Effect of eplerenone on the severity of obstructive sleep apnea and arterial stiffness in patients with resistant arterial hypertension
Open accessAbstract
INTRODUCTION Obstructive sleep apnea (OSA) is considered to be one of the major causes of resistant arterial hypertension (RAH). Apnea episodes cause hypoxia, which triggers the activation of the renin-angiotensin-aldosterone system. This leads to water retention and swelling in the neck region, exacerbating OSA symptoms. It is assumed that the use of eplerenone may reduce the swelling and thus alleviate the severity of OSA. OBJECTIVES We aimed to prospectively assess the impact of eplerenone on the severity of OSA and arterial stiffness in patients with RAH. PATIENTS AND METHODS The study included 31 patients with RAH and OSA. The exclusion criteria were as follows: secondary hypertension, myocardial infarction, stroke 6 months prior to the study, congestive heart failure, chronic kidney failure, alcohol or drug addiction, and active cancer. In all patients, the following tests were performed: blood pressure (BP) measurement (traditionally and using ambulatory BP measuring [ABPM]), applanation tonometry, polysomnography, and the apnea-hypopnea index (AHI) calculation. The tests were done before and after 3 months of eplerenone therapy. Patients received 50 mg of oral eplerenone daily, along with other hypertensive drugs. RESULTS The mean age of participants was 57.76 ±6.16 years. After 3 months of eplerenone therapy, we observed a significant reduction in the AHI, neck circumference, BP, aortic pulse wave, and arterial wall stiffness. There were significant correlations between the AHI and mean BP measured by ABPM and between the AHI and arterial stiffness parameters. CONCLUSIONS Our results provide evidence for the clinical significance of eplerenone, not only as an antihypertensive medication but also as a drug that may reduce the severity of OSA and arterial stiffness in patients with RAH and OSA.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The role of aldosterone in promoting obstructive sleep apnea is additionally supported by studies demonstrating that mineralocorticoid receptor antagonists reduce the severity of obstructive sleep apnea in patients with resistant hypertension.
“The role of aldosterone in promoting OSA is additionally supported by studies demonstrating that mineralocorticoid receptor antagonists reduce the severity of OSA in patients with RH.280–282”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [281]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077 · see citing works
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215 · see citing works
McNicholas, W. T., Strohl, K. P., White, D. P., Levy, P. A., Schmidt, W., Wheatley, J. R., Redline, S. S., Carley, D. W., Buysse, D. J., Young, T. B., et al. (1999) · PubMed · Cited by 3,665 · see citing works
Bortel, L. M. V., Laurent, S., Boutouyrie, P., Chowienczyk, P., Cruickshank, J. K., Backer, T. L. M. D., Filipovský, J., Huybrechts, S. A. M., Mattace-Raso, F. U. S., Protogerou, A. D., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834fa8b0 · Cited by 2,012 · see citing works
Pauca, A. L., O’Rourke, M. F., & Kon, N. D. (2001) · Hypertension · doi:10.1161/hy1001.096106 · Cited by 1,179 · see citing works
Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms
NICHOLS, W. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.10.009 · Cited by 1,002 · see citing works
Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension
Chapman, N., Dobson, J., Wilson, S. L., Dahlöf, B., Sever, P., Wedel, H., & Poulter, N. R. (2007) · Hypertension · doi:10.1161/01.hyp.0000259805.18468.8c · Cited by 630 · see citing works
Early Signs of Atherosclerosis in Obstructive Sleep Apnea
Drager, L. F., Bortolotto, L. A., Lorenzi, M. C., Figueiredo, A. C., Krieger, E. M., & Lorenzi‐Filho, G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200503-340oc · Cited by 596 · see citing works
Drager, L. F., Bortolotto, L. A., Figueiredo, A. C., Krieger, E. M., & Lorenzi‐Filho, G. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-500oc · Cited by 558 · see citing works
