide amidation: Structure, mechanism and function
Prigge, S. T., Mains, R. E., Eipper, B. A., & Amzel* **, L. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000763 · Cited by 460
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
Gonzales, E. B., Kawate, T., & Gouaux, E. (2009) · Nature · doi:10.1038/nature08218 · Cited by 455
The neprilysin (NEP) family of zinc metalloendopeptidases: Genomics and function
Turner, A. J., Isaac, R. E., & Coates, D. (2001) · BioEssays · doi:10.1002/1521-1878(200103)23:3<261::aid-bies1036>3.0.co;2-k · Cited by 452
Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
Becker-André, M., Wiesenberg, I., Schaeren-Wiemers, N., André, E., Missbach, M., Saurat, J. H., & Carlberg, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61934-4 · Cited by 434
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
Jackson, A. C., & Nicoll, R. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.007 · Cited by 410
Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport
Lytton, J. (2007) · Biochemical Journal · doi:10.1042/bj20070619 · Cited by 408
Non‐vertebrate melatonin
Hardeland, R., & Poeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 398
Systematic analysis of genes required for synapse structure and function
Sieburth, D., Ch'ng, Q., Dybbs, M., Tavazoie, M., Kennedy, S., Wang, D., Dupuy, D., Rual, J.-F., Hill, D. E., Vidal, M., et al. (2005) · Nature · doi:10.1038/nature03809 · Cited by 392
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Feng, W., & Zhang, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2540 · Cited by 388
Active Currents Regulate Sensitivity and Dynamic Range in C. elegans Neurons
Goodman, M. B., Hall, D. H., Avery, L., & Lockery, S. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)81014-4 · Cited by 370
Neurexins: Three genes and 1001 products
Missler, M., & Südhof, T. C. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(97)01324-3 · Cited by 356
Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins
Magalhaes, A. C., Dunn, H., & Ferguson, S. S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01552.x · Cited by 353
Analysis and update of the human solute carrier (SLC) gene superfamily
He, L., Vasiliou, K., & Nebert, D. W. (2009) · Human Genomics · doi:10.1186/1479-7364-3-2-195 · Cited by 349
Family-B G-protein-coupled receptors.
Harmar, A. J. (2001) · Genome biology · doi:10.1186/gb-2001-2-12-reviews3013 · Cited by 344
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species
Nathoo, A. N., Moeller, R. A., Westlund, B. A., & Hart, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241231298 · Cited by 340
Chloride Channels: Often Enigmatic, Rarely Predictable
Duran, C., Thompson, C. H., Xiao, Q., & Hartzell, H. C. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135811 · Cited by 338
Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly
Zipursky, S. L., & Sanes, J. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.009 · Cited by 323
Biogenic amine neurotransmitters in C. elegans
Chase, D. (2007) · WormBook · doi:10.1895/wormbook.1.132.1 · Cited by 316
The Insulin/PI 3-Kinase Pathway Regulates Salt Chemotaxis Learning in Caenorhabditis elegans
Tomioka, M., Adachi, T., Suzuki, H., Kunitomo, H., Schafer, W. R., & Iino, Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.024 · Cited by 307
Arrestins: ubiquitous regulators of cellular signaling pathways.
