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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism

Yu, Wen-Guang, Liu, Wei, Jin, Yi-He·2009·Environmental Toxicology and Chemistry
DOI 10.1897/08-345.1
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Abstract

The potential toxicity of perfluorooctane sulfonate (PFOS), an environmentally persistent organic pollutant, is of great concern. The present study examines the ability of PFOS to disturb thyroid function and the possible mechanisms involved in PFOS-induced thyroid hormone alteration. Male Sprague-Dawley rats were exposed to 1.7, 5.0, and 15.0 mg/L of PFOS in drinking water for 91 consecutive days. Serum was collected for analysis of total and free thyroxine (T4), total triiodothyronine (T3), and thyrotrophin (TSH). Thyroid and liver were removed for the measurement of endpoints closely related to thyroid hormone biosynthesis and metabolism following PFOS exposure. Determined endpoints were the messenger RNA (mRNA) levels for two isoforms of uridine diphosphoglucuronosyl transferases (UGT1A6 and UGT1A1) and type 1 deiodinase (DIO1) in liver, sodium iodide symporter (NIS), TSH receptor (TSHR), and DIO1 in thyroid as well as the activity of thyroid peroxidase (TPO). Serum total T4 level decreased significantly at all applied dosages, whereas total T3 level increased markedly only at 1.7 mg/L of PFOS. No statistically significant toxic effects of PFOS on serum TSH were observed. Hepatic UGT1A1, but not UGT1A6, mRNA was up-regulated at 5.0 and 15.0 mg/L of PFOS. Treatment with PFOS lowered hepatic DIO1 mRNA at 15.0 mg/L but increased thyroidal DIO1 mRNA dose dependently. The activity of TPO, NIS, and TSHR mRNA in thyroid were unaffected by PFOS treatment. These results indicate that increased hepatic T4 glucuronidation via UGT1A1 and increased thyroidal conversion of T4 to T3 via DIO1 were responsible in part for PFOS-induced hypothyroxinemia in rats.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 31

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Cited by

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Metadata

Authors
Yu, W.-G., Liu, W., & Jin, Y.-H.
Venue
Environmental Toxicology and Chemistry
Publisher
Oxford University Press (OUP)
Published
2009-05-01
Volume
28
Issue
5
Pages
990-996
ISSN
  • 0730-7268 (ISSN-L)
  • 1552-8618
DOI
10.1897/08-345.1
OpenAlex
W2172114836
Cited by
193
References
9
FWCI
5.61
Type
journal article
Language
en
Open access
closed
Licence

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Yu, W.-G., Liu, W., & Jin, Y.-H. (2009). Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environmental Toxicology and Chemistry. https://doi.org/10.1897/08-345.1

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