Human skin models: From healthy to disease-mimetic systems; characteristics and applications

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

Rheinwatd, J. G., & Green, H. (1975) · Cell · doi:10.1016/s0092-8674(75)80001-8 · Cited by 4,528 · see citing works

Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Kansy, M., Senner, F., & Gubernator, K. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm970530e · Cited by 1,304 · see citing works

Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

Alkilani, A. Z., McCrudden, M., & Donnelly, R. F. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7040438 · Cited by 1,157 · see citing works

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes

Rheinwald, J. G., & Green, H. (1977) · Nature · doi:10.1038/265421a0 · Cited by 1,067 · see citing works

Preparation of Isolated Sheets of Human Stratum Corneum

Kligman, A. M. (1963) · Archives of Dermatology · doi:10.1001/archderm.1963.01590240026005 · Cited by 776 · see citing works

Design and Fabrication of Human Skin by Three-Dimensional Bioprinting

Lee, V., Singh, G., Trasatti, J. P., Bjornsson, C. S., Xu, X., Tran, T. N., Yoo, S., Dai, G., & Karande, P. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0335 · Cited by 728 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14748 · Cited by 704 · see citing works

Skin tissue generation by laser cell printing

Koch, L., Deiwick, A., Schlie, S., Michael, S., Gruene, M., Coger, V., Zychlinski, D., Schambach, A., Reimers, K., Vogt, P. M., et al. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24455 · Cited by 611 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 605 · see citing works

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

Szabowski, A., Maas‐Szabowski, N., Andrecht, S., Kolbus, A., Schorpp‐Kistner, M., Fusenig, N. E., & Angel, P. E. (2000) · Cell · doi:10.1016/s0092-8674(00)00178-1 · Cited by 423 · see citing works

Skin models for the testing of transdermal drugs

Abd, E., Yousuf, S. A., Pastore, M. N., Telaprolu, K. C., Mohammed, Y., Namjoshi, S., Grice, J. E., & Roberts, M. S. (2016) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s64788 · Cited by 418 · see citing works

Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions

Vestergaard, C., Yoneyama, H., Murai, M., Nakamura, K., Tamaki, K., Terashima, Y., Imai, T., Yoshie, O., Irimura, T., Mizutani, H., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7613 · Cited by 406 · see citing works

Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics

Chen, Y., Wu, Q., Zhang, Z., Yuan, L., Liu, X., & Zhou, L. (2012) · Molecules · doi:10.3390/molecules17055972 · Cited by 316 · see citing works

An Update of the Defensive Barrier Function of Skin

Lee, S. H., Jeong, S. K., & Ahn, S. K. (2006) · Yonsei Medical Journal · doi:10.3349/ymj.2006.47.3.293 · Cited by 277 · see citing works

Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes

Rheinwald, J. G. (1980) · Methods in cell biology · doi:10.1016/s0091-679x(08)60769-4 · Cited by 266 · see citing works

Full-thickness human skin-on-chip with enhanced epidermal morphogenesis and barrier function

Sriram, G., Alberti, M., Dancik, Y., Wu, B., Wu, R., Feng, Z., Ramasamy, S., Bigliardi, P. L., Bigliardi‐Qi, M., & Wang, Z. (2017) · Materials Today · doi:10.1016/j.mattod.2017.11.002 · Cited by 258 · see citing works

Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid

Junyaprasert, V. B., Singhsa, P., Suksiriworapong, J., & Chantasart, D. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.11.032 · Cited by 257 · see citing works

The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

Schäfer‐Korting, M., Bock, U., Diembeck, W., Düsing, H., Gamer, A. O., Haltner‐Ukomadu, E., Hoffmann, C., Kaca, M., Kamp, H., Kersen, S., et al. (2008) · Alternatives to Laboratory Animals · doi:10.1177/026119290803600207 · Cited by 239 · see citing works

Strat-M® synthetic membrane: Permeability comparison to human cadaver skin

Haq, A., Goodyear, B., Ameen, D., Joshi, V., & Michniak-Kohn, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.012 · Cited by 231 · see citing works

IFATS Collection: Using Human Adipose-Derived Stem/Stromal Cells for the Production of New Skin Substitutes

Trottier, V., Marceau-Fortier, G., Germain, L., Vincent, C., & Fradette, J. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0031 · Cited by 231 · see citing works

Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application

Yu, J. R., Navarro, J., Coburn, J., Mahadik, B. P., Molnar, J. A., Holmes, J. H., Nam, A. J., & Fisher, J. P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801471 · Cited by 225 · see citing works

In vitro skin models as a tool in optimization of drug formulation.

Flaten, G., Palac, Z., Engesland, A., Filipović-Grčić, J., Vanić, Ž., & Škalko-Basnet, N. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.02.018 · Cited by 207 · see citing works

Parallel Artificial Membrane Permeability Assay: A New Membrane for the Fast Prediction of Passive Human Skin Permeability

Ottaviani, G., Martel, S., & Carrupt, P. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060230+ · Cited by 195 · see citing works

Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.

Groves, R. W., Mizutani, H., Kieffer, J. D., & Kupper, T. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11874 · Cited by 193 · see citing works

Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models

Randall, M. J., Jüngel, A., Rimann, M., & Wuertz‐Kozak, K. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00154 · Cited by 193 · see citing works

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors

Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14751 · Cited by 192 · see citing works

Bioprinting of biomimetic skin containing melanocytes

Min, D., Lee, W., Bae, I., Lee, T. R., Croce, P., & Yoo, S. (2017) · Experimental Dermatology · doi:10.1111/exd.13376 · Cited by 191 · see citing works

Skin–PAMPA: A new method for fast prediction of skin penetration

Sinkó, B., Garrigues, T., Balogh, G. T., Nagy, Z. K., Tsinman, O., Avdeef, A., & Takács‐Novák, K. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.01.011 · Cited by 187 · see citing works

RT-PCR detection of Candida albicans ALS gene expression in the reconstituted human epithelium (RHE) model of oral candidiasis and in model biofilms.

Green, C. B., Cheng, G., Chandra, J., Mukherjee, P., Ghannoum, M., & Hoyer, L. (2004) · Microbiology · doi:10.1099/mic.0.26699-0 · Cited by 183 · see citing works

Drug permeability across a phospholipid vesicle based barrier: A novel approach for studying passive diffusion

Flaten, G. E., Dhanikula, A. B., Luthman, K., & Brandl, M. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.007 · Cited by 180 · see citing works

IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

Chiricozzi, A., Nograles, K. E., Johnson-Huang, L. M., Fuentes‐Duculan, J., Cardinale, I. R., Bonifacio, K. M., Gulati, N., Mitsui, H., Guttman‐Yassky, E., Suárez‐Fariñas, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090284 · Cited by 180 · see citing works

Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing

Vörsmann, H., Groeber, F., Walles, H., Busch, S., Beissert, S., Walczak, H., & Kulms, D. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.249 · Cited by 168 · cited 2× · see citing works

Microemulsion formulations for the transdermal delivery of testosterone

Hathout, R. M., Woodman, T. J., Mansour, S., Mortada, N. D., Geneidi, A. S., & Guy, R. H. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.03.008 · Cited by 166 · see citing works

Nanocarriers for topical administration of resveratrol: A comparative study

Scognamiglio, I., Stefano, D. D., Campani, V., Mayol, L., Carnuccio, R., Fabbrocini, G., Ayala, F., Rotonda, M. I. L., & Rosa, G. D. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.009 · Cited by 154 · see citing works

Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin

Şenyiğit, T., Sonvico, F., Barbieri, S., Özer, Ö., Santi, P., & Colombo, P. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.013 · Cited by 152 · see citing works

Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation

Pendaries, V., Malaisse, J., Pellerin, L., Lamer, M. L., Nachat, R., Kežić, S., Schmitt, A.-M., Paul, C. F., Poumay, Y., Serre, G., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.259 · Cited by 143 · see citing works

Development and Validation of Human Psoriatic Skin Equivalents

Tjabringa, G. S., Bergers, M., van Rens, D., de Boer, R., Lamme, E. N., & Schalkwijk, J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080173 · Cited by 143 · see citing works

Nanoemulsions (NEs), liposomes (LPs) and solid lipid nanoparticles (SLNs) for retinyl palmitate: Effect on skin permeation

Clares, B., Calpena, A. C., Parra, A., Abrego, G., Alvarado, H. L., Fangueiro, J. F., & Souto, E. B. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.08.001 · Cited by 140 · see citing works

Models in the Research Process of Psoriasis

Bocheńska, K., Smolińska, E., Moskot, M., Jakóbkiewicz‐Banecka, J., & Gabig‐Cimińska, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122514 · Cited by 135 · see citing works

Flaky Tail Mouse Denotes Human Atopic Dermatitis in the Steady State and by Topical Application with Dermatophagoides pteronyssinus Extract

Moniaga, C. S., Egawa, G., Kawasaki, H., Hara‐Chikuma, M., Honda, T., Tanizaki, H., Nakajima, S., Otsuka, A., Matsuoka, H., Kubo, A., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090957 · Cited by 134 · see citing works

A comparison between in vitro rat and human and in vivo rat skin absorption studies

van Ravenzwaay, B., & Leibold, E. (2004) · Human & Experimental Toxicology · doi:10.1191/0960327104ht471oa · Cited by 128 · see citing works

Reconstructed epidermis versus human and animal skin in skin absorption studies.

Schreiber, S., Mahmoud, A. M., Vuia, A., Rübbelke, M., Schmidt, E., Schaller, M., Kandarova, H., Haberland, A., Schäfer, U., Bock, U., et al. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.04.004 · Cited by 119 · see citing works

Skin Deep: The Basics of Human Skin Structure and Drug Penetration

Ng, K. W., & Lau, W. M. (2015) · Springer eBooks · doi:10.1007/978-3-662-45013-0_1 · Cited by 118 · see citing works

Determination of the Effect of Lipophilicity on the in vitro Permeability and Tissue Reservoir Characteristics of Topically Applied Solutes in Human Skin Layers

Cross, S. E., Magnusson, B. M., Winckle, G., Anissimov, Y. G., & Roberts, M. S. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12131.x · Cited by 118 · see citing works

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Li, L., Fukunaga‐Kalabis, M., & Herlyn, M. (2011) · Journal of Visualized Experiments · doi:10.3791/2937 · Cited by 116 · see citing works

Transferosomal gel for transdermal delivery of risperidone: Formulation optimization and ex vivo permeation

Das, B., Sen, S. O., Maji, R., Nayak, A. K., & Sen, K. K. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.01.006 · Cited by 116 · see citing works

Determination of in vitro drug release from hydrocortisone creams

Shah, V. P., Elkins, J. S., Lam, S.-Y., & Skelly, J. P. (1989) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(89)90361-x · Cited by 115 · see citing works

Psoriasis-Like Cutaneous Inflammation in Mice Lacking Interleukin-1 Receptor Antagonist

Shepherd, J., Little, M. C., & Nicklin, M. J. H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22305.x · Cited by 115 · see citing works

Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing

Salton, M., Kasprzak, W. K., Voss, T. C., Shapiro, B. A., Poulikakos, P. I., & Misteli, T. (2015) · Nature Communications · doi:10.1038/ncomms8103 · Cited by 107 · see citing works

Skin Tissue Engineering: Application of Adipose-Derived Stem Cells

Klar, A. S., Zimoch, J., & Biedermann, T. (2017) · BioMed Research International · doi:10.1155/2017/9747010 · Cited by 107 · see citing works

A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model

Ma, Y., Kurtyka, C. A., Boyapalle, S., Sung, S., Lawrence, H. R., Guida, W. C., & Cress, W. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0121 · Cited by 106 · see citing works

Next generation human skin constructs as advanced tools for drug development

Abaci, H., Guo, Z., Doucet, Y., Jacków, J., & Christiano, A. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217712690 · Cited by 104 · see citing works

Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

Elias, P. M., Arbiser, J. L., Brown, B. E., Rossiter, H., Man, M., Cerimele, F., Crumrine, D. A., Gunathilake, R., Choi, E. H., Uchida, Y., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080088 · Cited by 102 · see citing works

Calcipotriol delivery into the skin with PEGylated liposomes

Knudsen, N. Ø., Rønholt, S., Salte, R. D., Jørgensen, L., Thormann, T., Basse, L. H., Hansen, J., Frøkjær, S., & Foged, C. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.04.005 · Cited by 99 · see citing works

Newborn pig skin as model membrane in in vitro drug permeation studies: A technical note

Cilurzo, F., Minghetti, P., & Sinico, C. (2007) · AAPS PharmSciTech · doi:10.1208/pt0804094 · Cited by 89 · see citing works

Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations

Gele, M. V., Geusens, B., Brochez, L., Speeckaert, R., & Lambert, J. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.568937 · Cited by 88 · see citing works

Topical delivery of cosmetics and drugs. Molecular aspects of percutaneous absorption and delivery

Förster, M., Bolzinger, M., Fessi, H., & Briançon, S. (2009) · European Journal of Dermatology · doi:10.1684/ejd.2009.0676 · Cited by 87 · see citing works

A new reconstructed human epidermis for in vitro skin irritation testing

Pedrosa, T. D. N., Catarino, C. M., Pennacchi, P. C., de Assis, S. R., Gimenes, F., Consolaro, M. E. L., Barros, S. B. D. M., & Maria–Engler, S. S. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.03.010 · Cited by 85 · see citing works

Assessing vehicle effects on skin absorption using artificial membrane assays

Karadzovska, D., & Riviere, J. E. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.02.020 · Cited by 79 · see citing works

In vitro cultured human skin cells as alternatives to animals for skin irritancy screening

Ponec, M. (1992) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.1992.tb00058.x · Cited by 79 · see citing works

Application of standard cell cultures and 3D in vitro tissue models as an effective tool in drug design and development

Amelian, A., Wasilewska, K., Megı́as, D., & Winnicka, K. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.03.014 · Cited by 76 · see citing works

Drug permeability across a phospholipid vesicle-based barrier

Flaten, G. E., Bunjes, H., Luthman, K., & Brandl, M. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.03.008 · Cited by 75 · see citing works

Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties

Wu, H., Deng, Z., Zhou, B.-J., Qi, M., Hong, M., & Ren, G. (2019) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2019.03.046 · Cited by 75 · see citing works

Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis – Xenograft model

Kundu‐Raychaudhuri, S., Chen, Y., Wulff, H., & Raychaudhuri, S. P. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.07.003 · Cited by 74 · see citing works