Gurevich, E. V., & Gurevich, V. V. (2006) · Genome biology · doi:10.1186/gb-2006-7-9-236 · Cited by 303
A Novel Molecular Solution for Ultraviolet Light Detection in Caenorhabditis elegans
Edwards, S. L., Charlie, N. K., Milfort, M. C., Brown, B. S., Gravlin, C. N., Knecht, J. E., & Miller, K. G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060198 · Cited by 299
Molecular physiology of cation-coupled Cl? cotransport: the SLC12 family
Hebert, S. C., Mount, D. B., & Gamba, G. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1066-3 · Cited by 295
Differential Expression of Glutamate Receptor Subunits in the Nervous System of Caenorhabditis elegans and Their Regulation by the Homeodomain Protein UNC-42
Brockie, P. J., Madsen, D. M., Zheng, Y., Mellem, J., & Maricq, A. V. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01510.2001 · Cited by 287
Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases
Zimmer, M., Gray, J. M., Pokala, N., Chang, A. J., Karow, D. S., Marletta, M. A., Hudson, M. L., Morton, D. B., Chronis, N., & Bargmann, C. I. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.013 · Cited by 282
The cat-1 Gene of Caenorhabditis elegans Encodes a Vesicular Monoamine Transporter Required for Specific Monoamine-Dependent Behaviors
Duerr, J. S., Frisby, D. L., Gaskin, J., Duke, A., Asermely, K., Huddleston, D., Eiden, L. E., & Rand, J. B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00072.1999 · Cited by 282
Guanylyl cyclase structure, function and regulation
Potter, L. R. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.001 · Cited by 274
Identification and Characterization of a Novel Monoamine Transporter in the Human Brain
Engel, K., Zhou, M., & Wang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407913200 · Cited by 267
Ancillary Subunits Associated With Voltage-Dependent K+Channels
Pongs, O., & Schwarz, J. R. (2010) · Physiological Reviews · doi:10.1152/physrev.00020.2009 · Cited by 267
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior
Garrison, J. L., Macosko, E. Z., Bernstein, S., Pokala, N., Albrecht, D. R., & Bargmann, C. I. (2012) · Science · doi:10.1126/science.1226201 · Cited by 266
Zinc: The brain's dark horse
Bitanihirwe, B. K. Y., & Cunningham, M. G. (2009) · Synapse · doi:10.1002/syn.20683 · Cited by 265
The continuing disappearance of “pure” Ca2+ buffers
Schwaller, B. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8564-6 · Cited by 257
Odorant Receptor Localization to Olfactory Cilia Is Mediated by ODR-4, a Novel Membrane-Associated Protein
Dwyer, N. D., Troemel, E. R., Sengupta, P., & Bargmann, C. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81173-3 · Cited by 248
On the origins of arrestin and rhodopsin
Alvarez, C. E. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-222 · Cited by 241
Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors
McGrath, P. T., Rockman, M. V., Zimmer, M., Jang, H., Macosko, E. Z., Kruglyak, L., & Bargmann, C. I. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.012 · Cited by 241
An Imbalancing Act: Gap Junctions Reduce the Backward Motor Circuit Activity to Bias C. elegans for Forward Locomotion
Kawano, T., Po, M. D., Gao, S., Leung, G., Ryu, W. S., & Zhen, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.005 · Cited by 240
Genomic cis-Regulatory Architecture and trans-Acting Regulators of a Single Interneuron-Specific Gene Battery in C. elegans
Wenick, A. S., & Hobert, O. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.05.004 · Cited by 239
Self-citation
Adhesion-GPCRs: emerging roles for novel receptors
Yona, S., Lin, H.-H., Siu, W. O., Gordon, S., & Stacey, M. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.07.005 · Cited by 232
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes
McGrath, P. T., Xu, Y., Ailion, M., Garrison, J. L., Butcher, R. A., & Bargmann, C. I. (2011) · Nature · doi:10.1038/nature10378 · Cited by 231
Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
Askwith, C. C., Cheng, C., Ikuma, M., Benson, C., Price, M. P., & Welsh, M. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81144-7 · Cited by 221
Dscam-Mediated Cell Recognition Regulates Neural Circuit Formation
Hattori, D., Millard, S. S., Wojtowicz, W. M., & Zipursky, S. L. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175250 · Cited by 203
C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog
