Efficacy of probiotics in the treatment of acute diarrhea in children: A systematic review and meta-analysis of clinical trials
Open accessAbstract
Background: If acute diarrhea in children is not treated promptly and effectively, it can lead to severe dehydration and serious sequelae.Due to the imbalance of intestinal bacteria in children with acute diarrhea, the supplementation with probiotics is important, which can improve the intestinal microenvironment, promote immunity, and enhance resistance.This meta-analysis provides further evidence and discussion of the therapeutic effect of probiotics on acute diarrhea in children.Methods: MEDLINE, EMBASE, PubMed, and the Cochrane Library databases were searched by rapid matching.The input keywords were as follows: (probiotics/synbiotics) and (child/children) and (acute diarrhea/acute gastroenteritis).Articles reporting on randomized controlled trials (RCTs) of probiotics in treating acute diarrhea in children were retrieved.The studies were published from 2010 to 2020.After screening and quality evaluation, Stata 16.0 software was used for the analysis.Results: Twelve articles with 744 patients were included in the study, and the overall quality of the articles was excellent.Meta-analysis showed that the duration of diarrhea in the probiotics group was shorter than that in the control group [standard mean difference (SMD) =-0.74, 95% CI: -1.11 to -0.37, Z=-3.935,P=0.000], the 2-day treatment efficacy for diarrhea in the probiotics group was greater than that in the control group [odds ratio (OR) =2.12, 95% CI: 1.47-3.05,Z=3.998, P=0.000], and the length of hospital stay in the probiotics group was shorter than that of the control group (SMD =-0.60, 95% CI: -0.74 to -0.47, Z=-8.781,P=0.000).In the subgroup analysis, combined probiotics shortened the duration of diarrhea compared with single probiotic use, and Lactobacillus reuteri and Saccharomyces boulardii had a better therapeutic effect than Lactobacillus rhamnosus or Lactobacillus acidophilus.Discussion: In the treatment of acute diarrhea in children, the addition of probiotics can shorten the duration of diarrhea, increase treatment efficacy after 2 days of treatment, and shorten the length of hospital stay.However, because of possible publication bias in the current study, further high-quality RCT studies in clinical settings are needed to verify the current results and continue the exploration of this topic.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is substantial evidence in the literature of the beneficial effects of probiotics on diarrhea, especially the prevention of traveler's diarrhea and the treatment of acute diarrhea in children.
“There is substantial evidence in the literature of the beneficial effects of probiotics on diarrhea, especially the prevention of traveler’s diarrhea [105,106] and the treatment of acute diarrhea in children [107].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [107]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cumpston, M., Li, T., Page, M. J., Chandler, J., Welch, V. A., Higgins, J. P., & Thomas, J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.ed000142 · Cited by 7,218 · see citing works
Probiotics for treating acute infectious diarrhoea
Allen, S. J., Martinez, E. G., Gregorio, G. V., & Dans, L. F. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003048.pub3 · Cited by 628 · see citing works
Sarker, S. A., Sultana, S., Reuteler, G., Moine, D., Descombes, P., Charton, F., Bourdin, G., McCallin, S. E., Ngom‐Bru, C., Neville, T., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2015.12.023 · Cited by 543 · see citing works
Treatment of Acute Otitis Media in Children under 2 Years of Age
Hoberman, A., Paradise, J. L., Rockette, H. E., Shaikh, N., Wald, E. R., Kearney, D. H., Colborn, D. K., Kurs‐Lasky, M., Bhatnagar, S., Haralam, M. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0912254 · Cited by 299 · see citing works
Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis
Freedman, S. B., Williamson-Urquhart, S., Farion, K. J., Gouin, S., Willan, A. R., Poonai, N., Hurley, K. F., Sherman, P. M., Finkelstein, Y., Lee, B. E., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802597 · Cited by 239 · see citing works
Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea
Rosenfeldt, V., Michaelsen, K. F., Jakobsen, M., Larsen, C. N., Møller, P. L., Pedersen, P., Tvede, M., WEYREHTER, H., Valerius, N. H., & Pærregaard, A. (2002) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200205000-00012 · Cited by 207 · see citing works
Sindhu, K. N., Sowmyanarayanan, T. V., Paul, A., Babji, S., Ajjampur, S. S. R., Priyadarshini, S. J., Sarkar, R., Balasubramanian, K. A., WANKE, C. A., Ward, H., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu065 · Cited by 155 · see citing works
Lai, H.-H., Chiu, C., Kong, M., Chang, C., & Chen, C. (2019) · Nutrients · doi:10.3390/nu11051150 · Cited by 118 · see citing works
Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting
Dinleyici, E. Ç., Dalgıç, N., Güven, Ş., Akcan, Ö. M., Yasa, O., Kurugöl, Z., Türel, Ö., Tanır, G., Yazar, A. S., Arıca, V., et al. (2015) · Jornal de Pediatria · doi:10.1016/j.jped.2014.10.009 · Cited by 75 · see citing works
Dinleyici, E. Ç., Dalgıç, N., Güven, Ş., Özen, M., Kara, A., Arıca, V., Timur, Ö. M., Sancar, M., Kurugöl, Z., Tanır, G., et al. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-012-1903-5 · Cited by 63 · see citing works
Effect of Probiotics on Diarrhea in Children With Severe Acute Malnutrition
Grenov, B., Namusoke, H., Lanyero, B., Nabukeera‐Barungi, N., Ritz, C., Mølgaard, C., Friis, H., & Michaelsen, K. F. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001515 · Cited by 62 · see citing works
Aggarwal, S., Upadhyay, A., Shah, D., Teotia, N., Agarwal, A., & Jaiswal, V. K. (2014) · Europe PMC (PubMed Central) · Cited by 56 · see citing works
Treatment of Acute Diarrhea With Saccharomyces boulardii in Infants
Corrêa, N. B. O., Penna, F. J., Lima, F. M. L. S., Nicoli, J. R., & Filho, L. A. P. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31822b7ab0 · Cited by 55 · see citing works
A meta-analysis of the effects of probiotics and synbiotics in children with acute diarrhea
Yang, B., Lü, P., Li, M., Cai, X., Xiong, W., Hou, H.-J., & Ha, X. (2019) · Medicine · doi:10.1097/md.0000000000016618 · Cited by 55 · see citing works
Castro-Mejía, J. L., O’Ferrall, S., Krych, Ł., O’Mahony, E., Namusoke, H., Lanyero, B., Kot, W., Nabukeera‐Barungi, N., Michaelsen, K. F., Mølgaard, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1712982 · Cited by 55 · see citing works
Szymański, H., & Szajewska, H. (2019) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002355 · Cited by 44 · see citing works
Riaz, M., Alam, S., Malik, A., & Ali, S. M. (2012) · The Indian Journal of Pediatrics · doi:10.1007/s12098-011-0573-z · Cited by 43 · see citing works
Probiotics for treating acute infectious diarrhoea
Allen, S. J., Martinez, E. G., Gregorio, G. V., & Dans, L. F. (2011) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802011000300012 · Cited by 40 · see citing works
Eren, M., Dinleyici, E. Ç., & Vandenplas, Y. (2010) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2010.09-0529 · Cited by 36 · see citing works
Chau, T. T. H., Chau, N. N. M., Nhat, L. T. H., The, H. C., Vinh, P. V., To, N. T. N., Ngọc, N. M., Tuấn, H. M., Ngoc, T. L. C., Kolader, M.-E., et al. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001712 · Cited by 33 · see citing works
Maragkoudaki, M., Chouliaras, G., Moutafi, A. C., Thomas, A., Orfanakou, A., & Papadopoulou, A. (2018) · Nutrients · doi:10.3390/nu10091189 · Cited by 33 · see citing works
