CoChat
Sign Up
Cited by 51Agricultural and Biological ResearchMedicinal Plant ResearchChromatography in Natural Products

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Different methods of extraction of bioactive compounds and their effect on biological activity: A review

Open access
GHENABZİA, Imane, HEMMAMİ, Hadia, BEN AMOR, Ilham, ZEGHOUD, Soumeia, BEN SEGHİR, Bachir, HAMMOUDİ, Rokaia·2023·International Journal of Secondary Metabolite
DOI 10.21448/ijsm.1225936
Open this paper in CoChat — free accountOpen PDF

Abstract

As of yet, there isn't a single technique that is accepted as the standard for extracting bioactive chemicals from plants. Methods. The effectiveness of both traditional and unconventional extraction methods largely depends on key input variables, knowledge of the composition of plant matter, bioactive chemical chemistry, and scientific knowledge. Results. The necessity for the most suitable and standardized technology to separate active ingredients for plant matter is highlighted by the utilization of bioactive chemicals in several economic sectors, including the pharmaceutical, food, and chemical industries. This review aimed to discuss there are several extraction methods and their basic mechanisms for the extraction of bioactive substances from medicinal plants.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.21448/ijsm.1225936

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 6 references

Research works printed but not linked: 107

  1. Adegbola, P., Aderibigbe, I., Hammed, W., & Omotayo, T. (2017). Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review. American journal of Cardiovascular Disease, 7(2), 19.
  2. Afroz, R.D., Nurunnabi, A.S.M., Khan, M.I., & Jahan, T. (2015). Effect of wheatgrass (Triticum aestivum) juice on high density lipoprotein (HDL) level in experimentally induced dyslipidaemic male long evans rat. Delta Medical College Journal, 3(1), 18-24. http://dx.doi.org/10.3329/dmcj.v3i1.22235 · DOI
  3. Ahmad, T., Masoodi, F., Rather, S.A., Wani, S., & Gull, A. (2019). Supercritical fluid extraction: A review. J. Biol. Chem. Chron, 5(1), 114 122. http://dx.doi.org/10.33980/jbcc.2019.v05i01.019 · DOI
  4. Álvarez-Muñoz, D., Sáez, M., Lara-Martín, P., Gómez-Parra, A., & González-Mazo, E. (2004). New extraction method for the analysis of linear alkylbenzene sulfonates in marine organisms: Pressurized liquid extraction versus Soxhlet extraction. Journal of Chromatography A, 1052(1-2), 33-38. https://doi.org/10.1016/j.chroma.2004.08.014 · DOI
  5. Annadurai, P. (2021). Extraction and Isolation of bioactive compounds from Lantana camara leaves by column Chromatographic techniques. Research Journal of Pharmacy and Technology, 14(3), 1607-1611. http://dx.doi.org/10.5958/0974-360X.2021.00285.7 · DOI
  6. Bajpai, V.K., Majumder, R., & Park, J.G. (2016). Isolation and purification of plant secondary metabolites using column-chromatographic technique. Bangladesh Journal of Pharmacology, 11(4), 844-848. https://doi.org/10.3329/bjp.v11i4.28185 · DOI
  7. Barzegar, E., Fouladdel, S., Movahhed, T.K., Atashpour, S., Ghahremani, M.H., Ostad, S.N., & Azizi, E. (2015). Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines. Iranian journal of Basic Medical Sciences, 18(4), 334.
  8. Bast, F., Rani, P., & Meena, D. (2014). Chloroplast DNA phylogeography of holy basil (Ocimum tenuiflorum) in Indian subcontinent. The Scientific World Journal, 2014. https://doi.org/10.1155/2014/847482 · DOI
  9. Bernhoft, A. (2010). A brief review on bioactive compounds in plants. Bioactive Compounds in Plants-Benefits and Risks for Man And Animals, 50, 11-17.