Liu, J., Ward, A., Gao, J., Dong, Y., Nishio, N., Inada, H., Kang, L., Yu, Y., Ma, D., Xu, T., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2540 · Cited by 200
The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species
Hoglund, P. J., Nordstrom, K. J. V., Schioth, H. B., & Fredriksson, R. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq350 · Cited by 198
The sensory cilia of Caenorhabditis elegans_Revised
Scholey, J. (2007) · WormBook · doi:10.1895/wormbook.1.126.2 · Cited by 196
Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor
Boulin, T., Gielen, M., Richmond, J. E., Williams, D. C., Paoletti, P., & Bessereau, J.-L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806933105 · Cited by 195
Two Chemoreceptors Mediate Developmental Effects of Dauer Pheromone in C. elegans
Kim, K., Sato, K., Shibuya, M., Zeiger, D. M., Butcher, R. A., Ragains, J. R., Clardy, J., Touhara, K., & Sengupta, P. (2009) · Science · doi:10.1126/science.1176331 · Cited by 191
Connexins, pannexins, innexins: novel roles of “hemi-channels”
Scemes, E., Spray, D. C., & Meda, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0591-5 · Cited by 190
Vasopressin/Oxytocin-Related Signaling Regulates Gustatory Associative Learning in C. elegans
Beets, I., Janssen, T., Meelkop, E., Temmerman, L., Suetens, N., Rademakers, S., Jansen, G., & Schoofs, L. (2012) · Science · doi:10.1126/science.1226860 · Cited by 183
eat-2 and eat-18 Are Required for Nicotinic Neurotransmission in the Caenorhabditis elegans Pharynx
McKay, J. P., Raizen, D. M., Gottschalk, A., Schafer, W. R., & Avery, L. (2004) · Genetics · doi:10.1534/genetics.166.1.161 · Cited by 183
Organic anion transport is the primary function of the SLC17/type I phosphate transporter family
Reimer, R. J., & Edwards, R. H. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1087-y · Cited by 181
High resolution map of Caenorhabditis elegans gap junction proteins
Altun, Z. F., Chen, B., Wang, Z., & Hall, D. H. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22025 · Cited by 181
Wnt signaling
Eisenmann, D. M. (2005) · WormBook · doi:10.1895/wormbook.1.7.1 · Cited by 181
The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
Dolan, J., Walshe, K., Alsbury, S., Hokamp, K., O'Keeffe, S., Okafuji, T., Miller, S. F., Tear, G., & Mitchell, K. J. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-320 · Cited by 180
Acetylcholine
Rand, J. B. (2007) · WormBook · doi:10.1895/wormbook.1.131.1 · Cited by 170
A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response
Pirri, J. K., McPherson, A. D., Donnelly, J. L., Francis, M. M., & Alkema, M. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.013 · Cited by 169
Mechanosensation
Goodman, M. B. (2006) · WormBook · doi:10.1895/wormbook.1.62.1 · Cited by 168
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia
Silverman, M. A., & Leroux, M. R. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.04.002 · Cited by 164
The EGL-21 Carboxypeptidase E Facilitates Acetylcholine Release at Caenorhabditis elegans Neuromuscular Junctions
Jacob, T. C., & Kaplan, J. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02122.2003 · Cited by 163
Role of Leucine-Rich Repeat Proteins in the Development and Function of Neural Circuits
de Wit, J., Hong, W., Luo, L., & Ghosh, A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154111 · Cited by 159
The EGL-3 Proprotein Convertase Regulates Mechanosensory Responses ofCaenorhabditis elegans
Kass, J., Jacob, T. C., Kim, P., & Kaplan, J. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09265.2001 · Cited by 156
Neurogenesis in the nematode Caenorhabditis elegans
Hobert, O. (2010) · WormBook · doi:10.1895/wormbook.1.12.2 · Cited by 150
Self-citation
Action potentials drive body wall muscle contractions in Caenorhabditis elegans
Gao, S., & Zhen, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012346108 · Cited by 149
Protons Act as a Transmitter for Muscle Contraction in C. elegans
Beg, A. A., Ernstrom, G. G., Nix, P., Davis, M. W., & Jørgensen, E. M. (2008) · Cell · doi:10.1016/j.cell.2007.10.058 · Cited by 145
Temperature, Oxygen, and Salt-Sensing Neurons in C. elegans Are Carbon Dioxide Sensors that Control Avoidance Behavior
Bretscher, A. J., Kodama, E., Busch, K. E., Murphy, R. J., Soltész, Z., Laurent, P., & de Bono, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.023 · Cited by 143
The putative chemoreceptor families of C. elegans
Robertson, H. M., & Thomas, J. H. (2006) · WormBook · doi:10.1895/wormbook.1.66.1 · Cited by 143
