The Endometriotic Tumor Microenvironment in Ovarian Cancer

Wendel, Jillian R. Hufgard; Wang, Xiyin; Hawkins, Shannon M.

doi:10.3390/cancers10080261

Cited by 51Endometriosis Research and TreatmentOvarian cancer diagnosis and treatmentEndometrial and Cervical Cancer Treatments

The Endometriotic Tumor Microenvironment in Ovarian Cancer

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Wendel, Jillian R. Hufgard, Wang, Xiyin, Hawkins, Shannon M.·2018·Cancers

DOI 10.3390/cancers10080261PMC PMC6115869

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Abstract

Women with endometriosis are at increased risk of developing ovarian cancer, specifically ovarian endometrioid, low-grade serous, and clear-cell adenocarcinoma. An important clinical caveat to the association of endometriosis with ovarian cancer is the improved prognosis for women with endometriosis at time of ovarian cancer staging. Whether endometriosis-associated ovarian cancers develop from the molecular transformation of endometriosis or develop because of the endometriotic tumor microenvironment remain unknown. Additionally, how the presence of endometriosis improves prognosis is also undefined, but likely relies on the endometriotic microenvironment. The unique tumor microenvironment of endometriosis is composed of epithelial, stromal, and immune cells, which adapt to survive in hypoxic conditions with high levels of iron, estrogen, and inflammatory cytokines and chemokines. Understanding the unique molecular features of the endometriotic tumor microenvironment may lead to impactful precision therapies and/or modalities for prevention. A challenge to this important study is the rarity of well-characterized clinical samples and the limited model systems. In this review, we will describe the unique molecular features of endometriosis-associated ovarian cancers, the endometriotic tumor microenvironment, and available model systems for endometriosis-associated ovarian cancers. Continued research on these unique ovarian cancers may lead to improved prevention and treatment options.

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The inflammatory tumor microenvironment and its main components play an impact on endometriosis and tumor and malignancy development.
“The inflammatory tumor microenvironment and its main components, non-tumoral cells (different immune cell types, fibroblasts tumor-associated), soluble factors secreted by both tumoral and non-tumoral cells, such as VEGF, FGF, EGF, IL-6, TNFα and immune checkpoint molecules, play an impact on endometriosis and tumor and malignancy development [45,46].”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [45]
Section 3 describes immune cells, fibroblasts and inflammatory mediators in the endometriotic microenvironment, and Section 3.3 links macrophages, IL-6 and TNFα to endometriosis or potential tumor promotion. The cited paper also discusses VEGF, but the passages found do not support the sentence’s specific inclusion of FGF, EGF or immune-checkpoint molecules. Its Abstract says whether the microenvironment causes endometriosis-associated ovarian cancers remains unknown. (LLM, conf=0.86)
Experimental — accuracy not yet measured
The hypoxic microenvironment of endometriosis causes excessive oxidative stress.
“This effect is promoted by the hypoxic microenvironment of endometriosis, which is known to cause excessive oxidative stress.”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [45]
Section 3.1, “Hypoxia and Endothelial Cells” (page unavailable), describes a hypoxic endometriotic microenvironment. Section 3.4, “Altered Metabolism” (page unavailable), says excessive oxidative stress results from high iron in endometriotic cysts, not from hypoxia. The source supports both features of the microenvironment but not the claimed causal link between them. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The high iron content present in endometriotic lesions may contribute to excessive oxidative stress, which may favor the induction of mutations.
“The high iron content present in endometriotic lesions may also contribute to this excessive oxidative stress, which may favor the inductions of mutations [45,49].”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [45]
Angiogenesis promoted by VEGF can establish a local vascular network within endometriotic lesions.
“An additional important role is played by the angiogenesis promoted by the vascular endothelial growth factor (VEGF) which can establish a local vascular network within endometriotic lesions.”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [45]