Mourey, F., Sureja, V., Kheni, D., Shah, P., Parikh, D., Upadhyay, U., Satia, M., Shah, D., Troise, C., & Decherf, A. (2020) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002849 · Cited by 33 · see citing works
Chen, K. G., Xin, J., Zhang, G., Xie, H. W., Luo, L., Yuan, S., Bu, Y., Yang, X., Ge, Y., & Liu, C. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0046 · Cited by 31 · see citing works
Phavichitr, N., Puwdee, P., & Tantibhaedhyangkul, R. (2013) · PubMed · Cited by 30 · see citing works
Hegar, B., Waspada, I. M. I., Gunardi, H., & Vandenplas, Y. (2014) · The Indian Journal of Pediatrics · doi:10.1007/s12098-014-1408-5 · Cited by 27 · see citing works
Treatment of Acute Otitis Media in Children Under 2 Years of Age
Arens, A. M. (2011) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2011.04.009 · Cited by 24 · see citing works
Effects of Probiotic Intake and Gender on Nontyphoid Salmonella Infection
Lönnermark, E., Lappas, G., Friman, V., Wold, A. E., Backhaus, E., & Adlerberth, I. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000120 · Cited by 18 · see citing works
di, J.-B., & Gai, Z. (2020) · European Review for Medical and Pharmacological Sciences · doi:10.26355/eurrev_202009_23057 · Cited by 14 · see citing works
Schnadower, D., Sapién, R. E., Casper, T. C., Vance, C., Tarr, P. I., O’Connell, K. J., Levine, A. C., Roskind, C. G., Rogers, A. J., Bhatt, S. R., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa313 · Cited by 12 · see citing works
Aziz, A. B., Ali, M., Basunia, A.-U. H., Yunus, M., Clemens, J. D., & Zaman, K. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.01.041 · Cited by 10 · see citing works
New therapeutic options for bile acid malabsorption diarrhea
Valencia-Rodríguez, A., Aquino-Matus, J. E., Vera-Barajas, A., Qi, X., & Méndez‐Sánchez, N. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.112 · Cited by 5 · see citing works
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Petrariu, O.-A., Barbu, I. C., Niculescu, A.-G., Constantin, M., Grigore, G. A., Cristian, R.-E., Mihăescu, G., & Vrâncianu, C. O. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1296447 · Cited by 154 · see citing works
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 121 · see citing works
Probiotics as Antibiotic Alternatives for Human and Animal Applications
Rabetafika, H. N., Razafindralambo, A., Ebenso, B., & Razafindralambo, H. L. (2023) · Encyclopedia · doi:10.3390/encyclopedia3020040 · Cited by 93 · see citing works
Liu, Y., Nawazish, H., Farid, M. S., Qadoos, K. A., Habiba, U. E., Muzamil, M., Tanveer, M., Sienkiewicz, M., Lichota, A., & Łopusiewicz, Ł. (2024) · Fermentation · doi:10.3390/fermentation10080380 · Cited by 66 · see citing works
Selection of appropriate probiotic yeasts for use in dairy products: a narrative review
Kazemi, S., Rad, A. H., Kafil, H. S., Sarabi‐Aghdam, V., Zeynolabedini, P., Agha, B. P., & Madadi, S. A. (2025) · Food Production Processing and Nutrition · doi:10.1186/s43014-024-00293-x · Cited by 31 · see citing works
Gill Jenkins, P. M. (2022) · Food & Nutrition Journal · doi:10.29011/2575-7091.100245 · Cited by 21 · see citing works
Chen, K. G., Jin, S., Ma, Y., Cai, L., Xu, P., Nie, Y., Luo, L., Yu, Q., Shen, Y., Zhou, Z., et al. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01428-6 · Cited by 19 · see citing works
El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Alkafaas, S. S., Dladla, M., Ghosh, S., Mohammed, D. M., Ibrahim, E. H., Fahmy, M. A., Elkelish, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713426 · Cited by 13 · see citing works
Chen, K. G., Jin, S., Ma, Y., Cai, L., Xu, P., Nie, Y., Luo, L., Yu, Q., Shen, Y., Ma, W., et al. (2023) · Nutrition · doi:10.1016/j.nut.2023.112052 · Cited by 16 · see citing works
McFarland, L. V., & Li, T. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1587792 · Cited by 13 · see citing works
