The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony
Open accessAbstract
Septic syndromes represent a major although largely underrecognized healthcare problem worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis deeply perturbs immune homeostasis by inducing an initial tremendous systemic inflammatory response which is accompanied by an antiinflammatory process, acting as negative feedback. This compensatory inhibitory response secondly becomes deleterious as nearly all immune functions are compromised. These alterations might be directly responsible for worsening outcome, as they may play a major role in the decreased resistance to nosocomial infections in patients who survived initial resuscitation. Consequently, immunostimulatory therapies may now be assessed for the treatment of sepsis. This review focuses on immune dysfunctions described in septic patients and on their potential use as markers on a routine standardized basis for prediction of adverse outcome or of occurrence of secondary nosocomial infections. This constitutes a prerequisite to a staging system for individualized treatment for these hitherto deadly syndromes.
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Cited by
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
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Self-citationEndotoxin tolerance: new mechanisms, molecules and clinical significance
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The immune system’s role in sepsis progression, resolution, and long-term outcome
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Self-citation
Metadata
- Authors
- Monneret, G., Venet, F., Pachot, A., & Lepape, A.
- Venue
- Molecular Medicine
- Published
- 2008-01
- Volume
- 14
- Issue
- 1-2
- Pages
- 64-78
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- OpenAlex
- W2110068780
- Cited by
- 340
- References
- 9
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Monneret, G., Venet, F., Pachot, A., & Lepape, A. (2008). Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony. Molecular Medicine. https://doi.org/10.2119/2007-00102.monneret
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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