A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies
Open accessAbstract
Multipotent mesenchymal stem cells (MSCs) have been considerably inspected as effective tool for cell-based therapy of inflammatory, immune-mediated, and degenerative diseases, attributed to their immunomodulatory, immunosuppressive, and regenerative potentials. In the present review, we focus on recent research findings of the clinical applications and therapeutic potential of this cell type, MSCs' mechanisms of therapy, strategies to improve their therapeutic potentials such as manipulations and preconditioning, and potential/unexpected risks which should be considered as a prerequisite step before clinical use. The potential risks would probably include undesirable immune responses, tumor formation and the transmission of incidental agents. Then, we also review some of the milestones in the field, briefly discuss challenges and highlight the new guideline suggested for future directions and perspectives.
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Many soluble factors and EVs released by MSCs modulate immune responses via cell-to-cell contact and by cytokines and regulatory factors that influence the recruitment, proliferation, activation, function, and survival of several immune cells.
“Many soluble factors and EVs released by MSCs are known to modulate immune responses via cell-to-cell contact and by an ample number of cytokines and regulatory factors that influence the recruitment, proliferation, activation, function, and survival of several immune cells (Table 1) [60], [61].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [61]
The Immunomodulation section (page unavailable) says MSC-associated cytokines and regulatory factors affect the proliferation, function, activation, and infiltration of several immune-cell types, though it frames some effects as probable or possible. The retrieved passages do not establish that MSC-released extracellular vesicles modulate immune responses, or that cell-to-cell contact is an immune-modulation mechanism; the cell-to-cell passage concerns resident stem-cell proliferation. (LLM, conf=0.85)
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Emerging Prevention and Treatment Strategies to Control COVID-19
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Extracellular Vesicles in Lung Cancer Metastasis and Their Clinical Applications
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Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases
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Self-citationPotential Cell-Based and Cell-Free Therapy for Patients with COVID-19
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- Authors
- Saeedi, P., Halabian, R., & Imani Fooladi, A. A.
- Affiliations
- Baqiyatallah University of Medical Sciences (IR)
- Corresponding author
- Halabian, Raheleh
- Venue
- Stem Cell Investigation
- Publisher
- AME Publishing Company
- Published
- 2019-09
- Volume
- 6
- Pages
- 34-34
- ISSN
- 2306-9759 (ISSN-L)
- 2313-0792
- PMC
- PMC6789202
- OpenAlex
- W2975889028
- Cited by
- 251
- References
- 69
- Citations by year
- 2026: 8 · 2025: 29 · 2024: 44 · 2023: 43 · 2022: 35 · 2021: 57 · 2020: 34 · 2019: 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Stem Cell Investigation (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, cell therapy, immunomodulation, immunosuppression, regenerative medicine, preconditioning, treatment options, clinical application, tumor formation, infectious agent transmission
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