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Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Cancer statistics, 2018
Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,632 · see citing works
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927 · see citing works
Endometriosis
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works
Distinct role of macrophages in different tumor microenvironments
Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225 · see citing works
Endometriosis
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works
<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas
Wiegand, K. C., Shah, S. P., Al-Agha, O. M., Zhao, Y., Tse, K., Zeng, T., Senz, J., McConechy, M. K., Anglesio, M. S., Kalloger, S. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1008433 · Cited by 1,712 · see citing works
Epidemiology of ovarian cancer: a review
Reid Brett, M., Reid Brett, M., Permuth, J. B., Sellers Thomas, A., Permuth, J. B., & Sellers Thomas, A. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2016.0084 · Cited by 1,536 · see citing works
Evaluating cell lines as tumour models by comparison of genomic profiles
Domcke, S., Sinha, R., Levine, D. A., Sander, C., & Schultz, N. D. (2013) · Nature Communications · doi:10.1038/ncomms3126 · Cited by 1,426 · see citing works
Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs
Bartel, D. P., & Chen, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1328 · Cited by 1,417 · see citing works
MicroRNA Signatures in Human Ovarian Cancer
Iorio, M. V., Visone, R., Leva, G. D., Donati, V. L., Petrocca, F., Casalini, P., Taccioli, C., Volinia, S., Liu, C.-G., Alder, H., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1936 · Cited by 1,396 · see citing works
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
Jones, S., Wang, T., Shih, I., Mao, T., Nakayama, K., Roden, R. B. S., Glas, R., Slamon, D. J., Diaz, L. A., Vogelstein, B., et al. (2010) · Science · doi:10.1126/science.1196333 · Cited by 1,218 · see citing works
Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene
Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M., & Taketo, M. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,198 · see citing works
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
Kurman, R. J., & Shih, I. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.03.003 · Cited by 1,076 · see citing works
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies
Pearce, C. L., Templeman, C., Rossing, M. A., Lee, A., Near, A. M., Webb, P. M., Nagle, C. M., Doherty, J. A., Cushing-Haugen, K. L., Wicklund, K. G., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70404-1 · Cited by 939 · see citing works
The Dualistic Model of Ovarian Carcinogenesis
Kurman, R. J., & Shih, I. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.011 · Cited by 933 · see citing works
Mutation of the PIK3CA Gene in Ovarian and Breast Cancer
Campbell, I., Russell, S. E., Choong, D. Y. H., Montgomery, K. G., Ciavarella, M. L., Hooi, C. S. F., Cristiano, B. E., Pearson, R. B., & Phillips, W. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2933 · Cited by 917 · see citing works
Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma
Singer, G., Oldt, R. F., Cohen, Y., Wang, B. G., Sidransky, D., Kurman, R. J., & Shih, I. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.6.484 · Cited by 857 · see citing works
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium
Turco, M. Y., Gardner, L., Hughes, J., Cindrová‐Davies, T., Gómez‐Ruíz, M., Farrell, L. E., Hollinshead, M. S., Marsh, S. G. E., Brosens, J. J., Critchley, H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3516 · Cited by 795 · see citing works
Construction of adenovirus vectors through Cre-lox recombination
Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y., & Phipps, M. L. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.1842-1849.1997 · Cited by 791 · see citing works
Cancer-associated mutations in endometriosis without cancer
Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614814 · Cited by 628 · see citing works
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
Dinulescu, D. M., Ince, T. A., Quade, B. J., Shafer, S. A., Crowley, D. G., & Jacks, T. (2004) · Nature Medicine · doi:10.1038/nm1173 · Cited by 601 · see citing works
Cancer risk after a hospital discharge diagnosis of endometriosis
Brinton, L. A., Gridley, G., Persson, I. R., Baron, J. A., & Bergqvist, A. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70550-7 · Cited by 549 · see citing works
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells
Eva, A., Robbins, K. C., Andersen, P. R., Srinivasan, A., Tronick, S. R., Reddy, E. P., Ellmore, N., Galen, A. T., Lautenberger, J. A., Papas, T. S., et al. (1982) · Nature · doi:10.1038/295116a0 · Cited by 498 · see citing works
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Boretto, M., Cox, B., Noben, M., Hendriks, N., Fassbender, A., Roose, H., Amant, F., Timmerman, D., Tomassetti, C., Vanhie, A., et al. (2017) · Development · doi:10.1242/dev.148478 · Cited by 459 · see citing works
Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease
Bacci, M., Capobianco, A., Monno, A., Cottone, L., Di Puppo, F., Camisa, B., Mariani, M., Brignole, C., Ponzoni, M., Ferrari, S., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.081011 · Cited by 458 · see citing works
Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary.
Sato, N., Tsunoda, H., Nishida, M., Morishita, Y., Takimoto, Y., Kubo, T., & Noguchi, M. (2000) · PubMed · Cited by 451 · see citing works
Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes
Beaufort, C. M., Helmijr, J. C. A., Piskorz, A. M., Hoogstraat, M., Ruigrok-Ritstier, K., Besselink, N., Murtaza, M., van IJcken, W. F. J., Heine, A. A. J., Smid, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103988 · Cited by 403 · cited 2× · see citing works
“COV362 Endometrioid (pleural effusion) Serous TP53, BRCA1, RB1 *, EGFR, APC MYC [178,180,182,196]”
Background
Requirement of Bmpr1a for Müllerian duct regression during male sexual development
Jamin, S. P., Arango, N. A., Mishina, Y. M., Hanks, M. C., & Behringer, R. R. (2002) · Nature Genetics · doi:10.1038/ng1003 · Cited by 399 · see citing works
Practice Bulletin No. 114: Management of Endometriosis
(2010) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181e8b073 · Cited by 382 · see citing works
Cre-mediated recombination in cell lineages that express the progesterone receptor
Soyal, S. M., Mukherjee, A., Lee, K. Y.-S., Li, J., Li, H., DeMayo, F. J., & Lydon, J. P. (2005) · genesis · doi:10.1002/gene.20098 · Cited by 380 · see citing works
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis
Han, S. J., Jung, S. Y., Wu, S.-P., Hawkins, S. M., Park, M. J., Kyo, S., Qin, J., Lydon, J. P., Tsai, S. Y., Tsai, M.-J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.034 · Cited by 380 · see citing works
Self-citation
MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer
Mitra, A. K., Zillhardt, M., Hua, Y., Tiwari, P., Murmann, A. E., Peter, M. E., & Lengyel, E. R. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0206 · Cited by 371 · see citing works
Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.
Palacios, J., & Gamallo, C. (1998) · PubMed · Cited by 344 · see citing works
The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy
Humphries, B. A., & Yang, C. (2015) · Oncotarget · doi:10.18632/oncotarget.3052 · Cited by 343 · see citing works
Surgical Treatment of Endometriosis: A 7-Year Follow-up on the Requirement for Further Surgery
Shakiba, K., Bena, J. F., McGill, K. M., Minger, J., & Falcone, T. (2008) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181758ec6 · Cited by 339 · see citing works
<b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b>
FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S. (1997) · Histopathology · doi:10.1046/j.1365-2559.1997.d01-592.x · Cited by 333 · see citing works
Comparative properties of five human ovarian adenocarcinoma cell lines.
Buick, R. N., Pullano, R., & Trent, J. M. (1985) · PubMed · Cited by 326 · see citing works
Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress
Yamaguchi, K., Mandai, M., Toyokuni, S., Hamanishi, J., Higuchi, T., Takakura, K., & Fujii, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1614 · Cited by 324 · see citing works
Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Chandler, R. L., Damrauer, J. S., Raab, J. R., Schisler, J. C., Wilkerson, M. D., Didion, J. P., Starmer, J., Serber, D., Yee, D., Xiong, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7118 · Cited by 320 · see citing works
Mouse Model of Human Ovarian Endometrioid Adenocarcinoma Based on Somatic Defects in the Wnt/β-Catenin and PI3K/Pten Signaling Pathways
WU, R. T., Hendrix, N. D., Kuick, R. D., Zhai, Y., Schwartz, D. R., Akyol, A., Hanash, S., Misek, D. E., Katabuchi, H., Williams, B. O., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.016 · Cited by 312 · see citing works
Incidence of endometriosis by study population and diagnostic method: the ENDO study
Buck Louis, G. M., Hediger, M. L., Peterson, C. M., Croughan, M., Sundaram, R., Stanford, J., Chen, Z., Fujimoto, V. Y., Varner, M. W., Trumble, A., et al. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.087 · Cited by 309 · see citing works
Endometriosis, a disease of the macrophage
Capobianco, A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00009 · Cited by 306 · see citing works
Risk of developing ovarian cancer among women with ovarian endometrioma: A cohort study in Shizuoka, Japan
Kobayashi, H., Sumimoto, K., Moniwa, N., Imai, M., Takakura, K., Kuromaki, T., Morioka, E., Arisawa, K., & Terao, T. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00754.x · Cited by 305 · see citing works
Endometriosis and the development of malignant tumours of the pelvis. A review of literature
Gorp, T. V., Amant, F. C., Neven, P., Vergote, I. B., & Moerman, P. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2003.03.001 · Cited by 302 · see citing works