  10. Bhateja, S., & Arora, G. (2012). Therapeutic benefits of holy basil (Tulsi) in general and oral medicine: a review. International Journal of Research in Ayurveda and Pharmacy (IJRAP), 3(6), 761-764. http://dx.doi.org/10.7897/2277-4343.03611 · DOI
  11. Biswas, N., & Biswas, A. (2005). Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.). Environment and Ecology, 23(3), 485.
  12. Bitwell, C., Sen, I.S., Luke, C., & Kakoma, M.K. (2023). A review of modern and conventional extraction techniques and their applications for extracting phytochemicals from plants. Scientific African, e01585. https://doi.org/10.1016/j.sciaf.2023.e01585 · DOI · Paper page
  13. Brusotti, G., Cesari, I., Dentamaro, A., Caccialanza, G., & Massolini, G. (2014). Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach. Journal of pharmaceutical and Biomedical Analysis, 87, 218-228. https://doi.org/10.1016/j.jpba.2013.03.007 · DOI
  14. Carroll, K.C., Taylor, R., Gray, E., & Brusseau, M.L. (2009). The impact of composition on the physical properties and evaporative mass transfer of a PCE–diesel immiscible liquid. Journal of Hazardous Materials, 164(2 3), 1074 1081. https://doi.org/10.1016/j.jhazmat.2008.09.003 · DOI
  15. Chhipa, A.S., & Sisodia, S. (2019). Indian medicinal plants with antidiabetic potential. Journal of Drug Delivery and Therapeutics, 9(1), 257-265. https://doi.org/10.22270/jddt.v9i1.2282 · DOI
  16. Chiremba, C., Rooney, L.W., & Beta, T. (2012). Microwave-assisted extraction of bound phenolic acids in bran and flour fractions from sorghum and maize cultivars varying in hardness. Journal of Agricultural and Food Chemistry, 60(18), 4735-4742. https://doi.org/10.1021/jf300279t · DOI
  17. Cohen, M.M. (2014). Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251. https://doi.org/10.4103%2F0975-9476.146554 · DOI
  18. Concha, J., Soto, C., Chamy, R., & Zuniga, M. (2004). Enzymatic pretreatment on rose-hip oil extraction: hydrolysis and pressing conditions. Journal of the American Oil Chemists' Society, 81(6), 549-552. https://doi.org/10.1007/s11746-006-0939-y · DOI
  19. Dar, N.G., Hussain, A., Paracha, G.M., & Akhter, S. (2015). Evaluation of different techniques for extraction of antioxidants as bioactive compounds from citrus peels (industrial by products). American-Eurasian Journal of Agricultural and Environmental Sciences, 15(4), 676-682. https://doi.org/10.5829/idosi.aejaes.2015.15.4.12604 · DOI
  20. Dhobi, M., Mandal, V., & Hemalatha, S. (2009). Optimization of microwave assisted extraction of bioactive flavonolignan-silybinin. Journal of chemical metrology, 3(1), 13.
  21. Donn, P., Prieto, M.A., Mejuto, J.C., Cao, H., & Simal-Gandara, J. (2022). Functional foods based on the recovery of bioactive ingredients from food and algae by-products by emerging extraction technologies and 3D printing. Food Bioscience, 49, 101853. https://doi.org/10.1016/j.fbio.2022.101853 · DOI
  22. Dudareva, N., & Pichersky, E. (2000). Biochemical and molecular genetic aspects of floral scents. Plant physiology, 122(3), 627-634. https://doi.org/10.1104/pp.122.3.627 · DOI
  23. Fabricant, D.S., & Farnsworth, N.R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75. · DOI
  24. Fotsing Yannick Stéphane, F., Kezetas Jean Jules, B., El-Saber Batiha, G., Ali, I., & Ndjakou Bruno, L. (2022). Extraction of Bioactive Compounds from Medicinal Plants and Herbs. IntechOpen. https://doi.org/10.5772/intechopen.98602 · DOI
  25. Francis, G., Kerem, Z., Makkar, H.P., & Becker, K. (2002). The biological action of saponins in animal systems: a review. British journal of Nutrition, 88(6), 587-605. https://doi.org/10.1079/BJN2002725 · DOI
  26. García-Risco, M.R., Mouhid, L., Salas-Pérez, L., López-Padilla, A., Santoyo, S., Jaime, L., . . . Fornari, T. (2017). Biological activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts. Plant Foods for Human Nutrition, 72(1), 96-102. https://doi.org/10.1007/s11130-016-0596-8 · DOI
  27. Gaur, R., Sharma, A., Khare, S., & Gupta, M.N. (2007). A novel process for extraction of edible oils: Enzyme assisted three phase partitioning (EATPP). Bioresource Technology, 98(3), 696-699. https://doi.org/10.1016/j.biortech.2006.01.023 · DOI
  28. George, A., Thankamma, A., Devi, V.R., & Fernandez, A. (2007). Phytochemical investigation of Insulin plant (Costus pictus). Asian Journal of Chemistry, 19(5), 3427.
