Mining novel specific rumen bacteria to enhance the bioactive function of mulberry leaf in promoting host antioxidant activity and immunomodulatory
Open accessAbstract
Abstract Background: Rumen is a natural fermentation system and the microorganisms inside can effectively utilize plant bioresource and interact with host metabolism. Here, analysis of rumen microbiome, together with animal performance and serum metabolism in a lamb model were performed to identify the potential use of mulberry leaf silage (MS) to replace alfalfa silage (AS) as a new functional feed resource and to mining the novel specific mulberry leaf associated rumen bacteria interact with host metabolism. Results: The lambs fed with MS diet showed improved antioxidant capacity and immune function compared to those fed AS diet. The MS diet significantly altered rumen microbiota α- and β-diversity and taxonomic composition. Microbial analysis revealed that Bifidobacterium, Lactobacillus and Schwartzia were enhanced, and Ruminococcaceae UCG-010 and Lachnospiraceae_XPB1014_group were down-regulated in the rumen of MS group. A strong association was also found between these rumen microbial taxa and host antioxidant capacity and immunomodulatory. Conclusion: These findings indicated that mulberry leaf silage can be a high-quality feed source or bioactive pharmaceutical that is responsible for ruminants health benefits by modifying the rumen microbial community with potentially enhanced probiotics and inhibited biohydrogenation and methane emission.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rumen microbial taxa (Bifidobacterium, Lactobacillus, and Schwartzia) exhibit a strong association with host antioxidant capacity and immunomodulatory functions.
“A recent study has revealed that rumen microbial taxa (Bifidobacterium, Lactobacillus, and Schwartzia) exhibited a strong association with host antioxidant capacity and immunomodulatory functions (225).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [225]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
fastp: an ultra-fast all-in-one FASTQ preprocessor
(2018) · doi:10.1093/bioinformatics/bty560 · Cited by 29,721 · see citing works
Silage review: Interpretation of chemical, microbial, and organoleptic components of silages
Kung, L., Shaver, R. D., Grant, R. J., & Schmidt, R. J. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13909 · Cited by 1,316 · see citing works
Xue, M., Sun, H., Wu, X., Liu, J., & Guan, L. L. (2020) · Microbiome · doi:10.1186/s40168-020-00819-8 · Cited by 516 · see citing works
Nutrition, immune function and health of dairy cattle
Ingvartsen, K. L., & Moyes, K. M. (2012) · animal · doi:10.1017/s175173111200170x · Cited by 389 · see citing works
Mulberry: A review of bioactive compounds and advanced processing technology
Wen, P., Hu, T., Linhardt, R. J., Liao, S., Wu, H., & Zou, Y. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.11.017 · Cited by 257 · see citing works
Phytochemistry, pharmacology, and clinical trials of Morus alba
Eric, E., Wei-Chiang, Chan, E. W. C., et al. (2016) · 中国天然药物 · Cited by 242 · see citing works
Antioxidant systems and erythrocyte life-span in mammals
Kurata, M., Suzuki, M., & Agar, N. S. (1993) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(93)90121-k · Cited by 240 · see citing works
Lin, L., Xie, F., Sun, D., Liu, J., Zhu, W., & Mao, S. (2019) · Microbiome · doi:10.1186/s40168-019-0701-y · Cited by 233 · see citing works
He, X., Fang, J., Ruan, Y., Wang, X., Sun, Y., Wu, N., Zhao, Z., Chang, Y., Ning, N., Guo, H., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.11.084 · Cited by 203 · see citing works
Phytochemistry, pharmacology, and clinical trials of Morus alba.