Production of human tissue-engineered skin trilayer on a plasma-based hypodermis

Monfort, A., Soriano‐Navarro, M., García‐Verdugo, J. M., & Izeta, A. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.548 · Cited by 74 · see citing works

Antifungal Activity of Ellagic Acid In Vitro and In Vivo

Li, Z., Guo, X., Dawuti, G., & Aibai, S. (2015) · Phytotherapy Research · doi:10.1002/ptr.5340 · Cited by 72 · see citing works

Secreted subtilisin Sub3 from Microsporum canis is required for adherence to but not for invasion of the epidermis

Baldo, A., Mathy, A., Tabart, J., Camponova, P., Vermout, S., Massart, L., Maréchal, F., Galleni, M., & Mignon, B. R. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09608.x · Cited by 72 · see citing works

Alpha tocopherol loaded chitosan oleate nanoemulsions for wound healing. Evaluation on cell lines and ex vivo human biopsies, and stabilization in spray dried Trojan microparticles

Bonferoni, M. C., Riva, F., Invernizzi, A., Dellera, E., Sandri, G., Rossi, S., Marrubini, G., Bruni, G., Vigani, B., Caramella, C., et al. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.11.008 · Cited by 72 · see citing works

Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments.

Netzlaff, F., Schaefer, U. F., Lehr, C., Meiers, P., Stahl, J., Kietzmann, M., & Niedorf, F. (2006) · PubMed · Cited by 69 · see citing works

Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

Tang, T., Tang, J. Y., Li, D., Reich, M., Callahan, C. A., Fu, L., Yauch, R. L., Wang, F., Kotkow, K. J., Chang, K. S., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3370 · Cited by 68 · see citing works

Two New Mutations in Linkage Group XVI of the House Mouse

LANE, P. W. (1972) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108252 · Cited by 67 · see citing works

Preparation of Model Membranes for Skin Permeability Studies Using Stratum Corneum Lipids

Abraham, W. H., & Downing, D. T. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12284431 · Cited by 66 · see citing works

Hallmarks of Atopic Skin Mimicked In Vitro by Means of a Skin Disease Model Based on FLG Knock-down

Küchler, S., Henkes, D., Eckl, K., Ackermann, K., Plendl, J., Korting, H.-C., Hennies, H.-C., & Schäfer‐Korting, M. (2011) · Alternatives to Laboratory Animals · doi:10.1177/026119291103900508 · Cited by 65 · see citing works

Current advances in skin-on-a-chip models for drug testing

Zhang, Q., Sito, L., Mao, M., He, J., Zhang, Y. S., & Zhao, X. (2018) · Microphysiological Systems · doi:10.21037/mps.2018.08.01 · Cited by 63 · see citing works

Artificial skin models for animal-free testing

Yun, Y. E., Jung, Y. J., Choi, Y. J., Choi, J. S., & Cho, Y. W. (2018) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-018-0389-1 · Cited by 62 · see citing works

Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma

Yue, L., Huang, Z., Fong, S., Leong, S. P. L., Jakowatz, J. G., Charruyer, A., Wei, M. L., & Ghadially, R. (2015) · Melanoma Research · doi:10.1097/cmr.0000000000000144 · Cited by 60 · see citing works

Forskolin protects keratinocytes from UVB-induced apoptosis and increases DNA repair independent of its effects on melanogenesis

Passeron, T., Namiki, T., Passeron, H. J., Le Pape, E., & Hearing, V. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.182 · Cited by 60 · see citing works

In vitro dermal absorption of pyrethroid pesticides in human and rat skin

Hughes, M. F., & Edwards, B. C. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.04.003 · Cited by 59 · see citing works

The stratum corneum: a double paradox

Pouillot, A., Dayan, N., Polla, A. S., Polla, L. L., & Polla, B. S. (2008) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2008.00379.x · Cited by 57 · see citing works

Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model

Frederiksen, M., Stapleton, H. M., Vorkamp, K., Webster, T. F., Jensen, N. M., Sørensen, J. A., Nielsen, F., Knudsen, L. E., Sørensen, L. S., Clausen, P. A., et al. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.01.032 · Cited by 56 · see citing works

Development and evaluation of an artificial membrane for determination of drug availability

Loftsson, Þ., Konrádsdóttir, F., & Másson, M. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.009 · Cited by 55 · see citing works

Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novelin vitro stratum corneummodel in formulation development

Palac, Z., Engesland, A., Flaten, G. E., Škalko‐Basnet, N., Filipović‐Grčić, J., & Vanić, Ž. (2014) · Journal of Liposome Research · doi:10.3109/08982104.2014.899368 · Cited by 54 · see citing works

In vitro reproduction of clinical hallmarks of eczematous dermatitis in organotypic skin models

Engelhart, K., Hindi, T. E., Biesalski, H. K., & Pfitzner, I. (2005) · Archives of Dermatological Research · doi:10.1007/s00403-005-0575-7 · Cited by 53 · see citing works

A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model

Zhang, Y., Lane, M. E., Hadgraft, J., Heinrich, M., Chen, T., Lian, G., & Sinkó, B. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.11.065 · Cited by 52 · see citing works

Therapeutic and immune effects of 5‐aminolevulinic acid photodynamic therapy on UVB ‐induced squamous cell carcinomas in hairless mice

Wang, H., Li, J., Lv, T., Tu, Q., Huang, Z. W., & Wang, X. (2013) · Experimental Dermatology · doi:10.1111/exd.12132 · Cited by 52 · see citing works

Progress in melanoma modelling in vitro

Marconi, A., Quadri, M., Saltari, A., & Pincelli, C. (2018) · Experimental Dermatology · doi:10.1111/exd.13670 · Cited by 51 · see citing works

Deformable liposomes for skin therapy with human epidermal growth factor: The effect of liposomal surface charge

Ternullo, S., Basnet, P., Holsæter, A. M., Flaten, G. E., de Weerd, L., & Škalko‐Basnet, N. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.10.005 · Cited by 49 · see citing works

Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane

Uchino, T., Takezawa, T., & Ikarashi, Y. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2008.12.003 · Cited by 48 · see citing works

Solid Lipid Nanoparticles of Guggul Lipid as Drug Carrier for Transdermal Drug Delivery

Gaur, P. K., Mishra, S., & Purohit, S. (2013) · BioMed Research International · doi:10.1155/2013/750690 · Cited by 47 · see citing works

Development of a 3D human in vitro skin co‐culture model for detecting irritants in real‐time

Cantón, I., Cole, D. M., Kemp, E. H., Watson, P. F., Chunthapong, J., Ryan, A. J., MacNeil, S., & Haycock, J. W. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22742 · Cited by 47 · see citing works

Assessment of the cutaneous immune response duringArthroderma benhamiaeandA. vanbreuseghemiiinfection using an experimental mouse model

Cambier, L., Weatherspoon, A., Defaweux, V., Bagut, E. T., Heinen, M.-P., Antoine, N., & Mignon, B. R. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12673 · Cited by 45 · see citing works

Design, Synthesis of Novel Lipids as Chemical Permeation Enhancers and Development of Nanoparticle System for Transdermal Drug Delivery

Marepally, S. K., Boakye, C. H. A., Shah, P. P., Etukala, J. R., Vemuri, A., & Singh, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082581 · Cited by 45 · see citing works

In vitro and ex vivo infection models help assess the molecular aspects of the interaction of Trichophyton rubrum with the host milieu

