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PreprintCited by 6Ferroptosis and cancer prognosisNeonatal and Maternal InfectionsIron Metabolism and Disorders

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Unveiling the Crucial Role of Ferroptosis in Host Resistance to Streptococcus agalactiae Infection

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jiang, Hua, yi, Jiaxuan, sun, zeyu, Li, Jing, Jiang, Yongqiang, Liu, Peng, Wang, Yuhang, Liu, Hui, Lv, Qingyu, Kong, Decong, Huang, Wenhua, Ren, Yuhao, Li, Qian·2024·Cell Death Discovery
DOI 10.21203/rs.3.rs-4121017/v1PMC PMC11445261

Preprint — published as 10.1038/s41420-024-02189-8

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Abstract

IL-1β represents an important inflammatory factor involved in the host response against GBS infection. Prior research has suggested a potential involvement of IL-1β in the process of ferroptosis. However, the relationship between IL-1β and ferroptosis in the context of anti-GBS infection remains uncertain. This research demonstrates that the significance of ferroptosis in the host's immune defense against GBS infection in a mouse model of abdominal infection, with peritoneal macrophages identified as the primary cells undergoing ferroptosis. Subsequent studies have shown that IL-1β promotes lipid oxidation in macrophages by upregulating pathways associated with lipid oxidation. Concurrently, IL-1β is not only involved in the initiation of ferroptosis in macrophages, but its production is intricately linked to the onset of ferroptosis. Ultimately, we posit that ferroptosis acts as a crucial initiating factor in the host response to GBS infection, with IL-1β playing a significant role in the resistance to infection by serving as a key inducer of ferroptosis.

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Metadata

Authors
jiang, H., yi, J., sun, Z., Li, J., Jiang, Y., Liu, P., Wang, Y., Liu, H., Lv, Q., Kong, D., Huang, W., Ren, Y., & Li, Q.
Affiliations
  • Academy of Military Medical Sciences (CN)
  • Life Science College, Southwest Forestry University
  • Southwest Forestry University (CN)
Corresponding author
  • jiang, Hua
  • Li, Jing
  • Jiang, Yongqiang
ORCID
Venue
Cell Death Discovery
Publisher
Springer Science and Business Media LLC
Published
2024-04-18
Volume
10
Issue
1
Pages
423-423
ISSN
2058-7716 (ISSN-L)
DOI
10.21203/rs.3.rs-4121017/v1
PMC
PMC11445261
OpenAlex
W4403032921
Cited by
6
References
1
Citations by year
2026: 3 · 2025: 3
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Death Discovery (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
State Key Laboratory of Pathogen and Biosecurity
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
ferroptosis, Streptococcus agalactiae, IL-1β, peritoneal macrophages, lipid peroxidation, host resistance to infection, intra-abdominal infection, innate immunity

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