Chan, E. W. C., Lye, P.-Y., & Wong, S.-K. (2016) · PubMed · doi:10.3724/sp.j.1009.2016.00017 · Cited by 189 · see citing works
Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling
Torres‐Fuentes, C., Golubeva, A. V., Zhdanov, A. V., Wallace, S., Arboleya, S., Papkovsky, D. B., Aidy, S. E., Ross, P., Roy, B. L., Stanton, C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901433r · Cited by 154 · see citing works
Sánchez-Salcedo, E. M., Mena, P. R., García‐Viguera, C., Hernández, F., & Nicolás, J. J. M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.053 · Cited by 152 · see citing works
Bioactivity of Food Melanoidins Is Mediated by Gut Microbiota
Pérez-Burillo, S., Rajakaruna, S., Pastoriza, S., Paliy, O., & Ángel Rufián-Henares, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126309 · Cited by 138 · see citing works
Phenotypic Characterization of Polysaccharidases Produced by Four Prevotella Type Strains
Matsui, H., Ogata, K., Tajima, K., Nakamura, M., Nagamine, T., Aminov, R. I., & Benno, Y. (2000) · Current Microbiology · doi:10.1007/s002840010089 · Cited by 130 · see citing works
The nutritive value of mulberry leaves (Morus alba) as a feed supplement for sheep
Kandylis, K., Hadjigeorgiou, I., & Harizanis, P. C. (2008) · Tropical Animal Health and Production · doi:10.1007/s11250-008-9149-y · Cited by 123 · see citing works
Wang, Y., Chen, X., Wang, C., He, L., Zhou, W. J., Yang, F., & Zhang, Q. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122059 · Cited by 115 · see citing works
Preference of horses for grass conserved as hay, haylage or silage
Müller, C. E., & Uden, P. C. (2006) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2006.02.013 · Cited by 91 · see citing works
He, L., Zhou, W., Wang, C., Yang, F., Chen, X., & Zhang, Q. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16468 · Cited by 84 · see citing works
Alfalfa Intervention Alters Rumen Microbial Community Development in Hu Lambs During Early Life
Yang, B., Le, J., Wu, P., Liu, J., Guan, L. L., & Wang, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00574 · Cited by 77 · see citing works
Therapeutic Potential of Temperate Forage Legumes: A Review
Cornara, L., Xiao, J., & Burlando, B. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1038378 · Cited by 76 · see citing works
Lin, W. C., Lee, M. T., Chang, S.-C., Chang, Y. L., Shih, C. H., Yu, B., & Lee, T.-T. (2016) · Poultry Science · doi:10.3382/ps/pew350 · Cited by 76 · see citing works
Kuang, Y.-C., Wang, Y., Zhang, Y., Song, Y., Zhang, X., Lin, Y., Che, L., Xu, S., Wu, D., Xue, B., et al. (2015) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2015.07.010 · Cited by 74 · see citing works
Lee, W. J., & Choi, S. W. (2012) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2012.17.4.280 · Cited by 68 · see citing works
Liu, J. X., Yao, J., Yan, B., et al. (2001) · Small Ruminant Research · doi:10.1016/s0921-4488(00)00180-2 · Cited by 65 · see citing works
Zhao, X., Lin, L., Luo, Q., Ye, M., Luo, G., & Kuang, Z. (2015) · Livestock Science · doi:10.1016/j.livsci.2015.03.001 · Cited by 64 · see citing works
Doran, M. P., Laca, E. A., & Sainz, R. D. (2006) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2006.11.016 · Cited by 62 · see citing works
Lyons, T., Boland, T. M., Storey, S., & Doyle, E. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01656 · Cited by 60 · see citing works
Cunha, C. S., Veloso, C. M., Marcondes, M. I., Mantovani, H. C., Tomich, T. R., Pereira, L. G. R., Ferreira, M. F. L., Dill‐McFarland, K. A., & Suen, G. (2017) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2017.07.008 · Cited by 53 · see citing works
Perilla frutescens Leaf Alters the Rumen Microbial Community of Lactating Dairy Cows
Sun, Z., Yu, Z., & Wang, B. (2019) · Microorganisms · doi:10.3390/microorganisms7110562 · Cited by 51 · see citing works
Self-citationLiang, Y., Bao, Y., Gao, X., Deng, K., An, S., Wang, Z., Huang, X., Liu, D., Liu, Z., Wang, F., et al. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108094 · Cited by 46 · see citing works
Memon, M. A., Wang, Y., Xu, T., Ma, N., Zhang, H., Roy, A. C., Aabdin, Z. U., & Shen, X. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.01.005 · Cited by 44 · see citing works
Zhao, X., Yang, R., Bi, Y., et al. (2019) · Animals · doi:10.3390/ani10010035 · Cited by 44 · see citing works
Assessment of mulberry leaf as a potential feed supplement for animal feeding in P.R. China
Cai, M., Mu, L., Wang, Z., et al. (2019) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.18.0671 · Cited by 42 · see citing works
Enhancing Mulberry Leaf Meal with Urea by Pelleting to Improve Rumen Fermentation in Cattle
Tan, N. D., Wanapat, M., Uriyapongson, S., et al. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2011.11270 · Cited by 35 · see citing works
Oxidative Stress - Threat to Animal Health and Production -
Nisar, N. A., Sultana, M., Waiz, H. A., Para, P. A., & Dar, S. A. (2013) · International Journal of Livestock Research · Cited by 32 · see citing works
Niu, Y., Meng, Q., Li, S., Ren, L., Zhou, B., Schonewille, J. T., & Zhou, Z. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156836 · Cited by 24 · see citing works
Jetana, T., Vongpipatana, C., Usawang, S., et al. (2010) · Tropical Animal Health and Production · doi:10.1007/s11250-010-9654-7 · Cited by 18 · see citing works
[Advances in the pharmacological study of Morus alba L].