  29. Ghafoor, K., Park, J., & Choi, Y.-H. (2010). Optimization of supercritical fluid extraction of bioactive compounds from grape (Vitis labrusca B.) peel by using response surface methodology. Innovative Food Science & Emerging Technologies, 11(3), 485-490. https://doi.org/10.1016/j.ifset.2010.01.013 · DOI · Paper page
  30. Ghandahari Yazdi, A.P., Barzegar, M., Sahari, M.A., & Ahmadi Gavlighi, H. (2019). Optimization of the enzyme‐assisted aqueous extraction of phenolic compounds from pistachio green hull. Food Science & Nutrition, 7(1), 356 366. https://doi.org/10.1002/fsn3.900 · DOI
  31. Gholamhoseinian, A., Shahouzehi, B., Joukar, S., & Iranpoor, M. (2012). Effect of Quercus infectoria and Rosa damascena on lipid profile and atherosclerotic plaque formation in rabbit model of hyperlipidemia. Pakistan Journal of Biological Sciences, 15(1), 27-33. https://doi.org/10.3923/pjbs.2012.27.33 · DOI
  32. Gholap, S., & Kar, A. (2003). Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 58(6), 413-415.
  33. Giannuzzo, A.N., Boggetti, H.J., Nazareno, M.A., & Mishima, H.T. (2003). Supercritical fluid extraction of naringin from the peel of Citrus paradisi. Phytochemical Analysis, 14(4), 221-223. · DOI
  34. Guaadaoui, A., Benaicha, S., Elmajdoub, N., Bellaoui, M., & Hamal, A. (2014). What is a bioactive compound? A combined definition for a preliminary consensus. International Journal of Nutrition and Food Sciences, 3(3), 174 179. https://doi.org/10.11648/j.ijnfs.20140303.16 · DOI
  35. Gülçin, İ., Mshvildadze, V., Gepdiremen, A., & Elias, R. (2004). Antioxidant activity of saponins isolated from ivy: α-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta medica, 70(06), 561-563. https://doi.org/10.1055/s-2004-827158 · DOI
  36. Hegde, P.K., Rao, H.A., & Rao, P.N. (2014). A review on Insulin plant (Costus igneus Nak). Pharmacognosy Reviews, 8(15), 67. https://doi.org/10.4103%2F0973-7847.125536 · DOI
  37. Hemmami, H., Ben Seghir, B., Ben Ali, M., Rebiai, A., Zeghoud, S., & Brahmia, F. (2020). Phenolic profile and antioxidant activity of bee pollen extracts from different regions of Algeria. Ovidius Univ. Ann. Chem, 31, 93-98. https://doi.org/10.2478/auoc-2020-0017 · DOI
  38. Hemmami, H., Seghir, B.B., Rebiai, A., Khelef, A., & Soumeia, Z. (2020). Comparative Study on Polyphenols Content and Antioxid ant Activity of Three Sweet Peppers Varieties (Capsicum annuum L.). Current Chemical Biology, 14(4), 250-261. https://doi.org/10.2174/2212796814999200907162105 · DOI
  39. Hernández, Y., Lobo, M.G., & González, M. (2009). Factors affecting sample extraction in the liquid chromatographic determination of organic acids in papaya and pineapple. Food Chemistry, 114(2), 734-741. https://doi.org/10.1016/j.foodchem.2008.10.021 · DOI
  40. Herrera, M., & De Castro, M.L. (2005). Ultrasound-assisted extraction of phenolic compounds from strawberries prior to liquid chromatographic separation and photodiode array ultraviolet detection. Journal of Chromatography A, 1100(1), 1 7. https://doi.org/10.1016/j.chroma.2005.09.021 · DOI
