Existing data sources for clinical epidemiology: The Danish Study Group of Infections of the Brain Database (DASGIB)
Open accessAbstract
Central nervous system (CNS) infections are rare diseases that are associated with considerable morbidity and mortality. Increased knowledge based on contemporary data is a prerequisite for improved management and prevention of these serious conditions. Yet, population-based databases of patients hospitalized with CNS infections remain scarce. The Danish Study Group of Infections of the Brain (DASGIB) has prospectively registered information on all adults ≥18 years of age admitted with CNS infections at departments of infectious diseases in Denmark since 2015. The main variables collected are baseline demographics, blood and cerebrospinal fluid tests, imaging results, and outcome using the Glasgow Outcome Scale score. To investigate important aspects for each type of CNS infections, additional variables are included specifically for bacterial meningitis, viral meningitis, encephalitis, brain abscess, neurosyphilis, and Lyme neuroborreliosis. From 2015 to 2020, a total of 3579 cases of CNS infections have been recorded in the DASGIB database. Using the unique civil registration number assigned to all Danish residents, the database can be unambiguously linked with nationwide healthcare registries at the individual level. This enables researchers to conduct detailed population-based and longitudinal observational studies of risk and prognosis of CNS infections and to compare them with matched population cohorts. The database is well-suited for epidemiological research and the DASGIB network forms a solid infrastructure for future national and international collaborations.
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The DASGIB database contains data on prospectively included episodes of CNS infections hospitalized at departments of infectious diseases in Denmark since 1 January 2015.
“The DASGIB database has previously been described and contains data on prospectively included episodes of CNS infections hospitalized at the departments of infectious diseases in Denmark since 1 January 2015.10”
From Clinical features and prognostic factors in adults with viral meningitis. (2023) · cites this paper as [10]
The completeness of the DASGIB database is ensured by annual searches of ICD-10 code of CNS infections or review of patients with CSF pleocytosis at local sites.
“the completeness of the DASGIB database is ensured by annual searches of ICD-10 code of CNS infections or review of patients with CSF pleocytosis at local sites,10”
From Clinical features and prognostic factors in adults with viral meningitis. (2023) · cites this paper as [10]
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Self-citationFlorescu, A. M., Bryrup, T., Larsen, C. S., Larsen, L., Wiese, L., Lüttichau, H. R., Jepsen, M. P. G., Hansen, B. R., Østergaard, C., Søndergaard, A., et al. (2025) · Journal of Neurology · doi:10.1007/s00415-025-12986-5 · Cited by 5 · see citing works
Self-citationEriksen, E. M., Larsen, L., Storgaard, M., Mens, H., Wiese, L., Jepsen, M. P. G., Hansen, B. R., Lüttichau, H. R., Nielsen, H. I., & Bodilsen, J. (2025) · Clinical Infectious Diseases · doi:10.1093/cid/ciaf304 · Cited by 5 · see citing works
Self-citationViral lumbosacral radiculitis (Elsberg syndrome) in Denmark
Petersen, P. T., Bodilsen, J., Jepsen, M. P. G., Larsen, L., Storgaard, M., Hansen, B. R., Lüttichau, H. R., Helweg‐Larsen, J., Wiese, L., Andersen, C. Ø., et al. (2023) · Infection · doi:10.1007/s15010-023-02113-9 · Cited by 5 · see citing works
Self-citationSensorineural hearing loss in Lyme neuroborreliosis
Jensen, E. S., Cayé‐Thomasen, P., Bodilsen, J., Hansen, B. R., Hovmand, N., Winther, R., Kirchmann, M., & Brandt, C. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2411014 · Cited by 5 · see citing works
Self-citationEncephalitis in travellers: a prospective multicentre study
