CPAP and measures of cardiovascular risk in males with OSAS

Kohler, M.; Pepperell, J. C. T.; Casadei, B.; Craig, S.; Crosthwaite, N.; Stradling, J. R.; Davies, R. J. O.

doi:10.1183/09031936.00026608

Cited by 197Obstructive Sleep Apnea ResearchHeart Rate Variability and Autonomic ControlCardiovascular Health and Disease Prevention

CPAP and measures of cardiovascular risk in males with OSAS

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Kohler, M., Pepperell, J. C. T., Casadei, B., Craig, S., Crosthwaite, N., Stradling, J. R., Davies, R. J. O.·2008·European Respiratory Journal

DOI 10.1183/09031936.00026608

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Abstract

Obstructive sleep apnoea syndrome (OSAS) has been associated with hypertension, stroke and myocardial ischaemia in epidemiological and observational studies. Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on established risk factors for cardiovascular disease remains incompletely understood. A total of 102 males with moderate-to-severe OSAS were randomised to therapeutic (n = 51) or subtherapeutic (n = 51) CPAP treatment for 4 weeks to investigate the effects of active treatment on 24-h urinary catecholamine excretion, baroreflex sensitivity (BRS), arterial stiffness (augmentation index) and 24-h ambulatory blood pressure (ABP). After 4 weeks of therapeutic CPAP, significant reductions were seen in urine normetanephrine excretion (from mean±sd 179.7±80.1 to 132.7±46.5 µmol·mol−1 creatinine) and augmentation index (from 14.5±11.3 to 9.1±13.8%) compared with the subtherapeutic control group. Furthermore, therapeutic CPAP significantly improved BRS (from 7.1±3.3 to 8.8±4.2 ms·mmHg−1) and reduced mean arterial ABP by 2.6±5.4 mmHg. In conclusion, treatment of obstructive sleep apnoea with continuous positive airway pressure may lower cardiovascular risk by reducing sympathetic nerve activity, ambulatory blood pressure and arterial stiffness and by increasing sensitivity of the arterial baroreflex.

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Authors: Kohler, M., Pepperell, J. C. T., Casadei, B., Craig, S., Crosthwaite, N., Stradling, J. R., & Davies, R. J. O.
Affiliations: Churchill Hospital (GB)
Musgrove Park Hospital (GB)
John Radcliffe Hospital (GB)
ORCID: Kohler, M.
Pepperell, J. C. T.
Casadei, B.
Craig, S.
Stradling, J. R.
Davies, R. J. O.
Venue: European Respiratory Journal
Publisher: European Respiratory Society (ERS)
Published: 2008-07-24
Volume: 32
Issue: 6
Pages: 1488-1496
ISSN: 0903-1936 (ISSN-L)
1399-3003
DOI: 10.1183/09031936.00026608
OpenAlex: W2134126089
Cited by: 197
References: 56
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 10 · 2013: 14 · 2012: 22
FWCI: 13.57
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Respiratory Journal (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: European Respiratory Society
Universität Zürich
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: obstructive sleep apnea, continuous positive airway pressure, cardiovascular risk, sympathetic activity, baroreflex sensitivity, arterial stiffness, augmentation index, ambulatory blood pressure, hypertension
MeSH terms: Adult, Aged, Blood Pressure, Cardiovascular Diseases, Catecholamines, Humans, Male, Middle Aged, Normetanephrine, Risk Factors, Sleep, Treatment Outcome, Baroreflex, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure

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