  41. Herrera, M., & Luque de Castro, M. (2004). Ultrasound-assisted extraction for the analysis of phenolic compounds in strawberries. Analytical and Bioanalytical Chemistry, 379(7), 1106-1112. https://doi.org/10.1007/s00216-004-2684-0 · DOI
  42. Hewavitharana, G.G., Perera, D.N., Navaratne, S., & Wickramasinghe, I. (2020). Extraction methods of fat from food samples and preparation of fatty acid methyl esters for gas chromatography: A review. Arabian Journal of Chemistry, 13(8), 6865-6875. https://doi.org/10.1016/j.arabjc.2020.06.039 · DOI
  43. Howard, L., & Pandjaitan, N. (2008). Pressurized liquid extraction of flavonoids from spinach. Journal of Food Science, 73(3), C151-C157. https://doi.org/10.1111/j.1750-3841.2007.00658.x · DOI
  44. Howes, M.J.R., Perry, N.S., & Houghton, P.J. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(1), 1-18. https://doi.org/10.1002/ptr.1280 · DOI
  45. Huie, C.W. (2002). A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Analytical and Bioanalytical Chemistry, 373(1), 23-30. https://doi.org/10.1007/s00216-002-1265-3 · DOI
  46. Ibañez, E., Herrero, M., Mendiola, J.A., & Castro-Puyana, M. (2012). Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates. In: Hayes, M. (eds) Marine Bioactive Compounds. Springer. https://doi.org/10.1007/978-1-4614-1247-2_2 · DOI
  47. Iqbal, J., Abbasi, B.A., Mahmood, T., Kanwal, S., Ali, B., Shah, S.A., & Khalil, A.T. (2017). Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine, 7(12), 1129-1150. https://doi.org/10.1016/j.apjtb.2017.10.016 · DOI
  48. Jamshidi, N., & Cohen, M.M. (2017). The clinical efficacy and safety of Tulsi in humans: a systematic review of the literature. Evidence-Based Complementary and Alternative Medicine, 2017. https://doi.org/10.1155/2017/9217567 · DOI
  49. Jha, A.K., & Sit, N. (2022). Extraction of bioactive compounds from plant materials using combination of various novel methods: A review. Trends in Food Science & Technology, 119, 579-591. https://doi.org/10.1016/j.tifs.2021.11.019 · DOI
  50. Jila, A., Bernd, O., & Mohsen, M. (2011). Extraction of bioactive chemical compounds from the medicinal Asian plants by microwave irradiation. Journal of Medicinal Plants Research, 5(4), 495-506.
  51. Khennouf, S., Benabdallah, H., Gharzouli, K., Amira, S., Ito, H., Kim, T.-H., . . . Gharzouli, A. (2003). Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice. Journal of Agricultural and Food Chemistry, 51(5), 1469-1473. https://doi.org/10.1021/jf020808y · DOI
  52. Kumar, A., Sreedharan, S., Kashyap, A.K., Singh, P., & Ramchiary, N. (2021). A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.). Heliyon, e08669. https://doi.org/10.1016/j.heliyon.2021.e08669 · DOI
  53. Kumar, B.S., Swamy, B.V., Archana, S., & Anitha, M. (2010). A review on natural diuretics. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(4), 615-634.
