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Cited by 802Sepsis Diagnosis and TreatmentSelenium in Biological SystemsVitamin C and Antioxidants Research

A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis

Open access
Li, Shaojun, Tang, Tian, Guo, Pengfei, Zou, Qing, Ao, Xiaoxiao, Hu, Lan, Tan, Liping·2019·Medicine
DOI 10.1097/md.0000000000014733PMC PMC6831114
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Abstract

Background: To understand the clinical outcomes of selenium therapy in patients with sepsis syndrome, we conducted a meta-analysis of randomized controlled trials (RCT). Methods: A total of 13 RCTs comparing selenium and placebo for patients with sepsis were reviewed systematically. Results: However, we could not detect the association of selenium treatment with a decreased mortality at different time course (relative risk [RR] [95% confidence interval, CI]: 0.94 [0.82–1.06] at day 28; 0.73 [0.36–1.47] at day 90; 1.16 [0.78–1.71] at 6 months; respectively). Selenium supplementation did not show favorable efficacy in the incidence of renal failure, secondary infection or duration of mechanical ventilation (RR [95% CI]: 0.65 [0.41–1.03]; 0.96 [0.87–1.06]; standard mean difference [SMD] [95% CI]: 0.17 [−0.30–0.63]; respectively). Interestingly, we found that selenium therapy was benefit for sepsis patients with reduced duration of vasopressor therapy, staying time in intensive care unit and hospital, and incidence of ventilator-associated pneumonia (SMD [95% CI]: −0.75 [−1.37 to −0.13]; −0.15 [CI: −0.25 to −0.04]; −1.22 [−2.44 to −0.01]; RR [95% CI]: 0.61 [0.42–0.89]; respectively). Conclusion: Based on our findings, intravenous selenium supplementation could not be suggested for routine use.

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  • The most recent meta-analysis, including 13 RCTs comparing intravenous selenium and placebo in septic patients, failed to detect an association of selenium treatment with decreased mortality.

    “The most recent meta-analysis, including 13 RCTs comparing intravenous selenium and placebo in septic patients, failed to detect an association of selenium treatment with decreased mortality.”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [77]

  • Selenium supplementation was associated with earlier shock reversal and less ventilator-associated pneumonia, but did not decrease the incidence of renal failure, secondary infection, or duration of mechanical ventilation.

    “Selenium supplementation was associated with earlier shock reversal and less ventilator-associated pneumonia, but did not decrease the incidence of renal failure, secondary infection, or duration of mechanical ventilation [77].”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [77]

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Research works printed but not linked: 29

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Cited by

Sorted by citations

Authors
Li, S., Tang, T., Guo, P., Zou, Q., Ao, X., Hu, L., & Tan, L.
Affiliations
  • Children's Hospital of Chongqing Medical University (CN)
  • Ministry of Education Key Laboratory of Child Development and Disorders
Corresponding author
Tan, Liping
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-03
Volume
98
Issue
9
Pages
e14733
ISSN
  • 0025-7974 (ISSN-L)
  • 1536-5964
DOI
10.1097/md.0000000000014733
PMC
PMC6831114
OpenAlex
W2918689133
Cited by
802
References
13
Citations by year
2026: 1 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 16 · 2021: 27 · 2020: 41 · 2019: 26 · 2018: 21 · 2017: 14 · 2016: 25 · 2015: 87 · 2014: 123 · 2013: 130 · 2012: 96
FWCI
4.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Keywords
selenium supplementation, sepsis, mortality, renal failure, secondary infection, mechanical ventilation duration, vasopressor therapy, ICU length of stay, ventilator-associated pneumonia
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Respiration, Artificial, Selenium, Time Factors, Randomized Controlled Trials as Topic, Sepsis, Renal Insufficiency, Pneumonia, Ventilator-Associated, Young Adult

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