The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
EXTRACELLULAR MATRIX BIOSCAFFOLDS FOR ORTHOPAEDIC APPLICATIONS: A COMPARATIVE HISTOLOGIC STUDY
Abstract
BACKGROUND: Biologic scaffold materials prepared from extracellular matrix are currently available for the surgical repair of damaged or missing musculotendinous tissue. These scaffolds differ in their species and tissue of origin, methods of processing, and methods of terminal sterilization. The purpose of the present study was to evaluate the host-tissue morphologic response to five commercially available extracellular matrix-derived biologic scaffolds used for orthopaedic soft-tissue repair in a rodent model. METHODS: One hundred twenty-six Sprague-Dawley rats were divided into six groups of twenty-one animals each. A defect was created in the musculotendinous tissue of the abdominal wall of each animal and then was repaired with one of five different scaffold materials (GraftJacket, Restore, CuffPatch, TissueMend, Permacol) or with the excised autologous tissue. Three animals from each group were killed at one of seven time-points after surgery (two, four, seven, fourteen, twenty-eight, fifty-six, and 112 days), and the specimens were examined with histologic and morphologic methods. The degree of cellular infiltration, multinucleated giant cell presence, vascularity, and organization of the replacement connective tissue were evaluated with semiquantitative methods. RESULTS: Each device elicited a distinct morphologic response that differed with respect to cellularity (p<0.001), vascularity (p<0.01), the presence of multinucleated giant cells (p<0.01), and organization of the remodeled tissue (p<0.01) at or after the Day 7 time-point. More rapidly degraded devices such as Restore and autologous tissue showed the greatest amount of cellular infiltration, especially at the early time-points. Devices that degraded slowly, such as CuffPatch, TissueMend, and Permacol, were associated with the presence of foreign-body giant cells, chronic inflammation, and/or the accumulation of dense, poorly organized fibrous tissue. CONCLUSIONS: Biologic scaffold materials composed of extracellular matrix elicit distinct host-tissue histologic and morphologic responses, depending on species of origin, tissue of origin, processing methods, and/or method of terminal sterilization.
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Citations
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Xenogeneic extracellular matrix as a scaffold for tissue reconstruction
Badylak, S. F. (2004) · Transplant Immunology · doi:10.1016/j.trim.2003.12.016 · Cited by 747
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Cited by
Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391
Brown, B. N., Valentin, J. E., Stewart-Akers, A. M., McCabe, G. P., & Badylak, S. F. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.040 · Cited by 896
“Interestingly, although the host response involves a large infiltration of mononuclear cells [22], an event conventionally associated with inflammation, there is a lack of the usual cytotoxic mediators of inflammation and graft rejection, with resultant formation of a polarized type 2 T lymphocyte (Th2) response [26].”
BackgroundMethodInfluentialSelf-citationImmune response to biologic scaffold materials
Badylak, S. F., & Gilbert, T. W. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.003 · Cited by 857
Self-citationMacrophage Phenotype as a Determinant of Biologic Scaffold Remodeling
Badylak, S. F., Valentin, J. E., Ravindra, A. K., McCabe, G. P., & Stewart-Akers, A. M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0264 · Cited by 729
Self-citationConsequences of ineffective decellularization of biologic scaffolds on the host response
Keane, T. J., Londono, R., Turner, N. J., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.054 · Cited by 613
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Metadata
- Authors
- VALENTIN, J. E., BADYLAK, J. S., MCCABE, G. P., & BADYLAK, S. F.
- Venue
- The Journal of Bone and Joint Surgery-American Volume
- Published
- 2006-12
- Volume
- 88
- Issue
- 12
- Pages
- 2673-2686
- ISSN
- 0021-9355 (ISSN-L)
- OpenAlex
- W2031013234
- Cited by
- 411
- References
- 1
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- closed
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