Peres, N. T. A., Silva, L. G., Santos, R. D. S., Jacob, T. R., Persinoti, G. F., Rocha, L. B., Falcão, J. P., Rossi, A., & Martinez-Rossi, N. M. (2016) · Medical Mycology · doi:10.1093/mmy/myv113 · Cited by 45 · see citing works

Bioengineered Skin Intended for Skin Disease Modeling

Sarkiri, M., Fox, S., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061407 · Cited by 45 · see citing works

Controlled penetration of ceramides into and across the stratum corneum using various types of microemulsions and formulation associated toxicity studies

Sahle, F. F., Wohlrab, J., & Neubert, R. H. H. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.07.011 · Cited by 44 · see citing works

Epidermal growth factor receptor activation and inhibition in 3 D in vitro models of normal skin and human cutaneous squamous cell carcinoma

Commandeur, S., van Drongelen, V., de Gruijl, F. R., & Ghalbzouri, A. E. (2012) · Cancer Science · doi:10.1111/cas.12026 · Cited by 43 · see citing works

The Structure and Function of Skin

Walters, K., & Roberts, M. (2002) · Drugs and the pharmaceutical sciences · doi:10.1201/9780824743239.ch1 · Cited by 42 · see citing works

New Applications of Phospholipid Vesicle-Based Permeation Assay: Permeation Model Mimicking Skin Barrier

Engesland, A., Skar, M. L., Hansen, T., Škalko‐Basnet, N., & Flaten, G. E. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23509 · Cited by 42 · see citing works

Models for Skin Absorption and Skin Toxicity Testing

Schaefer, U. F., Hansen, S., Schneider, M., contreras, J. L., & Lehr, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-74901-3_1 · Cited by 40 · see citing works

Reconstructed human epidermis for in vitro studies on atopic dermatitis: A review

Huet, F., Severino‐Freire, M., Chéret, J., Gouin, O., Praneuf, J., Pierre, O., Misery, L., & Gall‐Ianotto, C. L. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.11.015 · Cited by 39 · see citing works

Skin corrosion test: a comparison between reconstructed human epidermis and full thickness skin models

Catarino, C. M., Pedrosa, T. D. N., Pennacchi, P. C., de Assis, S. R., Gimenes, F., Consolaro, M. E. L., Barros, S. B. D. M., & Maria–Engler, S. S. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.01.002 · Cited by 39 · see citing works

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Li, L., Fukunaga‐Kalabis, M., & Herlyn, M. (2011) · Journal of Visualized Experiments · doi:10.3791/2937-v · Cited by 39 · see citing works

Influence of drug content, type of semi-solid vehicle and rheological properties on the skin penetration of the model drug fludrocortisone acetate

Nagelreiter, C., Raffeiner, S., Geyerhofer, C., Klang, V., & Valenta, C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.03.042 · Cited by 39 · see citing works

The role of vehicle interactions on permeation of an active through model membranes and human skin

de Oliveira, G. B., Hadgraft, J., & Lane, M. E. (2012) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2012.00753.x · Cited by 39 · see citing works

Release, Uptake, and Permeation Behavior of Salicylic Acid in Ointment Bases

Nakano, M., & Patel, N. K. (1970) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600590714 · Cited by 39 · see citing works

Investigation of the Efficacy of Transdermal Penetration Enhancers Through the Use of Human Skin and a Skin Mimic Artificial Membrane

Balázs, B., Vizserálek, G., Berkó, S., Budai-Szűcs, M., Kelemen, A., Sinkó, B., Takács‐Novák, K., Szabó‐Révész, P., & Csányi, E. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/s0022-3549(15)00172-0 · Cited by 38 · see citing works

Infection of Keratinocytes with Trichophytum rubrum Induces Epidermal Growth Factor-Dependent RNase 7 and Human Beta-Defensin-3 Expression

Firat, Y. H., Simanski, M., Rademacher, F., Schröder, L. C., Brasch, J., & Harder, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093941 · Cited by 38 · see citing works

Cellular interactions of a lipid-based nanocarrier model with human keratinocytes: Unravelling transport mechanisms

Silva, E., Barreiros, L., Segundo, M. A., Lima, S. A. C., & Reis, S. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.057 · Cited by 38 · see citing works

Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma

Burns, E. M., Tober, K. L., Riggenbach, J. A., Schick, J. S., Lamping, K. N., Kusewitt, D. F., Young, G. S., & Oberyszyn, T. M. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs349 · Cited by 37 · see citing works

Phospholipid vesicle-based permeation assay and EpiSkin® in assessment of drug therapies destined for skin administration.

Engesland, A., Škalko-Basnet, N., & Flaten, G. (2015) · Journal of Pharmacy and Science · doi:10.1002/jps.24315 · Cited by 36 · see citing works

In vitro models of dermatophyte infection to investigate epidermal barrier alterations

Faway, É., de Rouvroit, C. L., & Poumay, Y. (2018) · Experimental Dermatology · doi:10.1111/exd.13726 · Cited by 36 · see citing works

Alternatives to animal testing in basic and preclinical research of atopic dermatitis

Löwa, A., Jevtić, M., Gorreja, F., & Hedtrich, S. (2018) · Experimental Dermatology · doi:10.1111/exd.13498 · Cited by 35 · see citing works

17β-carboxamide steroids – in vitro prediction of human skin permeability and retention using PAMPA technique

Dobričić, V., Marković, B. D., Nikolic, K. M., Savić, V., Vladimirov, S. M., & Cudina, O. A. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.10.017 · Cited by 35 · see citing works

Self-assembled nanoparticles of PLGA-conjugated glucosamine as a sustained transdermal drug delivery vehicle

Marimuthu, M., Bennet, D., & Kim, S. (2012) · Polymer Journal · doi:10.1038/pj.2012.103 · Cited by 33 · see citing works

Optimisation of Cosolvent Concentration for Topical Drug Delivery III – Influence of Lipophilic Vehicles on Ibuprofen Permeation

Watkinson, R. M., Guy, R. H., de Oliveira, G. B., Hadgraft, J., & Lane, M. E. (2010) · Skin Pharmacology and Physiology · doi:10.1159/000315139 · Cited by 32 · see citing works

Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas

Singh, A., Singh, A. K., Sand, J. M., Bauer, S. J., Hafeez, B. B., Meske, L. M., & Verma, A. K. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.460 · Cited by 32 · see citing works

An integrated testing strategy for in vitro skin corrosion and irritation assessment using SkinEthic™ Reconstructed Human Epidermis

Alépée, N., Grandidier, M.-H., Tornier, C., & Cotovio, J. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.07.012 · Cited by 32 · see citing works

Modeling dermatophytosis in reconstructed human epidermis: A new tool to study infection mechanisms and to test antifungal agents

Faway, É., Cambier, L., Mignon, B. R., Poumay, Y., & de Rouvroit, C. L. (2016) · Medical Mycology · doi:10.1093/mmy/myw111 · Cited by 32 · see citing works

From the morphological to the transcriptomic characterization of a compromised three-dimensionalin vitromodel mimicking atopic dermatitis

Rouaud, P., Boudier, D., Marchand, L., Barruche, V., Bordes, S., Coppin, H., Roth, M., & Closs, B. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14012 · Cited by 31 · see citing works

Dermatophytes Activate Skin Keratinocytes via Mitogen-Activated Protein Kinase Signaling and Induce Immune Responses