Yang, S. C., Wang, B., & Li, Y. (2014) · PubMed · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 15
- Butt MS, Nazir A, Sultan MT, Schroen K. Morus alba L. nature's functional tonic. Trends Food Sci Tech. 2008;19:505-12.
- He L, Chen N, Lv H, Wang C, Zhou W, Chen X, Zhang Q. Gallic acid in uencing fermentation quality, nitrogen distribution and bacterial community of high-moisture mulberry leaves and stylo silage. Bioresour Technol. 2020;295:122255.
- Li F, Li C, Chen Y, Liu J, Zhang C, Irving B, Fitzsimmons C, Plastow G, Guan LL. Host genetics in uence the rumen microbiota and heritable rumen microbial features associate with feed e ciency in cattle. Microbiome. 2019;7:92.
- Pandey V, Singh A, Singh A, Krishna A, Pandey U, Tripathi YB. Role of oxidative stress and low-grade in ammation in letrozole-induced polycystic ovary syndrome in the rat. Reprod Biol. 2016;16:70-7.
- Wang Y, Li M, Yu X, He S, Wu X, Wang Y. Mulberry leaf avonoids protect against glucotoxicity- induced INS-1 cell apoptosis. J Tradit Chin Med. 2019;39:153-9.
- Hu C, Li F, Duan Y, Yin Y, Kong X. Glutamic acid supplementation reduces body fat weight in nishing pigs when provided solely or in combination with arginine and it is associated with colonic propionate and butyrate concentrations. Food Funct. 2019;10:4693-704.
- Ma T, Chen DD, Tu Y, Zhang NF, Si BW, Diao QY. Dietary supplementation with mulberry leaf avonoids inhibits methanogenesis in sheep. Anim Sci J. 2017;88:72-8.
- Tian S, Wang M, Liu C, Zhao H, Zhao B. Mulberry leaf reduces in ammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway. BMC Complement Altern Med. 2019;19:326.
- Gessner DK, Bonarius M, Most E, Fiesel A, Eder K. Effects of polyphenol-rich plant products from grape or hop as feed supplements on the expression of in ammatory, antioxidative, cytoprotective and endoplasmic reticulum stress-related genes and the antioxidative status in the liver of piglets. J Anim Physiol Anim Nutr (Berl). 2017;101:e185-94.
- Slovakova L, Duskova D, Marounek M. Fermentation of pectin and glucose, and activity of pectin- degrading enzymes in the rabbit caecal bacterium Bi dobacterium pseudolongum. Lett Appl Microbiol. 2002;35:126-30.
- Vlkova E, Trojanova I, Rada V. Distribution of bi dobacteria in the gastrointestinal tract of calves. Folia Microbiol (Praha). 2006;51:325-8.
- Zhang Q, Li XJ, Zhao MM, Yu Z. Isolating and evaluating lactic acid bacteria strains for effectiveness of Leymus chinensis silage fermentation. Lett Appl Microbiol. 2014;59:391-7.
- Fan Y, Ren C, Meng F, Deng K, Zhang G, Wang F. Effects of algae supplementation in high-energy dietary on fatty acid composition and the expression of genes involved in lipid metabolism in Hu sheep managed under intensive nishing system. Meat Sci. 2019;157:107872.
- Broderick G, Kang J. Automated simultaneous determination of ammonia and total amino acids in ruminal uid and in vitro media1. J Dairy Sci. 1980;63:64-75.
- Bokulich NA, Subramanian S, Faith JJ, Gevers D, Gordon JI, Knight R, Mills DA, Caporaso JG. Quality- ltering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods. 2013;10:57-9. Tables Table 1 Effect of alfalfa silage (AS) and mulberry leaf silage (MS) based diets on growth performance, organ index, and meat quality characteristics in lambs
Cited by
Sorted by citations
Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 160 · see citing works
- Authors
- Wang, B., & Luo, H.
- Affiliations
- China Agricultural University (CN)
- Corresponding author
- Wang, Bing
- Published
- 2020-06-29
- OpenAlex
- W3113177348
- Cited by
- 1
- References
- 38
- Citations by year
- 2020: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Funders
- National Natural Science Foundation of China (31902181)
- China Agricultural University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- rumen microbiota, rumen bacteria, antioxidant activity, immunomodulation, lamb feeding, Bifidobacterium, Lactobacillus, Ruminococcaceae, Lachnospiraceae, probiotics, biohydrogenation, methane emissions, ruminant health, functional feed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