Gaddam, K., Pimenta, E., Thomas, S. J., Cofield, S. S., Oparil, S., Harding, S. M., & Calhoun, D. A. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2009.96 · Cited by 289 · see citing works
Drager, L. F., Bortolotto, L. A., Figueiredo, A. C., da Silva, B. C., Krieger, E. M., & Lorenzi‐Filho, G. (2007) · CHEST Journal · doi:10.1378/chest.06-2703 · Cited by 284 · see citing works
CPAP and measures of cardiovascular risk in males with OSAS
Kohler, M., Pepperell, J. C. T., Casadei, B., Craig, S., Crosthwaite, N., Stradling, J. R., & Davies, R. J. O. (2008) · European Respiratory Journal · doi:10.1183/09031936.00026608 · Cited by 197 · see citing works
Gonzaga, C. C., Gaddam, K. K., Ahmed, M. I., Pimenta, E., Thomas, S. J., Harding, S. M., Oparil, S., Cofield, S. S., & Calhoun, D. A. (2010) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27878 · Cited by 188 · see citing works
Hu, X., Fan, J., Chen, S., Yin, Y., & Zrenner, B. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12472 · Cited by 156 · see citing works
Obstructive Sleep Apnea, Masked Hypertension, and Arterial Stiffness in Men
Drager, L. F., Diegues‐Silva, L., Diniz, P. M., Bortolotto, L. A., Pedrosa, R. P., Couto, R. B., Marcondes, B. F., Giorgi, D. M. A., Lorenzi‐Filho, G., & Krieger, E. M. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.246 · Cited by 118 · see citing works
Aldosterone antagonist therapy in resistant hypertension
Zannad, F. M. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280d9434e · Cited by 46 · see citing works
Aldosterone excess and resistance to 24-h blood pressure control
Pimenta, E., Gaddam, K. K., Pratt-Ubunama, M. N., Nishizaka, M., Cofield, S. S., Oparil, S., & Calhoun, D. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282a9be30 · Cited by 43 · see citing works
Phenotypic characteristics associated with hypertension in patients with obstructive sleep apnea
Drager, L. F., Pereira, A. C., Barreto-Filho, J. A. S., Figueiredo, A. C., Krieger, J. E., Krieger, E. M., & Lorenzi‐Filho, G. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002012 · Cited by 41 · see citing works
Surveillance of cardiovascular risk in the normotensive patient with repaired aortic coarctation
Swan, L., Kraidly, M., Muhll, I. V., Collins, P. D., & Gatzoulis, M. Α. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.10.043 · Cited by 29 · see citing works
Trojnarska, O., Szczepaniak‐Chicheł, L., Mizia‐Stec, K., et al. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0263-2 · Cited by 29 · see citing works
Self-citationRecommendations and supporting evidence in guidelines for referral of patients to sleep laboratories
Hailey, D. M., Tran, K., Dales, R., et al. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.10.004 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Yumino D, Redolfi S, Ruttanaumpawan P, et al. Nocturnal rostral flu- id shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation. 2010; 121: 1598-1605.
- Shahar E, Whitney CW, Redline S, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001; 163: 19-25.
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
- Authors
- Krasińska, B., Miazga, A., Cofta, S., Szczepaniak-Chicheł, L., Trafas, T., Krasiński, Z., Pawlaczyk-Gabriel, K., & Tykarski, A.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Corresponding author
- Krasińska, Beata
- Venue
- Polish Archives of Internal Medicine
- Publisher
- Medycyna Praktyczna
- Published
- 2016-05-27
- Volume
- 126
- Issue
- 5
- Pages
- 330-339
- ISSN
- 0032-3772 (ISSN-L)
- 1897-9483
- OpenAlex
- W2415752760
- Cited by
- 43
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Polskie Archiwum Medycyny Wewnętrznej (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- eplerenone, obstructive sleep apnea, resistant hypertension, arterial stiffness, apnea-hypopnea index, renin-angiotensin-aldosterone system, neck circumference, aortic pulse wave, antihypertensive therapy
- MeSH terms
- Eplerenone, Aged, Female, Humans, Hypertension, Male, Middle Aged, Severity of Illness Index, Spironolactone, Sleep Apnea, Obstructive, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