A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro
Lee, J. M., Mhawech-Fauceglia, P. Y., Lee, N., Parsanian, L. C., Lin, Y. G., Gayther, S. A., & Lawrenson, K. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.41 · Cited by 302 · see citing works
Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence
Somigliana, E., Viganò, P., Parazzini, F., Stoppelli, S., Giambattista, E., & Vercellini, P. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.11.033 · Cited by 296 · see citing works
Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice.
Bénard, J., Silva, J. D., Blois, M. C. D., Boyer, P. J. J., Duvillard, P., Chiric, E., & RIOU, G. F. (1985) · PubMed · Cited by 287 · see citing works
Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why
Lessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works
Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery
Eisermann, J., Gast, M. J., Pineda, J. A., Odem, R. R., & Collins, J. L. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60185-1 · Cited by 276 · see citing works
Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model
Zeitvogel, A., Baumann, R., & Starzinski‐Powitz, A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63030-1 · Cited by 275 · see citing works
Functional MicroRNA Involved in Endometriosis
Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0371 · Cited by 264 · see citing works
Self-citation
Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model
Arnold, J. T., Kaufman, D. G., Seppälä, M. T., & Lessey, B. A. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.836 · Cited by 260 · see citing works
Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations
Yamamoto, S., Tsuda, H., Takano, M., Tamai, S., & Matsubara, O. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.189 · Cited by 259 · see citing works
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
WU, R. T., Zhai, Y., Fearon, E. R., & Cho, K. R. (2001) · PubMed · Cited by 256 · see citing works
Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research
Anglesio, M. S., Wiegand, K. C., Melnyk, N., Chow, C., Salamanca, C. M., Prentice, L., Senz, J., Yang, W., Spillman, M. A., Cochrane, D. R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072162 · Cited by 255 · see citing works
Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion
Zhang, Y., Tang, H., Cai, J., Zhang, T., Guo, J., Feng, D., & Wang, Z. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.01.011 · Cited by 244 · see citing works
Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis
Khorram, O., Taylor, R. N., Ryan, I. P., Schall, T. J., & LANDERS, D. V. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90433-j · Cited by 244 · see citing works
In ovarian neoplasms, BRAF , but not KRAS , mutations are restricted to low‐grade serous tumours
Sieben, N. L. G., Macropoulos, P., Roemen, G. M. J. M., Kolkman-Uljee, S. M., Fleuren, G. J., Houmadi, R., Diss, T. C., Warren, B. K., Al‐Adnani, M., de Goeij, A. F. P. M., et al. (2004) · The Journal of Pathology · doi:10.1002/path.1521 · Cited by 237 · see citing works
Loss of BAF250a (ARID1A) is frequent in high‐grade endometrial carcinomas
Wiegand, K. C., Lee, A. F., Al‐Agha, O. M., Chow, C., Kalloger, S. E., Scott, D. W., Steidl, C., Wiseman, S. M., Gascoyne, R. D., Gilks, C. B., et al. (2011) · The Journal of Pathology · doi:10.1002/path.2911 · Cited by 235 · see citing works
Repertoire of microRNAs in Epithelial Ovarian Cancer as Determined by Next Generation Sequencing of Small RNA cDNA Libraries
Wyman, S. K., Parkin, R. K., Mitchell, P. S., Fritz, B. R., O'Briant, K. C., Godwin, A. K., Urban, N. D., Drescher, C. W., Knudsen, B. S., & Tewari, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005311 · Cited by 233 · see citing works
Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology
LIU, D. T. Y., & HITCHCOCK, A. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07995.x · Cited by 230 · see citing works
BRAF Mutation is associated with early stage disease and improved outcome in patients with low‐grade serous ovarian cancer
Grisham, R. N., Iyer, G., Garg, K., DeLair, D. F., Hyman, D. M., Zhou, Q. C., Iasonos, A. E., Berger, M. F., Dao, F., Spriggs, D. R., et al. (2012) · Cancer · doi:10.1002/cncr.27782 · Cited by 221 · see citing works
β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas
Gamallo, C., Palacios, J., Moreno‐Bueno, G., de Mora, J. C., Suárez, A., & Armas, A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65148-6 · Cited by 220 · see citing works
Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis
Modugno, F., Ness, R. B., Allen, G. O., Schildkraut, J. M., Davis, F. G., & Goodman, M. T. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.035 · Cited by 202 · see citing works
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
Ince, T. A., Sousa, A. D., Jones, M., Harrell, J. C., Agoston, E. S., Krohn, M., Selfors, L. M., Liu, W., Chen, K., Mao, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8419 · Cited by 199 · see citing works
Plasma MicroRNAs as Novel Biomarkers for Endometriosis and Endometriosis-Associated Ovarian Cancer
Suryawanshi, S., Vlad, A. M., Lin, H.-M., Mantia-Smaldone, G., Laskey, R., Lee, M., Lin, Y., Donnellan, N., Klein-Patel, M., Lee, T., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2726 · Cited by 197 · see citing works
Spectrum of symptoms in women diagnosed with endometriosis during adolescence vs adulthood
DiVasta, A. D., Vitonis, A. F., Laufer, M. R., & Missmer, S. A. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.007 · Cited by 191 · see citing works
Frequent nuclear ?-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation
Saegusa, M., & Okayasu, I. (2001) · The Journal of Pathology · doi:10.1002/path.856 · Cited by 189 · see citing works
Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium.
Osteen, K. G., Rodgers, W. H., Gaire, M., Hargrove, J. T., Gorstein, F., & Matrisian, L. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10129 · Cited by 185 · see citing works
Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes
Hills, C. A., Kèlland, L. R., Abel, G., Siracký, J., Wilson, A., & Harrap, K. R. (1989) · British Journal of Cancer · doi:10.1038/bjc.1989.108 · Cited by 183 · see citing works
Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis
Worley, M. J., Welch, W., Berkowitz, R. S., & Ng, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035367 · Cited by 175 · see citing works
Molecular and Cellular Pathogenesis of Endometriosis
Klemmt, P. A. B., & Starzinski‐Powitz, A. (2017) · Current Women s Health Reviews · doi:10.2174/1573404813666170306163448 · Cited by 175 · see citing works
Endometriosis and Ovarian Cancer
Wei, J., William, J., & Bulun, S. E. (2011) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31821f4b85 · Cited by 174 · see citing works
miR-126 in human cancers: Clinical roles and current perspectives
Ebrahimi, F., Gopalan, V., Smith, R. A., & Lam, A. K.-Y. (2013) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2013.12.004 · Cited by 170 · see citing works
A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium.
Greaves, E., Cousins, F., Murray, A., Esnal-Zufiaurre, A., Fassbender, A., Horne, A., & Saunders, P. (2014) · American Journal of Pathology · doi:10.1016/j.ajpath.2014.03.011 · Cited by 170 · see citing works
Steroidogenic Enzyme and Key Decidualization Marker Dysregulation in Endometrial Stromal Cells from Women with Versus Without Endometriosis1
Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K. C., & Giudice, L. C. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070300 · Cited by 168 · see citing works
Transforming Growth Factor-β Induced Warburg-Like Metabolic Reprogramming May Underpin the Development of Peritoneal Endometriosis
Young, V. J., Brown, J. K., Maybin, J. A., Saunders, P. T. K., Duncan, W. C., & Horne, A. W. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1026 · Cited by 168 · see citing works
Loss of ARID1A Expression Is an Early Molecular Event in Tumor Progression From Ovarian Endometriotic Cyst to Clear Cell and Endometrioid Carcinoma
Ayhan, A., Mao, T., Seckin, T. A., Wu, C., Guan, B., Ogawa, H., Futagami, M., Mizukami, H., Yokoyama, Y., Kurman, R. J., et al. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31826b5dcc · Cited by 166 · see citing works
Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial
Koninckx, P. R., Craessaerts, M., Timmerman, D., Cornillie, F., & Kennedy, S. (2008) · Human Reproduction · doi:10.1093/humrep/den177 · Cited by 165 · see citing works
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
Stordal, B., Timms, K. M., Farrelly, A. M., Gallagher, D., Busschots, S., Renaud, M., Thery, J., Williams, D., Potter, J., Tran, T., et al. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2012.12.007 · Cited by 157 · see citing works
Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells.
Tsai, S.-J., Wu, M.-H., Lin, C.-C., Sun, H. S., & Chen, H.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8082 · Cited by 155 · see citing works
Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis1
Barragan, F., Irwin, J. C., Balayan, S., Erikson, D. W., Chen, J. C., Houshdaran, S., Piltonen, T. T., Spitzer, T. L. B., George, A., Rabban, J. T., et al. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.136010 · Cited by 152 · see citing works
Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation
Fan, H., Shimada, M., Liu, Z., Cahill, N., Noma, N., Wu, Y., Gossen, J. A., & Richards, J. S. (2008) · Development · doi:10.1242/dev.020560 · Cited by 151 · see citing works
A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis
Han, S. J., Hawkins, S. M., Begum, K., Jung, S. Y., Kovanci, E., Qin, J., Lydon, J. P., DeMayo, F. J., & O'Malley, B. W. (2012) · Nature Medicine · doi:10.1038/nm.2826 · Cited by 149 · see citing works
Self-citation
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: Growth features and cytogenetics