Achterman, R. R., Moyes, D. L., Thavaraj, S., Smith, A. R., Blair, K. M., White, T. C., & Naglik, J. R. (2015) · Infection and Immunity · doi:10.1128/iai.02776-14 · Cited by 31 · see citing works

Roscovitine Inhibits Differentiation and Invasion in a Three-Dimensional Skin Reconstruction Model of Metastatic Melanoma

Mohapatra, S., Coppola, D., Riker, A. I., & Pledger, W. J. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0300 · Cited by 30 · see citing works

Cell Growth and Division

Lynch, M. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780192847287.003.0009 · Cited by 29 · see citing works

Development of a membrane impregnated with a poly(dimethylsiloxane)/poly(ethylene glycol) copolymer for a high-throughput screening of the permeability of drugs, cosmetics, and other chemicals across the human skin

Miki, R., Ichitsuka, Y., Yamada, T., Kimura, S., Egawa, Y., Seki, T., Juni, K., UEDA, H. M. D., & Morimoto, Y. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.09.024 · Cited by 26 · see citing works

Development of a Novel Pre-Vascularized Three-Dimensional Skin Substitute Using Blood Plasma Gel

Dai, N., Huang, W.-S., Chang, F.-W., Wei, L.-G., Huang, T., Li, J.-K., Fu, K., Dai, L., Hsieh, P., Huang, N.-C., et al. (2018) · Cell Transplantation · doi:10.1177/0963689718797570 · Cited by 26 · see citing works

Effect of synthetic surfactants and soapwort (Saponaria officinalis L.) extract on skin-mimetic model lipid monolayers

Jurek, I., Góral, I., Mierzyńska, Z., Moniuszko‐Szajwaj, B., & Wojciechowski, K. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.12.005 · Cited by 26 · see citing works

Photodynamic therapy efficiently controls dermatophytosis caused byTrichophyton rubrumin a murine model

Baltazar, L. M., Werneck, S. M. C., Carneiro, H. C. S., Gouveia, L. F., de Paula, T. P., Byrro, R. M. D., Silva‐Cunha, A., Soares, B. M., Ferreira, M. V. L., Souza, D. G., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13494 · Cited by 24 · see citing works

In vitro models to estimate drug penetration through the compromised stratum corneum barrier

Engesland, A., Škalko‐Basnet, N., & Flaten, G. E. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2016.1171334 · Cited by 24 · see citing works

Development of phospholipid vesicle-based permeation assay models capable of evaluating percutaneous penetration enhancing effect

Ma, M., Di, H., Zhang, H., Yao, J., Dong, J., Yan, G., Qiao, H., & Chen, J. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1371730 · Cited by 24 · see citing works

Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model

Ternullo, S., de Weerd, L., Holsæter, A. M., Flaten, G. E., & Škalko‐Basnet, N. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.09.006 · Cited by 24 · see citing works

A Trichophyton Rubrum Infection Model Based on the Reconstructed Human Epidermis - Episkin®

Liang, P., Huang, X.-Z., Yi, J., Chen, Z., Ma, H., Ye, C., Chen, X.-Y., Lai, W., & Chen, J. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.172573 · Cited by 23 · see citing works

In Vitro Release of Nitroglycerin from Topical Products by Use of Artificial Membranes

Wu, S. T., Shiu, G. K., Simmons, J. E., Bronaugh, R. L., & Skelly, J. P. (1992) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600811204 · Cited by 22 · see citing works

Melanoma therapy with transdermal mitoxantrone cubic phases

Yu, X., Du, L., Zhu, L., Liu, X., Zhang, B., Gui-ying, F., & Jin, Y. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1024898 · Cited by 21 · see citing works

MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma

Filocamo, G., Brunetti, M., Colaceci, F., Sasso, R., Tanori, M., Pasquali, E., Alfonsi, R., Mancuso, M., Saran, A., Lahm, A., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0371 · Cited by 21 · see citing works

The isolated perfused human skin flap model: A missing link in skin penetration studies?

Ternullo, S., de Weerd, L., Flaten, G. E., Holsæter, A. M., & Škalko‐Basnet, N. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.003 · Cited by 18 · see citing works

Activity of terbinafine onTrichophyton mentagrophytesin a human living skin equivalent model

Rashid, A., Edward, M., & Richardson, M. D. (1995) · Medical Mycology · doi:10.1080/02681219580000471 · Cited by 17 · see citing works

Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations

Shakel, Z., Nunes, C., Lima, S. A. C., & Reis, S. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118571 · Cited by 16 · see citing works

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Benny, P., Badowski, C., Lane, E. B., & Raghunath, M. (2016) · Journal of Visualized Experiments · doi:10.3791/53642 · Cited by 15 · see citing works

Investigation of the compatibility of the skin PAMPA model with topical formulation and acceptor media additives using different assay setups

Köllmer, M., Mossahebi, P., Sacharow, E., Gorissen, S., Gräfe, N., Evers, D.-H., & Herbig, M. E. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1305-3 · Cited by 15 · see citing works

Evaluation of the Mechanism of Skin Enhancing Surfactants on the Biomembrane of Shed Snake Skin

Wonglertnirant, N., Ngawhirunpat, T., & Kumpugdee-Vollrath, M. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.523 · Cited by 13 · see citing works

A novel hairless mouse model for malignant melanoma

Thang, N. D., Yajima, I., Nakagawa, K., Tsuzuki, T., Kumasaka, M. Y., Ohgami, N., Ly, B.-T., Iwamoto, T., Watanabe, D., & Kato, M. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.10.010 · Cited by 11 · see citing works

Stratum Corneum

Uchida, Y., & Park, K. (2016) · Springer eBooks · doi:10.1007/978-4-431-55855-2_2 · Cited by 11 · see citing works

A lamellar body mimetic system for the treatment of oxazolone-induced atopic dermatitis in hairless mice

Moner, V., Fernández, E., Calpena, A. C., García‐Herrera, A., Cócera, M., & Serrano, O. L. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.01.010 · Cited by 10 · see citing works

Anatomy and Physiology

Weller, R. O. (2014) · Springer eBooks · doi:10.1007/978-3-642-13706-8_3 · Cited by 9 · see citing works

Reconstructed interfollicular feline epidermis as a model for the screening of antifungal drugs againstMicrosporum canis

Tabart, J., Baldo, A., Vermout, S., Losson, B., & Mignon, B. R. (2008) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2008.00661.x · Cited by 9 · see citing works

A note on integumental (1→3)(1→6)β‐ d ‐glucan permeation, using the porcine ear skin model

Meyer, W., Schoennagel, B., & Fleischer, L. ‐. (2006) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2006.00239.x · Cited by 7 · see citing works

Model Membrane From Shed Snake Skins

Kumpugdee-Vollrath, M., Subongkot, T., & Ngawhirunpat, T. (2013) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.1089203 · Cited by 6 · see citing works

Nanotechnological approaches in drug absorption through skin topical delivery

Lima, S. A. C., & Reis, S. (2018) · doi:10.1201/9781351207355-7 · Cited by 4 · see citing works

Dermal and Transdermal Delivery

Godin, B., & Touítou, E. (2012) · Springer eBooks · doi:10.1007/978-90-481-9751-4_81 · Cited by 4 · see citing works

Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle

Schröder, H., Komljenovic, D., Hecker, M., & Korff, T. (2015) · The FASEB Journal · doi:10.1096/fj.15-279240 · Cited by 2 · see citing works

Human disease models in drug development

Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331 · see citing works

3D-printed microneedle arrays for drug delivery

Li, R., Zhang, L., Jiang, X., Li, L., Wu, S., Yuan, X., Cheng, H., Jiang, X. L., & Gou, M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.022 · Cited by 129 · see citing works

Dermal uptake: An important pathway of human exposure to perfluoroalkyl substances?

