Cited by 190Drug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismComputational Drug Discovery Methods

Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies

Nishimura, Masuhiro, Naito, Shinsaku·2008·Drug Metabolism and Pharmacokinetics

Abstract

Pairs of forward and reverse primers and TaqMan probes specific to each of 173 human solute carrier (SLC) transporters were prepared. The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bladder, bone marrow, brain, colon, heart, kidney, liver, lung, mammary gland, ovary, pancreas, peripheral leukocytes, placenta, prostate, retina, salivary gland, skeletal muscle, small intestine, smooth muscle, spinal cord, spleen, stomach, testis, thymus, thyroid gland, trachea, and uterus) by real-time reverse transcription PCR using an Applied Biosystems 7500 Fast Real-Time PCR System. Individual differences in the mRNA expression of human SLC transporters in the liver were also evaluated. These newly determined expression profiles were used to study the gene expression in the 28 different human tissues listed above, and tissues with high transcriptional activity for human SLC transporters were identified. These results are expected to be valuable for research concerning the clinical diagnosis of disease.

Integrity signals

Registry

Crossref · 10.2133/dmpk.23.22

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • One mechanism for increased L-T4 requirements with tyrosine kinase inhibitors can be inhibition of MCT8-dependent T3 and T4 uptake, since MCT8 is expressed by the gastrointestinal tract.

    “One mechanism for the L-T4 increased requirements, further to T4 increased metabolism, can be inhibition of MCT8-dependent T3 and T4 uptake (64), since MCT8 is expressed by the gastrointestinal tract (65).”

    From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [65]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nishimura, M., & Naito, S.
Affiliations
Otsuka Pharmaceutical Factory (Japan) (JP)
Corresponding author
Naito, Shinsaku
Venue
Drug Metabolism and Pharmacokinetics
Published
2008
Volume
23
Issue
1
Pages
22-44
ISSN
1347-4367 (ISSN-L)
OpenAlex
W2045690571
Cited by
190
References
72
Citations by year
2026: 2 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 13 · 2012: 10
FWCI
5.63
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Metabolism and Pharmacokinetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
solute carrier transporters, tissue-specific gene expression, mRNA expression profiles, human tissue, transporter gene expression
MeSH terms
Gene Expression Regulation, Humans, RNA, Messenger, Solutions, Tissue Distribution, Gene Expression Profiling, Membrane Transport Proteins, Amino Acid Transport Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review