Mitra, A. K., Asala, A. F., Malone, S., & Mridha, M. K. (2023) · Diseases · doi:10.3390/diseases11040138 · Cited by 13 · see citing works
Martínez-Ruiz, S., Olivo-Martínez, Y., Cordero, C., Rodríguez-Lagunas, M. J., Pérez-Cano, F. J., Badı́a, J., & Baldomà, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021184 · Cited by 12 · see citing works
Majeed, M. A., Nagabhushanam, K., Arumugam, S., Chadalavada, N., Seepana, J., Annamalai, T., Murali, A., Prakasan, P., & Mundkur, L. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1338126 · Cited by 11 · see citing works
Minaz, A., Alam, R., Jiwani, U., Vadsaria, K., Khan, A., Ishaq, A., Sultan, S., Mohsin, M., Sharif, A., Nisar, Y. B., et al. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04236 · Cited by 12 · see citing works
The effect of periodontal treatment on Helicobacter pylori-infection: a systematic review
Inchingolo, A. M., Inchingolo, A. D., Fatone, M. C., Ferrante, L., Casamassima, L., Trilli, I., Inchingolo, F., Palermo, A., & Dipalma, G. (2025) · Periodontal and Implant Research · doi:10.1007/s41894-025-00146-x · Cited by 8 · see citing works
Darbandi, A., Navidifar, T., Koupaei, M., Afifirad, R., Nezhad, R. A., Emamie, A. D., Talebi, M., & Kakanj, M. (2025) · Health Science Reports · doi:10.1002/hsr2.70521 · Cited by 6 · see citing works
Hidayat, K., Zhang, L., Wei, H., Zhang, W., Qin, L., Ou, Y., & Li, N. (2025) · Food & Function · doi:10.1039/d5fo01780g · Cited by 5 · see citing works
Sorensen, K., Jog, P. P., Mankar, S. V., Holz, C., & Ss, J. (2025) · Beneficial Microbes · doi:10.1163/18762891-bja00086 · Cited by 5 · see citing works
Wang, Q., Ren, T., Wang, H., & Lin, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1606264 · Cited by 5 · see citing works
Essawy, M., Badr, E. A., & Abohadida, R. M. (2024) · Egyptian Journal of Health Care · doi:10.21608/ejhc.2024.344641 · Cited by 3 · see citing works
Rerksuppaphol, L., & Rerksuppaphol, S. (2025) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmaf027 · Cited by 3 · see citing works
Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis
Chen, L., Wang, Y., Liu, X., Wong, H., & Huang, C. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-06002-y · Cited by 2 · see citing works
Chen, S., Tan, M. T. H., Toh, J. Y. L., Bai, H., Hua, Q., Mok, Y., Wang, W., Chen, S., & Li, D. (2025) · Food Microbiology · doi:10.1016/j.fm.2025.104970 · Cited by 1 · see citing works
Cordero, C., Caballero-Román, A., Martínez-Ruiz, S., Olivo-Martínez, Y., Baldomà, L., & Badı́a, J. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18010120 · Cited by 1 · see citing works
Christi, H., Tjahjono, K., & Syauqy, A. (2023) · Jurnal Aisyah Jurnal Ilmu Kesehatan · doi:10.30604/jika.v8i3.2041 · Cited by 1 · see citing works
Practical aspects of probiotics application: A Delphi study
Gorelov, A. V., Livzan, M. A., Zyryanov, S. K., Belmer, S. V., Zolnikova, O. Y., Михайлович, З. С., Usenko, D. V., & Dovgan, Y. V. (2024) · Terapevticheskii arkhiv · doi:10.26442/00403660.2024.12.203102 · Cited by 1 · see citing works
Effect of Probiotics on Rotavirus and Non-Rotavirus Diarrhea in Infants: Randomized Controlled Trial
Khan, F. A., Irum, Z., Khan, M. Z., Yousaf, N., Piracha, M. I., & Zaheer, S. (2022) · Esculapio · doi:10.51273/esc22.251831
Limonitum Ameliorates Castor Oil-Induced Diarrhoea in Mice by Modulating Gut Microbiota
L., Y., Yan, B., Liu, S., Dai, S. L., Liu, J., Wang, X. X., Fang, F., Wu, S.-H., Wang, Y., Chen, X., et al. (2022) · Folia Biologica · doi:10.14712/fb2022068040133
Mukhlif, Z., & Ali, W. I. (2024) · International Journal of Innovative Research in Medical Science · doi:10.23958/ijirms/vol09-i05/1895
Probiotics and its Application in Humans: An Overview
Arunavarsini, K., Yuvansasi, V. , Sekar, M., Durga Devi., L., & Mahenthiran, R. (2024) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2024/v36i77552