  54. Lakkakula, N.R., Lima, M., & Walker, T. (2004). Rice bran stabilization and rice bran oil extraction using ohmic heating. Bioresource Technology, 92(2), 157-161. https://doi.org/10.1016/j.biortech.2003.08.010 · DOI
  55. Landbo, A.-K., & Meyer, A.S. (2001). Enzyme-assisted extraction of antioxidative phenols from black currant juice press residues (Ribes nigrum). Journal of Agricultural and Food Chemistry, 49(7), 3169-3177. https://doi.org/10.1021/jf001443p · DOI
  56. Latif, S., & Anwar, F. (2009). Physicochemical studies of hemp (Cannabis sativa) seed oil using enzyme‐assisted cold‐pressing. European Journal of Lipid Science and Technology, 111(10), 1042-1048. https://doi.org/10.1002/ejlt.200900008 · DOI
  57. Lee, J., Cho, J.-Y., & Kim, W.-K. (2014). Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutrition Research and Practice, 8(3), 284-291. https://doi.org/10.4162/nrp.2014.8.3.284 · DOI
  58. Li, B., Smith, B., & Hossain, M.M. (2006). Extraction of phenolics from citrus peels: II. Enzyme-assisted extraction method. Separation and Purification Technology, 48(2), 189-196. https://doi.org/10.1016/j.seppur.2005.07.019 · DOI
  59. Li, H., Chen, B., & Yao, S. (2005). Application of ultrasonic technique for extracting chlorogenic acid from Eucommia ulmodies Oliv.(E. ulmodies). Ultrasonics Sonochemistry, 12(4), 295-300. https://doi.org/10.1016/j.ultsonch.2004.01.033 · DOI
  60. Liu, D., Zhen, W., Yang, Z., Carter, J.D., Si, H., & Reynolds, K.A. (2006). Genistein acutely stimulates insulin secretion in pancreatic β-cells through a cAMP-dependent protein kinase pathway. Diabetes, 55(4), 1043-1050. https://doi.org/10.2337/diabetes.55.04.06.db05-1089 · DOI
  61. Liu, J., Li, Y., Shi, H., Wang, T., Wu, X., Sun, X., & Yu, L.L. (2016). Components characterization of total tetraploid jiaogulan (Gynostemma pentaphyllum) saponin and its cholesterol-lowering properties. Journal of Functional Foods, 23, 542-555. https://doi.org/10.1016/j.jff.2016.03.013 · DOI
  62. Liu, S., Gallo, D.J., Green, A.M., Williams, D.L., Gong, X., Shapiro, R.A., . . . Billiar, T.R. (2002). Role of toll-like receptors in changes in gene expression and NF-κB activation in mouse hepatocytes stimulated with lipopolysaccharide. Infection and Immunity, 70(7), 3433-3442. https://doi.org/10.1128/iai.70.7.3433-3442.2002 · DOI · Paper page
  63. Łubek-Nguyen, A., Ziemichód, W., & Olech, M. (2022). Application of Enzyme-Assisted Extraction for the Recovery of Natural Bioactive Compounds for Nutraceutical and Pharmaceutical Applications. Applied Sciences, 12(7), 3232. https://doi.org/10.3390/app12073232 · DOI
  64. Luthria, D.L. (2008). Influence of experimental conditions on the extraction of phenolic compounds from parsley (Petroselinum crispum) flakes using a pressurized liquid extractor. Food Chemistry, 107(2), 745-752. https://doi.org/10.1016/j.foodchem.2007.08.074 · DOI
  65. Lyons, G., Carmichael, E., McRoberts, C., Aubry, A., Thomson, A., & Reynolds, C.K. (2018). Prediction of Lignin Content in Ruminant Diets and Fecal Samples Using Rapid Analytical Techniques. Journal of Agricultural and Food Chemistry, 66(49), 13031-13040. https://doi.org/10.1021/acs.jafc.8b03808 · DOI
  66. Mallikharjuna, P., Rajanna, L., Seetharam, Y., & Sharanabasappa, G. (2007). Phytochemical studies of Strychnos potatorum Lf-A medicinal plant. E-journal of Chemistry, 4(4), 510-518. https://doi.org/10.1155/2007/687859 · DOI
