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Review of Recent Methodological Developments in Group-Randomized Trials: Part 2—Analysis
Open accessAbstract
In 2004, Murray et al. reviewed methodological developments in the design and analysis of group-randomized trials (GRTs). We have updated that review with developments in analysis of the past 13 years, with a companion article to focus on developments in design. We discuss developments in the topics of the earlier review (e.g., methods for parallel-arm GRTs, individually randomized group-treatment trials, and missing data) and in new topics, including methods to account for multiple-level clustering and alternative estimation methods (e.g., augmented generalized estimating equations, targeted maximum likelihood, and quadratic inference functions). In addition, we describe developments in analysis of alternative group designs (including stepped-wedge GRTs, network-randomized trials, and pseudocluster randomized trials), which require clustering to be accounted for in their design and analysis.
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Metadata
- Authors
- Turner, E. L., Prague, M., Gallis, J. A., Li, F., & Murray, D. M.
- Affiliations
- Institut national de recherche en sciences et technologies du numérique (FR)
- Elizabeth L. Turner and John A. Gallis are with the Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, and the Duke Global Health Institute, Duke University. Melanie Prague is with the Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, and Inria, project team SISTM, Bordeaux, France. Fan Li is with the Department of Biostatistics and Bioinformatics, Duke University. David M. Murray is with the Office of Disease Prevention, Division of Program...
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 2017-07
- Volume
- 107
- Issue
- 7
- Pages
- 1078-1086
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC5463203
- OpenAlex
- W2605791502
- Cited by
- 195
- References
- 255
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 16 · 2023: 22 · 2022: 38 · 2021: 26 · 2020: 28 · 2019: 15 · 2018: 13 · 2017: 6
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of Mental Health (K01MH104310)
- National Institute of Allergy and Infectious Diseases (R37AI051164, R01AI110478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD075875)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Bayesian Inference
- Keywords
- group-randomized trials, statistical analysis methods, missing data, quadratic inference function, stepped wedge design
- MeSH terms
- Humans, Research Design, Models, Statistical, Cluster Analysis, Randomized Controlled Trials as Topic, Population Groups
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