Neurotransmitters, Drugs and Brain Function
Webster, R. A. (2001) · Wiley eBooks · doi:10.1002/0470846577 · Cited by 142
Searching for Neuronal Left/Right Asymmetry: Genomewide Analysis of Nematode Receptor-Type Guanylyl Cyclases
Ortiz, C. O., Etchberger, J. F., Posy, S., Frøkjær‐Jensen, C., Lockery, S. R., Honig, B. H., & Hobert, O. (2006) · Genetics · doi:10.1534/genetics.106.055749 · Cited by 139
Self-citation
An Innexin-Dependent Cell Network Establishes Left-Right Neuronal Asymmetry in C. elegans
Chuang, C., VanHoven, M. K., Fetter, R. D., Verselis, V. K., & Bargmann, C. I. (2007) · Cell · doi:10.1016/j.cell.2007.02.052 · Cited by 136
Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans
Persson, A., Gross, E., Laurent, P., Busch, K. E., Bretes, H., & de Bono, M. (2009) · Nature · doi:10.1038/nature07820 · Cited by 136
Serotonergic transcriptional networks and potential importance to mental health
Deneris, E. S., & Wyler, S. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3039 · Cited by 132
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans
Hallem, E. A., Spencer, W. C., McWhirter, R. D., Zeller, G., Henz, S. R., Rätsch, G., Miller, D. M., Horvitz, H. R., Sternberg, P. W., & Ringstad, N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017354108 · Cited by 131
Stomatin-domain proteins
Lapatsina, L., Brand, J., Poole, K., Daumke, O., & Lewin, G. R. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.01.018 · Cited by 131
Wnts: up-and-coming at the synapse
Speese, S. D., & Budnik, V. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.04.003 · Cited by 128
FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans
Ringstad, N., & Horvitz, H. R. (2008) · Nature Neuroscience · doi:10.1038/nn.2186 · Cited by 128
Identification of Thermosensory and Olfactory Neuron-Specific Genes via Expression Profiling of Single Neuron Types
Colosimo, M., Brown, A. R., Mukhopadhyay, S., Gabel, C. V., Lanjuin, A., Samuel, A. D. T., & Sengupta, P. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.030 · Cited by 127
A Family of Acetylcholine-gated Chloride Channel Subunits in Caenorhabditis elegans
Putrenko, I., Zakikhani, M., & Dent, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412644200 · Cited by 125
A secreted complement-control-related protein ensures acetylcholine receptor clustering
Gendrel, M., Rapti, G., Richmond, J. E., & Bessereau, J. (2009) · Nature · doi:10.1038/nature08430 · Cited by 121
Ligand-Gated Chloride Channels Are Receptors for Biogenic Amines in C. elegans
Ringstad, N., Abe, N., & Horvitz, H. R. (2009) · Science · doi:10.1126/science.1169243 · Cited by 119
Immunoglobulin-Domain Proteins Required for Maintenance of Ventral Nerve Cord Organization
Aurelio, O. N., Hall, D. H., & Hobert, O. (2002) · Science · doi:10.1126/science.1066642 · Cited by 119
Self-citation
GABA
Jørgensen, E. M. (2005) · WormBook · doi:10.1895/wormbook.1.14.1 · Cited by 119
The Caenorhabditis elegans seven-transmembrane protein ODR-10 functions as an odorant receptor in mammalian cells
Zhang, Y., Chou, J. H., Bradley, J., Bargmann, C. I., & Zinn, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12162 · Cited by 118
A Putative Cation Channel and Its Novel Regulator: Cross-Species Conservation of Effects on General Anesthesia
Humphrey, J. A., Hamming, K. S. C., Thacker, C. M., Scott, R. L., Sedensky, M. M., Snutch, T. P., Morgan, P. G., & Nash, H. A. (2007) · Current Biology · doi:10.1016/j.cub.2007.02.037 · Cited by 118
Evolution of the Human Ion Channel Set
Nayak, S. K., Batalov, S., Jegla, T. J., & Zmasek, C. M. (2009) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620709787047957 · Cited by 116
Whole-Genome Analysis of 60 G Protein-Coupled Receptors in Caenorhabditis elegans by Gene Knockout with RNAi
Keating, C. D., Kriek, N., Daniels, M., Ashcroft, N., Hopper, N. A., Siney, E. J., Holden-Dye, L. M., & Burke, J. F. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.003 · Cited by 115
Behavioral Choice between Conflicting Alternatives Is Regulated by a Receptor Guanylyl Cyclase, GCY-28, and a Receptor Tyrosine Kinase, SCD-2, in AIA Interneurons ofCaenorhabditis elegans
Shinkai, Y., Yamamoto, Y., Fujiwara, M., Tabata, T., Murayama, T., Hirotsu, T., Ikeda, D. D., Tsunozaki, M., Iino, Y., Bargmann, C. I., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4691-10.2011 · Cited by 114
Biogenic amine neurotransmitters in C.