van den Berg‐Bakker, C. A. M., Hagemeijer, A., Franken‐Postma, E. M., Smit, V. T. H. B. M., Kuppen, P. J. K., Claasen, H. H. V. R., Cornelisse, C. J., & Schrier, P. I. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910530415 · Cited by 140 · see citing works
Endometrioid Adenocarcinoma of the Ovary and Its Relationship to Endometriosis
McMeekin, D. S., Burger, R. A., Manetta, A., DiSaia, P. J., & Berman, M. L. (1995) · Gynecologic Oncology · doi:10.1006/gyno.1995.1271 · Cited by 140 · see citing works
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance
Yoo, J., Kim, T. H., Fazleabas, A. T., Palomino, W. A., Ahn, S. H., Tayade, C., Schammel, D. P., Young, S. L., Jeong, J., & Lessey, B. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-04577-w · Cited by 138 · see citing works
?-Catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours
Wright, K., Wilson, P. J., Morland, S. J., Campbell, I., Walsh, M. D., Hurst, T., Ward, B. G., Cummings, M. C., & Chenevix‐Trench, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990827)82:5 · Cited by 133 · see citing works
Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells
Lin, S., Wang, C.-C., Wu, M., Yang, S., Li, Y.-H., & Tsai, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1450 · Cited by 131 · see citing works
Integrated genomic analyses of ovarian carcinoma
The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129 · see citing works
When ‘never-events’ occur despite adherence to clinical guidelines: The case of venous thromboembolism in clear cell cancer of the ovary compared with other epithelial histologic subtypes
Duska, L., Garrett, L. A., Henretta, M. S., Ferriss, J. S., Lee, L. K., & Horowitz, N. S. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.10.069 · Cited by 127 · see citing works
Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis
Liu, H., Zhang, Z., Xiong, W., Zhang, L., Xiong, Y., Li, N., He, H., Du, Y., & Liu, Y. (2017) · Reproduction · doi:10.1530/rep-16-0643 · Cited by 127 · see citing works
The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention
Vercellini, P., Crosignani, P. G., Somigliana, E., Viganò, P., Buggio, L., Bolis, G., & Fedele, L. (2011) · Human Reproduction · doi:10.1093/humrep/der211 · Cited by 126 · see citing works
Roles of Deletion of Arid1a, a Tumor Suppressor, in Mouse Ovarian Tumorigenesis
Guan, B., Rahmanto, Y. S., Wu, R., Wang, Y., Wang, Z., Wang, T., & Shih, I. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju146 · Cited by 125 · see citing works
Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation
Cousins, F. L., Murray, A. A., Esnal‐Zufiaurre, A., Gibson, D. A., Critchley, H., & Saunders, P. T. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086378 · Cited by 124 · see citing works
Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis
Kim, B. G., Yoo, J., Kim, T. H., Shin, J., Langenheim, J. F., Ferguson, S. D., Fazleabas, A. T., Young, S. L., Lessey, B. A., & Jeong, J. (2015) · Human Reproduction · doi:10.1093/humrep/dev050 · Cited by 121 · see citing works
Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery
Rossing, M. A., Cushing-Haugen, K. L., Wicklund, K. G., Doherty, J. A., & Weiss, N. S. (2008) · Cancer Causes & Control · doi:10.1007/s10552-008-9207-9 · Cited by 117 · see citing works
Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker
Elgaaen, B. V., Olstad, O. K., Haug, K. B. F., Brusletto, B. S., Sandvik, L., Staff, A. C., Gautvik, K. M., & Davidson, B. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-80 · Cited by 116 · see citing works
Mimicking the Events of Menstruation in the Murine Uterus
Brasted, M. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.016550 · Cited by 113 · see citing works
Role of uterine stromal-epithelial crosstalk in embryo implantation
Hantak, A. M., Bagchi, I. C., & Bagchi, M. K. (2014) · The International Journal of Developmental Biology · doi:10.1387/ijdb.130348mb · Cited by 112 · see citing works
Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-1
Allavena, G., Carrarelli, P., Bello, B. D., Luisi, S. V., Petraglia, F., & Maellaro, E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.007 · Cited by 109 · see citing works
Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing
Shibuya, Y., Tokunaga, H., Saito, S., Shimokawa, K., Katsuoka, F., Li, B., Kojima, K., Nagasaki, M., Yamamoto, M. P., Yaegashi, N., et al. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22507 · Cited by 108 · see citing works
The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis
Young, V. J., Brown, J. K., Saunders, P. T. K., Duncan, W. C., & Horne, A. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106773 · Cited by 105 · see citing works
Endometrioid epithelial ovarian cancer
Storey, D. J., Rush, R., Stewart, M., Rye, T., Al-Nafussi, A., Williams, A. R. W., Smyth, J. F., & Gabra, H. (2008) · Cancer · doi:10.1002/cncr.23438 · Cited by 102 · see citing works
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma
Yamamoto, S., Tsuda, H., Takano, M., Tamai, S., & Matsubara, O. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1169-8 · Cited by 99 · see citing works
Unique Transcriptome, Pathways, and Networks in the Human Endometrial Fibroblast Response to Progesterone in Endometriosis
Aghajanova, L., Tatsumi, K., Horcajadas, J. A., Zamah, A. M., Esteban, F. J., Herndon, C. N., Conti, M., & Giudice, L. C. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.086181 · Cited by 99 · see citing works
Population Distribution of Lifetime Risk of Ovarian Cancer in the United States
Pearce, C. L., Stram, D. O., Ness, R. B., Stram, D. A., Roman, L. D., Templeman, C. E., Lee, A. W., Menon, U., Fasching, P. A., McAlpine, J. N., et al. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-1128 · Cited by 98 · see citing works
Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin.
Lau, D. H., Lewis, A. D., Ehsan, M. N., & Sikic, B. I. (1991) · PubMed · Cited by 97 · see citing works
Molecular Profiling of Clear Cell Ovarian Cancers
Friedlander, M. L., Russell, K., Millis, S. Z., Gatalica, Z., Bender, R. P., & Voß, A. (2016) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000677 · Cited by 97 · see citing works
The Protein Kinase A Pathway-Regulated Transcriptome of Endometrial Stromal Fibroblasts Reveals Compromised Differentiation and Persistent Proliferative Potential in Endometriosis
Aghajanova, L., Horcajadas, J. A., Weeks, J. L., Esteban, F. J., NEZHAT, C. R., Conti, M., & Giudice, L. C. (2010) · Endocrinology · doi:10.1210/en.2009-0923 · Cited by 94 · see citing works
Clear cell and endometrioid carcinomas: are their differences attributable to distinct cells of origin?
Cochrane, D. R., Tessier‐Cloutier, B., Lawrence, K. M., Nazeran, T. M., Karnezis, A. N., Salamanca, C. M., Cheng, A. S., McAlpine, J. N., Hoang, L. N., Gilks, C. B., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4934 · Cited by 94 · see citing works
Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3′,5′-Cyclic Adenosine 5′-Monophosphate Inhibition of Cyclin D1
Velarde, M. C., Aghajanova, L., NEZHAT, C. R., & Giudice, L. C. (2009) · Endocrinology · doi:10.1210/en.2009-0389 · Cited by 92 · see citing works
On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks
Valdez, J., Cook, C. D., Ahrens, C. C., Wang, A. J.-S., Brown, A., Kumar, M. P., Stockdale, L., Rothenberg, D., Renggli, K., Gordon, E. A., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.030 · Cited by 92 · see citing works
Psychosocial impact of endometriosis: From co-morbidity to intervention
Aerts, L., Grangier, L., Streuli, I., Dällenbach, P., Marci, R., Wenger, J., & Pluchino, N. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.008 · Cited by 92 · see citing works
Molecular and preclinical basis to inhibit PGE 2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
Arosh, J. A., Lee, J., Balasubbramanian, D., Stanley, J. A., Long, C. R., Meagher, M. W., Osteen, K. G., Bruner‐Tran, K. L., Burghardt, R. C., Starzinski‐Powitz, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507931112 · Cited by 89 · see citing works
Loss of ARID1A/BAF250a-expression in endometriosis: a biomarker for risk of carcinogenic transformation?
Samartzis, E. P., Samartzis, N., Noske, A., Fedier, A., Caduff, R. F., Dedes, K. J., Fink, D. A., & Imesch, P. (2012) · Modern Pathology · doi:10.1038/modpathol.2011.217 · Cited by 89 · see citing works
Endometrioid and clear cell ovarian cancers – A comparative analysis of risk factors
Nagle, C. M., Olsen, C. M., Webb, P. M., Jordan, S. J., Whiteman, D. C., & Green, A. C. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.07.009 · Cited by 89 · see citing works
Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression
Laguë, M.-N., Paquet, M., Fan, H., Kaartinen, J., Chu, S., Jamin, S. P., Behringer, R. R., Fuller, P. J., Mitchell, A., Doré, M., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn186 · Cited by 88 · see citing works
Endometriosis-associated Ovarian Cancers
Anglesio, M. S., & Yong, P. J. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000320 · Cited by 86 · see citing works
The Progesterone Receptor Coactivator Hic-5 Is Involved in the Pathophysiology of Endometriosis
Aghajanova, L., Velarde, M. C., & Giudice, L. C. (2009) · Endocrinology · doi:10.1210/en.2009-0008 · Cited by 82 · see citing works
Cell Type–Specific Targeted Mutations of Kras and Pten Document Proliferation Arrest in Granulosa Cells versus Oncogenic Insult to Ovarian Surface Epithelial Cells
Fan, H., Liu, Z., Paquet, M., Wang, J., Lydon, J. P., DeMayo, F. J., & Richards, J. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3363 · Cited by 80 · see citing works
Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated?
Vercellini, P., Viganò, P., Buggio, L., Makieva, S., Scarfone, G., Cribiù, F. M., Parazzini, F., & Somigliana, E. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.017 · Cited by 80 · see citing works
Pathology of borderline and invasive cancers
Prat, J. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.08.007 · Cited by 78 · see citing works