  67. Manthey, J.A., & Guthrie, N. (2002). Antiproliferative activities of citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50(21), 5837-5843. https://doi.org/10.1021/jf020121d · DOI
  68. Martins, P.M., Lanchote, A.D., Thorat, B.N., & Freitas, L.A. (2017). Turbo-extraction of glycosides from Stevia rebaudiana using a fractional factorial design. Revista Brasileira de Farmacognosia, 27, 510-518. https://doi.org/10.1016/j.bjp.2017.02.007 · DOI
  69. Medina‐Remón, A., Casas, R., Tressserra‐Rimbau, A., Ros, E., Martínez‐González, M.A., Fitó, M., . . . Estruch, R. (2017). Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. British Journal of Clinical Pharmacology, 83(1), 114 128. https://doi.org/10.1111/bcp.12986 · DOI
  70. Meini, M.-R., Cabezudo, I., Boschetti, C.E., & Romanini, D. (2019). Recovery of phenolic antioxidants from Syrah grape pomace through the optimization of an enzymatic extraction process. Food Chemistry, 283, 257-264. https://doi.org/10.1016/j.foodchem.2019.01.037 · DOI
  71. Meyers, C.D., Kamanna, V. S., & Kashyap, M. L. (2004). Niacin therapy in atherosclerosis. Current Opinion in Lipidology, 15(6), 659-665. · DOI
  72. Moldoveanu, S.C., & David, V. (2002). Sample preparation in chromatography. Elsevier. · DOI
  73. Mroczek, T., & Mazurek, J. (2009). Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids. Analytica Chimica Acta, 633(2), 188-196. https://doi.org/10.1016/j.aca.2008.11.053 · DOI
  74. Mukherjee, S., & Patra, C. R. (2016). Therapeutic application of anti-angiogenic nanomaterials in cancers. Nanoscale, 8(25), 12444-12470. https://doi.org/10.1039/C5NR07887C · DOI
  75. Niranjan, K., & Hanmoungjai, P. (2004). Enzyme-aided aquous extraction. In book: Nutritionally Enhanced Edible Oil Processing. AOCS Publishing. http://dx.doi.org/10.1201/9781439822272.ch5 · DOI
  76. Nitiéma, M., Ilboudo, S., Belemnaba, L., Ouédraogo, G., Ouédraogo, S., Ouédraogo, N., . . . Guissou, I. (2018). Acute and sub-acute toxicity studies of aqueous decoction of the trunk barks from Lannea microcarpa Engl. and K. Krause (anacardiaceae) in rodents. World Journal of Pharmacy and Pharmaceutical Sciences, 7(9), 30 42. http://dx.doi.org/10.20959/wjpps20189-12185 · DOI
  77. Palma, M., & Barroso, C. G. (2002). Ultrasound-assisted extraction and determination of tartaric and malic acids from grapes and winemaking by-products. Analytica Chimica Acta, 458(1), 119-130. https://doi.org/10.1016/S0003-2670(01)01527-6 · DOI
  78. Pan, X., Niu, G., & Liu, H. (2003). Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves. Chemical Engineering and Processing: Process Intensification, 42(2), 129-133. https://doi.org/10.1016/S0255-2701(02)00037-5 · DOI
  79. Pandey, G., & Madhuri, S. (2010). Pharmacological activities of Ocimum sanctum (tulsi): a review. Int J Pharm Sci Rev Res, 5(1), 61-66.
  80. Patel, D., Kumar, R., Prasad, S., Sairam, K., & Hemalatha, S. (2011). Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin–induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 1(4), 316-322. https://doi.org/10.1016/S2221-1691(11)60051-8 · DOI
  81. Prakash, P., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian Journal of Physiology and Pharmacology, 49(2), 125.
