Cited by 126Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Microglial priming in Alzheimer’s disease

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Li, Jun-Wei, Zong, Yu, Cao, Xi-Peng, Tan, Lin, Tan, Lan·2018·Annals of Translational Medicine

DOI 10.21037/atm.2018.04.22PMC PMC5994530

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Abstract

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease of central nervous system (CNS). Nowadays, increasing evidence suggests that immune system plays a significant role in the mechanisms of AD's onset and progression. Microglia, the main participator in the immune system of CNS, is always regarded as a protector of our brain in a healthy state and also has a beneficial role in maintaining the homeostasis of CNS microenvironment. However, chronic and sustained stimulation can push microglia into the state termed priming. Primed microglia can induce the production of amyloid β (Aβ), tau pathology, neuroinflammation and reduce the release of neurotrophic factors, resulting in loss of normal neurons in quantity and function that has immense relationship with AD. The therapeutic strategies mainly aimed at modulating the microenvironment and microglial activity in CNS to delay progression and alleviate pathogenesis of AD. Overall, in this review, we highlight the mechanism of microglial priming, and discuss the profound relationship between microglial priming and AD. Besides, we also pay attention to the therapeutic strategies targeting at microglial priming.

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Authors: Li, J.-W., Zong, Y., Cao, X.-P., Tan, L., & Tan, L.
Affiliations: Qingdao University (CN)
Corresponding author: Tan, Lin
Tan, Lan
ORCID: Tan, Lin
Tan, Lan
Venue: Annals of Translational Medicine
Publisher: AME Publishing Company
Published: 2018-05
Volume: 6
Issue: 10
Pages: 176-176
ISSN: 2305-5839 (ISSN-L)
2305-5847
DOI: 10.21037/atm.2018.04.22
PMC: PMC5994530
OpenAlex: W2800869030
Cited by: 122
References: 133
Citations by year: 2026: 8 · 2025: 11 · 2024: 26 · 2023: 22 · 2022: 13 · 2021: 18 · 2020: 13 · 2019: 9 · 2018: 2
FWCI: 0.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
Locations: Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Qingdao Key Health Discipline Development Fund
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, microglial priming, microglia, neuroinflammation, amyloid-beta, tau pathology, neurotrophic factors, neurodegeneration

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