Ragnarsdóttir, O., Abdallah, M. A., & Harrad, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119478 · Cited by 122 · see citing works

Microbial Biosurfactant as an Alternate to Chemical Surfactants for Application in Cosmetics Industries in Personal and Skin Care Products: A Critical Review

Karnwal, A., Srivastava, S., Al-Tawaha, A. R., Kumar, G., Singh, R., Kumar, A., Mohan, A., Yogita, & Malik, T. (2023) · BioMed Research International · doi:10.1155/2023/2375223 · Cited by 108 · see citing works

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

Krysiak, Z. J., & Stachewicz, U. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1829 · Cited by 95 · see citing works

Marine polymeric microneedles for transdermal drug delivery

Moniz, T., Lima, S. A. C., & Reis, S. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118098 · Cited by 82 · see citing works

Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin

Esposito, L., Barbosa, A. I., Moniz, T., Lima, S. A. C., Costa, P. C., Celia, C., & Reis, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121149 · Cited by 71 · see citing works

Encapsulation of thymus vulgaris essential oil in caseinate/gelatin nanocomposite hydrogel: In vitro antibacterial activity and in vivo wound healing potential

Alsakhawy, S. A., Baghdadi, H. H., El-Shenawy, M., Sabra, S. A., & El‐Hosseiny, L. S. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122280 · Cited by 71 · see citing works

Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Zoio, P., & Oliva, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030682 · Cited by 65 · see citing works

Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review

Nitsche, K. S., Müller, I. I., Malcomber, S., Carmichael, P. L., & Bouwmeester, H. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03234-0 · Cited by 66 · see citing works

Bioactive lipids in the skin barrier mediate its functionality in health and disease

Nicolaou, A., & Kendall, A. C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108681 · Cited by 56 · see citing works

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin, T., Tonon, G., Botter, E., Canale, V. C., Hasanzadeh, M., Cuscela, D. M., Buschini, A., Zarepour, A., Khosravi, A., Cordani, M., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00312h · Cited by 38 · see citing works

Engineering and Development of a Tissue Model for the Evaluation of Microneedle Penetration Ability, Drug Diffusion, Photothermal Activity, and Ultrasound Imaging: A Promising Surrogate to Ex Vivo and In Vivo Tissues

Makvandi, P., Shabani, M., Rabiee, N., Anjani, Q. K., Maleki, A., Zare‬, E. N., Sabri, A. H. B., Pasquale, D. D., Koskinopoulou, M., Sharifi, E., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210034 · Cited by 37 · see citing works

Influence of enzyme immobilization and skin-sensor interface on non-invasive glucose determination from interstitial fluid obtained by magnetohydrodynamic extraction

Kemp, E., Palomäki, T., Ruuth, I. A., Boeva, Z. A., Nurminen, T. A., Vänskä, R. T., Zschaechner, L. K., Pérez, A. G., Hakala, T. A., Wardale, M., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114123 · Cited by 39 · see citing works

Skin-on-a-chip technologies towards clinical translation and commercialization

Ismayilzada, N., Tarar, C., Dabbagh, S. R., Tokyay, B. K., Dilmani, S. A., Sokullu, E., Abaci, H. E., & Taşoğlu, S. (2024) · Biofabrication · doi:10.1088/1758-5090/ad5f55 · Cited by 37 · see citing works

A Paradigm Shift in Tissue Engineering: From a Top–Down to a Bottom–Up Strategy

Schmidt, T., Yu, X., Bao, X., & Sun, T. (2021) · Processes · doi:10.3390/pr9060935 · Cited by 33 · see citing works

Epidermis-on-a-chip system to develop skin barrier and melanin mimicking model

Li, Q., Wang, C., Li, X., Zhang, J., Zhang, Z., Yang, K., Ouyang, J., Zha, S., Sha, L., Ge, J., et al. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231168529 · Cited by 31 · see citing works

Toxicity assessment of nanoparticles in contact with the skin

Zaiter, T., Cornu, R., Basset, W. E., Martin, H., Diab, M., & Béduneau, A. (2022) · Journal of Nanoparticle Research · doi:10.1007/s11051-022-05523-2 · Cited by 31 · see citing works

A suspended layer additive manufacturing approach to the bioprinting of tri-layered skin equivalents

Moakes, R. J. A., Senior, J. J., Robinson, T. E., Chipara, M., Atansov, A., Naylor, A. J., Metcalfe, A. D., Smith, A. M., & Grover, L. M. (2021) · APL Bioengineering · doi:10.1063/5.0061361 · Cited by 27 · see citing works

Organoids/organs-on-chips towards biomimetic human artificial skin

Huang, Y., Wu, X., Xu, Y., Yang, N., Xi, P., Wang, Y., Zhu, Y., & Chen, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf029 · Cited by 20 · see citing works

Challenges in Psoriasis Research: A Systematic Review of Preclinical Models

Ubago-Rodríguez, A., Quiñones-Vico, M. I., Sánchez‐Díaz, M., la Torre, R. S.-D., Sierra-Sánchez, Á., Montero‐Vílchez, T., Fernández‐González, A., & Arias‐Santiago, S. (2024) · Dermatology · doi:10.1159/000538993 · Cited by 19 · see citing works

Towards skin-on-a-chip for screening the dermal absorption of cosmetics

Govey-Scotland, J., Johnstone, L., Myant, C., & Friddin, M. S. (2023) · Lab on a Chip · doi:10.1039/d3lc00691c · Cited by 17 · see citing works

Effect of Staphylococcus aureus colonization and immune defects on the pathogenesis of atopic dermatitis

Özdemіr, E., & Öksüz, L. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04134-w · Cited by 18 · see citing works

Auxetic incisions with alternating slit shapes: a promising technique for enhancing synthetic skin grafts expansion

Gupta, V., & Chanda, A. (2023) · Materials Research Express · doi:10.1088/2053-1591/ace611 · Cited by 15 · see citing works

Application of the human stratum corneum lipid-based mimetic model in assessment of drug-loaded nanoparticles for skin administration

Moniz, T., Lima, S. A. C., & Reis, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119960 · Cited by 15 · see citing works

Are Antimicrobial Peptides a 21st-Century Solution for Atopic Dermatitis?

Machado, M., Silva, S., & Costa, E. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713460 · Cited by 14 · see citing works

Mechanical characterisation of commercial artificial skin models

Kho, A. S. K., Béguin, S., O’Cearbhaill, E. D., & Annaidh, A. N. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106090 · Cited by 14 · see citing works

Recent advances in in vitro skin-on-a-chip models for drug testing

Sung, J. H., & Kim, J. J. (2023) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2023.2227379 · Cited by 13 · see citing works

Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?

Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11 · see citing works

Octenidine effectively reduces Candida auris colonisation on human skin

Cerbu, D., Seiser, S., Phan-Canh, T., Moser, D., Freystätter, C., Matiasek, J., Kuchler, K., & Elbe‐Bürger, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-11914-x · Cited by 11 · see citing works

Validation and testing of a new artificial biomimetic barrier for estimation of transdermal drug absorption

Magnano, G. C., Sut, S., Dall’Acqua, S., di Cagno, M. P., Lee, L. P., Lee, M. J., Filon, F. L., Perissutti, B., Hasa, D., & Voinovich, D. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122266 · Cited by 11 · see citing works

Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application

Selivanova, N. M., Galeeva, A. I., Зиганшин, М. А., & Galyametdinov, Y. G. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c00929 · Cited by 11 · see citing works

Guidelines for Manufacturing and Application of Organoids: Skin

Lee, S., Rim, Y. A., Kim, J., Lee, S. H., Park, H. J., Kim, H., Ahn, S.-J., & Ju, J. H. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc24045 · Cited by 13 · see citing works

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Xie, J., Yang, Q., Zhang, Y., Zheng, K., Geng, H., & Wu, Y. (2025) · Advanced Science · doi:10.1002/advs.202416863 · Cited by 11 · see citing works

Spheroid-based skin-on-a-chip platform for the evaluation of the toxicity of small molecules and nanoparticles

Kalhori, D., Rakhshani, F., Ma, Y., Yakavets, I., Kheiri, S., Zeyons, O., Kolle, S. N., Deisenroth, T. W., Qu, L., Chen, Z., et al. (2025) · Lab on a Chip · doi:10.1039/d5lc00311c · Cited by 10 · see citing works

A Review of Anti-Inflammatory Phytoconstituents Used in Herbal Cosmeceuticals for the Treatment of Atopic Dermatitis

Gangane, P. S., Sharma, V., Selokar, M., Vidhate, D., Pawar, K., & Mahajan, N. M. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230512110344 · Cited by 10 · see citing works

Systems of conductive skin for power transfer in clinical applications

Kourouklis, A. P., Kaemmel, J., Wu, X., Potapov, E. V., Cesarovic, N., Ferrari, A., Starck, C. T., Falk, V., & Mazza, E. (2021) · European Biophysics Journal · doi:10.1007/s00249-021-01568-8 · Cited by 10 · see citing works

Exceed the Traditional Dead Leather to Intelligent E‐Skin

Yao, Y., Fan, Z., Gong, X., Li, D., Yang, W., Leung, K. C., Wang, X., Liu, S., Yang, J., & Xuan, S. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202500572 · Cited by 9 · see citing works

In vitro assessment of dermal penetration and skin barrier impairment by per- and polyfluoroalkyl substances (PFASs) from consumer products

Zhao, X., Han, Y., Fu, M., Zhou, S., Yang, Y., Zhang, W., Peng, C., Zhang, W., Li, Q., Zhu, Q., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127049 · Cited by 8 · see citing works

An Innovative Fluid Dynamic System to Model Inflammation in Human Skin Explants

Galvan, A., Cappellozza, E., Pellequer, Y., Conti, A., Pozza, E. D., Vigato, E., Malatesta, M., & Calderan, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076284 · Cited by 8 · see citing works

Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture

Jürgens, F. M., Herrmann, F. C., Robledo, S. M., & Schmidt, T. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040742 · Cited by 8 · see citing works

Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment

Sanches, P. L., Carias, R. B. V., Alves, G. G., Catarino, C. M., Bosquetti, B., Costa, M. C. D. C., Canavez, A. D. P. M., Schuck, D. C., Granjeiro, J. M., & Ribeiro, A. R. (2025) · Nanoscale Advances · doi:10.1039/d4na00804a · Cited by 7 · see citing works

Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro

Nuwayhid, R., Ngoc-Huyen, N., Notov, D., Langer, S., & Kurow, O. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1621566 · Cited by 8 · see citing works

Imaging and Characterization of Oxidative Protein Modifications in Skin

Prasad, A., Duchová, H., Manoharan, R. R., Rathi, D., & Pospı́šil, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043981 · Cited by 7 · see citing works

Protocol for the Isolation of Stratum Corneum from Pig Ear Skin: Evaluation of the Trypsin Digestion Conditions

Moniz, T., Lima, S. A. C., & Reis, S. (2021) · Methods and Protocols · doi:10.3390/mps4040080 · Cited by 6 · see citing works

In vitro diffusion of plant phenolics through the skin: A review update

Silva, G. C., Rodrigues, R. A. F., & Bottoli, C. B. G. (2023) · International Journal of Cosmetic Science · doi:10.1111/ics.12927 · Cited by 7 · see citing works

Wetting and Adhesive Properties of Biopolymer-Based Organized Condensed Phases as Drug Delivery Systems

Galeeva, A. I., Selivanova, N. M., & Galyametdinov, Y. G. (2023) · Liquid Crystals and their Application · doi:10.18083/lcappl.2023.4.38 · Cited by 6 · see citing works

Direct Capture and Early Detection of Lyme Disease Spirochete in Skin with a Microneedle Patch

Kight, E., Alfaro, R., Gadila, S. K. G., Chang, S., Evans, D., Embers, M. E., & Haselton, F. R. (2022) · Biosensors · doi:10.3390/bios12100819 · Cited by 6 · see citing works

Saikosaponin A Recovers Impaired Filaggrin Levels in Inflamed Skin by Downregulating the Expression of FRA1 and c-Jun

Ahn, S. S., Yeo, H., Jung, E., Kim, T. Y., Han, J., Lee, Y. H., & Shin, S. Y. (2024) · Molecules · doi:10.3390/molecules29174064 · Cited by 6 · see citing works

The Relationship between Time, Race, and Estrogen Receptor Alpha in Estradiol-Induced Dermal Fibrosis

Frost, D. B., Savchenko, A., Feghali‐Bostwick, C. A., & Wolf, B. J. (2024) · Biomedicines · doi:10.3390/biomedicines12010182 · Cited by 5 · see citing works

Artificial Intelligence in Dermatology Research and Drug Discovery

Utti, V., Bikias, T., Agarwal, A. A., Bikia, V., Zhou, A. Y., Shah, M. M., & Daneshjou, R. (2025) · Dermatologic Clinics · doi:10.1016/j.det.2025.05.008 · Cited by 4 · see citing works

Recent developments in in vitro skin-on-a-chip technology: a narrative review

Kim, J. J., Choi, C. W., & Sung, J. H. (2025) · Journal of Korean Medical Association · doi:10.5124/jkma.25.0081 · Cited by 4 · see citing works

Skin-on-Chip

Chaturvedi, D., Mukherjee, S., Sawant, P., Jain, P. D., & Majumder, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-1379-2_22 · Cited by 4 · see citing works

Disease-related biomarkers as experimental endpoints in 3D skin culture models

Chaturvedi, D., Paranjape, S., Jain, R. D., & Dandekar, P. P. (2023) · Cytotechnology · doi:10.1007/s10616-023-00574-2 · Cited by 4 · see citing works

Development of Pluronic-Based Micelles from Palm Oil Bioactive Compounds Incorporated by a Dissolvable Microarray Patch to Enhance the Efficacy of Atopic Dermatitis Therapy

Jannah, K. H., Ko, C. K., Thios, F. V., Isma, J. N., Aziz, A. Y. R., & Permana, A. D. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00990 · Cited by 4 · see citing works

Advancements in in vitro psoriasis models: relevance for drug discovery and therapeutic development

Devaraj, Jain, D., Maharana, S. K., Sawant, P., & Jain, A. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126097 · Cited by 3 · see citing works

Cell Cultures as a Versatile Tool in the Research and Treatment of Autoimmune Connective Tissue Diseases

Ejma-Multański, A., Wajda, A., & Paradowska‐Gorycka, A. (2023) · Cells · doi:10.3390/cells12202489 · Cited by 3 · see citing works

Transferosomes: Advancing Vesicular Drug Delivery Systems for Dermatological Disorders - A Comprehensive Review

Kumar, A., Kumar, A., Islam, M. M., Gupta, G. D., & Kumar, M. (2024) · Current Nanomedicine · doi:10.2174/0124681873307635240520074626 · Cited by 2 · see citing works

Membrane Stabilization of Helical Previtamin D Conformers as Possible Enhancement of Vitamin D Photoproduction

Smith, A. C., Plazola, M., Hudson, P. S., & Tapavicza, E. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c03835 · Cited by 2 · see citing works

Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs?