Chase, D. L., & Koelle, M. R. (2007) · Cited by 114
Lateralized Gustatory Behavior of C. elegans Is Controlled by Specific Receptor-Type Guanylyl Cyclases
Ortiz, C. O., Faumont, S., Takayama, J., Ahmed, H. K., Goldsmith, A. D., Pocock, R., McCormick, K. E., Kunimoto, H., Iino, Y., Lockery, S. R., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.043 · Cited by 113
Self-citation
The immunoglobulin superfamily inDrosophila melanogasterandCaenorhabditis elegansand the evolution of complexity
Vogel, C., Teichmann, S. A., & Chothia, C. (2003) · Development · doi:10.1242/dev.00848 · Cited by 113
TheCaenorhabditis elegans odr-2Gene Encodes a Novel Ly-6-Related Protein Required for Olfaction
Chou, J. H., Bargmann, C. I., & Sengupta, P. (2001) · Genetics · doi:10.1093/genetics/157.1.211 · Cited by 111
Interaction of structure-specific and promiscuous G-protein–coupled receptors mediates small-molecule signaling in Caenorhabditis elegans
Park, D., O’Doherty, I. M., Somvanshi, R. K., Bethke, A., Schroeder, F. C., Kumar, U., & Riddle, D. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202216109 · Cited by 111
TRP CHANNELS IN C. ELEGANS
Kahn-Kirby, A. H., & Bargmann, C. I. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100715 · Cited by 110
Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans
Mukhopadhyay, S., Lu, Y., Qin, H., Lanjuin, A., Shaham, S., & Sengupta, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601717 · Cited by 110
The molecular and gene regulatory signature of a neuron
Hobert, O., Carrera, I., & Stefanakis, N. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.05.006 · Cited by 109
Self-citation
Receptor and nonreceptor protein tyrosine phosphatases in the nervous system
Paul, S., & Lombroso, P. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3123-7 · Cited by 109
Guanylate cyclase-activating proteins: structure, function, and diversity
Palczewski, K., Sokal, I., & Baehr, W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.122 · Cited by 109
The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans
Jones, A. K., & Sattelle, D. B. (2008) · Invertebrate Neuroscience · doi:10.1007/s10158-008-0068-4 · Cited by 109
Cloning and Functional Characterization of a Cation-Cl− Cotransporter-interacting Protein
Caron, L., Rousseau, F., Gagnon, É., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000108200 · Cited by 102
Expression Profiling of the Solute Carrier (SLC) Gene Family in the Mouse Brain
Dahlin, A., Royall, J., Hohmann, J., & Wang, J. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149831 · Cited by 102
Olfactory Plasticity Is Regulated by Pheromonal Signaling in Caenorhabditis elegans
Yamada, K., Hirotsu, T., Matsuki, M., Butcher, R. A., Tomioka, M., Ishihara, T., Clardy, J., Kunitomo, H., & Iino, Y. (2010) · Science · doi:10.1126/science.1192020 · Cited by 100
The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans
Liu, O. W., & Shen, K. (2011) · Nature Neuroscience · doi:10.1038/nn.2978 · Cited by 100
Unusual Regulation of a STAT Protein by an SLC6 Family Transporter in C. elegans Epidermal Innate Immunity
Dierking, K., Polanowska, J., Omi, S., Engelmann, I., Gut, M., Lembo, F., Ewbank, J. J., & Pujol, N. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.011 · Cited by 100
UNC-80 and the NCA Ion Channels Contribute to Endocytosis Defects in Synaptojanin Mutants
Jospin, M., Watanabe, S., Joshi, D., Young, S., Hamming, K. S. C., Thacker, C. M., Snutch, T. P., Jørgensen, E. M., & Schuske, K. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.036 · Cited by 99
Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum
Melani, A., Corti, F., Stephan, H., Müller, C. E., Donati, C., Bruni, P., Vannucchi, M. G., & Pedata, F. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.036 · Cited by 99
An evolutionary history of P2X receptors
Fountain, S. J., & Burnstock, G. (2008) · Purinergic Signalling · doi:10.1007/s11302-008-9127-x · Cited by 98
Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system
Starich, T. A., Xu, J. P., Skerrett, I. M., Nicholson, B. J., & Shaw, J. E. (2009) · Neural Development · doi:10.1186/1749-8104-4-16 · Cited by 98
LIN-23-Mediated Degradation of β-Catenin Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
Dreier, L., Burbea, M., & Kaplan, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.058 · Cited by 95
LAR, liprin α and the regulation of active zone morphogenesis
Stryker, E., & Johnson, K. G. (2007) · Journal of Cell Science · doi:10.1242/jcs.03491 · Cited by 95