ARID1A Is Essential for Endometrial Function during Early Pregnancy
Kim, T. H., Yoo, J., Wang, Z., Lydon, J. P., Khatri, S., Hawkins, S. M., Leach, R. E., Fazleabas, A. T., Young, S. L., Lessey, B. A., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005537 · Cited by 77 · see citing works
Self-citation
Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse
WU, R. T., Zhai, Y., Kuick, R. D., Karnezis, A. N., Garcia, P. E., Naseem, A. F., Hu, T. C., Fearon, E. R., & Cho, K. R. (2016) · The Journal of Pathology · doi:10.1002/path.4783 · Cited by 75 · see citing works
Age-specific ovarian cancer incidence rate patterns in the United States
Quirk, J. T., Natarajan, N., & Mettlin, C. J. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.06.052 · Cited by 74 · see citing works
Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo
Mullany, L. K., Fan, H.-Y., Liu, Z., White, L. D., Marshall, A. N., Gunaratne, P. H., Anderson, M. L., Creighton, C. J., Xin, L., Deavers, M. T., et al. (2011) · Oncogene · doi:10.1038/onc.2011.70 · Cited by 73 · see citing works
miRNA Landscape in Stage I Epithelial Ovarian Cancer Defines the Histotype Specificities
Calura, E., Fruscio, R., Paracchini, L., Bignotti, E., Ravaggi, A., Martini, P. G. V., Sales, G., Beltrame, L., Clivio, L., Ceppi, L., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0360 · Cited by 71 · see citing works
MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis
Nothnick, W. B. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1599089 · Cited by 69 · see citing works
PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation
Russo, A., Czarnecki, A. A., Dean, M., Modi, D., Lantvit, D. D., Hardy, L. R., Baligod, S., Davis, D. A., Wei, J., & Burdette, J. E. (2018) · Oncogene · doi:10.1038/s41388-017-0097-8 · Cited by 69 · see citing works
Discovery of Phosphatidic Acid, Phosphatidylcholine, and Phosphatidylserine as Biomarkers for Early Diagnosis of Endometriosis
Li, J., Gao, Y., Guan, L., Zhang, H., Sun, J., Gong, X., Li, D., Chen, P., Ma, Z., Liang, X., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00014 · Cited by 68 · see citing works
Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma.
Xiao, W., Awadallah, A., & Xin, W. (2012) · Europe PMC (PubMed Central) · Cited by 67 · see citing works
The activation function-1 domain of estrogen receptor α in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen
Kurita, T., Medina, R. T., Schabel, A. B., Young, P., Gama, P., Parekh, T. V., Brody, J. R., Cunha, G. R., Osteen, K. G., Bruner‐Tran, K. L., et al. (2005) · Differentiation · doi:10.1111/j.1432-0436.2005.00033.x · Cited by 67 · see citing works
miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples
Braicu, O. L., Budişan, L., Buiga, R., Jurj, A. M., Achimaș-Cădariu, P., Pop, L., Braicu, C., Irimie, A., & Berindan‐Neagoe, I. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s137107 · Cited by 67 · see citing works
Activation of mutated K‐ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis
Cheng, C., Licence, D. R., Cook, E., Luo, F., Arends, M. J., Smith, S. K., Print, C. G., & Jones, D. S. (2011) · The Journal of Pathology · doi:10.1002/path.2852 · Cited by 63 · see citing works
Establishment and Characterization of Two Human Ovarian Clear Cell Adenocarcinoma Lines from Metastatic Lesions with Different Properties
Gorai, I., Nakazawa, T., Miyagi, E., Hirahara, F., Nagashima, Y., & MINAGUCHI, H. (1995) · Gynecologic Oncology · doi:10.1006/gyno.1995.1097 · Cited by 62 · see citing works
Relevant human tissue resources and laboratory models for use in endometriosis research
Greaves, E., Critchley, H., Horne, A. W., & Saunders, P. T. K. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13119 · Cited by 62 · see citing works
Pathological functions of hypoxia in endometriosis
Hsiao, K.-Y. (2015) · Frontiers in Bioscience · doi:10.2741/e736 · Cited by 61 · see citing works
Endometriosis as a prognostic factor for cancer survival
Melin, A., Lundholm, C., Malki, N., Swahn, M. L., Sparén, P., & Bergqvist, A. (2010) · International Journal of Cancer · doi:10.1002/ijc.25718 · Cited by 59 · see citing works
Treatment of Ovarian Cancer in Young Women
Gershenson, D. M. (2012) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e318248045b · Cited by 59 · see citing works
BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer
Stamp, J. P., Gilks, C. B., Wesseling, M., Eshragh, S., Ceballos, K. M., Anglesio, M. S., Kwon, J. S., Tone, A. A., Huntsman, D. D., & Carey, M. S. (2016) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000698 · Cited by 59 · see citing works
MicroRNA-532 and microRNA-3064 inhibit cell proliferation and invasion by acting as direct regulators of human telomerase reverse transcriptase in ovarian cancer
Bai, L., Wang, H., Wang, A., Zhang, L.-Y., & Bai, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173912 · Cited by 59 · see citing works
Hypoxia Promotes Ectopic Adhesion Ability of Endometrial Stromal Cells via TGF-β1/Smad Signaling in Endometriosis
Lin, X., Dai, Y., Xu, W., Shi, L., Jin, X., Li, C., Zhou, F., Pan, Y., Zhang, Y., Lin, X., et al. (2018) · Endocrinology · doi:10.1210/en.2017-03227 · Cited by 58 · see citing works
The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis
Zou, Y., Zhou, J., Guo, J.-B., Wang, L., Luo, Y., Zhang, Z., Liu, F., Tan, J., Wang, F., & Huang, O. (2018) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2018.03.001 · Cited by 57 · see citing works
Systematic Identification of Druggable Epithelial–Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, T.-L., Sheng, J., Leung, C. S., Li, F., Kim, J., Ho, S., Matzuk, M. M., Lu, K. H., Wong, S. T. C., & Mok, S. C. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy097 · Cited by 57 · see citing works
Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17β-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism
Cheng, Y.-H., Imir, A. G., Fenkçi, V., Yılmaz, M. B., & Bulun, S. E. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.12.014 · Cited by 56 · see citing works
KRAS mutations in ovarian low-grade endometrioid adenocarcinoma: association with concurrent endometriosis
Stewart, C. J. R., Leung, Y. C., Walsh, M. D., Walters, R., Young, J. P., & Buchanan, D. D. (2012) · Human Pathology · doi:10.1016/j.humpath.2011.10.009 · Cited by 56 · see citing works
Type I to Type II Ovarian Carcinoma Progression
WU, R. T., Baker, S. J., Hu, T. C., Norman, K. M., Fearon, E. R., & Cho, K. R. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.031 · Cited by 56 · see citing works
Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors
Chowanadisai, W., Messerli, S. M., Miller, D. H., Medina, J. E., Hamilton, J. W., Messerli, M. A., & Brodsky, A. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151089 · Cited by 56 · see citing works
Creation of immortalised epithelial cells from ovarian endometrioma
Bono, Y., Kyo, S., Takakura, M., Maida, Y., Mizumoto, Y., Nakamura, M., Nomura, K., Kiyono, T., & Inoue, M. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.26 · Cited by 55 · see citing works
Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis
Hsiao, K., Chang, N., Lin, S., Li, Y.-H., & Wu, M. (2014) · Human Reproduction · doi:10.1093/humrep/deu255 · Cited by 55 · see citing works
The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer
Banz, C., Ungethuem, U., Kuban, R.-J., Diedrich, K., Lengyel, E. R., & Hornung, D. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.06.039 · Cited by 53 · see citing works
Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis
Liu, H., Du, Y., Zhang, Z., Lv, L., Xiong, W., Zhang, L., Li, N., He, H., Li, Q., & Liu, Y. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy128 · Cited by 53 · see citing works
Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma
King, C. M., Barbara, C., Prentice, A., Brenton, J. D., & Jones, D. S. (2015) · The Journal of Pathology · doi:10.1002/path.4657 · Cited by 52 · see citing works
A conditional mouse model for human MUC1-positive endometriosis shows the presence of anti-MUC1 antibodies and Foxp3+ regulatory T cells
Budiu, R. A., Diaconu, I., Chrissluis, R., Dricu, A., Edwards, R. P., & Vlad, A. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.002535 · Cited by 52 · see citing works
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron
Mori, M., Ito, F., Shi, L., Wang, Y., Ishida, C., Hattori, Y., Niwa, M., Hirayama, T., Nagasawa, H., Iwase, A., et al. (2015) · Redox Biology · doi:10.1016/j.redox.2015.10.001 · Cited by 52 · see citing works
Ovarian clear cell carcinoma as a stress-responsive cancer: Influence of the microenvironment on the carcinogenesis and cancer phenotype
Mandai, M., Matsumura, N., Baba, T., Yamaguchi, K. D., Hamanishi, J., & Konishi, I. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.06.039 · Cited by 51 · see citing works
miR-30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma
Sestito, R., Cianfrocca, R., Rosanò, L., Tocci, P., Semprucci, E., Castro, V. D., Caprara, V., Ferrandina, G., Sacconi, A., Blandino, G., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6546 · Cited by 51 · see citing works
Establishment of a human ovarian clear cell carcinoma cell line (RMG-I) and its single cell cloning--with special reference to the stem cell of the tumor.
Nozawa, S., Tsukazaki, K., Sakayori, M., H.Jeng, C., & IIZUKA, R. (1988) · PubMed · Cited by 50 · see citing works
Lipidomic profiling of endometrial fluid in women with ovarian endometriosis†
Domı́nguez, F., Ferrando, M., Díaz-Gimeno, P., Quintana, F., Fernández, G., Castells, I., & Simón, C. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox014 · Cited by 50 · see citing works
Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression
Liu, S., Gao, S., Wang, X. Y., & Wang, D. B. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2112-6 · Cited by 49 · see citing works
Self-citation
Hypoxia responsive miR-210 promotes cell survival and autophagy of endometriotic cells in hypoxia.
Tx, X., Sz, Z., Dong, M., & Xr, Y. (2016) · PubMed · Cited by 49 · see citing works
Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/β-Catenin and PTEN
Tanwar, P. S., Zhang, L., Kaneko-Tarui, T., Curley, M. D., Taketo, M. M., Rani, P., Roberts, D. J., & Teixeira, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020715 · Cited by 48 · see citing works
Novel three-dimensional in vitro models of ovarian endometriosis
Brueggmann, D., Templeman, C. E., Starzinski‐Powitz, A., Rao, N. P., Gayther, S. A., & Lawrenson, K. (2014) · Journal of Ovarian Research · doi:10.1186/1757-2215-7-17 · Cited by 48 · see citing works
Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis
Zhan, L., Wang, W., Zhang, Y., Song, E., Fan, Y., & Wei, B. (2016) · Biochimie · doi:10.1016/j.biochi.2016.01.006 · Cited by 48 · see citing works
Long Term Survival of Ovarian Endometriosis Associated Clear Cell and Endometrioid Ovarian Cancers
Noli, S. A., Cipriani, S., Scarfone, G., Villa, A., Grossi, E., Monti, E., Vercellini, P., & Parazzini, F. (2013) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31827aa0bb · Cited by 48 · see citing works
Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis
Dharmaraj, N., Chapela, P., Morgado, M., Hawkins, S. M., Lessey, B. A., Young, S. L., & Carson, D. D. (2014) · Human Reproduction · doi:10.1093/humrep/deu146 · Cited by 47 · see citing works
Self-citation
Co-culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells
Chan, R. W. S., Lee, C., Ng, E. H. Y., & Yeung, W. S. B. (2017) · Cell Proliferation · doi:10.1111/cpr.12330 · Cited by 45 · see citing works
Complexity of expression of the intermediate filaments of six new human ovarian carcinoma cell lines: new expression of cytokeratin 20
Yanagibashi, T., Gorai, I., NAKAZAWA, T., Miyagi, E., Hirahara, F., Kitamura, H., & MINAGUCHI, H. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.471 · Cited by 42 · see citing works
A potential link of oxidative stress and cell cycle regulation for development of endometriosis
Shigetomi, H., Higashiura, Y., Kajihara, H., & Kobayashi, H. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.683071 · Cited by 40 · see citing works
Chemerin Expression in the Peritoneal Fluid, Serum, and Ovarian Endometrioma of Women with Endometriosis
Jin, C. H., Yi, K. W., Ha, Y. R., Shin, J., Park, H. T., Kim, T., & Hur, J. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12405 · Cited by 38 · see citing works
Ten-Eleven Translocation Genes are Downregulated in Endometriosis
Roca, F. J., Loomans-Kropp, H. A., Wittman, A. T., Creighton, C., & Hawkins, S. M. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666160225153844 · Cited by 38 · see citing works
Self-citation
Comparative Analysis of Differentially Expressed miRNAs and their Downstream mRNAs in Ovarian Cancer and its Associated Endometriosis
Wu, R. L., Sudeshna, S. A., Alosh, B. B., & Hayek, K. (2015) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000359 · Cited by 38 · see citing works
Minireview: The Roles of Small RNA Pathways in Reproductive Medicine
Hawkins, S. M., Buchold, G. M., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0099 · Cited by 37 · see citing works
Self-citation
Correction: Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research
Anglesio, M. S., Wiegand, K. C., Melnyk, N., Chow, C., Salamanca, C. M., Prentice, L., Senz, J., Yang, W., Spillman, M. A., Cochrane, D. R., et al. (2013) · PLoS ONE · doi:10.1371/annotation/ffcaf179-872f-470b-8bb6-f06d8ba6d03a · Cited by 36 · see citing works
Hypoxia‐inhibited DUSP2 expression promotes IL‐6/STAT3 signaling in endometriosis
Hsiao, K., Chang, N., Tsai, J., Lin, S., Tsai, S., & Wu, M. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12690 · Cited by 36 · see citing works
Establishment and characterization of a new human cell line derived from ovarian clear cell carcinoma
Wong, W. S. F., Wong, Y., Ng, Y. T. A., Huang, P. D., Chew, E. C., Ho, T. H., & Chang, M.-C. (1990) · Gynecologic Oncology · doi:10.1016/0090-8258(90)90008-9 · Cited by 34 · see citing works
Correction: Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research
Anglesio, M. S., Wiegand, K. C., Melnyk, N., Chow, C., Salamanca, C. M., Prentice, L., Senz, J., Yang, W., Spillman, M. A., Cochrane, D. R., et al. (2013) · PLoS ONE · doi:10.1371/annotation/856f0890-9d85-4719-8e54-c27530ac94f4 · Cited by 34 · see citing works
Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis
Furuya, M., Tanaka, R. J., Miyagi, E., Kami, D., Nagahama, K., Miyagi, Y., Nagashima, Y., Hirahara, F., Inayama, Y., & Aoki, I. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20084 · Cited by 33 · see citing works
ID2 mediates the transforming growth factor-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis
Young, V. J., Ahmad, S. F., Brown, J. K., Duncan, W. C., & Horne, A. W. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw045 · Cited by 33 · see citing works
A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth
Lal-Nag, M., McGee, L., Guha, R., Lengyel, E., Kenny, H. A., & Ferrer, M. (2017) · SLAS Discovery · doi:10.1177/2472555216687082 · Cited by 33 · see citing works
Tumour necrosis factor α concentrations in the peritoneal fluid of infertile women with minimal or mild endometriosis are lower in patients with red lesions only than in patients without red lesions
Calhaz–Jorge, C., Costa, A. P., Barata, M. J., dos Santos, M. C., de Melo, A. K. R., & Palma-Carlos, M. L. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1256 · Cited by 32 · see citing works
Endometriosis: Its association with retrograde menstruation, dysmenorrhoea and tubal pathology
Liu, D., & Hitchcock, A. (1987) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(87)90386-9 · Cited by 32 · see citing works
Prior knowledge transfer across transcriptional data sets and technologies using compositional statistics yields new mislabelled ovarian cell line
Blayney, J. K., Davison, T. S., McCabe, N., Walker, S. M., Keating, K., Delaney, T., Greenan, C., Williams, A. R. W., McCluggage, W. G., Capes‐Davis, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw578 · Cited by 31 · see citing works
Cyclophosphamide and 5-fluorouracil act synergistically in ovarian clear cell adenocarcinoma cells
Ohta, I., Gorai, I., Miyamoto, Y., Yang, J., Zheng, J. H., Kawata, N., Hirahara, F., & Shirotake, S. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00605-4 · Cited by 29 · see citing works
Quantitative Cellular and Molecular Analysis of the Effect of Progesterone Withdrawal in a Murine Model of Decidualization1
Cheng, C.-W., Bielby, H., Licence, D. R., Smith, S. K., Print, C. G., & Jones, D. S. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.057950 · Cited by 29 · see citing works
MicroRNA Gene Expression Signature Driven by miR-9 Overexpression in Ovarian Clear Cell Carcinoma
Yanaihara, N., Noguchi, Y., Saito, M., Takenaka, M., Takakura, S., Yamada, K., & Okamoto, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162584 · Cited by 29 · see citing works
Endometriosis: benign, malignant, or something in between?
Chui, M. H., Wang, T., & Shih, I. (2017) · Oncotarget · doi:10.18632/oncotarget.21051 · Cited by 28 · see citing works
Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
He, J., Chang, W., Feng, C., Cui, M., & Xu, T. (2018) · International Journal of Genomics · doi:10.1155/2018/1465348 · Cited by 28 · see citing works
A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis
Altan, Z. M., Denis, D., Kagan, D., Grund, E. M., Palmer, S. S., & Nataraja, S. G. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.166488 · Cited by 27 · see citing works
Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma
Zhang, X., Guo, G., Wang, G., Zhao, J., Wang, B., Yu, X., & Ding, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4485 · Cited by 25 · see citing works
A mouse model for endometrioid ovarian cancer arising from the distal oviduct
van der Horst, P. H., van der Zee, M., Heijmans‐Antonissen, C., Jia, Y., DeMayo, F. J., Lydon, J. P., van Deurzen, C. H. M., Ewing, P. C., Burger, C. W., & Blok, L. J. (2014) · International Journal of Cancer · doi:10.1002/ijc.28746 · Cited by 24 · see citing works
The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer
Wang, X., Ivan, M., & Hawkins, S. M. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.08.027 · Cited by 24 · see citing works
Self-citation
Prevalence of endometriosis in epithelial ovarian cancer. Analysis of the associated clinical features and study on molecular mechanisms involved in the possible causality.
Machado‐Linde, F., Sánchez-Ferrer, M. L., Cascales, P., Torroba, A., Orozco, R., Silva Sánchez, Y., Nieto, A., & Fiol, G. (2015) · PubMed · Cited by 22 · see citing works
Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients
Ishikawa, M., Nakayama, K., Nakamura, K., Ono, R., Sanuki, K., Yamashita, H., Ishibashi, T., Minamoto, T., Iida, K., Razia, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24546 · Cited by 22 · see citing works
Establishment and characterization of cell lines derived from serous adenocarcinoma (JHOS-2) and clear cell adenocarcinoma (JHOC-5, JHOC-6) of human ovary.
Yamada, K., Tachibana, T., Hashimoto, H., Suzuki, K., Yanagida, S., Endoh, H., Kimura, E., Yasuda, M., Tanaka, T., & Ishikawa, H. (1999) · PubMed · Cited by 20 · see citing works
Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
Lu, J., Tao, X., Zhou, J., Lu, Y., Wang, Z., Liu, H., & Xu, C. (2016) · Oncotarget · doi:10.18632/oncotarget.13967 · Cited by 20 · see citing works
Aberrant Expression of the Mammalian Target of Rapamycin, Hypoxia-inducible Factor-1α, and Glucose Transporter 1 in the Development of Ovarian Clear-cell Adenocarcinoma
Kato, M., Yamamoto, S., Takano, M., Matsubara, O., & Furuya, K. (2012) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318237d66c · Cited by 19 · see citing works
miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC
Zhao, H., Ding, Y., BI, T., SUN, Z.-F., JIANG, J.-Y., Zhao, J., Lin, X.-C., & Cui, S. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1988 · Cited by 18 · see citing works

