The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery
Open accessAbstract
Obesity is a significant public health challenge worldwide and is inextricably linked to adverse cardiovascular outcomes. The relationship between excess adiposity and increased blood pressure is well established, and it is estimated that obesity accounts for 65-78% of cases of primary hypertension. The mechanisms through which obesity causes hypertension are complex and include sympathetic nervous system overactivation, stimulation of the renin-angiotensin-aldosterone system, alterations in adipose-derived cytokines, insulin resistance, and structural and functional renal changes. Weight loss is the primary goal of treatment for obesity-related hypertension, although few individuals achieve success with nonpharmacological management alone. Specific considerations apply when selecting the most appropriate pharmacological therapy for obese hypertensive patients. Metabolic surgery has proved to be the most effective means of ensuring substantial and sustained weight loss and has also been shown to confer beneficial effects in type 2 diabetes mellitus. Increasing evidence suggests that metabolic surgery may also be an effective treatment for obesity-related hypertension, although prospective data on long-term blood pressure outcomes are awaited. This review will discuss the pathophysiological mechanisms that link obesity with hypertension and will provide an overview of treatment strategies, with a focus on metabolic surgery.
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Cited by
Obesity and cardiovascular health
Welsh, A., Hammad, M., Piña, I. L., & Kulinski, J. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae025 · Cited by 239
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Biesiekierska, M., Strigini, M., Śliwińska, A., Pirola, L., & Balcerczyk, A. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf010 · Cited by 18
Lee, H. Y., Ko, S.-H., Park, S., Kim, K., Kim, S.-Y., Cho, I.-J., Cho, E. J., Kim, H. C., Park, J.-H., Ryu, S. K., et al. (2024) · Clinical Hypertension · doi:10.1186/s40885-024-00279-4 · Cited by 10
“In addition, there are some drugs and metabolic surgeries along with lifestyle modification to treat obesity, but they also showed limited efficacy [4, 12, 13].”
BackgroundPrevalence of Undiagnosed Hypertension in Young Adults: A Community-Based Study
Mughal, M. Z. U. A., Saad, M., Singh, G. D., Tariq, O. M., Farooq, M. A., & Ahmad, M. (2025) · Cureus · doi:10.7759/cureus.88426 · Cited by 3
Metadata
- Authors
- Shariq, O. A., & McKenzie, T. J.
- Venue
- Gland Surgery
- Publisher
- AME Publishing Company
- Published
- 2020-02
- Volume
- 9
- Issue
- 1
- Pages
- 80-93
- ISSN
- 2227-684X (ISSN-L)
- 2227-8575
- OpenAlex
- W2998556922
- Cited by
- 359
- References
- 148
- FWCI
- 19.30
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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