  82. Puri, H.S. (2002). Rasayana: Ayurvedic herbs for longevity and rejuvenation. CRC press. · DOI
  83. Puri, M., Sharma, D., & Barrow, C.J. (2012). Enzyme-assisted extraction of bioactives from plants. Trends in biotechnology, 30(1), 37-44. https://doi.org/10.1016/j.tibtech.2011.06.014 · DOI
  84. Rostagno, M.A., Palma, M., & Barroso, C.G. (2003). Ultrasound-assisted extraction of soy isoflavones. Journal of Chromatography A, 1012(2), 119 128. https://doi.org/10.1016/S0021-9673(03)01184-1 · DOI · Paper page
  85. Sarkar, A., Bhattacharjee, S., & Mandal, D.P. (2015). Induction of apoptosis by eugenol and capsaicin in human gastric cancer AGS cells-elucidating the role of p53. Asian Pacific Journal of Cancer Prevention, 16(15), 6753-6759. · DOI
  86. Sasidharan, S., Chen, Y., Saravanan, D., Sundram, K., & Latha, L.Y. (2011). Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African Journal of Traditional, Complementary and Alternative Medicines, 8(1), 1 10. https://doi.org/10.4314/ajtcam.v8i1.60483 · DOI
  87. Sharma, A., Khare, S., & Gupta, M. (2002). Enzyme‐assisted aqueous extraction of peanut oil. Journal of the American Oil Chemists' Society, 79(3), 215 218. https://doi.org/10.1007/s11746-002-0463-0 · DOI
  88. Shen, J., & Shao, X. (2005). A comparison of accelerated solvent extraction, Soxhlet extraction, and ultrasonic-assisted extraction for analysis of terpenoids and sterols in tobacco. Analytical and Bioanalytical Chemistry, 383(6), 1003-1008. https://doi.org/10.1007/s00216-005-0078-6 · DOI
  89. Shiny, C., Saxena, A., & Gupta, S.P. (2013). Phytochemical investigation of the insulin plant “Costus pictus” D. Don. Int J Pharm Biomed Res, 4(2), 97-104.
  90. Shrinet, K., Singh, R.K., Chaurasia, A.K., Tripathi, A., & Kumar, A. (2021). Bioactive compounds and their future therapeutic applications Natural Bioactive Compounds (pp. 337-362). Elsevier. https://doi.org/10.1016/B978-0-12-820655-3.00017-3 · DOI · Paper page
  91. Smith, R.M. (2003). Before the injection—modern methods of sample preparation for separation techniques. Journal of Chromatography A, 1000(1 2), 3 27. https://doi.org/10.1016/S0021-9673(03)00511-9 · DOI · Paper page
  92. Sohgaura, A., Bigoniya, P., & Shrivastava, B. (2018). Diuretic potential of Cynodon dactylon, Emblica officinalis, Kalanchoe pinnata and Bambusa nutans. Journal of Pharmacognosy and Phytochemistry, 7(3), 2895-2900.
  93. Sy, G., Cissé, A., Nongonierma, R., Sarr, M., Mbodj, N., & Faye, B. (2005). Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats. Journal of Ethnopharmacology, 98(1-2), 171-175. https://doi.org/10.1016/j.jep.2005.01.024 · DOI
  94. Teng, H., Ghafoor, K., & Choi, Y.H. (2009). Optimization of microwave-assisted extraction of active components from Chinese quince using response surface methodology. Journal of the Korean Society for Applied Biological Chemistry, 52(6), 694 701. https://doi.org/10.3839/jksabc.2009.115 · DOI
  95. Toepfl, S., Mathys, A., Heinz, V., & Knorr, D. (2006). Potential of high hydrostatic pressure and pulsed electric fields for energy efficient and environmentally friendly food processing. Food Reviews International, 22(4), 405-423. https://doi.org/10.1080/87559120600865164 · DOI
  96. Triveni, K., Lakshmi, V., Shashidhara, S., & Anitha, S. (2012). Gymnema Sylvestre: a comprehensive review. Pharma Science Monitor, 3(4).