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Cell Origins of High-Grade Serous Ovarian Cancer
Kim, J., Park, E. Y., Kim, O., Schilder, J. M., Coffey, D., Cho, C., & Bast, R. C. (2018) · Cancers · doi:10.3390/cancers10110433 · Cited by 267 · see citing works
M2 macrophages promote NSCLC metastasis by upregulating CRYAB
Guo, Z., Song, J., Hao, J., Zhao, H., Du, X., Li, E., Kuang, Y., Yang, F., Wang, W. T., Deng, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1618-x · Cited by 140 · see citing works
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar, A., Reschke, L. D., Kirschen, G. W., & Borahay, M. A. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab054 · Cited by 121 · see citing works
Incidence of endometrioid and clear-cell ovarian cancer in histological proven endometriosis: the ENOCA population-based cohort study
Hermens, M., van Altena, A. M., Nieboer, T. E., Schoot, B. C., van Vliet, H. A. A. M., Siebers, A. G., & Bekkers, R. L. M. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.01.041 · Cited by 73 · see citing works
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary
Fadare, O., & Parkash, V. (2019) · Surgical pathology clinics · doi:10.1016/j.path.2019.01.009 · Cited by 65 · see citing works
Endometriosis-associated ovarian cancer: What have we learned so far?
Herreros‐Villanueva, M., Chen, C.-C., Tsai, E., & Er, T. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.016 · Cited by 57 · see citing works
Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review
Михалева, Л. М., Davydov, A. I., Игоревна, П. О., Вячеславовна, М. Е., Nikolenko, V. N., Евгеньевна, Н. М., Klochkov, S. G., Somasundaram, S. G., Kirkland, C. E., & Aliev, G. M. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01363-5 · Cited by 59 · see citing works
A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer
Chen, S., Li, Y., Qian, L., Deng, S., Liu, L., Xiao, W., & Zhou, Y. Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.668151 · Cited by 46 · see citing works
Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment
Wendel, J. R. H., Wang, X., Smith, L. J., & Hawkins, S. M. (2020) · Biomedicines · doi:10.3390/biomedicines8110525 · Cited by 35 · see citing works
Self-citation
Immunologic factors involved in the malignant transformation of endometriosis to endometriosis-associated ovarian carcinoma
Leenen, S., Hermens, M., van Steenwijk, P. J. D. V., Bekkers, R. L. M., & van Esch, E. M. G. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02831-1 · Cited by 31 · see citing works
S100A10 silencing suppresses proliferation, migration and invasion of ovarian cancer cells and enhances sensitivity to carboplatin
Wang, L., Yan, W., Li, X., Liu, Z., Tian, T., Chen, T., Zou, L., & Cui, Z. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0592-3 · Cited by 30 · see citing works
Bevacizumab in First-Line Chemotherapy Improves Progression-Free Survival for Advanced Ovarian Clear Cell Carcinoma
Tate, S., Nishikimi, K., Matsuoka, A., Otsuka, S., Shiko, Y., Ozawa, Y., Kawasaki, Y., & Shozu, M. (2021) · Cancers · doi:10.3390/cancers13133177 · Cited by 29 · see citing works
The Tumor Microenvironment of High Grade Serous Ovarian Cancer
Stack, M. S., Nephew, K. P., Burdette, J. E., & Mitra, A. K. (2018) · Cancers · doi:10.3390/cancers11010021 · Cited by 24 · see citing works
Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis
Collins, K. E., Wang, X., Klymenko, Y., Davis, N. B., Martinez, M. C., Zhang, C., So, K., Buechlein, A. M., Rusch, D. B., Creighton, C. J., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1162786 · Cited by 21 · see citing works
Self-citation
Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy
Takeuchi, M., Matsuzaki, K., & Harada, M. (2024) · Japanese Journal of Radiology · doi:10.1007/s11604-024-01569-5 · Cited by 22 · see citing works
Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., & Yoshimoto, C. (2018) · Oncology Reports · doi:10.3892/or.2018.6946 · Cited by 19 · see citing works
Hypoxia-induced HIF1α dependent COX2 promotes ovarian cancer progress
Ding, Y., Zhuang, S., Li, Y., Yu, X., Lü, M., & Ding, N. (2021) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-021-09900-9 · Cited by 17 · see citing works
Molecular dysregulations underlying the pathogenesis of endometriosis
Balasubramanian, V., Saravanan, R., Joseph, L. D., Dev, B., Shanmugasundaram, G., Srinivasan, B., Dharmarajan, A., Rayala, S. K., & Venkatraman, G. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110139 · Cited by 15 · see citing works
Clinicopathological characteristics, molecular features and novel diagnostic strategies for the detection of malignant transformation of endometriosis (Review)
Kobayashi, H. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11978 · Cited by 13 · see citing works
Potential clinical implications of iron metabolism in ovarian endometriosis
Liu, M.-N., Chen, L., Xu, T., & Zhang, K. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127017 · Cited by 13 · see citing works
Global epidemiology, risk factors, and histological types of ovarian cancers in Trinidad
Umakanthan, S., Chattu, V. K., & Kalloo, S. (2019) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_384_18 · Cited by 12 · see citing works
The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas
Heinze, K., Cairns, E. S., Thornton, S., Harris, B., Milne, K., Grube, M. P., Meyer, C., Karnezis, A. N., Fereday, S., Garsed, D. W., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3815 · Cited by 11 · see citing works
Labile Heme and Heme Oxygenase-1 Maintain Tumor-Permissive Niche for Endometriosis-Associated Ovarian Cancer
Hecht, J. L., Janíková, M., Choudhury, R., Liu, F., Canesin, G., Janovičová, Ľ., Csizmadia, E., Jorgensen, E. M., Esselen, K. M., Celec, P., et al. (2022) · Cancers · doi:10.3390/cancers14092242 · Cited by 10 · see citing works
Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review
Alaert, J., Lancelle, M., Timmermans, M., Tanos, P., Nisolle, M., & Karampelas, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082282 · Cited by 9 · see citing works
“The high iron content present in endometriotic lesions may also contribute to this excessive oxidative stress, which may favor the inductions of mutations [45,49].”
Background
Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer
Jeong, H., Jung, J., Oh, H. E., Choi, J.-W., Lee, E. S., Kim, Y., & Lee, J. H. (2018) · BioMed Research International · doi:10.1155/2018/9207153 · Cited by 9 · see citing works
Decreased expression of KLF6 in ectopic endometrial stromal cells contributes to endometriosis progression by targeting CTNNB1
Shi, J., Jing, W., He, Y., & Huang, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111230 · Cited by 8 · see citing works
Identification of iron metabolism-related predictive markers of endometriosis and endometriosis-relevant ovarian cancer
Wang, X., Zhou, L., Dong, Z., & Wang, G. (2023) · Medicine · doi:10.1097/md.0000000000033478 · Cited by 9 · see citing works
Self-citation
Vaginal Squamous Cell Carcinoma Develops in Mice with Conditional Arid1a Loss and Gain of Oncogenic Kras Driven by Progesterone Receptor Cre
Wang, X., Praça, M. S. L., Wendel, J. R. H., Emerson, R. E., DeMayo, F. J., Lydon, J. P., & Hawkins, S. M. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.03.013 · Cited by 7 · see citing works
Self-citation
Pelvic inflammatory disease is associated with ovarian cancer development in women with endometriosis: A cohort study in Taiwan
Lo, H., Weng, S., Chen, H., & Tsai, E. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13935 · Cited by 7 · see citing works
Is there a relationship in-between ovarian endometriosis and ovarian cancer? Immunohistochemical profile of four cases with coexisting ovarian endometriosis and cancer
Penciu, R. C., Postolache, I., Steriu, L., Izvoranu, S., Tica, A.-A., Mocanu, I.-D., Sârbu, V., Deacu, M., Tica, I., Bălţătescu, G. I., et al. (2020) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.1.18 · Cited by 7 · see citing works
Knockdown of ENTPD5 inhibits tumor metastasis and growth via regulating the GRP78/p-eIF-2α/CHOP pathway in serous ovarian cancer
Chen, X., Zha, Z., Wang, Y., Chen, Y., Pang, M., Huang, L., & Chen, Y. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-00996-0 · Cited by 6 · see citing works
MicroRNAs as Key Regulators of Ovarian Cancers
Satapathy, S., Kumar, C., & Singh, R. K. (2019) · Cell Medicine · doi:10.1177/2155179019873849 · Cited by 6 · see citing works
How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence
Ghosh, D., Geethadevi, A., Bhat, M. A., Bharti, J. N., Mridha, A., Jb, S., Kk, R., & Sengupta, J. (2019) · Current Opinion in Gynecology and Obstetrics · doi:10.18314/cogo.v2i1.1840 · Cited by 6 · see citing works
Establishment of a novel model of endometriosis-associated ovarian cancer by transplanting uterine tissue from Arid1a/Pten knockout mice
Ono, M., Miyamoto, T., Asaka, R., Uchikawa, J., Ando, H., Tanaka, Y., Shinagawa, M., Yokokawa, Y., Asaka, S., Wang, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35292-4 · Cited by 5 · see citing works
BET inhibitor JQ1 induces apoptosis of ovarian and endometrial endometrioid carcinoma cells by downregulating c‑Myc
Tanimoto, S., Sone, K., Jonouchi, Y., Hachijo, R., Suzuki, E., Tsuboyama, N., Toyohara, Y., Inoue, F., Honjoh, H., Fukuda, T., et al. (2024) · Oncology Letters · doi:10.3892/ol.2024.14852 · Cited by 4 · see citing works
Translational Applications of Linear and Circular Long Noncoding RNAs in Endometriosis
Wang, X., Parodi, L., & Hawkins, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910626 · Cited by 5 · see citing works
Self-citation
Ovarian Cancer Screening and Early Detection
Levine, M. D., & Naumann, R. W. (2022) · Springer eBooks · doi:10.1007/978-3-031-09169-8_2 · Cited by 4 · see citing works
From Endometriosis to Endometriosis-Associated Ovarian Cancer: Molecular Mechanisms, Risk Stratification and Clinical Implications
Sorrentino, F., Nappi, L., Vona, L., Vasciaveo, L., Campitiello, M. R., Vitrani, P., Taurino, G., Tinelli, R., & Grandone, E. (2026) · Cancers · doi:10.3390/cancers18081233 · Cited by 3 · see citing works
Pathogenesis and MRI findings in two cases of seromucinous borderline tumors coexisting with carcinoma in endometriotic cysts: Case reports and literature review
Takeuchi, M., Matsuzaki, K., Bando, Y., Nishimura, M., & Harada, M. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.16368 · Cited by 1 · see citing works
The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer
Rogers, M. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_28 · Cited by 1 · see citing works
Endometrial Immune-Inflammatory Gene Signatures in Endometriosis
Miller, J. E., Symons, L. K., Marks, R. M., & Tayade, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_10 · Cited by 1 · see citing works
Vaginal squamous cell carcinoma develops in mice with Arid1a loss and gain of oncogenic KrasPreprint
Wang, X., Praça, M. S. L., Wendel, J. R. H., Emerson, R. E., DeMayo, F. J., Lydon, J. P., & Hawkins, S. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.15.422959
Self-citation
Clinically Suspected Dysgerminoma Sent for Frozen Section Confirmation: A Case With Review and Differential Diagnosis of Clear Cell Carcinoma
Russell, D. H. (2020) · AJSP Review and Reports · doi:10.1097/pcr.0000000000000409
The Hallmarks of Ovarian Cancer: Actionable Genetics, Targetable Pathways, and Predictive Biomarkers
Bairi, K. E., Jarroudi, O. A., & Afqir, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-1873-4_3
Endometriosis: not just a benign disease
Hermens, M. (2022) · doi:10.26481/dis.20220627mh
Proficiência de tumores de ovário quanto ao sistema de reparo de pareamento incorreto de DNA
de Sousa, A. B. (2022) · doi:10.11606/d.17.2022.tde-20062022-154721
Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum
Djordjevic, B. (2023) · Encyclopedia of pathology · doi:10.1007/978-3-319-28845-1_5679-1
Data from The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas
Heinze, K., Cairns, E. S., Thornton, S., Harris, B., Milne, K., Grube, M. P., Meyer, C., Karnezis, A. N., Fereday, S., Garsed, D. W., et al. (2023) · doi:10.1158/1078-0432.c.6740546.v1
Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum
Djordjevic, B. (2023) · Encyclopedia of pathology · doi:10.1007/978-3-030-97378-0_5679
The occurrence and histopathological recognition of atypical endometriosis in patients with ovarian endometriosis – a retrospective cohort study
Leenen, S., Kooreman, L. F. S., Bulten, J., van Esch, E. M. G., van Steenwijk, P. J. D. V., Nieboer, T. E., Bekkers, R. L. M., & van Altena, A. M. (2025) · Human Pathology · doi:10.1016/j.humpath.2025.105875
Spatiotemporal Evolutionary Mechanisms and Translational Research Progress in the Malignant Transformation of Endometriosis: A Comprehensive Review
刘, 少. (2026) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2026.52170