Picard, L., Mailles, A., Fillâtre, P., Tattevin, P., Stahl, J. ‐., Abgrall, S., Argaud, L., Argemi, X., Asseray, N., Baille, G., et al. (2022) · Journal of Travel Medicine · doi:10.1093/jtm/taac145 · Cited by 5 · see citing works
Tenascin-C in patients with central nervous system infections
Zachariassen, M., Thomsen, M. M., Hillig, T., Petersen, P. T., Jensen, A. V., Friis-Hansen, L. J., & Brandt, C. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578373 · Cited by 3 · see citing works
Self-citationEriksen, E. M., Bijlsma, M. W., Olie, S. E., Larsen, L., Storgaard, M., Mens, H., Nielsen, H., Brouwer, M. C., Bodilsen, J., & the DASGIB study group (2025) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2025.2607395 · Cited by 2 · see citing works
Self-citationNielsen, H., Storgaard, M., Larsen, L., Hansen, B. R., Mens, H., Petersen, P. T., Tetens, M. M., Andersen, C. Ø., Jepsen, M. P. G., Lüttichau, H. R., et al. (2026) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2026.101628 · Cited by 2 · see citing works
Self-citationImishti, A., Nissen, M. J., Øvrehus, A. L. H., & Larsen, L. (2025) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2025.2463960 · Cited by 2 · see citing works
Self-citationEinfluss der COVID-19-Pandemie auf das Auftreten neuroinfektiologischer Erkrankungen
Völk, S., Ködel, U., Pfister, H., & Klein, M. (2022) · Der Nervenarzt · doi:10.1007/s00115-022-01420-0
Jespersen, F. V. B., Hansen, S. U.-B., Ostrowski, S. R., Nielsen, C. H., Omland, L. H., Jensen, S. S., & Markvart, M. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1547826
Chemych, M. D., Chemych, O. M., Saienko, O., Світайло, В. С., & Klymenko, N. (2025) · Інфекційні хвороби · doi:10.11603/1681-2727.2025.3.15596
Infectious encephalitis among adults: a prospective and population-based cohort study
Duerlund, L. S., Larsen, L., Storgaard, M., Mens, H., Wiese, L., Jepsen, M. P. G., Hansen, B. R., Lüttichau, H. R., Andersen, C. Ø., Blaabjerg, M., et al. (2026) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2026.04.002
Self-citationEarly vs late diagnosis in infectious encephalitis: a population-based cohort study
Duerlund, L. S., Larsen, L., Storgaard, M., Mens, H., Wiese, L., Jepsen, M. P. G., Hansen, B. R., Lüttichau, H. R., Andersen, C. Ø., Blaabjerg, M., et al. (2026) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2026.04.009
Self-citationDos, A. H., Florescu, A. M., Bryrup, T., Larsen, L., Storgaard, M., Wiese, L., Jepsen, M. P. G., Hansen, B. R., Lüttichau, H. R., Bodilsen, J., et al. (2026) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2026.102704
Self-citationOccurrence of Sensorineural Hearing Loss in Viral Meningitis and Encephalitis
Jensen, E. S., Jensen, A. V., Cayé‐Thomasen, P., Petersen, P. T., Hansen, B. R., Hovmand, N., Winther, R., Kjærsgaard, J. B., Kirchmann, M., Brandt, C., et al. (2026) · Journal of Medical Virology · doi:10.1002/jmv.71171
Self-citation
- Authors
- Bodilsen, J., Larsen, L., Brandt, C. T., Wiese, L., Hansen, B. R., Andersen, C. Ø., Lüttichau, H. R., Helweg-Larsen, J., Storgaard, M., & Nielsen, H.
- Affiliations
- Aalborg University Hospital (DK)
- Odense University Hospital (DK)
- Roskilde Sygehus (DK)
- Hvidovre Hospital (DK)
- Herlev Hospital (DK)
- Aarhus University Hospital (DK)
- Corresponding author
- Bodilsen, Jacob
- ORCID
- Venue
- Clinical Epidemiology
- Publisher
- Informa UK Limited
- Published
- 2021-10
- Volume
- Volume 13
- Pages
- 921-933
- ISSN
- 1179-1349 (ISSN-L)
- PMC
- PMC8500496
- OpenAlex
- W3201897616
- Cited by
- 33
- References
- 60
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 4 · 2021: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Epidemiology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by-nc)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- central nervous system infection, bacterial meningitis, viral meningitis, encephalitis, brain abscess, neurosyphilis, Lyme neuroborreliosis, cerebrospinal fluid analysis, Glasgow Outcome Scale, hospitalization outcomes
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