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi‐channels
Morciano, M., Beckhaus, T., Karas, M., Zimmermann, H., & Volknandt, W. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05824.x · Cited by 94
Genetic dissection of ion currents underlying all‐or‐none action potentials in C. elegans body‐wall muscle cells
Liu, P., Ge, Q., Chen, B., Salkoff, L., Kotlikoff, M. I., & Wang, Z. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.200683 · Cited by 93
InterPro Protein Classification
McDowall, J., & Hunter, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-977-2_3 · Cited by 92
Presynaptic Ryanodine Receptors Are Required for Normal Quantal Size at theCaenorhabditis elegansNeuromuscular Junction
Liu, Q., Chen, B., Yankova, M. P., Morest, D. K., Maryon, E. B., Hand, A. R., Nonet, M. L., & Wang, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1730-05.2005 · Cited by 92
Understanding the physiological roles of the neuronal calcium sensor proteins
Burgoyne, R. D., & Haynes, L. P. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-2 · Cited by 91
Evolutionary Relationship of the Ligand-Gated Ion Channels and the Avermectin-Sensitive, Glutamate-Gated Chloride Channels
Vassilatis, D. K., Elliston, K. O., Paress, P. S., Hamelin, M., Arena, J. P., Schaeffer, J. M., der Ploeg, L. H. T. V., & Cully, D. F. (1997) · Journal of Molecular Evolution · doi:10.1007/pl00006174 · Cited by 91
The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons inC. elegans
Steimel, A., Wong, L., Najarro, E. H., Ackley, B. D., Garriga, G., & Hutter, H. (2010) · Development · doi:10.1242/dev.054320 · Cited by 91
Heterotrimeric G proteins in C. elegans
Bastiani, C. A. (2006) · WormBook · doi:10.1895/wormbook.1.75.1 · Cited by 87
Ionotropic glutamate receptors: genetics, behavior and electrophysiology
Brockie, P. J. (2006) · WormBook · doi:10.1895/wormbook.1.61.1 · Cited by 86
The Potassium Chloride Cotransporter KCC-2 Coordinates Development of Inhibitory Neurotransmission and Synapse Structure in Caenorhabditis elegans
Tanis, J. E., Bellemer, A., Moresco, J. J., Forbush, B., & Koelle, M. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1989-09.2009 · Cited by 85
Synaptic function
Richmond, J. E. (2006) · WormBook · doi:10.1895/wormbook.1.69.1 · Cited by 82
The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature
Jones, A. K., Davis, P. A., Hodgkin, J., & Sattelle, D. B. (2007) · Invertebrate Neuroscience · doi:10.1007/s10158-007-0049-z · Cited by 81
Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in C. elegans.
Willson, J., Amliwala, K., Davis, A., Cook, A., Cuttle, M., Kriek, N., Hopper, N., O'Connor, V., Harder, A., Walker, R. J., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.056 · Cited by 80
Characterization of the DEG-3/DES-2 Receptor: A Nicotinic Acetylcholine Receptor That Mutates to Cause Neuronal Degeneration
Yassin, L., Gillo, B., Kahan, T., Halevi, S., Eshel, M., & Treinin, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0944 · Cited by 77
The Arrestin Fold: Variations on a Theme
Aubry, L., Guetta, D., & Klein, G. (2009) · Current Genomics · doi:10.2174/138920209787847014 · Cited by 77
Presynaptic Regulation of Neurotransmission in Drosophila by the G Protein-Coupled Receptor Methuselah
Song, W., Ranjan, R., Dawson-Scully, K. D., Bronk, P., Marin, L., Seroude, L., Lin, Y.-J., Nie, Z., Atwood, H. L., Benzer, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00932-7 · Cited by 76
UNC-1 Regulates Gap Junctions Important to Locomotion in C. elegans
Chen, B., Liu, Q., Ge, Q., Xie, J., & Wang, Z.-W. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.060 · Cited by 76
Histamine Action on Vertebrate GABAA Receptors
Saras, A., Gisselmann, G., Vogt-Eisele, A. K., Erlkamp, K. S., Kletke, O., Pusch, H., & Hatt, H. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709993200 · Cited by 76
Function and regulation of TRP family channels in C. elegans
Xiao, R., & Xu, X. Z. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0678-7 · Cited by 75
Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression
Sreedharan, S., Shaik, J. H. A., Olszewski, P. K., Levine, A. S., Schiöth, H. B., & Fredriksson, R. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-17 · Cited by 72
Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect
Rufener, L., Keiser, J., Kaminsky, R., Mäser, P., & Nilsson, D. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001091 · Cited by 72