Ovarian cancer in endometriosis
Konishi, I. (2009) · International Journal of Clinical Oncology · doi:10.1007/s10147-009-0930-3 · Cited by 7 · see citing works
Endometriosis-associated Ovarian Cancers
Anglesio, M. S., & Yong, P. J. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000320 · Cited by 86 · see citing works
From Endometriosis to Endometriosis-Associated Ovarian Cancer: Molecular Mechanisms, Risk Stratification and Clinical Implications
Sorrentino, F., Nappi, L., Vona, L., Vasciaveo, L., Campitiello, M. R., Vitrani, P., Taurino, G., Tinelli, R., & Grandone, E. (2026) · Cancers · doi:10.3390/cancers18081233 · Cited by 3 · see citing works
Factors in malignant transformation of ovarian endometriosis: A narrative review
Giannini, A., Massimello, F., Caretto, M., Cosimi, G., Mannella, P., Luisi, S. V., Gadducci, A., & Simoncini, T. (2024) · Gynecological Endocrinology · doi:10.1080/09513590.2024.2409911 · Cited by 22 · see citing works
Endometriosis and Ovarian Cancer
Wei, J., William, J., & Bulun, S. E. (2011) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31821f4b85 · Cited by 174 · see citing works

Authors: Wendel, J. R. H., Wang, X., & Hawkins, S. M.
Affiliations: Indiana University Indianapolis (US)
Corresponding author: Hawkins, Shannon M.
ORCID: Wendel, Jillian R. Hufgard
Wang, Xiyin
Hawkins, Shannon M.
Venue: Cancers
Publisher: MDPI AG
Published: 2018-08-07
Volume: 10
Issue: 8
Pages: 261
ISSN: 2072-6694 (ISSN-L)
DOI: 10.3390/cancers10080261
PMC: PMC6115869
OpenAlex: W2885482298
Cited by: 51
References: 221
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 8 · 2018: 4
FWCI: 1.06
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Cancers (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
IUScholarWorks (Indiana University) (submittedVersion, cc-by)
Publisher
Funders: National Cancer Institute (R03CA19127)
Rivkin Center for Ovarian Cancer (Pilot Award)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometriosis-associated ovarian cancer, endometrioid ovarian cancer, low-grade serous carcinoma, clear cell adenocarcinoma, hypoxia, iron metabolism, estrogen, inflammatory cytokines, chemokines, tumor stroma, immune cells, precision therapy, cancer prevention, animal models

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The Endometriotic Tumor Microenvironment in Ovarian Cancer

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