Guía colombiana para el uso de probióticos en patologías pediátricas
Monroy, F. A. M., Ángel, A. F. G., Carrillo, M. M. H., Camacho, J. F. G., López, J. P. R., Calderón-Guerrero, O. G., Becerra, M. E., Sarmiento, G. E. S., Hernández, H. H. L., Giraldo, F. J. S., et al. (2024) · Acta gastroenteorológica latinoamericana/Acta gastroenterológica latinoamericana · doi:10.52787/agl.v54i2.395
Willemse, T. W. J., & Schmitz, S. S. (2024) · Vlaams Diergeneeskundig Tijdschrift · doi:10.21825/vdt.93194
Rahmati, M. B., khodadadzade, R., Ahmadi, M., & Teshnizi, S. H. (2025) · Discover Medicine · doi:10.1007/s44337-025-00375-w
Are Probiotics a Panacea for All Diseases? A Scientific Opinion
Catarina, R. G., & Vasco, A. (2025) · Food Research and Supplementation · doi:10.70322/frs.2025.10002
Clinical Applications of Probiotics: A Comprehensive Review of Benefits and Challenges
Hassan, R. W. (2025) · Maaen Journal for Medical Sciences · doi:10.55810/2789-9136.1080
Development and Psychometric Properties of the Diarrhea Management Scale for Mothers (DiMaM)
Aközlü, Z., Göbekli, A., & Yıldız, S. (2025) · Maternal and Child Health Journal · doi:10.1007/s10995-025-04176-6
Almalki, F., Felemban, F., Alahmadi, G. A., Alsaedi, H., Warsi, S. A., Alsulmi, F., Almoalem, A., Shah, M., Alotaibi, M. S. A., & Alharbi, L. A. (2025) · Research Square · doi:10.21203/rs.3.rs-7494860/v1
Sosa, M. C. S., Vite, J. E. B., & Ariza‐Ortega, J. A. (2025) · South Florida Journal of Development · doi:10.46932/sfjdv6n10-015
Efficacy of Bovine Colostrum in The Treatment of Acute Diarrhea in Infants and Children
Hameed, H., Rafique, A., Tariq, N., Zulfiqar, R., Aslam, S., & Zholdabeskova, A. (2025) · Journal of Rawalpindi Medical College · doi:10.37939/jrmc.v29i3.2803
Li, T., & McFarland, L. V. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1747695
Safabakhsh, M., Mohammadpour, M., Rohani, P., Ekbatani, M., Pourhadi, Z., Imani, H., & Shab‐Bidar, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-45936-w
Maina, J. N., Makokha, A. O., & Aduol, K. O. (2026) · Journal of Human Environment and Health Promotion · doi:10.66224/jhehp.715
Jamil, R., Pracha, H. S., Jamil, H., Shabbir, S., & Paracha, U. A. (2025) · Journal of Basic & Clinical Medical Sciences · doi:10.58398/0002.000028
EFFECTS OF RACECADOTRIL ON THE TREATMENT OF ACUTE WATERY DIARRHEA IN CHILDREN
Hashmi, H. A., Shoaib, M., Yasmeen, S., Asif, A., Pervaiz, M., & Qahir, A. (2026) · The Professional Medical Journal · doi:10.29309/tpmj/2026.33.07.10567
Namazova-Baranova, L. S., Gorelov, A. V., Belmer, S. V., Gundobina, O. S., Духанин, А. С., Kaytukovа, E. V., Petrov, V. A., Selimzianova, L. R., Usenko, D. V., & Efendieva, K. E. (2026) · Педиатрическая фармакология · doi:10.15690/pf.v23i3.3038
Mishra, S., & Saxena, S. K. (2026) · Clinical Pediatrics · doi:10.1177/00099228261480530
- Authors
- Huang, R., Xing, H.-Y., Liu, H.-J., Chen, Z.-F., & Tang, B.-B.
- Affiliations
- Hainan Maternal and Child Health Hospital (CN)
- Hainan General Hospital (CN)
- Venue
- Translational Pediatrics
- Publisher
- AME Publishing Company
- Published
- 2021-12
- Volume
- 10
- Issue
- 12
- Pages
- 3248-3260
- ISSN
- 2224-4336 (ISSN-L)
- 2224-4344
- PMC
- PMC8753473
- OpenAlex
- W4206235229
- Cited by
- 48
- References
- 32
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 14 · 2023: 4 · 2022: 3 · 2021: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Translational Pediatrics (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, acute diarrhea, children, acute gastroenteritis, synbiotics, Lactobacillus reuteri, Saccharomyces boulardii, Lactobacillus rhamnosus, Lactobacillus acidophilus, diarrhea duration, length of hospital stay, gut microbiota, dehydration prevention, treatment efficacy comparison, publication bias, subgroup analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