SNAREs in neurons – beyond synaptic vesicle exocytosis (Review)
Wang, Y., & Tang, B. L. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600776734 · Cited by 71
P2X receptors: dawn of the post-structure era
Young, M. T. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.006 · Cited by 71
Neuropeptidases and the metabolic inactivation of insect neuropeptides
Isaac, R. E., Bland, N. D., & Shirras, A. D. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.12.011 · Cited by 64
Innexins in C. elegans
Starich, T. A., Sheehan, M., Jadrich, J. L., & Shaw, J. E. (2001) · Cell Communication & Adhesion · doi:10.3109/15419060109080744 · Cited by 64
Potassium channels in C. elegans
Salkoff, L., Wei, A. D., Baban, B., Butler, A., Fawcett, G., Ferreira, G., & Santi, C. M. (2006) · WormBook · doi:10.1895/wormbook.1.42.1 · Cited by 64
Discovery and characterization of a conserved pigment dispersing factor‐like neuropeptide pathway inCaenorhabditis elegans
Janssen, T., Husson, S. J., Meelkop, E., Temmerman, L., Lindemans, M., Verstraelen, K., Rademakers, S., Mertens, I., Nitabach, M. N., Jansen, G., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06323.x · Cited by 63
A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands
Kostenis, E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.04.005 · Cited by 61
An ER‐resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse
Almedom, R. B., Liewald, J. F., Hernando, G., Schultheis, C., Rayes, D., Pan, J., Schedletzky, T., Hutter, H., Bouzat, C., & GOTTSCHALK, A. R. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.204 · Cited by 61
Caenorhabditis elegans Glutamate Transporters Influence Synaptic Function and Behavior at Sites Distant from the Synapse
Mano, I., Straud, S., & Driscoll, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704134200 · Cited by 58
Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit
Boulin, T., Rapti, G., Briseño-Roa, L., Stigloher, C., Richmond, J. E., Paoletti, P., & Bessereau, J. (2012) · Nature Neuroscience · doi:10.1038/nn.3197 · Cited by 57
A single immunoglobulin‐domain protein required for clustering acetylcholine receptors in C. elegans
Rapti, G., Richmond, J. E., & Bessereau, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.355 · Cited by 56
Carboxypeptidase D is a potential candidate to carry out redundant processing functions of carboxypeptidase E based on comparative distribution studies in the rat central nervous system
Dong, W., Fricker, L. D., & Day, R. W. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00381-9 · Cited by 56
CLC Chloride Channels in Caenorhabditis elegans
Schriever, A. M., Friedrich, T., Pusch, M., & Jentsch, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34238 · Cited by 56
Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors
Metpally, R. P. R., & Sowdhamini, R. (2005) · BMC Genomics · doi:10.1186/1471-2164-6-106 · Cited by 55
UNC-46 is required for trafficking of the vesicular GABA transporter
Schuske, K. R., Palfreyman, M. T., Watanabe, S., & Jørgensen, E. M. (2007) · Nature Neuroscience · doi:10.1038/nn1920 · Cited by 54
SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans
Kim, H., Rogers, M. J., Richmond, J. E., & McIntire, S. L. (2004) · Nature · doi:10.1038/nature02798 · Cited by 53
Multiple lineage specific expansions within the guanylyl cyclase gene family
Fitzpatrick, D. A., O’Halloran, D. M., & Burnell, A. M. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-26 · Cited by 52
Caenorhabditis elegansFlamingo Cadherinfmi-1Regulates GABAergic Neuronal Development
Najarro, E. H., Wong, L., Zhen, M., Carpio, E. P., Goncharov, A., Garriga, G., Lundquist, E. A., Jin, Y., & Ackley, B. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3094-11.2012 · Cited by 52
IgCAMs redundantly control axon navigation in Caenorhabditis elegans
Schwarz, V., Pan, J., Voltmer-Irsch, S., et al. (2009) · Neural Development · doi:10.1186/1749-8104-4-13 · Cited by 52
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Auerbach, R. K., Clawson, H., Niu, W., Nostrand, E. L. V., Morris, M., Brennan, J., Lu, Z., Gerstein, M., Cheung, M.-S., Alexander, R. P., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/ssw3-m456 · Cited by 52
The Evolution of GABAA Receptor–Like Genes
Tsang, S., Ng, S.-K., Xu, Z., & Xue, H. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl188 · Cited by 51
The cadherin superfamily
Pettitt, J. (2005) · WormBook · doi:10.1895/wormbook.1.50.1 · Cited by 51
Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans
Tanaka, D., Furusawa, K., Kameyama, K., Okamoto, H., & Doi, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.017 · Cited by 50
A P2X receptor from the tardigrade species Hypsibius dujardiniwith fast kinetics and sensitivity to zinc and copper
Bavan, S., Straub, V. A., Blaxter, M., & Ennion, S. J. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-17 · Cited by 50
Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors
Kuang, D., Yao, Y., MacLean, D. M., Wang, M., Hampson, D. R., & Chang, B. S. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604717103 · Cited by 49
The neurexin superfamily of Caenorhabditis elegans
Haklai-Topper, L., Soutschek, J., Sabanay, H., Scheel, J., Hobert, O., & Peles, E. (2010) · Gene Expression Patterns · doi:10.1016/j.gep.2010.10.008 · Cited by 49
Self-citation
The Caenorhabditis elegans snf-11 Gene Encodes a Sodium-dependent GABA Transporter Required for Clearance of Synaptic GABA
Mullen, G. P., Mathews, E., Saxena, P., Fields, S. D., McManus, J. R., Moulder, G. L., Barstead, R. J., Quick, M. W., & Rand, J. B. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0155 · Cited by 49
Metabotropic histamine receptors—nothing for invertebrates?
Roeder, T. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01553-x · Cited by 47
Peptide-Induced Modulation of Synaptic Transmission and Escape Response inDrosophilaRequires Two G-Protein-Coupled Receptors
Klose, M. K., Dason, J. S., Atwood, H. L., Boulianne, G. L., & Mercier, A. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3612-10.2010 · Cited by 45
Respiratory gas concentrations in the microhabitats of some florida arthropods
Anderson, J. F., & Ultsch, G. R. (1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90086-7 · Cited by 45
Neurotransmitters, drugs and brain function
Duncan, J. S. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01607.x · Cited by 44
Cloning and expression of a FMRFamide‐gated Na+ channel from Helisoma trivolvis and comparison with the native neuronal channel
Jeziorski, M. C., Green, K. A., Sommerville, J., & Cottrell, G. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00013.x · Cited by 43
Coevolution of neuropeptidergic signaling systems: from worm to man
Janssen, T. A. H., Lindemans, M., Meelkop, E., Temmerman, L., & Schoofs, L. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05506.x · Cited by 43
SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying
Xiao, H., Hapiak, V., Smith, K., Lin, L., Hobson, R. J., Plenefisch, J. D., & Komuniecki, R. W. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.044 · Cited by 42
Feeding and the Rhodopsin Family G-Protein Coupled Receptors in Nematodes and Arthropods
Cardoso, J. C. R., Félix, R. C., Fonseca, V. G., & Power, D. M. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00157 · Cited by 42
Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons
Jones, A. K., Buckingham, S. D., & Sattelle, D. B. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.07.001 · Cited by 41
Two types of chloride transporters are required for GABAA receptor‐mediated inhibition in C. elegans
Bellemer, A., Hirata, T., Romero, M. F., & Koelle, M. R. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.83 · Cited by 40
The Drosophila G protein‐coupled receptor, Methuselah, exhibits a promiscuous response to peptides
Ja, W. W., Carvalho, G. B., Madrigal, M., et al. (2009) · Protein Science · doi:10.1002/pro.221 · Cited by 40
A Family of K+ Channel Ancillary Subunits Regulate Taste Sensitivity in Caenorhabditis elegans
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The Multilayer Connectome of Caenorhabditis elegans
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Serrano-Saiz, E., Pereira, L., Gendrel, M., Aghayeva, U., Bhattacharya, A., Howell, K., Garcia, L. R., & Hobert, O. (2017) · Genetics · doi:10.1534/genetics.117.202127 · Cited by 64
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A transcription factor collective defines the HSN serotonergic neuron regulatory landscape
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See all 279

Authors: Hobert, O.
Venue: WormBook
Publisher: WormBook
Published: 2013-08-13
Pages: 1-106
ISSN: 1551-8507 (ISSN-L)
DOI: 10.1895/wormbook.1.161.1
OpenAlex: W2037077087
Cited by: 279
References: 219
FWCI: 5.68
Type: journal article
Language: en
Open access: bronze

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The neuronal genome of Caenorhabditis elegans

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