Grygor’yeva, L., Carvalheiro, M. C., & Simões, S. (2025) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575358373241220043138 · Cited by 2 · see citing works

The Capacity of Wharton's Jelly to Prolong the Survival of Skin Tissues ex vivo

Minh, N. Q., Dai, N. D., & Than, U. T. T. (2024) · VNU Journal of Science Natural Sciences and Technology · doi:10.25073/2588-1140/vnunst.5593 · Cited by 1 · see citing works

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds

Hacini‐Rachinel, F., Hauchard, A., Bruno, S., Paulat, G., Cojean, C., Loesle, P., Schneider, M. A., Bourne, M., Elain, G., Roth, L., et al. (2024) · Experimental Dermatology · doi:10.1111/exd.15099 · Cited by 1 · see citing works

Skin-on-chip: Quo vadis?

Răileanu, M., Tihăuan, B.-M., Lixandru-Petre, I.-O., Gheorghiu, G.-L., Pîrcălăbioru, G. G., Cioca, G., Iliescu, F. S., & Iliescu, C. (2025) · APL Bioengineering · doi:10.1063/5.0268706 · Cited by 1 · see citing works

Autonomous AI‐Driven Design for Skin Product Formulations

Zhang, Y., Xiao, Y., Chen, C., Tsaoulidis, D. A., Yang, K., & Chen, T. (2026) · Advanced Intelligent Discovery · doi:10.1002/aidi.202500239 · Cited by 1 · see citing works

The influence of the lipid composition on drug permeation though stratum corneum-mimicking biomimetic artificial barriers

Corte, E., Filon, F. L., Abrami, M., Voinovich, D., di Cagno, M. P., & Magnano, G. C. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127170 · Cited by 1 · see citing works

Dimethoate absorption: A complementary in vitro and in vivo assessment

de Andrade, A. R. B., de Carvalho, D. L., Kishishita, J., Pimenta, C. D. A. P., Souza, A. T. M., de Santana, D. P., & Leal, L. B. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103961 · Cited by 1 · see citing works

Human Skin Reconstructs Model Systems in Mechanistic Research, Safety, and Efficacy Studies of Cosmetics: Pros and Cons

Bhat, D., Goyal, S., & Poojan, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-2804-0_3 · Cited by 1 · see citing works

Dermal and Transdermal Novel Drug Delivery Systems

Hashemi, S., Abedin, S., Moghaddam, A. V., & Tabatabaei, M. S. (2024) · doi:10.1002/9781119852476.ch10 · Cited by 1 · see citing works

Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro

Kim, M.-J., Lee, S., & Kang, K.-S. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01840-x

Introduction

Zidarič, T., Kleinschek, K. S., Maver, U., & Maver, T. (2023) · Springer briefs in molecular science · doi:10.1007/978-3-031-21298-7_1

Innovación y desafíos en la medicina regenerativa de tejidos en el Perú

Serquén-López, L. M. (2024) · Revista Experiencia en Medicina del Hospital Regional Lambayeque · doi:10.37065/rem.v10i1.750

Translational potential of test systems in modelling thermal burn wounds

Sultanova, K. T., Kryshen, K. L., & Makarova, M. N. (2024) · Translational Medicine · doi:10.18705/2311-4495-2024-11-4-334-341

Investigation of Light Propagation in Human Skin Using Zemax OpticStudio

Mallick, S. P., Parishkrith, A., Sajeevan, A., Sooraj, R. S., Sharma, V., & Gopal, R. (2024) · Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) · doi:10.1109/cleo-pr60912.2024.10676621

Bio-metal-organic framework-enhanced acrylate pressure-sensitive adhesive for transdermal drug delivery with improved adhesion and drug release

Liu, X., Dong, X., Song, Z., Nan, L., & Guo, J. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.175783

Effect of Microfocused Ultrasound on the Rheological Properties of Crosslinked Hyaluronic Acid: An In Vitro Study

Pinheiro, F. L., Barradas, T. N., dos Santos, A. R., & Pereira, W. C. D. A. (2026) · Global Medical Engineering Physics Exchanges/Pan American Health Care Exchanges (GMEPE/PAHCE) · doi:10.1109/gmepe/pahce69420.2026.11550294

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Surucu, Y., Malekzadeh, H., Hernandez, A. R. D. R., Mahajan, N., Banks, E., Rahman, D. I. A., Arellano, J. A., Yang, K. S., Altman, A., Kumar, G. V. N., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71445

Advances in organoids for drug development: From discovery to delivery

Liang, J., Yao, H., Feng, Y., Shu, X., Zheng, Y., Gao, X., & Zhou, W. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108876

Three-Dimensional Human Skin Models for Translational Dermatology: Current Platforms, Applications, and Open Questions

Toral-Orduno, J., Reddy, R. D., & Yusuf, N. (2026) · International Journal of Translational Medicine · doi:10.3390/ijtm6030039

Pharmacokinetic Relevance of In Vitro Skin Models: Absorption, Cutaneous Distribution, Metabolism, and Clearance-like Removal in Dermal and Transdermal Drug Testing

DUGONIK, F., JERŠIČ, U., KAČ, L., Maver, U., & Maver, T. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091152

Mimicking skin: healthy and disease models for transdermal permeation studiesPreprint

Moniz, T., Lima, S. A. C., & Reis, S. (2020) · doi:10.22541/au.158471540.05280788

Enhancing Transcutaneous Drug Delivery: Advanced Perspectives on Skin Models

Ribeiro, A. R., Pereira‐Leite, C., Rosado, C., Aruci, E., Colley, H. E., Krohn, I. K., Baldea, I., Pantelić, I., Fluhr, J. W., Simões, S., et al. (2024) · JID Innovations · doi:10.1016/j.xjidi.2024.100340 · Cited by 12 · see citing works

Skin models of cutaneous toxicity, transdermal transport and wound repair

Vilela de Sousa, I., Ferreira, M. J. S., Bebiano, L. B., Simões, S., Matos, A. F., Pereira, R. F., & Granja, P. L. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad014 · Cited by 17 · see citing works

Skin Models for Drug Development and Biopharmaceutical Industry

Ruffner, H., Graf‐Hausner, U., & Mathes, S. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801654-1.00018-8 · Cited by 1 · see citing works

The use of skin models in drug development

Mathes, S. H., Ruffner, H., & Graf‐Hausner, U. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.006 · Cited by 321 · see citing works