The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Skin models for the testing of transdermal drugs
Open accessAbstract
The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment is the in vivo human. However, this may not be possible for ethical, practical, or economic reasons, particularly in the early phases of development. It is thus necessary to find alternative methods using accessible and reproducible surrogates for in vivo human skin. A range of models has been developed, including ex vivo human skin, usually obtained from cadavers or plastic surgery patients, ex vivo animal skin, and artificial or reconstructed skin models. Increasingly, largely driven by regulatory authorities and industry, there is a focus on developing standardized techniques and protocols. With this comes the need to demonstrate that the surrogate models produce results that correlate with those from in vivo human studies and that they can be used to show bioequivalence of different topical products. This review discusses the alternative skin models that have been developed as surrogates for normal and diseased skin and examines the concepts of using model systems for in vitro-in vivo correlation and the demonstration of bioequivalence.
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Cites
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“Using combination therapies, Vörsmann et al 118 showed significant advantages in using their 3-”
Animal models of skin disease for drug discovery
Avci, P., Sadasivam, M., Gupta, A., De Melo, W. C., Huang, Y.-Y., Yin, R., Chandran, R., Kumar, R., Otufowora, A., Nyame, T., et al. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.761202 · Cited by 130 · cited 2×
“106 An overview of animal models for a wide range of skin conditions, with an emphasis on their application to drug discovery, has been published by Avci et al. 107 Of particular interest are the chimeric models, in which living human skin is grafted on to the skin of severe combined immunodeficient (SCID) mice.”
BARBER, E. (1992) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(92)90086-w · Cited by 119
An organotypic model of skin to study photodamage and photoprotection in vitro
Bernerd, F., & Asselineau, D. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.08.050 · Cited by 86
Cited by
Mechanisms of sampling interstitial fluid from skin using a microneedle patch
Samant, P. P., & Prausnitz, M. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716772115 · Cited by 363
Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities
Neupane, R., Boddu, S. H. S., Renukuntla, J., Babu, R. J., & Tiwari, A. K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020152 · Cited by 351
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
You, Y., Tian, Y., Yang, Z., Shi, J., Kwak, K. J., Tong, Y., Estania, A. P., Cao, J., Hsu, W.-H., Liu, Y., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00989-w · Cited by 258
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202
Human skin models: From healthy to disease-mimetic systems; characteristics and applications
Moniz, T., Costa Lima, S. A., & Reis, S. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15184 · Cited by 80
Metadata
- Authors
- Abd, E., Yousuf, S., Pastore, M., Telaprolu, K., Mohammed, Y., Namjoshi, S., Grice, J., & Roberts, M.
- Venue
- Clinical Pharmacology: Advances and Applications
- Publisher
- Informa UK Limited
- Published
- 2016-10
- Volume
- Volume 8
- Pages
- 163-176
- ISSN
- 1179-1438 (ISSN-L)
- OpenAlex
- W2532874665
- Cited by
- 413
- References
- 6
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Abd, E., Yousuf, S., Pastore, M., Telaprolu, K., Mohammed, Y., Namjoshi, S., Grice, J., & Roberts, M. (2016). Skin models for the testing of transdermal drugs. Clinical Pharmacology: Advances and Applications. https://doi.org/10.2147/cpaa.s64788
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
