The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Pathophysiological Relationships Between Periodontitis and Systemic Disease: Recent Concepts Involving Serum Lipids
Abstract
Periodontitis has been traditionally regarded as a chronic inflammatory oral infection. However, recent studies indicate that this oral disease may have profound effects on systemic health. The search for cellular/molecular mechanisms linking periodontitis to changes in systemic health and systemic physiology has resulted in the evolution of a new area of lipid research establishing linkages between existing multidisciplinary biomedical literature, recent observations concerning the effects of serum lipids on immune cell phenotype/function, and a heightened interest in systemic responses to chronic localized infections. There appears to be more than a casual relationship between serum lipid levels and systemic health (particularly cardiovascular disease, diabetes, tissue repair capacity, and immune cell function), susceptibility to periodontitis, and serum levels of pro‐inflammatory cytokines. In terms of the potential relationship between periodontitis and systemic disease, it is possible that periodontitis‐induced changes in immune cell function cause metabolic dysregulation of lipid metabolism through mechanisms involving proinflammatory cytokines. Sustained elevations of serum lipids and/or pro‐inflammatory cytokines may have a serious negative impact on systemic health. The purpose of this paper is to present the background, supporting data, and hypotheses related to this concept. As active participants in this emerging and exciting area of investigation, we hope to stimulate interest and awareness among biomedical scientists and practitioners. J Periodontol 2000;71:1375‐1384.
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Cites
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Stubbs, C. D., & Smith, A. D. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(84)90005-4 · Cited by 1,618
Periodontal Disease: The sixth complication of diabetes mellitus
Löe, H. (1993) · Diabetes Care · doi:10.2337/diacare.16.1.329 · Cited by 1,580
Neeper, M., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y. C., Elliston, K., Stern, D., & Shaw, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,541
Periodontal infection as a possible risk factor for preterm low birth weight
Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R., & Beck, J. (1996) · Journal of Periodontology · doi:10.1902/jop.1996.67.10s.1103 · Cited by 1,455
The Bacterial Etiology of Destructive Periodontal Disease: Current Concepts
Socransky, S. S., & Haffajee, A. D. (1992) · Journal of Periodontology · doi:10.1902/jop.1992.63.4s.322 · Cited by 1,198
Assessment of Risk for Periodontal Disease. I. Risk Indicators for Attachment Loss
Grossi, S. G., Zambon, J. J., Ho, A. W., Koch, G., Dunford, R. G., Machtei, E. E., Norderyd, O. M., & Genco, R. J. (1994) · Journal of Periodontology · doi:10.1902/jop.1994.65.3.260 · Cited by 1,129
Dental disease and risk of coronary heart disease and mortality.
DeStefano, F., Anda, R. F., Kahn, H. S., Williamson, D. F., & Russell, C. M. (1993) · BMJ · doi:10.1136/bmj.306.6879.688 · Cited by 1,112
Association between dental health and acute myocardial infarction.
Mattila, K. J., Nieminen, M. S., Valtonen, V. V., Rasi, V. P., Kesäniemi, Y. A., Syrjälä, S. L., Jungell, P. S., Isoluoma, M., Hietaniemi, K., & Jokinen, M. J. (1989) · BMJ · doi:10.1136/bmj.298.6676.779 · Cited by 1,059
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Li, S., Tang, T., Guo, P., Zou, Q., Ao, X., Hu, L., & Tan, L. (2019) · Medicine · doi:10.1097/md.0000000000014733 · Cited by 802
Beck, J. D., Elter, J. R., Heiss, G., Couper, D., Mauriello, S. M., & Offenbacher, S. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq1101.097803 · Cited by 414
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S., Suvan, J., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 298
The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health
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Metadata
- Authors
- Iacopino, A. M., & Cutler, C. W.
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2000-08
- Volume
- 71
- Issue
- 8
- Pages
- 1375-1384
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W1984111270
- Cited by
- 279
- References
- 96
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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