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PreprintCited by 4Cardiac Imaging and DiagnosticsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

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Presence of Coronary Artery Disease in Adults with Newly Detected Diabetes Mellitus

Open access
Lai, Cheng-Chien, Chang, Betty Chia-Chen, Hwang, Lee-Ching·2023·BMC Cardiovascular Disorders
DOI 10.21203/rs.3.rs-3120566/v1PMC PMC11789286

Preprint — published as 10.1186/s12872-024-04463-0

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Abstract

Purpose We aimed to analyze the presence and extent of coronary artery disease in patients with newly detected diabetes mellitus. Methods Clinical health examinations of asymptomatic community-dwelling adults between 2008 and 2018 at a medical center in Taiwan were reviewed. Coronary computed tomography angiography was performed in 444 participants, of which 338, 54, and 52 were categorized as ‘without diabetes mellitus’, ‘newly detected diabetes mellitus’, and ‘known diabetes mellitus’, respectively. Results Prevalence of significant coronary artery disease (≥ 50% stenosis) was higher in participants with newly detected diabetes mellitus than participants without diabetes mellitus (40.7% vs 20.1%, p < 0.0001). Among those with coronary artery stenosis, the number of coronary vessels with significant obstruction (0.72 vs 0.42, p = 0.0147) was also higher in participants with newly detected diabetes mellitus. Using multiple logistic regression analysis, new detection of diabetes mellitus was identified as an independent risk factor for significant coronary artery disease (odds ratio: 2.153, 95% confidence interval: 1.112–4.166). Conclusion Asymptomatic patients with newly detected diabetes mellitus had higher prevalence and greater extent of coronary artery disease than those without diabetes mellitus. More attention should thus be paid to the assessment of coronary artery disease in patients with newly detected diabetes mellitus.

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Fig. 1 Flowchart of participant inclusion and categorization. CCTA: Coronary computed tomography angiography; CAD: Coronary artery disease; DM: diabetes mellitus
Fig. 1 Flowchart of participant inclusion and categorization. CCTA: Coronary computed tomography angiography; CAD: Coronary artery disease; DM: diabetes mellitusCC BY-NC-ND · PubMed Central
Fig. 2 Prevalence of significant coronary artery disease among asymptomatic participants without diabetes mellitus, with newly detected diabetes mellitus, and with known diabetes mellitus. The standard error of the mean was shown in error bars. CAD: Coronary artery disease; DM: diabetes mellitus
Fig. 2 Prevalence of significant coronary artery disease among asymptomatic participants without diabetes mellitus, with newly detected diabetes mellitus, and with known diabetes mellitus. The standard error of the mean was shown in error bars. CAD: Coronary artery disease; DM: diabetes mellitusCC BY-NC-ND · PubMed Central
Fig. 3 Number of coronary vessels with significant obstruction in participants with coronary artery stenosis. The standard error of the mean was shown in error bars. DM: diabetes mellitus
Fig. 3 Number of coronary vessels with significant obstruction in participants with coronary artery stenosis. The standard error of the mean was shown in error bars. DM: diabetes mellitusCC BY-NC-ND · PubMed Central

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Metadata

Authors
Lai, C.-C., Chang, B. C.-C., & Hwang, L.-C.
Affiliations
  • Taipei Veterans General Hospital (TW)
  • Mackay Memorial Hospital (TW)
Corresponding author
Hwang, Lee-Ching
ORCID
Venue
BMC Cardiovascular Disorders
Publisher
Springer Science and Business Media LLC
Published
2023-07-12
Volume
25
Issue
1
Pages
76-76
ISSN
1471-2261 (ISSN-L)
DOI
10.21203/rs.3.rs-3120566/v1
PMC
PMC11789286
OpenAlex
W4407111461
Cited by
4
References
1
Citations by year
2026: 2 · 2025: 2
FWCI
2.30
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Cardiovascular Disorders (publishedVersion, cc-by-nc-nd)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Mackay Memorial Hospital
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
coronary artery disease, newly diagnosed diabetes, coronary artery stenosis, asymptomatic adults, coronary artery disease prevalence, coronary artery disease extent, diabetes as risk factor, coronary CT angiography
MeSH terms
Computed Tomography Angiography, Adult, Aged, Coronary Artery Disease, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Severity of Illness Index, Taiwan, Prevalence, Coronary Angiography, Risk Assessment, Coronary Stenosis, Asymptomatic Diseases

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