  97. Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., & Dinev, T. (2020). Selectivity of current extraction techniques for flavonoids from plant materials. Processes, 8(10), 1222. https://doi.org/10.3390/pr8101222 · DOI
  98. Uwineza, P.A., & Waśkiewicz, A. (2020). Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials. Molecules, 25(17), 3847. https://doi.org/10.3390/molecules25173847 · DOI · Paper page
  99. Vaidya, S. (2011). Review on gymnema: an herbal medicine for diabetes management. Pharmacia, 1(2), 37-42.
  100. Verma, A., Hartonen, K., & Riekkola, M.L. (2008). Optimisation of supercritical fluid extraction of indole alkaloids from Catharanthus roseus using experimental design methodology-comparison with other extraction techniques. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 19(1), 52-63. https://doi.org/10.1002/pca.1015 · DOI
  101. Vinatoru, M. (2001). An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrasonics Sonochemistry, 8(3), 303 313. https://doi.org/10.1016/S1350-4177(01)00071-2 · DOI
  102. Wani, M., Sarvar, F.A., Agrawal, J., Deshpande, J., Mathew, S., & Khetmalas, M. (2012). Qualitative phytochemical analysis and antimicrobial activity studies of Gymnema sylvestre R. Br. Acta Biologica Indica, 1(1), 121-124.
  103. Weaver, B.A. (2014). How Taxol/paclitaxel kills cancer cells. Molecular biology of the cell, 25(18), 2677-2681. https://doi.org/10.1091/mbc.e14-04-0916 · DOI
  104. Yang, Y., & Zhang, F. (2008). Ultrasound-assisted extraction of rutin and quercetin from Euonymus alatus (Thunb.) Sieb. Ultrasonics Sonochemistry, 15(4), 308-313. https://doi.org/10.1016/j.ultsonch.2007.05.001 · DOI
  105. Zeghoud, S., Seghir, B.B., Kouadri, I., Hemmami, H., Amor, I.B., Tliba, A., . . . Rebiai, A. (2023). Classification of plants medicine species from Algerian regions using UV spectroscopy, HPLC chromatography, and chemometrics analysis. Malaysian Journal of Chemistry, 25(1), 126-142. · DOI
  106. Zghaibi, N., Omar, R., Mustapa Kamal, S.M., Awang Biak, D.R., & Harun, R. (2019). Microwave-assisted brine extraction for enhancement of the quantity and quality of lipid production from microalgae Nannochloropsis sp. Molecules, 24(19), 3581. https://doi.org/10.3390/molecules24193581 · DOI
  107. Zhang, Q.-W., Lin, L.-G., & Ye, W.-C. (2018). Techniques for extraction and isolation of natural products: A comprehensive review. Chinese Medicine, 13(1), 1-26. https://doi.org/10.1186/s13020-018-0177-x · DOI · Paper page

Cited by

Sorted by citations

See all 51

Metadata

Authors
GHENABZİA, I., HEMMAMİ, H., BEN AMOR, I., ZEGHOUD, S., BEN SEGHİR, B., & HAMMOUDİ, R.
Affiliations
  • University of Sciences and Technology Houari Boumediene (DZ)
  • University of El Oued
  • University of Eloued (DZ)
  • University of Ouargla (DZ)
ORCID
Venue
International Journal of Secondary Metabolite
Publisher
International Journal of Secondary Metabolite
Published
2023-12-01
Volume
10
Issue
4
Pages
469-494
ISSN
2148-6905 (ISSN-L)
DOI
10.21448/ijsm.1225936
OpenAlex
W4388235100
Cited by
51
References
6
Citations by year
2026: 23 · 2025: 23 · 2024: 5
FWCI
7.36
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Secondary Metabolite (publishedVersion, cc-by)
  • DergiPark (Istanbul University) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
Keywords
extraction methods, bioactive compounds, medicinal plants, plant secondary metabolites, extraction mechanism, extraction efficiency

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Different methods of extraction of bioactive compounds and their effect on biological activity: A review. https://app.cochat.ai/papers/10.21448/ijsm.1225936
The paper
GHENABZİA, I., HEMMAMİ, H., BEN AMOR, I., ZEGHOUD, S., BEN SEGHİR, B., & HAMMOUDİ, R. (2023). Different methods of extraction of bioactive compounds and their effect on biological activity: A review. International Journal of Secondary Metabolite. https://doi.org/10.21448/ijsm.1225936